Author: Nevan J. Krogan

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Preprints

The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

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A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

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An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

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A CRISPR-Cas9 Genome Engineering Platform in Primary CD4+ T Cells for the Interrogation of HIV Host Factors

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Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses

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BAF chromatin remodeling complex subunit diversity promotes temporally distinct gene expression programs in cardiogenes

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Efficient Generation of Isogenic Primary Human Myeloid Cells using CRISPR-Cas9 Ribonucleoproteins

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Adhesion-mediated mechanosignaling forces mitohormesis

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SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells

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Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins

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Delineation of the SUMO-Modified Proteome Reveals Regulatory Functions Throughout Meiosis

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The cellular NMD pathway restricts Zika virus infection and is targeted by the viral capsid protein

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An Mtb-Human Protein-Protein Interaction Map Reveals that Bacterial LpqN Antagonizes CBL, a Host Ubiquitin Ligase that Regulates the Balance Between Anti-Viral and Anti-Bacterial Responses

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Global proteomic profiling of primary macrophages during M. tuberculosis infection identifies TAX1BP1 as a mediator of autophagy targeting

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Biophysical basis of cellular multi-specificity encoded in a model molecular switch

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Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

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Two accessory proteins govern MmpL3 mycolic acid transport in mycobacteria

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A tyrosine kinase protein interaction map reveals targetable EGFR network oncogenesis in lung cancer

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Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

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Conservation and structural analysis of the Xenopus laevis phospho-proteome

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Smoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits

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Dynamic proteomics profiling of Legionella pneumophila infection unveils modulation of the host mitochondrial stress response pathway

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Protein Moonlighting Revealed by Non-Catalytic Phenotypes of Yeast Enzymes

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Chaperone-Mediated Reflux of Secretory Proteins to the Cytosol During Endoplasmic Reticulum Stress

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Brown adipocyte NOSEMPE promotes nonmitochondrial thermogenesis and improves systemic metabolism through ATF4 activation

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Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the viral Core

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Comparative analysis of macrophage post-translational modifications during intracellular bacterial pathogen infection

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Non-canonical proline-tyrosine interactions with multiple host proteins regulate Ebola virus infection

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The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae

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Bimodal evolution of Src and Abl kinase substrate specificity revealed using mammalian cell extract as substrate pool

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