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Author: Phillip De Jager

Rankings

  • All-time downloads: 49,722 (rank: 2,664 )
  • Categories:
    • bioinformatics: 709 (rank: 18,509 (tie) )
    • cell biology: 1,430 (rank: 4,513 (tie) )
    • genetic and genomic medicine: 626 (rank: 2,730 (tie) )
    • genetics: 17,011 (rank: 796 )
    • genomics: 10,219 (rank: 1,739 )
    • immunology: 1,718 (rank: 4,635 )
    • neuroscience: 11,186 (rank: 972 )
    • pathology: 4,222 (rank: 269 (tie) )
    • systems biology: 2,601 (rank: 1,422 )

Downloads per author, site-wide

Preprints

Genetic determinants of co-accessible chromatin regions in T cell activation across humans

genomics more details view paper
  • Downloaded 5,019 times
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    • Site-wide: 1,846
    • In genomics: 191
  • Year to date:
    • Site-wide: 35,206
  • Since beginning of last month:
    • Site-wide: 23,522

A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain

neuroscience more details view paper
  • Downloaded 4,313 times
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    • Site-wide: 2,293
    • In neuroscience: 151
  • Year to date:
    • Site-wide: 22,325
  • Since beginning of last month:
    • Site-wide: 13,625

EXCEPTIONALLY LOW LIKELIHOOD OF ALZHEIMER'S DEMENTIA IN APOE2 HOMOZYGOTES

pathology more details view paper
  • Downloaded 4,072 times
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    • Site-wide: 2,474
    • In pathology: 18
  • Year to date:
    • Site-wide: 23,858
  • Since beginning of last month:
    • Site-wide: 27,839

A Bayesian approach to mediation analysis predicts 206 causal target genes in Alzheimer's disease

genetics more details view paper
  • Downloaded 3,309 times
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    • Site-wide: 3,360
    • In genetics: 136
  • Year to date:
    • Site-wide: 15,724
  • Since beginning of last month:
    • Site-wide: 16,671

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

genetics more details view paper
  • Downloaded 3,247 times
  • Download rankings, all-time:
    • Site-wide: 3,473
    • In genetics: 149
  • Year to date:
    • Site-wide: 25,922
  • Since beginning of last month:
    • Site-wide: 26,882

A Consensus Proteomic Analysis of Alzheimer’s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation

systems biology more details view paper
  • Downloaded 2,102 times
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    • Site-wide: 6,474
    • In systems biology: 113
  • Year to date:
    • Site-wide: 19,254
  • Since beginning of last month:
    • Site-wide: 14,547

Integrative analyses of splicing in the aging brain: role in susceptibility to Alzheimer's Disease

genomics more details view paper
  • Downloaded 1,784 times
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    • Site-wide: 8,270
    • In genomics: 930
  • Year to date:
    • Site-wide: 94,954
  • Since beginning of last month:
    • Site-wide: None

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
  • Downloaded 1,704 times
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    • Site-wide: 8,899
    • In genetics: 440
  • Year to date:
    • Site-wide: 57,604
  • Since beginning of last month:
    • Site-wide: 55,079

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

genetics more details view paper
  • Downloaded 1,700 times
  • Download rankings, all-time:
    • Site-wide: 8,934
    • In genetics: 442
  • Year to date:
    • Site-wide: 98,198
  • Since beginning of last month:
    • Site-wide: None

Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer's Disease: An Emerging Role for Gut Microbiome

neuroscience more details view paper
  • Downloaded 1,446 times
  • Download rankings, all-time:
    • Site-wide: 11,318
    • In neuroscience: 1,284
  • Year to date:
    • Site-wide: 39,741
  • Since beginning of last month:
    • Site-wide: 45,738

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology

cell biology more details view paper
  • Downloaded 1,430 times
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    • Site-wide: 11,511
    • In cell biology: 315
  • Year to date:
    • Site-wide: 51,222
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    • Site-wide: None

Epigenome-wide study uncovers tau pathology-driven changes of chromatin organization in the aging human brain

neuroscience more details view paper
  • Downloaded 1,167 times
  • Download rankings, all-time:
    • Site-wide: 15,640
    • In neuroscience: 1,934
  • Year to date:
    • Site-wide: None
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    • Site-wide: None

