Author: Nevan J. Krogan

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Preprints

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

• Downloaded 171,829 times
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  • Site-wide: 18
  • In systems biology: 1
• Year to date:
  • Site-wide: 162
• Since beginning of last month:
  • Site-wide: 225

Test performance evaluation of SARS-CoV-2 serological assays

• Downloaded 37,465 times
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  • Site-wide: 136
  • In infectious diseases: 55
• Year to date:
  • Site-wide: 363
• Since beginning of last month:
  • Site-wide: 460

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

• Downloaded 17,883 times
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  • Site-wide: 334
  • In biochemistry: 2
• Year to date:
  • Site-wide: 1,029
• Since beginning of last month:
  • Site-wide: 799

Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses

• Downloaded 2,460 times
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  • Site-wide: 4,803
  • In microbiology: 282
• Year to date:
  • Site-wide: 3,972
• Since beginning of last month:
  • Site-wide: 1,656

A CRISPR-Cas9 Genome Engineering Platform in Primary CD4+ T Cells for the Interrogation of HIV Host Factors

• Downloaded 2,421 times
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  • Site-wide: 4,937
  • In systems biology: 85
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 15,017

SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells

• Downloaded 1,370 times
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  • Site-wide: 11,515
  • In bioinformatics: 1,454
• Year to date:
  • Site-wide: 3,812
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  • Site-wide: 4,116

Adhesion-mediated mechanosignaling forces mitohormesis

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  • Site-wide: 11,654
  • In cell biology: 330
• Year to date:
  • Site-wide: 5,946
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  • Site-wide: 9,462

Efficient Generation of Isogenic Primary Human Myeloid Cells using CRISPR-Cas9 Ribonucleoproteins

• Downloaded 1,232 times
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  • Site-wide: 13,488
  • In genetics: 698
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 26,816

BAF chromatin remodeling complex subunit diversity promotes temporally distinct gene expression programs in cardiogenes

• Downloaded 1,188 times
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  • Site-wide: 14,232
  • In developmental biology: 230
• Year to date:
  • Site-wide: 61,632
• Since beginning of last month:
  • Site-wide: 44,520

Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins

• Downloaded 1,089 times
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  • Site-wide: 16,259
  • In molecular biology: 450
• Year to date:
  • Site-wide: 17,927
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  • Site-wide: 36,136

Delineation of the SUMO-Modified Proteome Reveals Regulatory Functions Throughout Meiosis

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  • Site-wide: 17,636
  • In genetics: 904
• Year to date:
  • Site-wide: 19,745
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  • Site-wide: 25,461

The cellular NMD pathway restricts Zika virus infection and is targeted by the viral capsid protein

• Downloaded 909 times
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  • Site-wide: 21,142
  • In microbiology: 1,206
• Year to date:
  • Site-wide: 77,746
• Since beginning of last month:
  • Site-wide: 74,323

Biophysical basis of cellular multi-specificity encoded in a model molecular switch

• Downloaded 832 times
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  • Site-wide: 24,080
  • In systems biology: 525
• Year to date:
  • Site-wide: 12,722
• Since beginning of last month:
  • Site-wide: 40,562

Global proteomic profiling of primary macrophages during M. tuberculosis infection identifies TAX1BP1 as a mediator of autophagy targeting

• Downloaded 824 times
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  • Site-wide: 24,440
  • In microbiology: 1,416
• Year to date:
  • Site-wide: 43,648
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  • Site-wide: 44,400

An Mtb-Human Protein-Protein Interaction Map Reveals that Bacterial LpqN Antagonizes CBL, a Host Ubiquitin Ligase that Regulates the Balance Between Anti-Viral and Anti-Bacterial Responses

• Downloaded 820 times
• Download rankings, all-time:
  • Site-wide: 24,602
  • In microbiology: 1,421
• Year to date:
  • Site-wide: 44,181
• Since beginning of last month:
  • Site-wide: 67,147

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

• Downloaded 779 times
• Download rankings, all-time:
  • Site-wide: 26,389
  • In microbiology: 1,547
• Year to date:
  • Site-wide: 51,062
• Since beginning of last month:
  • Site-wide: 56,336

A tyrosine kinase protein interaction map reveals targetable EGFR network oncogenesis in lung cancer

• Downloaded 702 times
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  • Site-wide: 30,434
  • In cancer biology: 820
• Year to date:
  • Site-wide: 21,885
• Since beginning of last month:
  • Site-wide: 28,350

