Author: James A Knowles

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,135
  • In genetics: 38
• Year to date:
  • Site-wide: 16,215
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Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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  • Site-wide: 4,114
  • In genetic and genomic medicine: 11
• Year to date:
  • Site-wide: 972
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  • Site-wide: 1,052

Ultra-rare genetic variation in the epilepsies: a whole-exome sequencing study of 17,606 individuals

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  • Site-wide: 6,904
  • In genetics: 338
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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 8,317
  • In genetics: 405
• Year to date:
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Deconvolution of Transcriptional Networks Identifies TCF4 as a Master Regulator in Schizophrenia

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  • Site-wide: 9,791
  • In neuroscience: 1,080
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  • Site-wide: 40,036
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Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

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  • Site-wide: 10,163
  • In psychiatry and clinical psychology: 32
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  • Site-wide: 3,435

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 11,309
  • In genomics: 1,258
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Assessing the measurement transfer function of single-cell RNA sequencing

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  • Site-wide: 17,180
  • In genomics: 1,796
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  • Site-wide: 118,771
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  • Site-wide: None

Polygenic selection underlies evolution of human brain structure and behavioral traits

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  • In evolutionary biology: 750
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  • Site-wide: 76,386

Rare copy number variants in NRXN1 and CNTN6 increase risk for Tourette syndrome

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  • In genetics: 1,038
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  • Site-wide: 91,662
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  • Site-wide: 79,619

Examination of the Shared Genetic Basis of Anorexia Nervosa and Obsessive-Compulsive Disorder

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  • In genetics: 1,043
• Year to date:
  • Site-wide: 75,480
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  • Site-wide: 51,293

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 23,215
  • In genetics: 1,150
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  • Site-wide: 3,545
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  • Site-wide: 2,711

Gene expression in patient-derived neural progenitors implicates WNT5A signaling in the etiology of schizophrenia

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  • Site-wide: 28,163
  • In genetics: 1,402
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Evolutionary and functional data power search for obsessive-compulsive disorder genes

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  • Site-wide: 31,047
  • In genomics: 2,818
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Contribution of rare copy number variants to bipolar disorder risk is limited to schizoaffective cases

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  • Site-wide: 48,162
  • In genetics: 2,299
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  • Site-wide: 92,313

Genetic variation in the Major Histocompatibility Complex and association with depression

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  • Site-wide: 60,114
  • In genetics: 2,848
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  • Site-wide: 118,046
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  • Site-wide: 90,521

Synaptic processes and immune-related pathways implicated in Tourette Syndrome

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  • Site-wide: 74,195
  • In genetic and genomic medicine: 228
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  • Site-wide: 35,655
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Concordance Of Genetic Variation That Increases Risk For Tourette Syndrome And That Influences Its Underlying Neurocircuitry

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  • Site-wide: 75,676
  • In genomics: 5,096
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  • Site-wide: 99,452
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Transcriptional Profiling of Primate Central Nucleus of the Amygdala Neurons to Understand the Molecular Underpinnings of Early Life Anxious Temperament

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  • Site-wide: 87,979
  • In neuroscience: 13,714
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A CTGF-YAP regulatory pathway is essential for angiogenesis and barriergenesis in the retina

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  • Site-wide: 93,330
  • In developmental biology: 2,532
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  • Site-wide: 46,717