Author: Anders M Dale

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Preprints

The genetic architecture of the human cerebral cortex

• Downloaded 7,906 times
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  • Site-wide: 1,009
  • In genetics: 30
• Year to date:
  • Site-wide: 16,899
• Since beginning of last month:
  • Site-wide: None

Genomewide association study identifies 30 loci associated with bipolar disorder

• Downloaded 7,266 times
• Download rankings, all-time:
  • Site-wide: 1,129
  • In genetics: 38
• Year to date:
  • Site-wide: 16,029
• Since beginning of last month:
  • Site-wide: 13,125

Image processing and analysis methods for the Adolescent Brain Cognitive Development Study

• Downloaded 5,337 times
• Download rankings, all-time:
  • Site-wide: 1,710
  • In neuroscience: 90
• Year to date:
  • Site-wide: 2,569
• Since beginning of last month:
  • Site-wide: 1,916

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,247 times
• Download rankings, all-time:
  • Site-wide: 3,468
  • In genetics: 149
• Year to date:
  • Site-wide: 25,947
• Since beginning of last month:
  • Site-wide: 25,762

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 3,098 times
• Download rankings, all-time:
  • Site-wide: 3,706
  • In genomics: 430
• Year to date:
  • Site-wide: 18,101
• Since beginning of last month:
  • Site-wide: 16,223

Genetics of brain age suggest an overlap with common brain disorders

• Downloaded 2,686 times
• Download rankings, all-time:
  • Site-wide: 4,524
  • In neuroscience: 413
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness

• Downloaded 1,872 times
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  • Site-wide: 7,676
  • In genomics: 853
• Year to date:
  • Site-wide: 7,024
• Since beginning of last month:
  • Site-wide: 6,935

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,700 times
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  • Site-wide: 8,923
  • In genetics: 442
• Year to date:
  • Site-wide: 99,169
• Since beginning of last month:
  • Site-wide: None

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

• Downloaded 1,664 times
• Download rankings, all-time:
  • Site-wide: 9,219
  • In genetics: 456
• Year to date:
  • Site-wide: 16,059
• Since beginning of last month:
  • Site-wide: 13,211

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

• Downloaded 1,557 times
• Download rankings, all-time:
  • Site-wide: 10,155
  • In psychiatry and clinical psychology: 32
• Year to date:
  • Site-wide: 2,678
• Since beginning of last month:
  • Site-wide: 3,241

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,447 times
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  • Site-wide: 11,298
  • In genomics: 1,257
• Year to date:
  • Site-wide: 59,275
• Since beginning of last month:
  • Site-wide: 55,050

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,406 times
• Download rankings, all-time:
  • Site-wide: 11,799
  • In genetics: 592
• Year to date:
  • Site-wide: 26,735
• Since beginning of last month:
  • Site-wide: 17,483

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

• Downloaded 1,240 times
• Download rankings, all-time:
  • Site-wide: 14,251
  • In genetics: 731
• Year to date:
  • Site-wide: 73,343
• Since beginning of last month:
  • Site-wide: 98,037

Polygenic Score of Intelligence is More Predictive of Crystallized than Fluid Performance Among Children

• Downloaded 1,209 times
• Download rankings, all-time:
  • Site-wide: 14,800
  • In neuroscience: 1,817
• Year to date:
  • Site-wide: 17,751
• Since beginning of last month:
  • Site-wide: 13,900

Partitioning the genetic architecture of amyotrophic lateral sclerosis

• Downloaded 1,090 times
• Download rankings, all-time:
  • Site-wide: 17,322
  • In genetics: 878
• Year to date:
  • Site-wide: 34,550
• Since beginning of last month:
  • Site-wide: 36,833

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

• Downloaded 1,077 times
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  • Site-wide: 17,612
  • In genetics: 888
• Year to date:
  • Site-wide: 49,810
• Since beginning of last month:
  • Site-wide: 50,839

Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

• Downloaded 994 times
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  • Site-wide: 19,850
  • In neuroscience: 2,535
• Year to date:
  • Site-wide: 12,511
• Since beginning of last month:
  • Site-wide: 7,078

Personalized genetic assessment of age associated Alzheimers disease risk

• Downloaded 961 times
• Download rankings, all-time:
  • Site-wide: 20,802
  • In genetics: 1,023
• Year to date:
  • Site-wide: 76,778
• Since beginning of last month:
  • Site-wide: 63,898

