Rxivist logo

Author: Philip L De Jager

  • ORCiD: http://orcid.org/0000-0002-8057-2505
  • Most recently observed institution: Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center

Rankings

  • All-time downloads: 37,493 (rank: 962 out of 364,858)
  • Categories:
    • bioinformatics: 667 (rank: 14,887 (tie) out of 31,493)
    • cell biology: 1,152 (rank: 3,746 (tie) out of 26,778)
    • genetics: 14,447 (rank: 747 out of 34,144)
    • genomics: 8,801 (rank: 1,595 out of 39,301)
    • immunology: 1,391 (rank: 2,217 out of 18,981)
    • neuroscience: 9,299 (rank: 731 out of 61,227)
    • systems biology: 1,736 (rank: 1,557 (tie) out of 10,834)

Downloads per author, site-wide

Preprints

Genetic determinants of co-accessible chromatin regions in T cell activation across humans

genomics more details view paper
  • Downloaded 4,856 times
  • Download rankings, all-time:
    • Site-wide: 731 out of 84,804
    • In genomics: 153 out of 5,471
  • Year to date:
    • Site-wide: 11,241 out of 84,804
  • Since beginning of last month:
    • Site-wide: 23,723 out of 84,804

A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain

neuroscience more details view paper
  • Downloaded 3,802 times
  • Download rankings, all-time:
    • Site-wide: 1,147 out of 84,804
    • In neuroscience: 128 out of 15,105
  • Year to date:
    • Site-wide: 2,250 out of 84,804
  • Since beginning of last month:
    • Site-wide: 4,089 out of 84,804

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

genetics more details view paper
  • Downloaded 3,068 times
  • Download rankings, all-time:
    • Site-wide: 1,639 out of 84,804
    • In genetics: 130 out of 4,448
  • Year to date:
    • Site-wide: 26,771 out of 84,804
  • Since beginning of last month:
    • Site-wide: 24,783 out of 84,804

A Bayesian approach to mediation analysis predicts 206 causal target genes in Alzheimer's disease

genetics more details view paper
  • Downloaded 2,915 times
  • Download rankings, all-time:
    • Site-wide: 1,813 out of 84,804
    • In genetics: 146 out of 4,448
  • Year to date:
    • Site-wide: 10,763 out of 84,804
  • Since beginning of last month:
    • Site-wide: 12,092 out of 84,804

A Consensus Proteomic Analysis of Alzheimer’s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation

systems biology more details view paper
  • Downloaded 1,736 times
  • Download rankings, all-time:
    • Site-wide: 4,329 out of 84,804
    • In systems biology: 110 out of 2,234
  • Year to date:
    • Site-wide: 1,136 out of 84,804
  • Since beginning of last month:
    • Site-wide: 7,705 out of 84,804

Integrative analyses of splicing in the aging brain: role in susceptibility to Alzheimer's Disease

genomics more details view paper
  • Downloaded 1,687 times
  • Download rankings, all-time:
    • Site-wide: 4,523 out of 84,804
    • In genomics: 771 out of 5,471
  • Year to date:
    • Site-wide: 44,135 out of 84,804
  • Since beginning of last month:
    • Site-wide: 46,741 out of 84,804

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

genetics more details view paper
  • Downloaded 1,622 times
  • Download rankings, all-time:
    • Site-wide: 4,842 out of 84,804
    • In genetics: 363 out of 4,448
  • Year to date:
    • Site-wide: 34,529 out of 84,804
  • Since beginning of last month:
    • Site-wide: 16,786 out of 84,804

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
  • Downloaded 1,602 times
  • Download rankings, all-time:
    • Site-wide: 4,948 out of 84,804
    • In genetics: 376 out of 4,448
  • Year to date:
    • Site-wide: 46,056 out of 84,804
  • Since beginning of last month:
    • Site-wide: 35,294 out of 84,804

Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer's Disease: An Emerging Role for Gut Microbiome

neuroscience more details view paper
  • Downloaded 1,315 times
  • Download rankings, all-time:
    • Site-wide: 6,866 out of 84,804
    • In neuroscience: 1,055 out of 15,105
  • Year to date:
    • Site-wide: 13,468 out of 84,804
  • Since beginning of last month:
    • Site-wide: 9,006 out of 84,804

