Author: Michael C O'Donovan

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Preprints

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,129
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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,029
  • In genomics: 216
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  • Site-wide: 15,119

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

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  • Site-wide: 2,763
  • In genetic and genomic medicine: 8
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Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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  • Site-wide: 3,001
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Psychiatric Genomics: An Update and an Agenda

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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

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  • Site-wide: 4,835
  • In genomics: 563
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Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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  • Site-wide: 5,053
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Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

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Sex differences in gene expression in the human fetal brain

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Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

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  • Site-wide: 10,155
  • In psychiatry and clinical psychology: 32
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  • Site-wide: 3,241

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 59,275
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  • Site-wide: 55,050

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 11,926
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  • Site-wide: 54,567

Genetic association study of psychotic experiences in UK Biobank

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  • Site-wide: 27,950
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  • Site-wide: 44,586
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The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

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  • Site-wide: 28,131
  • In genetics: 1,400
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Association between schizophrenia and both loss of function and missense mutations in paralog conserved sites of voltage-gated sodium channels

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Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia

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  • Site-wide: 30,583
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Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.

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  • Site-wide: 37,631
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A Transcriptome Wide Association Study implicates specific pre- and post-synaptic abnormalities in Schizophrenia

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  • Site-wide: 37,654
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Synaptic protein DLG2 controls neurogenic transcriptional programs disrupted in schizophrenia and related disorders

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  • Site-wide: 38,451
  • In genetics: 1,877
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Investigating the potential effect of antihypertensive medication on psychiatric disorders: a mendelian randomisation study

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  • Site-wide: 44,229
  • In genetic and genomic medicine: 124
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Genetic association of FMRP targets with psychiatric disorders

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  • Site-wide: 46,706
  • In neuroscience: 6,848
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  • Site-wide: 37,856
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  • Site-wide: 24,191

The independent and combined influence of schizophrenia polygenic risk score and heavy cannabis use on risk for psychotic disorder: A case-control analysis from the EUGEI study.

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  • Site-wide: 47,592
  • In genetics: 2,277
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  • Site-wide: 36,320
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Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

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  • Site-wide: 48,593
  • In genetics: 2,321
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Dynamic expression of risk genes for schizophrenia and bipolar disorder across development

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  • Site-wide: 52,895
  • In neuroscience: 7,911
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The role of rare copy number variants in depression

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  • Site-wide: 55,430
  • In neuroscience: 8,337
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  • Site-wide: 79,357

Effects of pathogenic CNVs on physical traits in participants of the UK Biobank

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  • Site-wide: 55,708
  • In genetics: 2,643
• Year to date:
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  • Site-wide: 37,975

Meta-analysis of Scandinavian Schizophrenia Exomes

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  • Site-wide: 57,535
  • In genetics: 2,717
• Year to date:
  • Site-wide: 40,199
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  • Site-wide: 42,958

Schizophrenia polygenic risk score and cannabis use modify psychosis expression in first episode psychosis patients and population controls

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  • Site-wide: 63,330
  • In psychiatry and clinical psychology: 189
• Year to date:
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  • Site-wide: 40,178

Novel Insight into the Aetiology of Autism Spectrum Disorder Gained by Integrating Expression Data with Genome-wide Association Statistics

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  • In genomics: 4,633
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Identifying novel subtypes of irritability using a developmental genetic approach

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  • Site-wide: 68,486
  • In genetics: 3,193
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  • Site-wide: 105,013
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  • Site-wide: 93,299

Differences in Genetic Liability for Insomnia and Hypersomnia in Bipolar Disorder Subtypes

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  • Site-wide: 70,194
  • In genomics: 4,891
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  • Site-wide: 80,099

The rate of de novo CNVs in healthy controls

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  • Site-wide: 73,820
  • In genomics: 5,035
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  • Site-wide: 86,838

Effects of pathogenic CNVs on biochemical markers: a study on the UK Biobank

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  • Site-wide: 82,844
  • In genomics: 5,380
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  • Site-wide: 32,148

Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by mutation of the psychiatric risk gene Cacna1c

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  • Site-wide: 101,169
  • In neuroscience: 15,817
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  • Site-wide: 46,725

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

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  • Site-wide: 102,282
  • In genetic and genomic medicine: 396
• Year to date:
  • Site-wide: 53,769
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  • Site-wide: 48,400

Clozapine metabolism is associated with Absolute Neutrophil Count in individuals with treatment-resistant schizophrenia

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  • Site-wide: 123,144
  • In pharmacology and therapeutics: 97
• Year to date:
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