Author: Daniel J Smith

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Preprints

Polygenic Risk for Schizophrenia, Brain Structure and Environmental Risk in UK Biobank

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci

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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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Seasonal and Daytime Variation in Multiple Immune Parameters in Humans: Evidence from 329,261 Participants of the UK Biobank Cohort

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Cannabis use and risk of schizophrenia: a Mendelian randomization study

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Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia.

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Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

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Visual Biochemistry: modular microfluidics enables kinetic insight from time-resolved cryo-EM

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Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

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Genome-wide analysis of risk-taking behaviour and cross-disorder genetic correlations in 116,255 individuals from the UK Biobank cohort

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The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

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Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

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Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure.

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Alzheimer's disease susceptibility gene apolipoprotein e (APOE) and blood biomarkers in UK Biobank (N=395,769).

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Carotid intima-media thickness in UK Biobank: Identification of novel genome-wide loci, sex-specific effects and genetic correlations with obesity and glucometabolic traits.

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Antihypertensive medications as repurposed treatments for mood disorders: analysis of linked healthcare data for 1.8 million patients

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Sex-Stratified Genome-Wide Association Study of Multisite Chronic Pain in UK Biobank

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Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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Novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide.

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Living alone, loneliness and lack of emotional support as predictors of suicide and self-harm: seven-year follow up of the UK Biobank cohort

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Mental Health in UK Biobank Revised

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Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

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Accelerometry-assessed sleep duration and timing in late childhood and adolescence in Scottish schoolchildren: a feasibility study.

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Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank

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The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals

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Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5.

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Comparison of algorithm-based versus single-item phenotyping measures of depression and anxiety disorders in the GLAD Study cohort

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Lack of evidence for interactions between APOE and Klotho genotypes on cognitive, dementia and brain imaging metrics in UK Biobank

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Protocol for rapid implementation of a SARS-CoV-2 sero-survey during the 2020 COVID-19 pandemic: who, where, how?

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