Author: Mike A Nalls

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Preprints

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

• Downloaded 10,602 times
• Download rankings, all-time:
  • Site-wide: 692
  • In genetics: 20
• Year to date:
  • Site-wide: 2,845
• Since beginning of last month:
  • Site-wide: 2,845

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,069 times
• Download rankings, all-time:
  • Site-wide: 3,715
  • In genetics: 164
• Year to date:
  • Site-wide: 33,644
• Since beginning of last month:
  • Site-wide: 33,644

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

• Downloaded 2,966 times
• Download rankings, all-time:
  • Site-wide: 3,881
  • In genomics: 457
• Year to date:
  • Site-wide: 1,254
• Since beginning of last month:
  • Site-wide: 1,254

Predicting onset, progression, and clinical subtypes of Parkinson disease using machine learning

• Downloaded 2,641 times
• Download rankings, all-time:
  • Site-wide: 4,610
  • In neuroscience: 426
• Year to date:
  • Site-wide: 10,808
• Since beginning of last month:
  • Site-wide: 10,808

Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms

• Downloaded 1,345 times
• Download rankings, all-time:
  • Site-wide: 12,482
  • In genetics: 632
• Year to date:
  • Site-wide: 46,714
• Since beginning of last month:
  • Site-wide: 46,714

Genome-wide association study of Parkinson’s disease progression biomarkers in 12 longitudinal patients’ cohorts

• Downloaded 1,262 times
• Download rankings, all-time:
  • Site-wide: 13,743
  • In genetics: 708
• Year to date:
  • Site-wide: 27,720
• Since beginning of last month:
  • Site-wide: 27,720

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,236 times
• Download rankings, all-time:
  • Site-wide: 14,181
  • In genomics: 1,509
• Year to date:
  • Site-wide: 60,212
• Since beginning of last month:
  • Site-wide: 60,212

Enrichment of rare protein truncating variants in amyotrophic lateral sclerosis patients

• Downloaded 1,185 times
• Download rankings, all-time:
  • Site-wide: 15,102
  • In genomics: 1,596
• Year to date:
  • Site-wide: 81,504
• Since beginning of last month:
  • Site-wide: 81,504

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability

• Downloaded 903 times
• Download rankings, all-time:
  • Site-wide: 22,545
  • In genomics: 2,231
• Year to date:
  • Site-wide: 82,930
• Since beginning of last month:
  • Site-wide: 82,930

Genetic modifiers of risk and age at onset in GBA associated Parkinson disease and Lewy body dementia

• Downloaded 806 times
• Download rankings, all-time:
  • Site-wide: 26,468
  • In genetics: 1,325
• Year to date:
  • Site-wide: 26,474
• Since beginning of last month:
  • Site-wide: 26,474

The Parkinson's Disease GWAS Locus Browser

• Downloaded 799 times
• Download rankings, all-time:
  • Site-wide: 26,803
  • In genetics: 1,339
• Year to date:
  • Site-wide: 14,114
• Since beginning of last month:
  • Site-wide: 14,114

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 794 times
• Download rankings, all-time:
  • Site-wide: 27,006
  • In genetics: 1,347
• Year to date:
  • Site-wide: 24,303
• Since beginning of last month:
  • Site-wide: 24,303

Dopaminergic stimulants and risk of Parkinson's disease

• Downloaded 777 times
• Download rankings, all-time:
  • Site-wide: 27,855
  • In pharmacology and therapeutics: 33
• Year to date:
  • Site-wide: 6,892
• Since beginning of last month:
  • Site-wide: 6,892

The Parkinson's Phenome: Traits Associated with Parkinson's Disease in a Large and Deeply Phenotyped Cohort

• Downloaded 762 times
• Download rankings, all-time:
  • Site-wide: 28,617
  • In epidemiology: 1,468
• Year to date:
  • Site-wide: 108,718
• Since beginning of last month:
  • Site-wide: 108,718

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 746 times
• Download rankings, all-time:
  • Site-wide: 29,509
  • In genomics: 2,699
• Year to date:
  • Site-wide: 61,125
• Since beginning of last month:
  • Site-wide: 61,125

Genetic variability and potential effects on clinical trial outcomes: perspectives in Parkinson's disease

• Downloaded 726 times
• Download rankings, all-time:
  • Site-wide: 30,657
  • In genomics: 2,781
• Year to date:
  • Site-wide: 33,930
• Since beginning of last month:
  • Site-wide: 33,930

Parkinsons disease determinants, prediction and gene-environment interactions in the UK Biobank

• Downloaded 683 times
• Download rankings, all-time:
  • Site-wide: 33,292
  • In genetics: 1,645
• Year to date:
  • Site-wide: 32,131
• Since beginning of last month:
  • Site-wide: 32,131

Predicting Alzheimer’s disease progression trajectory and clinical subtypes using machine learning

• Downloaded 672 times
• Download rankings, all-time:
  • Site-wide: 34,018
  • In neuroscience: 4,772
• Year to date:
  • Site-wide: 20,867
• Since beginning of last month:
  • Site-wide: 20,867

The genetic architecture of Parkinson disease in Spain: characterizing population-specific risk, differential haplotype structures, and providing etiologic insight