Two accessory proteins govern MmpL3 mycolic acid transport in mycobacteria

• Downloaded 653 times
• Download rankings, all-time:
  • Site-wide: 33,582
  • In microbiology: 1,999
• Year to date:
  • Site-wide: 16,079
• Since beginning of last month:
  • Site-wide: 70,391

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

• Downloaded 620 times
• Download rankings, all-time:
  • Site-wide: 35,921
  • In cancer biology: 976
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 104,579

Conservation and structural analysis of the Xenopus laevis phospho-proteome

• Downloaded 587 times
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  • Site-wide: 38,496
  • In evolutionary biology: 2,074
• Year to date:
  • Site-wide: 108,490
• Since beginning of last month:
  • Site-wide: 90,762

Smoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits

• Downloaded 563 times
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  • Site-wide: 40,570
  • In biochemistry: 1,025
• Year to date:
  • Site-wide: 26,505
• Since beginning of last month:
  • Site-wide: 33,843

Dynamic proteomics profiling of Legionella pneumophila infection unveils modulation of the host mitochondrial stress response pathway

• Downloaded 555 times
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  • Site-wide: 41,244
  • In cell biology: 1,740
• Year to date:
  • Site-wide: 8,740
• Since beginning of last month:
  • Site-wide: 32,914

Protein Moonlighting Revealed by Non-Catalytic Phenotypes of Yeast Enzymes

• Downloaded 412 times
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  • Site-wide: 57,830
  • In genetics: 2,778
• Year to date:
  • Site-wide: 99,250
• Since beginning of last month:
  • Site-wide: 73,932

Chaperone-Mediated Reflux of Secretory Proteins to the Cytosol During Endoplasmic Reticulum Stress

• Downloaded 404 times
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  • Site-wide: 58,917
  • In cell biology: 2,615
• Year to date:
  • Site-wide: 72,452
• Since beginning of last month:
  • Site-wide: 83,242

Comparative analysis of macrophage post-translational modifications during intracellular bacterial pathogen infection

• Downloaded 392 times
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  • Site-wide: 60,739
  • In microbiology: 4,088
• Year to date:
  • Site-wide: 22,555
• Since beginning of last month:
  • Site-wide: 29,858

Brown adipocyte NOSEMPE promotes nonmitochondrial thermogenesis and improves systemic metabolism through ATF4 activation

• Downloaded 383 times
• Download rankings, all-time:
  • Site-wide: 62,145
  • In physiology: 436
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 91,533

Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the viral Core

• Downloaded 381 times
• Download rankings, all-time:
  • Site-wide: 62,388
  • In microbiology: 4,232
• Year to date:
  • Site-wide: 107,623
• Since beginning of last month:
  • Site-wide: 91,435

The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

• Downloaded 239 times
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  • Site-wide: 88,777
  • In molecular biology: 2,653
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 36,201

Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes

• Downloaded 220 times
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  • Site-wide: 92,783
  • In genetics: 4,306
• Year to date:
  • Site-wide: 501
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  • Site-wide: None

Non-canonical proline-tyrosine interactions with multiple host proteins regulate Ebola virus infection

• Downloaded 193 times
• Download rankings, all-time:
  • Site-wide: 98,561
  • In microbiology: 7,372
• Year to date:
  • Site-wide: 76,960
• Since beginning of last month:
  • Site-wide: 76,177

Zika Virus Infection Prevents Host mRNA Nuclear Export by Disrupting UPF1 Function

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 101,550
  • In microbiology: 7,639
• Year to date:
  • Site-wide: 13,748
• Since beginning of last month:
  • Site-wide: 2,795

Bimodal evolution of Src and Abl kinase substrate specificity revealed using mammalian cell extract as substrate pool

• Downloaded 110 times
• Download rankings, all-time:
  • Site-wide: 114,099
  • In biochemistry: 3,467
• Year to date:
  • Site-wide: 57,303
• Since beginning of last month:
  • Site-wide: 47,837

The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae

• Downloaded 106 times
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  • Site-wide: 114,780
  • In genetics: 5,028
• Year to date:
  • Site-wide: 63,583
• Since beginning of last month:
  • Site-wide: 111,660

Endosomal cAMP production broadly impacts the cellular phosphoproteome

• Downloaded 73 times
• Download rankings, all-time:
  • Site-wide: 119,858
  • In cell biology: 5,535
• Year to date:
  • Site-wide: 2,315
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  • Site-wide: None