A genetic risk score to guide age-specific, personalized prostate cancer screening

• Downloaded 946 times
• Download rankings, all-time:
  • Site-wide: 21,300
  • In genetics: 1,052
• Year to date:
  • Site-wide: 98,508
• Since beginning of last month:
  • Site-wide: 86,290

Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers

• Downloaded 850 times
• Download rankings, all-time:
  • Site-wide: 24,854
  • In neuroscience: 3,311
• Year to date:
  • Site-wide: 73,420
• Since beginning of last month:
  • Site-wide: 62,435

Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD): findings from the ENIGMA-ADHD, -ASD, and -OCD working groups

• Downloaded 818 times
• Download rankings, all-time:
  • Site-wide: 26,205
  • In neuroscience: 3,525
• Year to date:
  • Site-wide: 71,928
• Since beginning of last month:
  • Site-wide: 77,193

Planar cell polarity pathway and development of the human visual cortex

• Downloaded 757 times
• Download rankings, all-time:
  • Site-wide: 29,168
  • In neuroscience: 3,991
• Year to date:
  • Site-wide: 44,895
• Since beginning of last month:
  • Site-wide: 55,129

Lipid associated polygenic enrichment in Alzheimer's disease

• Downloaded 755 times
• Download rankings, all-time:
  • Site-wide: 29,308
  • In genetics: 1,454
• Year to date:
  • Site-wide: 34,001
• Since beginning of last month:
  • Site-wide: 42,203

Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

• Downloaded 710 times
• Download rankings, all-time:
  • Site-wide: 31,954
  • In neuroscience: 4,437
• Year to date:
  • Site-wide: 19,255
• Since beginning of last month:
  • Site-wide: 13,662

Making the MOSTest of imaging genetics

• Downloaded 673 times
• Download rankings, all-time:
  • Site-wide: 34,312
  • In neuroscience: 4,819
• Year to date:
  • Site-wide: 71,431
• Since beginning of last month:
  • Site-wide: 85,374

Polygenic hazard scores in preclinical Alzheimer's disease

• Downloaded 618 times
• Download rankings, all-time:
  • Site-wide: 38,366
  • In genetics: 1,868
• Year to date:
  • Site-wide: 102,786
• Since beginning of last month:
  • Site-wide: 86,354

Immune-related genetic enrichment in frontotemporal dementia

• Downloaded 600 times
• Download rankings, all-time:
  • Site-wide: 39,777
  • In genetics: 1,924
• Year to date:
  • Site-wide: 81,629
• Since beginning of last month:
  • Site-wide: 78,702

Sex-dependent polygenic effects on the clinical progressions of Alzheimer's disease

• Downloaded 559 times
• Download rankings, all-time:
  • Site-wide: 43,531
  • In genetics: 2,097
• Year to date:
  • Site-wide: 100,189
• Since beginning of last month:
  • Site-wide: 96,335

Pupillary dilation responses as a midlife indicator of risk for Alzheimer's Disease: Association with Alzheimer's disease polygenic risk

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 44,204
  • In genetics: 2,130
• Year to date:
  • Site-wide: 97,544
• Since beginning of last month:
  • Site-wide: None

Four-Sphere Head Model For EEG Signals Revisited

• Downloaded 533 times
• Download rankings, all-time:
  • Site-wide: 46,133
  • In neuroscience: 6,735
• Year to date:
  • Site-wide: 66,512
• Since beginning of last month:
  • Site-wide: 66,457

Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment

• Downloaded 502 times
• Download rankings, all-time:
  • Site-wide: 49,489
  • In genomics: 3,920
• Year to date:
  • Site-wide: 82,956
• Since beginning of last month:
  • Site-wide: 46,154

Biophysical modeling of the neural origin of EEG and MEG signals

• Downloaded 475 times
• Download rankings, all-time:
  • Site-wide: 52,627
  • In neuroscience: 7,880
• Year to date:
  • Site-wide: 21,271
• Since beginning of last month:
  • Site-wide: 14,688

Brain structure mediates the association between height and cognitive ability

• Downloaded 473 times
• Download rankings, all-time:
  • Site-wide: 52,912
  • In neuroscience: 7,912
• Year to date:
  • Site-wide: 63,716
• Since beginning of last month:
  • Site-wide: 52,405

Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition

• Downloaded 451 times
• Download rankings, all-time:
  • Site-wide: 55,748
  • In genetics: 2,638
• Year to date:
  • Site-wide: 73,684
• Since beginning of last month:
  • Site-wide: 50,583

Williams Syndrome-Specific Neuroarchitectural Profile and Its Associations with Cognitive Features

• Downloaded 434 times
• Download rankings, all-time:
  • Site-wide: 58,045
  • In neuroscience: 8,795
• Year to date:
  • Site-wide: 107,665
• Since beginning of last month:
  • Site-wide: 95,875

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 421 times
• Download rankings, all-time:
  • Site-wide: 59,881
  • In genetics: 2,834
• Year to date:
  • Site-wide: 121,013
• Since beginning of last month:
  • Site-wide: 93,094

Polygenic hazard score predicts aggressive and fatal prostate cancer in multi-ethnic populations

• Downloaded 413 times
• Download rankings, all-time:
  • Site-wide: 60,961
  • In genetic and genomic medicine: 183
• Year to date:
  • Site-wide: 33,097
• Since beginning of last month:
  • Site-wide: 40,159

The Bayesian polyvertex score (PVS-B): a whole-brain phenotypic prediction framework for neuroimaging studies

• Downloaded 385 times
• Download rankings, all-time:
  • Site-wide: 65,364
  • In neuroscience: 9,974
• Year to date:
  • Site-wide: 28,054
• Since beginning of last month:
  • Site-wide: 23,209

A genetic hazard score to personalize prostate cancer screening, applied to population data

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 67,359
  • In genetics: 3,153
• Year to date:
  • Site-wide: 97,360
• Since beginning of last month:
  • Site-wide: 99,174

Annotation-Informed Causal Mixture Modeling (AI-MiXeR) reveals phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories

• Downloaded 370 times
• Download rankings, all-time:
  • Site-wide: 67,798
  • In genetics: 3,164
• Year to date:
  • Site-wide: 102,012
• Since beginning of last month:
  • Site-wide: None

CXCR4 involvement in neurodegenerative diseases

• Downloaded 367 times
• Download rankings, all-time:
  • Site-wide: 68,367
  • In genetics: 3,186
• Year to date:
  • Site-wide: 90,190
• Since beginning of last month:
  • Site-wide: 78,675

Improved characterization of diffusion in normal and cancerous prostate tissue through optimization of the restriction spectrum imaging signal model

• Downloaded 358 times
• Download rankings, all-time:
  • Site-wide: 69,831
  • In radiology and imaging: 96
• Year to date:
  • Site-wide: 43,908
• Since beginning of last month:
  • Site-wide: 41,135

Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area

• Downloaded 342 times
• Download rankings, all-time:
  • Site-wide: 72,633
  • In neuroscience: 11,167
• Year to date:
  • Site-wide: 117,459
• Since beginning of last month:
  • Site-wide: 105,592

The genetic architecture of human cortical folding

• Downloaded 337 times
• Download rankings, all-time:
  • Site-wide: 73,420
  • In genomics: 5,025
• Year to date:
  • Site-wide: 2,174
• Since beginning of last month:
  • Site-wide: 8,570

All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors

• Downloaded 321 times
• Download rankings, all-time:
  • Site-wide: 76,457
  • In neuroscience: 11,791
• Year to date:
  • Site-wide: 2,346
• Since beginning of last month:
  • Site-wide: 10,427

Multivariate genome-wide association study identifies 1735 unique genetic loci associated with cortical morphology.

• Downloaded 309 times
• Download rankings, all-time:
  • Site-wide: 78,804
  • In genetics: 3,647
• Year to date:
  • Site-wide: 87,894
• Since beginning of last month:
  • Site-wide: None

Improved prediction of schizophrenia by leveraging genetic overlap with brain morphology

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 80,063
  • In psychiatry and clinical psychology: 248
• Year to date:
  • Site-wide: 33,491
• Since beginning of last month:
  • Site-wide: 29,592

Continuity and discontinuity in human cortical development and change from embryonic stages to old age

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 80,128
  • In neuroscience: 12,427
• Year to date:
  • Site-wide: 113,013
• Since beginning of last month:
  • Site-wide: 99,419

Correction of Artifacts Induced by B0 Inhomogeneities in Breast MRI using Reduced Field-of-View Echo-Planar Imaging and Enhanced Reverse Polarity Gradient Method