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology

cell biology more details view paper
  • Downloaded 1,152 times
  • Download rankings, all-time:
    • Site-wide: 8,578 out of 84,804
    • In cell biology: 302 out of 4,301
  • Year to date:
    • Site-wide: 6,392 out of 84,804
  • Since beginning of last month:
    • Site-wide: 8,327 out of 84,804

Epigenome-wide study uncovers tau pathology-driven changes of chromatin organization in the aging human brain

neuroscience more details view paper
  • Downloaded 1,113 times
  • Download rankings, all-time:
    • Site-wide: 9,073 out of 84,804
    • In neuroscience: 1,430 out of 15,105
  • Year to date:
    • Site-wide: 57,899 out of 84,804
  • Since beginning of last month:
    • Site-wide: 46,943 out of 84,804

Systems genetics identifies modifiers of Alzheimer's disease risk and resilience

genetics more details view paper
  • Downloaded 1,074 times
  • Download rankings, all-time:
    • Site-wide: 9,597 out of 84,804
    • In genetics: 667 out of 4,448
  • Year to date:
    • Site-wide: 30,515 out of 84,804
  • Since beginning of last month:
    • Site-wide: 28,627 out of 84,804

Shared effect modeling reveals that a fraction of autoimmune disease associations are consistent with eQTLs in three immune cell types

genetics more details view paper
  • Downloaded 1,066 times
  • Download rankings, all-time:
    • Site-wide: 9,711 out of 84,804
    • In genetics: 669 out of 4,448
  • Year to date:
    • Site-wide: 70,137 out of 84,804
  • Since beginning of last month:
    • Site-wide: 56,304 out of 84,804

A cortical immune network map identifies a subset of human microglia involved in Tau pathology

neuroscience more details view paper
  • Downloaded 925 times
  • Download rankings, all-time:
    • Site-wide: 12,211 out of 84,804
    • In neuroscience: 1,937 out of 15,105
  • Year to date:
    • Site-wide: 38,175 out of 84,804
  • Since beginning of last month:
    • Site-wide: 30,279 out of 84,804

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection

genomics more details view paper
  • Downloaded 878 times
  • Download rankings, all-time:
    • Site-wide: 13,254 out of 84,804
    • In genomics: 1,787 out of 5,471
  • Year to date:
    • Site-wide: 43,479 out of 84,804
  • Since beginning of last month:
    • Site-wide: 41,629 out of 84,804

Deconvolving the contributions of cell-type heterogeneity on cortical gene expression

neuroscience more details view paper
  • Downloaded 864 times
  • Download rankings, all-time:
    • Site-wide: 13,567 out of 84,804
    • In neuroscience: 2,184 out of 15,105
  • Year to date:
    • Site-wide: 10,728 out of 84,804
  • Since beginning of last month:
    • Site-wide: 6,709 out of 84,804

A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System

immunology more details view paper
  • Downloaded 813 times
  • Download rankings, all-time:
    • Site-wide: 14,873 out of 84,804
    • In immunology: 339 out of 2,379
  • Year to date:
    • Site-wide: 24,294 out of 84,804
  • Since beginning of last month:
    • Site-wide: 23,369 out of 84,804

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

genetics more details view paper
  • Downloaded 804 times
  • Download rankings, all-time:
    • Site-wide: 15,130 out of 84,804
    • In genetics: 983 out of 4,448
  • Year to date:
    • Site-wide: 8,602 out of 84,804
  • Since beginning of last month:
    • Site-wide: 7,072 out of 84,804

Genetic control of the human brain proteome

genetics more details view paper
  • Downloaded 778 times
  • Download rankings, all-time:
    • Site-wide: 15,926 out of 84,804
    • In genetics: 1,039 out of 4,448
  • Year to date:
    • Site-wide: 6,857 out of 84,804
  • Since beginning of last month:
    • Site-wide: 3,989 out of 84,804

Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer's Disease

neuroscience more details view paper
  • Downloaded 667 times
  • Download rankings, all-time:
    • Site-wide: 20,017 out of 84,804
    • In neuroscience: 3,348 out of 15,105
  • Year to date:
    • Site-wide: 56,058 out of 84,804
  • Since beginning of last month:
    • Site-wide: 39,791 out of 84,804

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

bioinformatics more details view paper
  • Downloaded 667 times
  • Download rankings, all-time:
    • Site-wide: 20,009 out of 84,804
    • In bioinformatics: 2,938 out of 8,130
  • Year to date:
    • Site-wide: 63,038 out of 84,804
  • Since beginning of last month:
    • Site-wide: 46,833 out of 84,804

TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits

genetics more details view paper
  • Downloaded 589 times
  • Download rankings, all-time:
    • Site-wide: 23,892 out of 84,804
    • In genetics: 1,507 out of 4,448
  • Year to date:
    • Site-wide: 42,188 out of 84,804
  • Since beginning of last month:
    • Site-wide: 36,305 out of 84,804

The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions

immunology more details view paper
  • Downloaded 578 times
  • Download rankings, all-time:
    • Site-wide: 24,566 out of 84,804
    • In immunology: 566 out of 2,379
  • Year to date:
    • Site-wide: 41,341 out of 84,804
  • Since beginning of last month:
    • Site-wide: 26,347 out of 84,804

Genetic data and cognitively-defined late-onset Alzheimer's disease subgroups

genetics more details view paper
  • Downloaded 540 times
  • Download rankings, all-time:
    • Site-wide: 26,803 out of 84,804
    • In genetics: 1,655 out of 4,448
  • Year to date:
    • Site-wide: 65,832 out of 84,804
  • Since beginning of last month:
    • Site-wide: 69,261 out of 84,804

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

genomics more details view paper
  • Downloaded 498 times
  • Download rankings, all-time:
    • Site-wide: 29,603 out of 84,804
    • In genomics: 3,036 out of 5,471
  • Year to date:
    • Site-wide: 56,166 out of 84,804
  • Since beginning of last month:
    • Site-wide: 43,633 out of 84,804

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.

neuroscience more details view paper
  • Downloaded 487 times
  • Download rankings, all-time:
    • Site-wide: 30,394 out of 84,804
    • In neuroscience: 5,205 out of 15,105
  • Year to date:
    • Site-wide: 61,159 out of 84,804
  • Since beginning of last month:
    • Site-wide: 75,993 out of 84,804

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

genomics more details view paper
  • Downloaded 348 times
  • Download rankings, all-time:
    • Site-wide: 43,974 out of 84,804
    • In genomics: 3,890 out of 5,471
  • Year to date:
    • Site-wide: 5,036 out of 84,804
  • Since beginning of last month:
    • Site-wide: 9,149 out of 84,804

Meta-analysis of epigenome-wide association studies in Alzheime's disease highlights 220 differentially methylated loci across cortex

genomics more details view paper
  • Downloaded 327 times
  • Download rankings, all-time:
    • Site-wide: 46,658 out of 84,804
    • In genomics: 4,008 out of 5,471
  • Year to date:
    • Site-wide: 5,545 out of 84,804
  • Since beginning of last month:
    • Site-wide: 16,277 out of 84,804

Novel Bayesian transcriptome-wide association study method leveraging both cis- and trans- eQTL information through summary statistics

genetics more details view paper
  • Downloaded 232 times
  • Download rankings, all-time:
    • Site-wide: 60,463 out of 84,804
    • In genetics: 3,378 out of 4,448
  • Year to date:
    • Site-wide: 9,532 out of 84,804
  • Since beginning of last month:
    • Site-wide: 18,607 out of 84,804

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia

genomics more details view paper
  • Downloaded 207 times
  • Download rankings, all-time:
    • Site-wide: 64,720 out of 84,804
    • In genomics: 4,769 out of 5,471
  • Year to date:
    • Site-wide: 70,251 out of 84,804
  • Since beginning of last month:
    • Site-wide: 57,833 out of 84,804

Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline

genetics more details view paper
  • Downloaded 157 times
  • Download rankings, all-time:
    • Site-wide: 72,785 out of 84,804
    • In genetics: 3,948 out of 4,448
  • Year to date:
    • Site-wide: 40,671 out of 84,804
  • Since beginning of last month:
    • Site-wide: 36,284 out of 84,804

Peripheral Serum Metabolomic Profiles Inform Antecedent Central Cognitive Impairment in Older Adults

neuroscience more details view paper
  • Downloaded 126 times
  • Download rankings, all-time:
    • Site-wide: 76,923 out of 84,804
    • In neuroscience: 13,797 out of 15,105
  • Year to date:
    • Site-wide: 49,934 out of 84,804
  • Since beginning of last month:
    • Site-wide: 54,562 out of 84,804

PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News