Author: David A. Bennett

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Preprints

A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain

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  • Site-wide: 2,298
  • In neuroscience: 152
• Year to date:
  • Site-wide: 22,822
• Since beginning of last month:
  • Site-wide: 14,198

EXCEPTIONALLY LOW LIKELIHOOD OF ALZHEIMER'S DEMENTIA IN APOE2 HOMOZYGOTES

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  • Site-wide: 2,479
  • In pathology: 18
• Year to date:
  • Site-wide: 24,501
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  • Site-wide: 28,360

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 8,920
  • In genetics: 440
• Year to date:
  • Site-wide: 58,668
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  • Site-wide: 61,399

Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer's Disease: An Emerging Role for Gut Microbiome

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  • Site-wide: 11,339
  • In neuroscience: 1,288
• Year to date:
  • Site-wide: 40,723
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  • Site-wide: 51,856

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology

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  • Site-wide: 11,539
  • In cell biology: 316
• Year to date:
  • Site-wide: 51,929
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  • Site-wide: None

Systems genetics identifies modifiers of Alzheimer's disease risk and resilience

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  • Site-wide: 15,753
  • In genetics: 800
• Year to date:
  • Site-wide: 73,577
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  • Site-wide: 73,535

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into the complex genetic architecture

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  • Site-wide: 19,728
  • In genomics: 2,010
• Year to date:
  • Site-wide: 7,202
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  • Site-wide: 4,431

Meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex

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  • Site-wide: 28,907
  • In genomics: 2,666
• Year to date:
  • Site-wide: 15,965
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  • Site-wide: 11,974

Lipid associated polygenic enrichment in Alzheimer's disease

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  • Site-wide: 29,159
  • In genetics: 1,448
• Year to date:
  • Site-wide: 32,230
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  • Site-wide: 34,154

Cell type-specific histone acetylation profiling of Alzheimer's Disease subjects and integration with genetics

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  • Site-wide: 30,130
  • In genetics: 1,490
• Year to date:
  • Site-wide: 20,352
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  • Site-wide: 12,001

Bayesian Genome-wide TWAS method to leverage both cis- and trans- eQTL information through summary statistics

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  • Site-wide: 34,053
  • In genetics: 1,673
• Year to date:
  • Site-wide: 19,860
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  • Site-wide: 16,834

Genetic data and cognitively-defined late-onset Alzheimer's disease subgroups

• Downloaded 587 times
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  • Site-wide: 41,035
  • In genetics: 1,973
• Year to date:
  • Site-wide: 111,609
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  • Site-wide: 80,967

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

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  • Site-wide: 44,004
  • In genomics: 3,599
• Year to date:
  • Site-wide: 85,940
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  • Site-wide: 72,897

Multi-cellular communities are perturbed in the aging human brain and with Alzheimer's disease

• Downloaded 513 times
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  • Site-wide: 48,249
  • In neuroscience: 7,148
• Year to date:
  • Site-wide: 1,957
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  • Site-wide: 6,135

Perturbed functional networks in Alzheimers Disease reveal opposing roles for TGIF and EGR3

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  • Site-wide: 51,740
  • In bioinformatics: 5,345
• Year to date:
  • Site-wide: 66,721
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  • Site-wide: 53,317

Exome-wide age-of-onset analysis reveals exonic variants in ERN1, TACR3 and SPPL2C associated with Alzheimer's disease

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  • Site-wide: 51,897
  • In neuroscience: 7,759
• Year to date:
  • Site-wide: 50,970
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  • Site-wide: 44,924

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

• Downloaded 368 times
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  • Site-wide: 68,251
  • In genetic and genomic medicine: 202
• Year to date:
  • Site-wide: 21,475
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  • Site-wide: 20,620

Multiplexed fractionated proteomics reveals synaptic factors associated with cognitive resilience in Alzheimer's Disease

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  • Site-wide: 71,792
  • In neuroscience: 11,060
• Year to date:
  • Site-wide: 17,523
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  • Site-wide: 22,798

Cerebral atherosclerosis contributes to Alzheimer's dementia independently of its hallmark amyloid and tau pathologies

• Downloaded 331 times
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  • Site-wide: 74,835
  • In neuroscience: 11,515
• Year to date:
  • Site-wide: 90,280
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  • Site-wide: 92,500

Association between DNA Methylation Levels in Brain Tissue and Late-Life Depression in Community-Based Participants

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  • Site-wide: 89,560
  • In genetic and genomic medicine: 306
• Year to date:
  • Site-wide: 44,313
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  • Site-wide: 36,177

Deregulation of brain endothelial CD2AP in Alzheimer's disease impairs Reelin-mediated neurovascular coupling

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  • Site-wide: 99,823
  • In neuroscience: 15,632
• Year to date:
  • Site-wide: 20,278
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  • Site-wide: 18,382

Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline

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  • Site-wide: 100,023
  • In genetics: 4,519
• Year to date:
  • Site-wide: 69,280
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  • Site-wide: 42,933

Peripheral Serum Metabolomic Profiles Inform Antecedent Central Cognitive Impairment in Older Adults

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  • Site-wide: 106,398
  • In neuroscience: 16,616
• Year to date:
  • Site-wide: 104,445
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  • Site-wide: 93,128

Protein phosphatase 2A, complement component 4, and APOE genotype linked to Alzheimer disease using a systems biology approach

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  • Site-wide: 109,527
  • In genetic and genomic medicine: 454
• Year to date:
  • Site-wide: 46,086
• Since beginning of last month:
  • Site-wide: 31,235

Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on alzheimer’s disease risk in humans

• Downloaded 162 times
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  • Site-wide: 109,947
  • In neuroscience: 17,143
• Year to date:
  • Site-wide: 56,672
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  • Site-wide: 56,497

Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification

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  • Site-wide: 112,256
  • In pathology: 648
• Year to date:
  • Site-wide: 77,703
• Since beginning of last month:
  • Site-wide: None

Integrative Brain Transcriptome Analysis Links Complement Component 4 and HSPA2 to the APOE ε2 Protective Effect in Alzheimer Disease

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  • Site-wide: 115,580
  • In genetic and genomic medicine: 512
• Year to date:
  • Site-wide: 37,231
• Since beginning of last month:
  • Site-wide: 25,101