• Downloaded 642 times
• Download rankings, all-time:
  • Site-wide: 36,198
  • In neuroscience: 5,133
• Year to date:
  • Site-wide: 49,885
• Since beginning of last month:
  • Site-wide: 49,885

Genetic variation within genes associated with mitochondrial function is significantly associated with later age at onset of Parkinson disease and contributes to disease risk

• Downloaded 584 times
• Download rankings, all-time:
  • Site-wide: 40,789
  • In genetics: 1,965
• Year to date:
  • Site-wide: 69,611
• Since beginning of last month:
  • Site-wide: 69,611

Penetrance of Parkinson’s disease in LRRK2 p.G2019S carriers is modified by a polygenic risk score

• Downloaded 528 times
• Download rankings, all-time:
  • Site-wide: 46,189
  • In genetics: 2,220
• Year to date:
  • Site-wide: 47,087
• Since beginning of last month:
  • Site-wide: 47,087

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 504 times
• Download rankings, all-time:
  • Site-wide: 48,714
  • In neuroscience: 7,219
• Year to date:
  • Site-wide: 85,624
• Since beginning of last month:
  • Site-wide: 85,624

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 49,067
  • In genomics: 3,898
• Year to date:
  • Site-wide: 98,937
• Since beginning of last month:
  • Site-wide: 98,937

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

• Downloaded 496 times
• Download rankings, all-time:
  • Site-wide: 49,643
  • In molecular biology: 1,412
• Year to date:
  • Site-wide: 89,859
• Since beginning of last month:
  • Site-wide: 89,859

Regulatory sites for known and novel splicing in human basal ganglia are enriched for disease-relevant information

• Downloaded 410 times
• Download rankings, all-time:
  • Site-wide: 60,947
  • In bioinformatics: 6,025
• Year to date:
  • Site-wide: 62,370
• Since beginning of last month:
  • Site-wide: 62,370

Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

• Downloaded 406 times
• Download rankings, all-time:
  • Site-wide: 61,545
  • In genetics: 2,927
• Year to date:
  • Site-wide: 43,959
• Since beginning of last month:
  • Site-wide: 43,959

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 385 times
• Download rankings, all-time:
  • Site-wide: 64,806
  • In sexual and reproductive health: 30
• Year to date:
  • Site-wide: 1,536
• Since beginning of last month:
  • Site-wide: 1,536

Genome-wide estimates of heritability and genetic correlations in Essential Tremor

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 68,888
  • In genetics: 3,229
• Year to date:
  • Site-wide: 69,830
• Since beginning of last month:
  • Site-wide: 69,830

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

• Downloaded 349 times
• Download rankings, all-time:
  • Site-wide: 70,802
  • In genetics: 3,315
• Year to date:
  • Site-wide: 46,904
• Since beginning of last month:
  • Site-wide: 46,904

Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

• Downloaded 320 times
• Download rankings, all-time:
  • Site-wide: 76,061
  • In neurology: 168
• Year to date:
  • Site-wide: 32,416
• Since beginning of last month:
  • Site-wide: 32,416

Comprehensive assessment of PINK1 variants in Parkinson's disease

• Downloaded 299 times
• Download rankings, all-time:
  • Site-wide: 80,155
  • In genetic and genomic medicine: 257
• Year to date:
  • Site-wide: 75,663
• Since beginning of last month:
  • Site-wide: 75,663

Differences in the presentation and progression of Parkinson's disease by sex

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 85,048
  • In neurology: 206
• Year to date:
  • Site-wide: 76,156
• Since beginning of last month:
  • Site-wide: 76,156

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 89,202
  • In genetics: 4,094
• Year to date:
  • Site-wide: 114,497
• Since beginning of last month:
  • Site-wide: 114,497

Biomarkers of Parkinson's Disease: Screening Vital Signs and Routine Blood Tests

• Downloaded 243 times
• Download rankings, all-time:
  • Site-wide: 91,901
  • In neurology: 240
• Year to date:
  • Site-wide: 31,871
• Since beginning of last month:
  • Site-wide: 31,871

Evidence for GRN as part of a neuroinflammatory mechanism connecting common neurodegenerative diseases.

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 94,533
  • In neurology: 255
• Year to date:
  • Site-wide: 39,846
• Since beginning of last month:
  • Site-wide: 39,846

Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes

• Downloaded 198 times
• Download rankings, all-time:
  • Site-wide: 101,607
  • In genomics: 6,002
• Year to date:
  • Site-wide: 45,017
• Since beginning of last month:
  • Site-wide: 45,017

Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource

• Downloaded 192 times
• Download rankings, all-time:
  • Site-wide: 102,883
  • In neurology: 317
• Year to date:
  • Site-wide: 26,924
• Since beginning of last month:
  • Site-wide: 26,924

The Parkinson's Disease DNA Variant Browser

• Downloaded 186 times
• Download rankings, all-time:
  • Site-wide: 104,256
  • In genetic and genomic medicine: 413
• Year to date:
  • Site-wide: 42,412
• Since beginning of last month:
  • Site-wide: 42,412

A population scale analysis of rare SNCA variation in the UK Biobank

• Downloaded 164 times
• Download rankings, all-time:
  • Site-wide: 108,505
  • In genetic and genomic medicine: 450
• Year to date:
  • Site-wide: 39,982
• Since beginning of last month:
  • Site-wide: 39,982