• Downloaded 267 times
• Download rankings, all-time:
  • Site-wide: 87,505
  • In radiology and imaging: 139
• Year to date:
  • Site-wide: 36,536
• Since beginning of last month:
  • Site-wide: 22,500

Voxel-level Classification of Prostate Cancer Using a Four-Compartment Restriction Spectrum Imaging Model

• Downloaded 249 times
• Download rankings, all-time:
  • Site-wide: 91,326
  • In oncology: 156
• Year to date:
  • Site-wide: 34,877
• Since beginning of last month:
  • Site-wide: 27,647

The effect of sample size on polygenic hazard models for prostate cancer

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 93,693
  • In genetics: 4,261
• Year to date:
  • Site-wide: 119,674
• Since beginning of last month:
  • Site-wide: 94,955

Atypical genomic patterning of the cerebral cortex in autism with poor early language outcome

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 95,176
  • In neuroscience: 14,905
• Year to date:
  • Site-wide: 54,324
• Since beginning of last month:
  • Site-wide: 40,822

Age dependence of modern clinical risk groups for localized prostate cancer — a population-based study

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 97,986
  • In epidemiology: 3,981
• Year to date:
  • Site-wide: 67,300
• Since beginning of last month:
  • Site-wide: 81,596

MODE for detecting and estimating genetic causal variants

• Downloaded 215 times
• Download rankings, all-time:
  • Site-wide: 98,640
  • In bioinformatics: 8,513
• Year to date:
  • Site-wide: 119,504
• Since beginning of last month:
  • Site-wide: 83,900

Discrimination of breast cancer from healthy breast tissues using a three-component diffusion-weighted MRI model

• Downloaded 191 times
• Download rankings, all-time:
  • Site-wide: 103,912
  • In radiology and imaging: 186
• Year to date:
  • Site-wide: 66,073
• Since beginning of last month:
  • Site-wide: 56,603

Delineating genetic and familial risk for psychopathology in the ABCD study

• Downloaded 190 times
• Download rankings, all-time:
  • Site-wide: 103,947
  • In genetic and genomic medicine: 414
• Year to date:
  • Site-wide: 37,735
• Since beginning of last month:
  • Site-wide: 58,287

Movement abilities and brain development in preschoolers born very preterm

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 105,731
  • In neuroscience: 16,492
• Year to date:
  • Site-wide: 81,594
• Since beginning of last month:
  • Site-wide: 61,465

Correcting B0 inhomogeneity-induced distortions in whole-body diffusion MRI of bone metastases

• Downloaded 157 times
• Download rankings, all-time:
  • Site-wide: 110,769
  • In radiology and imaging: 212
• Year to date:
  • Site-wide: 20,217
• Since beginning of last month:
  • Site-wide: 21,471

Characterization of the Diffusion Signal of Breast Tissues using Multi-exponential Models

• Downloaded 152 times
• Download rankings, all-time:
  • Site-wide: 111,600
  • In radiology and imaging: 217
• Year to date:
  • Site-wide: 107,441
• Since beginning of last month:
  • Site-wide: 102,353

Spatially Resolved Estimation of Metabolic Oxygen Consumption From Optical Measurements in Cortex

• Downloaded 136 times
• Download rankings, all-time:
  • Site-wide: 114,762
  • In neuroscience: 17,813
• Year to date:
  • Site-wide: 106,124
• Since beginning of last month:
  • Site-wide: 78,758

Associations between Early Midlife Lifestyle Behaviors, Young Adult Cognitive Reserve and Advanced Predicted Brain Age in Late Midlife

• Downloaded 112 times
• Download rankings, all-time:
  • Site-wide: 119,200
  • In neuroscience: 18,469
• Year to date:
  • Site-wide: 54,763
• Since beginning of last month:
  • Site-wide: 74,284

Common genetic and clinical risk factors: Association with fatal prostate cancer in the Cohort of Swedish Men

• Downloaded 84 times
• Download rankings, all-time:
  • Site-wide: 123,722
  • In genetic and genomic medicine: 572
• Year to date:
  • Site-wide: 93,053
• Since beginning of last month:
  • Site-wide: 91,770

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

• Downloaded 78 times
• Download rankings, all-time:
  • Site-wide: 124,505
  • In genetic and genomic medicine: 576
• Year to date:
  • Site-wide: 15,601
• Since beginning of last month:
  • Site-wide: 13,688