Systems genetics identifies modifiers of Alzheimer's disease risk and resilience

genetics more details view paper
  • Downloaded 1,163 times
  • Download rankings, all-time:
    • Site-wide: 15,717
    • In genetics: 797
  • Year to date:
    • Site-wide: 71,660
  • Since beginning of last month:
    • Site-wide: 67,147

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

genetics more details view paper
  • Downloaded 1,117 times
  • Download rankings, all-time:
    • Site-wide: 16,739
    • In genetics: 846
  • Year to date:
    • Site-wide: 48,768
  • Since beginning of last month:
    • Site-wide: None

Shared effect modeling reveals that a fraction of autoimmune disease associations are consistent with eQTLs in three immune cell types

genetics more details view paper
  • Downloaded 1,105 times
  • Download rankings, all-time:
    • Site-wide: 17,008
    • In genetics: 864
  • Year to date:
    • Site-wide: 117,417
  • Since beginning of last month:
    • Site-wide: 87,579

Genetic control of the human brain proteome

genetics more details view paper
  • Downloaded 1,097 times
  • Download rankings, all-time:
    • Site-wide: 17,185
    • In genetics: 873
  • Year to date:
    • Site-wide: 14,885
  • Since beginning of last month:
    • Site-wide: 11,330

A cortical immune network map identifies a subset of human microglia involved in Tau pathology

neuroscience more details view paper
  • Downloaded 1,066 times
  • Download rankings, all-time:
    • Site-wide: 17,907
    • In neuroscience: 2,260
  • Year to date:
    • Site-wide: 37,920
  • Since beginning of last month:
    • Site-wide: 52,509

A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System

immunology more details view paper
  • Downloaded 1,054 times
  • Download rankings, all-time:
    • Site-wide: 18,225
    • In immunology: 510
  • Year to date:
    • Site-wide: 21,703
  • Since beginning of last month:
    • Site-wide: 29,458

Deconvolving the contributions of cell-type heterogeneity on cortical gene expression

neuroscience more details view paper
  • Downloaded 1,050 times
  • Download rankings, all-time:
    • Site-wide: 18,325
    • In neuroscience: 2,333
  • Year to date:
    • Site-wide: 51,109
  • Since beginning of last month:
    • Site-wide: 30,322

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection

genomics more details view paper
  • Downloaded 955 times
  • Download rankings, all-time:
    • Site-wide: 21,023
    • In genomics: 2,114
  • Year to date:
    • Site-wide: 92,514
  • Since beginning of last month:
    • Site-wide: None

Meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex

genomics more details view paper
  • Downloaded 763 times
  • Download rankings, all-time:
    • Site-wide: 28,851
    • In genomics: 2,664
  • Year to date:
    • Site-wide: 15,487
  • Since beginning of last month:
    • Site-wide: 11,191

Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer's Disease

neuroscience more details view paper
  • Downloaded 745 times
  • Download rankings, all-time:
    • Site-wide: 29,884
    • In neuroscience: 4,109
  • Year to date:
    • Site-wide: 70,754
  • Since beginning of last month:
    • Site-wide: 53,939

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

bioinformatics more details view paper
  • Downloaded 709 times
  • Download rankings, all-time:
    • Site-wide: 31,994
    • In bioinformatics: 3,633
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: None

TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits

genetics more details view paper
  • Downloaded 672 times
  • Download rankings, all-time:
    • Site-wide: 34,400
    • In genetics: 1,681
  • Year to date:
    • Site-wide: 74,341
  • Since beginning of last month:
    • Site-wide: None

Bayesian Genome-wide TWAS method to leverage both cis- and trans- eQTL information through summary statistics

genetics more details view paper
  • Downloaded 667 times
  • Download rankings, all-time:
    • Site-wide: 34,730
    • In genetics: 1,698
  • Year to date:
    • Site-wide: 23,300
  • Since beginning of last month:
    • Site-wide: 25,709

The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions

immunology more details view paper
  • Downloaded 664 times
  • Download rankings, all-time:
    • Site-wide: 34,958
    • In immunology: 951
  • Year to date:
    • Site-wide: 71,824
  • Since beginning of last month:
    • Site-wide: 86,217

Genetic data and cognitively-defined late-onset Alzheimer's disease subgroups

genetics more details view paper
  • Downloaded 587 times
  • Download rankings, all-time:
    • Site-wide: 40,936
    • In genetics: 1,971
  • Year to date:
    • Site-wide: 107,909
  • Since beginning of last month:
    • Site-wide: 82,229

