Author: Phillip De Jager

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Preprints

Genetic determinants of co-accessible chromatin regions in T cell activation across humans

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  • Site-wide: 1,846
  • In genomics: 191
• Year to date:
  • Site-wide: 35,206
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  • Site-wide: 23,522

A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain

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  • Site-wide: 2,293
  • In neuroscience: 151
• Year to date:
  • Site-wide: 22,325
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  • Site-wide: 13,625

EXCEPTIONALLY LOW LIKELIHOOD OF ALZHEIMER'S DEMENTIA IN APOE2 HOMOZYGOTES

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  • Site-wide: 2,474
  • In pathology: 18
• Year to date:
  • Site-wide: 23,858
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  • Site-wide: 27,839

A Bayesian approach to mediation analysis predicts 206 causal target genes in Alzheimer's disease

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  • Site-wide: 3,360
  • In genetics: 136
• Year to date:
  • Site-wide: 15,724
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  • Site-wide: 16,671

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 3,473
  • In genetics: 149
• Year to date:
  • Site-wide: 25,922
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  • Site-wide: 26,882

A Consensus Proteomic Analysis of Alzheimer’s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation

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  • Site-wide: 6,474
  • In systems biology: 113
• Year to date:
  • Site-wide: 19,254
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  • Site-wide: 14,547

Integrative analyses of splicing in the aging brain: role in susceptibility to Alzheimer's Disease

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  • Site-wide: 8,270
  • In genomics: 930
• Year to date:
  • Site-wide: 94,954
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  • Site-wide: None

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 8,899
  • In genetics: 440
• Year to date:
  • Site-wide: 57,604
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  • Site-wide: 55,079

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 8,934
  • In genetics: 442
• Year to date:
  • Site-wide: 98,198
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  • Site-wide: None

Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer's Disease: An Emerging Role for Gut Microbiome

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  • Site-wide: 11,318
  • In neuroscience: 1,284
• Year to date:
  • Site-wide: 39,741
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  • Site-wide: 45,738

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology

• Downloaded 1,430 times
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  • Site-wide: 11,511
  • In cell biology: 315
• Year to date:
  • Site-wide: 51,222
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  • Site-wide: None

Epigenome-wide study uncovers tau pathology-driven changes of chromatin organization in the aging human brain

• Downloaded 1,167 times
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  • Site-wide: 15,640
  • In neuroscience: 1,934
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Systems genetics identifies modifiers of Alzheimer's disease risk and resilience

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  • Site-wide: 15,717
  • In genetics: 797
• Year to date:
  • Site-wide: 71,660
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  • Site-wide: 67,147

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

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  • Site-wide: 16,739
  • In genetics: 846
• Year to date:
  • Site-wide: 48,768
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Shared effect modeling reveals that a fraction of autoimmune disease associations are consistent with eQTLs in three immune cell types

• Downloaded 1,105 times
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  • Site-wide: 17,008
  • In genetics: 864
• Year to date:
  • Site-wide: 117,417
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  • Site-wide: 87,579

Genetic control of the human brain proteome

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  • Site-wide: 17,185
  • In genetics: 873
• Year to date:
  • Site-wide: 14,885
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  • Site-wide: 11,330

A cortical immune network map identifies a subset of human microglia involved in Tau pathology

• Downloaded 1,066 times
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  • Site-wide: 17,907
  • In neuroscience: 2,260
• Year to date:
  • Site-wide: 37,920
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  • Site-wide: 52,509

A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System

• Downloaded 1,054 times
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  • Site-wide: 18,225
  • In immunology: 510
• Year to date:
  • Site-wide: 21,703
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  • Site-wide: 29,458

Deconvolving the contributions of cell-type heterogeneity on cortical gene expression

• Downloaded 1,050 times
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  • Site-wide: 18,325
  • In neuroscience: 2,333
• Year to date:
  • Site-wide: 51,109
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  • Site-wide: 30,322

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection

• Downloaded 955 times
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  • Site-wide: 21,023
  • In genomics: 2,114
• Year to date:
  • Site-wide: 92,514
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  • Site-wide: None

Meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex

• Downloaded 763 times
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  • Site-wide: 28,851
  • In genomics: 2,664
• Year to date:
  • Site-wide: 15,487
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  • Site-wide: 11,191

Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer's Disease

• Downloaded 745 times
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  • Site-wide: 29,884
  • In neuroscience: 4,109
• Year to date:
  • Site-wide: 70,754
• Since beginning of last month:
  • Site-wide: 53,939

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 709 times
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  • Site-wide: 31,994
  • In bioinformatics: 3,633
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  • Site-wide: None
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  • Site-wide: None

TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits

• Downloaded 672 times
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  • Site-wide: 34,400
  • In genetics: 1,681
• Year to date:
  • Site-wide: 74,341
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  • Site-wide: None

Bayesian Genome-wide TWAS method to leverage both cis- and trans- eQTL information through summary statistics

• Downloaded 667 times
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  • Site-wide: 34,730
  • In genetics: 1,698
• Year to date:
  • Site-wide: 23,300
• Since beginning of last month:
  • Site-wide: 25,709

The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions

• Downloaded 664 times
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  • Site-wide: 34,958
  • In immunology: 951
• Year to date:
  • Site-wide: 71,824
• Since beginning of last month:
  • Site-wide: 86,217

Genetic data and cognitively-defined late-onset Alzheimer's disease subgroups

• Downloaded 587 times
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  • Site-wide: 40,936
  • In genetics: 1,971
• Year to date:
  • Site-wide: 107,909
• Since beginning of last month:
  • Site-wide: 82,229

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

• Downloaded 555 times
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  • Site-wide: 43,924
  • In genomics: 3,594
• Year to date:
  • Site-wide: 81,219
• Since beginning of last month:
  • Site-wide: 69,361

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.

• Downloaded 551 times
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  • Site-wide: 44,305
  • In neuroscience: 6,466
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  • Site-wide: None
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  • Site-wide: None

Multi-cellular communities are perturbed in the aging human brain and with Alzheimer's disease

• Downloaded 513 times
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  • Site-wide: 48,236
  • In neuroscience: 7,121
• Year to date:
  • Site-wide: 1,914
• Since beginning of last month:
  • Site-wide: 5,641

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

• Downloaded 509 times
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  • Site-wide: 48,643
  • In genomics: 3,880
• Year to date:
  • Site-wide: 58,549
• Since beginning of last month:
  • Site-wide: 77,213

Single Cell-type Integrative Network Modeling Identified Novel Microglial-specific Targets for the Phagosome in Alzheimer's disease

• Downloaded 499 times
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  • Site-wide: 49,829
  • In systems biology: 1,180
• Year to date:
  • Site-wide: 27,115
• Since beginning of last month:
  • Site-wide: 21,228

Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia

• Downloaded 434 times
• Download rankings, all-time:
  • Site-wide: 58,029
  • In genetics: 2,747
• Year to date:
  • Site-wide: 13,136
• Since beginning of last month:
  • Site-wide: 18,682

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

• Downloaded 368 times
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  • Site-wide: 68,169
  • In genetic and genomic medicine: 201
• Year to date:
  • Site-wide: 20,959
• Since beginning of last month:
  • Site-wide: 19,306

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia

• Downloaded 259 times
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  • Site-wide: 89,133
  • In genomics: 5,602
• Year to date:
  • Site-wide: 87,233
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  • Site-wide: None

Association between DNA Methylation Levels in Brain Tissue and Late-Life Depression in Community-Based Participants

• Downloaded 258 times
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  • Site-wide: 89,532
  • In genetic and genomic medicine: 305
• Year to date:
  • Site-wide: 42,669
• Since beginning of last month:
  • Site-wide: 35,680

The Caribbean-Hispanic Alzheimer’s Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms

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  • Site-wide: 96,001
  • In genomics: 5,844
• Year to date:
  • Site-wide: 56,268
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  • Site-wide: 41,269

Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline

• Downloaded 209 times
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  • Site-wide: 99,887
  • In genetics: 4,517
• Year to date:
  • Site-wide: 67,959
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  • Site-wide: 39,041

Peripheral Serum Metabolomic Profiles Inform Antecedent Central Cognitive Impairment in Older Adults

• Downloaded 179 times
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  • Site-wide: 106,279
  • In neuroscience: 16,602
• Year to date:
  • Site-wide: 103,484
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  • Site-wide: 88,587

Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on alzheimer’s disease risk in humans

• Downloaded 156 times
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  • Site-wide: 111,083
  • In neuroscience: 17,265
• Year to date:
  • Site-wide: 72,645
• Since beginning of last month:
  • Site-wide: 91,980

Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification

• Downloaded 150 times
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  • Site-wide: 112,139
  • In pathology: 648
• Year to date:
  • Site-wide: 76,562
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  • Site-wide: None

Impact of genetic susceptibility to multiple sclerosis on the T cell epigenome: proximal and distal effects

• Downloaded 148 times
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  • Site-wide: 112,530
  • In genomics: 6,349
• Year to date:
  • Site-wide: 87,945
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  • Site-wide: None