Author: Daniel J. Smith

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci

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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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Cannabis use and risk of schizophrenia: a Mendelian randomization study

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Comparative genetic architectures of schizophrenia in East Asian and European populations

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Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia.

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Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

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Genome-wide analysis of risk-taking behaviour and cross-disorder genetic correlations in 116,255 individuals from the UK Biobank cohort

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Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

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Visual Biochemistry: modular microfluidics enables kinetic insight from time-resolved cryo-EM

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The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

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Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

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Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure.

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Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: meta-analysis of three treatment cohorts.

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Novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide.

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Genome-wide association study of circadian rhythmicity in 71 500 UK Biobank participants and polygenic association with mood instability

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Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

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Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5.

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