Author: Pedro Beltrao

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Preprints

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

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  • Site-wide: 19
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  • Site-wide: 183
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  • Site-wide: 245

The functional landscape of the human phosphoproteome

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  • Site-wide: 3,944
  • In genomics: 468
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  • Site-wide: 11,136
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  • Site-wide: 26,712

Genome-wide meta-analysis, fine-mapping, and integrative prioritization identify new Alzheimer's disease risk genes

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  • Site-wide: 4,208
  • In genetic and genomic medicine: 10
• Year to date:
  • Site-wide: 20,908
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  • Site-wide: 4,010

Phenotype prediction in an Escherichia coli strain panel

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  • Site-wide: 10,771
  • In systems biology: 213
• Year to date:
  • Site-wide: 45,265
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  • Site-wide: 59,486

Chromosomal rearrangements are commonly post-transcriptionally attenuated in cancer

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  • Site-wide: 12,559
  • In genomics: 1,399
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  • Site-wide: 64,329
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  • Site-wide: 117,880

Global analysis of specificity determinants in eukaryotic protein kinases

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  • Site-wide: 13,187
  • In cell biology: 390
• Year to date:
  • Site-wide: 10,069
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  • Site-wide: 35,797

An Atlas of Human Kinase Regulation

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  • Site-wide: 13,864
  • In systems biology: 280
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  • Site-wide: 114,816
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Exploring amino acid functions in a deep mutational landscape

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  • Site-wide: 14,408
  • In systems biology: 301
• Year to date:
  • Site-wide: 102,288
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  • Site-wide: 18,205

Evolution of protein kinase substrate recognition at the active site

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  • Site-wide: 18,334
  • In evolutionary biology: 814
• Year to date:
  • Site-wide: 28,562
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  • Site-wide: 38,524

Towards a systematic map of the functional role of protein phosphorylation

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  • Site-wide: 20,173
  • In systems biology: 434
• Year to date:
  • Site-wide: 7,787
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  • Site-wide: 38,818

Genomic determinants of protein abundance variation in colorectal cancer cells

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  • Site-wide: 20,776
  • In systems biology: 452
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  • Site-wide: 97,610
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  • Site-wide: 117,381

Comprehensive variant effect predictions of single nucleotide variants in model organisms

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  • Site-wide: 22,661
  • In genomics: 2,246
• Year to date:
  • Site-wide: 88,778
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  • Site-wide: 102,618

iProteinDB: an integrative database of Drosophila post-translational modifications

• Downloaded 850 times
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  • Site-wide: 23,475
  • In bioinformatics: 2,853
• Year to date:
  • Site-wide: 70,302
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  • Site-wide: 119,280

Conserved phosphorylation hotspots in eukaryotic protein domain families

• Downloaded 831 times
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  • Site-wide: 24,232
  • In cell biology: 895
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  • Site-wide: 58,860
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  • Site-wide: 77,042

Capturing variation impact on molecular interactions: the IMEx Consortium mutations data set

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  • Site-wide: 24,678
  • In bioinformatics: 2,985
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  • Site-wide: 68,136
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  • Site-wide: 116,117

The impact of the genetic background on gene deletion phenotypes in Saccharomyces cerevisiae

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  • Site-wide: 24,856
  • In genetics: 1,256
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  • Site-wide: 38,393
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  • Site-wide: 106,713

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

• Downloaded 779 times
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  • Site-wide: 26,477
  • In microbiology: 1,546
• Year to date:
  • Site-wide: 60,800
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  • Site-wide: 57,819

Sub-minute phosphoregulation of cell-cycle systems during Plasmodium gamete formation

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  • Site-wide: 28,407
  • In microbiology: 1,685
• Year to date:
  • Site-wide: 35,054
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  • Site-wide: 49,549

Major role of iron uptake systems in the intrinsic extra-intestinal virulence of the genus Escherichia revealed by a genome-wide association study

• Downloaded 733 times
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  • Site-wide: 28,857
  • In microbiology: 1,706
• Year to date:
  • Site-wide: 48,108
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  • Site-wide: 90,253

Spatiotemporal proteomics uncovers cathepsin-dependent host cell death during bacterial infection

• Downloaded 691 times
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  • Site-wide: 31,266
  • In systems biology: 728
• Year to date:
  • Site-wide: 77,978
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  • Site-wide: 71,177

Systematic analysis of transcriptional and post-transcriptional regulation of metabolism in yeast

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  • Site-wide: 33,770
  • In systems biology: 787
• Year to date:
  • Site-wide: 121,312
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  • Site-wide: 90,543

Proteome-wide inference of protein kinase regulatory circuits

• Downloaded 648 times
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  • Site-wide: 34,071
  • In systems biology: 792
• Year to date:
  • Site-wide: 69,207
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  • Site-wide: 104,503

Copy number aberrations drive kinase re-wiring leading to genetic vulnerabilities in cancer

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  • Site-wide: 35,487
  • In genomics: 3,100
• Year to date:
  • Site-wide: 23,500
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  • Site-wide: 52,775

A FGF2-mediated incoherent feedforward loop induces Erk inhibition and promotes naive pluripotency

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  • Site-wide: 35,888
  • In developmental biology: 812
• Year to date:
  • Site-wide: 7,083
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  • Site-wide: 6,855

Conservation and structural analysis of the Xenopus laevis phospho-proteome

• Downloaded 587 times
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  • Site-wide: 38,663
  • In evolutionary biology: 2,076
• Year to date:
  • Site-wide: 121,864
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  • Site-wide: 90,711

Multi-omics characterization of interaction-mediated control of human protein abundance levels

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  • Site-wide: 52,940
  • In genomics: 4,091
• Year to date:
  • Site-wide: 118,034
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  • Site-wide: 105,855

Benchmarking substrate-based kinase activity inference using phosphoproteomic data

• Downloaded 367 times
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  • Site-wide: 64,961
  • In bioinformatics: 6,372
• Year to date:
  • Site-wide: 122,141
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  • Site-wide: 118,271

Actionable druggable genome-wide Mendelian randomization identifies repurposingopportunities for COVID-19

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  • Site-wide: 79,078
  • In epidemiology: 3,213
• Year to date:
  • Site-wide: 6,015
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  • Site-wide: 5,529