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Author: Philip L. De Jager

  • ORCiD: http://orcid.org/0000-0002-8057-2505
  • Most recently observed institution: Center for Translational and Computational Neuroimmunology, Department of Neurology and Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center

Rankings

  • All-time downloads: 41,857 (rank: 1,025 out of 425,950)
  • Categories:
    • bioinformatics: 694 (rank: 16,736 (tie) out of 36,203)
    • cell biology: 1,343 (rank: 4,024 (tie) out of 32,905)
    • genetics: 15,990 (rank: 805 out of 37,998)
    • genomics: 9,684 (rank: 1,649 out of 44,631)
    • immunology: 1,565 (rank: 3,570 (tie) out of 26,443)
    • neuroscience: 10,142 (rank: 893 out of 72,361)
    • pathology: 99 (rank: 4,525 (tie) out of 4,810)
    • systems biology: 2,340 (rank: 1,371 out of 12,462)

Downloads per author, site-wide

Preprints

Genetic determinants of co-accessible chromatin regions in T cell activation across humans

genomics more details view paper
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A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain

neuroscience more details view paper
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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

genetics more details view paper
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A Bayesian approach to mediation analysis predicts 206 causal target genes in Alzheimer's disease

genetics more details view paper
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A Consensus Proteomic Analysis of Alzheimer’s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation

systems biology more details view paper
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Integrative analyses of splicing in the aging brain: role in susceptibility to Alzheimer's Disease

genomics more details view paper
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Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

genetics more details view paper
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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
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Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer's Disease: An Emerging Role for Gut Microbiome

neuroscience more details view paper
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    • Site-wide: 50,180 out of 100,840

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology

cell biology more details view paper
  • Downloaded 1,343 times
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    • In cell biology: 290 out of 5,216
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Epigenome-wide study uncovers tau pathology-driven changes of chromatin organization in the aging human brain

neuroscience more details view paper
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    • In neuroscience: 1,674 out of 17,974
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Systems genetics identifies modifiers of Alzheimer's disease risk and resilience

genetics more details view paper
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    • In genetics: 729 out of 5,020
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Shared effect modeling reveals that a fraction of autoimmune disease associations are consistent with eQTLs in three immune cell types

genetics more details view paper
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Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

genetics more details view paper
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    • In genetics: 831 out of 5,020
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Deconvolving the contributions of cell-type heterogeneity on cortical gene expression

neuroscience more details view paper
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A cortical immune network map identifies a subset of human microglia involved in Tau pathology

neuroscience more details view paper
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Genetic control of the human brain proteome

genetics more details view paper
  • Downloaded 958 times
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    • In genetics: 918 out of 5,020
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A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System

immunology more details view paper
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    • In immunology: 430 out of 3,140
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    • Site-wide: 18,054 out of 100,840

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection

genomics more details view paper
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Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer's Disease

neuroscience more details view paper
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Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

bioinformatics more details view paper
  • Downloaded 694 times
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    • In bioinformatics: 3,287 out of 9,259
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TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits

genetics more details view paper
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The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions

immunology more details view paper
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Genetic data and cognitively-defined late-onset Alzheimer's disease subgroups

genetics more details view paper
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    • In genetics: 1,829 out of 5,020
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Meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex

genomics more details view paper
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Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

genomics more details view paper
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Bayesian Genome-wide TWAS method to leverage both cis- and trans- eQTL information through summary statistics

genetics more details view paper
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Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.

neuroscience more details view paper
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Integrated analysis of the aging brain transcriptome and proteome in tauopathy

genomics more details view paper
  • Downloaded 452 times
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Single Cell-type Integrative Network Modeling Identified Novel Microglial-specific Targets for the Phagosome in Alzheimer's disease

systems biology more details view paper
  • Downloaded 391 times
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Powerful Variance-Component TWAS method identifies novel and known risk genes for clinical and pathologic Alzheimer's dementia phenotypes

genetics more details view paper
  • Downloaded 299 times
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Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia

genomics more details view paper
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The Caribbean-Hispanic Alzheimer’s Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms

genomics more details view paper
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Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline

genetics more details view paper
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Peripheral Serum Metabolomic Profiles Inform Antecedent Central Cognitive Impairment in Older Adults

neuroscience more details view paper
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Impact of genetic susceptibility to multiple sclerosis on the T cell epigenome: proximal and distal effects

genomics more details view paper
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Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification

pathology more details view paper
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Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on alzheimer’s disease risk in humans

neuroscience more details view paper
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    • In neuroscience: 16,742 out of 17,974
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