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

genomics more details view paper
  • Downloaded 555 times
  • Download rankings, all-time:
    • Site-wide: 43,924
    • In genomics: 3,594
  • Year to date:
    • Site-wide: 81,219
  • Since beginning of last month:
    • Site-wide: 69,361

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.

neuroscience more details view paper
  • Downloaded 551 times
  • Download rankings, all-time:
    • Site-wide: 44,305
    • In neuroscience: 6,466
  • Year to date:
    • Site-wide: None
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    • Site-wide: None

Multi-cellular communities are perturbed in the aging human brain and with Alzheimer's disease

neuroscience more details view paper
  • Downloaded 513 times
  • Download rankings, all-time:
    • Site-wide: 48,236
    • In neuroscience: 7,121
  • Year to date:
    • Site-wide: 1,914
  • Since beginning of last month:
    • Site-wide: 5,641

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

genomics more details view paper
  • Downloaded 509 times
  • Download rankings, all-time:
    • Site-wide: 48,643
    • In genomics: 3,880
  • Year to date:
    • Site-wide: 58,549
  • Since beginning of last month:
    • Site-wide: 77,213

Single Cell-type Integrative Network Modeling Identified Novel Microglial-specific Targets for the Phagosome in Alzheimer's disease

systems biology more details view paper
  • Downloaded 499 times
  • Download rankings, all-time:
    • Site-wide: 49,829
    • In systems biology: 1,180
  • Year to date:
    • Site-wide: 27,115
  • Since beginning of last month:
    • Site-wide: 21,228

Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia

genetics more details view paper
  • Downloaded 434 times
  • Download rankings, all-time:
    • Site-wide: 58,029
    • In genetics: 2,747
  • Year to date:
    • Site-wide: 13,136
  • Since beginning of last month:
    • Site-wide: 18,682

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

genetic and genomic medicine more details view paper
  • Downloaded 368 times
  • Download rankings, all-time:
    • Site-wide: 68,169
    • In genetic and genomic medicine: 201
  • Year to date:
    • Site-wide: 20,959
  • Since beginning of last month:
    • Site-wide: 19,306

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia

genomics more details view paper
  • Downloaded 259 times
  • Download rankings, all-time:
    • Site-wide: 89,133
    • In genomics: 5,602
  • Year to date:
    • Site-wide: 87,233
  • Since beginning of last month:
    • Site-wide: None

Association between DNA Methylation Levels in Brain Tissue and Late-Life Depression in Community-Based Participants

genetic and genomic medicine more details view paper
  • Downloaded 258 times
  • Download rankings, all-time:
    • Site-wide: 89,532
    • In genetic and genomic medicine: 305
  • Year to date:
    • Site-wide: 42,669
  • Since beginning of last month:
    • Site-wide: 35,680

The Caribbean-Hispanic Alzheimer’s Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms

genomics more details view paper
  • Downloaded 227 times
  • Download rankings, all-time:
    • Site-wide: 96,001
    • In genomics: 5,844
  • Year to date:
    • Site-wide: 56,268
  • Since beginning of last month:
    • Site-wide: 41,269

Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline

genetics more details view paper
  • Downloaded 209 times
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    • Site-wide: 99,887
    • In genetics: 4,517
  • Year to date:
    • Site-wide: 67,959
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    • Site-wide: 39,041

Peripheral Serum Metabolomic Profiles Inform Antecedent Central Cognitive Impairment in Older Adults

neuroscience more details view paper
  • Downloaded 179 times
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    • Site-wide: 106,279
    • In neuroscience: 16,602
  • Year to date:
    • Site-wide: 103,484
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    • Site-wide: 88,587

Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on alzheimer’s disease risk in humans

neuroscience more details view paper
  • Downloaded 156 times
  • Download rankings, all-time:
    • Site-wide: 111,083
    • In neuroscience: 17,265
  • Year to date:
    • Site-wide: 72,645
  • Since beginning of last month:
    • Site-wide: 91,980

Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification

pathology more details view paper
  • Downloaded 150 times
  • Download rankings, all-time:
    • Site-wide: 112,139
    • In pathology: 648
  • Year to date:
    • Site-wide: 76,562
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    • Site-wide: None

Impact of genetic susceptibility to multiple sclerosis on the T cell epigenome: proximal and distal effects

genomics more details view paper
  • Downloaded 148 times
  • Download rankings, all-time:
    • Site-wide: 112,530
    • In genomics: 6,349
  • Year to date:
    • Site-wide: 87,945
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