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Author: Stephen R Quake

Rankings

  • All-time downloads: 128,322 (rank: 685 )
  • Categories:
    • biochemistry: 317 (rank: 16,010 (tie) )
    • bioengineering: 2,214 (rank: 996 )
    • bioinformatics: 5,809 (rank: 1,989 )
    • biophysics: 538 (rank: 9,482 (tie) )
    • cancer biology: 3,290 (rank: 1,227 )
    • cell biology: 25,438 (rank: 4 )
    • developmental biology: 2,876 (rank: 770 )
    • genetics: 1,970 (rank: 9,144 (tie) )
    • genomics: 41,350 (rank: 187 )
    • immunology: 15,343 (rank: 503 )
    • microbiology: 7,312 (rank: 1,749 )
    • molecular biology: 430 (rank: 13,873 (tie) )
    • neuroscience: 19,393 (rank: 325 )
    • obstetrics and gynecology: 183 (rank: 817 (tie) )
    • systems biology: 1,859 (rank: 2,208 (tie) )

Downloads per author, site-wide

Preprints

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

cell biology more details view paper

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A molecular cell atlas of the human lung from single cell RNA sequencing

genomics more details view paper
  • Downloaded 18,885 times
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    • Site-wide: 356
    • In genomics: 16
  • Year to date:
    • Site-wide: 692
  • Since beginning of last month:
    • Site-wide: 737

Single-cell transcriptomic characterization of 20 organs and tissues from individual mice creates a Tabula Muris

cell biology more details view paper
  • Downloaded 13,251 times
  • Download rankings, all-time:
    • Site-wide: 544
    • In cell biology: 2
  • Year to date:
    • Site-wide: 13,934
  • Since beginning of last month:
    • Site-wide: 11,309

A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse

cell biology more details view paper
  • Downloaded 9,014 times
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    • Site-wide: 921
    • In cell biology: 9
  • Year to date:
    • Site-wide: 3,809
  • Since beginning of last month:
    • Site-wide: 4,585

c-Jun Overexpressing CAR-T Cells are Exhaustion-Resistant and Mediate Enhanced Antitumor Activity

immunology more details view paper
  • Downloaded 4,054 times
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    • Site-wide: 2,677
    • In immunology: 77
  • Year to date:
    • Site-wide: 14,641
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    • Site-wide: 14,308

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ pro-inflammatory macrophages

immunology more details view paper
  • Downloaded 3,547 times
  • Download rankings, all-time:
    • Site-wide: 3,257
    • In immunology: 93
  • Year to date:
    • Site-wide: 7,813
  • Since beginning of last month:
    • Site-wide: 10,027

The murine transcriptome reveals global aging nodes with organ-specific phase and amplitude

genomics more details view paper
  • Downloaded 3,335 times
  • Download rankings, all-time:
    • Site-wide: 3,557
    • In genomics: 400
  • Year to date:
    • Site-wide: 22,427
  • Since beginning of last month:
    • Site-wide: 31,780

Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencing

neuroscience more details view paper
  • Downloaded 3,135 times
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    • Site-wide: 3,885
    • In neuroscience: 322
  • Year to date:
    • Site-wide: 61,253
  • Since beginning of last month:
    • Site-wide: 40,792

Single cell profiling of total RNA using Smart-seq-total

genomics more details view paper
  • Downloaded 3,108 times
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    • Site-wide: 3,928
    • In genomics: 447
  • Year to date:
    • Site-wide: 3,048
  • Since beginning of last month:
    • Site-wide: 4,816

Classifying Drosophila Olfactory Projection Neuron Subtypes by Single-cell RNA Sequencing

genomics more details view paper
  • Downloaded 2,887 times
  • Download rankings, all-time:
    • Site-wide: 4,355
    • In genomics: 489
  • Year to date:
    • Site-wide: 81,573
  • Since beginning of last month:
    • Site-wide: 56,939

Pancreas patch-seq links physiologic dysfunction in diabetes to single-cell transcriptomic phenotypes

genomics more details view paper
  • Downloaded 2,629 times
  • Download rankings, all-time:
    • Site-wide: 4,988
    • In genomics: 561
  • Year to date:
    • Site-wide: 25,051
  • Since beginning of last month:
    • Site-wide: 19,460

Single cell RNAseq provides a molecular and cellular cartography of changes to the human endometrium through the menstrual cycle

genomics more details view paper
  • Downloaded 2,611 times
  • Download rankings, all-time:
    • Site-wide: 5,030
    • In genomics: 566
  • Year to date:
    • Site-wide: 17,989
  • Since beginning of last month:
    • Site-wide: 22,407

Serotonin Neurons in the Dorsal and Medial Raphe Nuclei: from Single-Cell Transcriptomes to Whole-Brain Projections

neuroscience more details view paper
  • Downloaded 2,412 times
  • Download rankings, all-time:
    • Site-wide: 5,674
    • In neuroscience: 530
  • Year to date:
    • Site-wide: 17,465
  • Since beginning of last month:
    • Site-wide: 19,360

Brain endothelial cells are exquisite sensors of age-related circulatory cues

neuroscience more details view paper
  • Downloaded 2,234 times
  • Download rankings, all-time:
    • Site-wide: 6,351
    • In neuroscience: 620
  • Year to date:
    • Site-wide: 21,431
  • Since beginning of last month:
    • Site-wide: 33,439

Cell-Surface Proteomic Profiling in the Fly Brain Uncovers New Wiring Regulators

neuroscience more details view paper
  • Downloaded 2,219 times
  • Download rankings, all-time:
    • Site-wide: 6,416
    • In neuroscience: 632
  • Year to date:
    • Site-wide: 63,899
  • Since beginning of last month:
    • Site-wide: 70,814

Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA

cancer biology more details view paper
  • Downloaded 2,115 times
  • Download rankings, all-time:
    • Site-wide: 6,885
    • In cancer biology: 106
  • Year to date:
    • Site-wide: 31,988
  • Since beginning of last month:
    • Site-wide: 22,321

A mouse tissue atlas of small non-coding RNA

genomics more details view paper
  • Downloaded 2,009 times
  • Download rankings, all-time:
    • Site-wide: 7,403
    • In genomics: 803
  • Year to date:
    • Site-wide: 21,394
  • Since beginning of last month:
    • Site-wide: 20,743

Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks

neuroscience more details view paper
  • Downloaded 1,989 times
  • Download rankings, all-time:
    • Site-wide: 7,528
    • In neuroscience: 760
  • Year to date:
    • Site-wide: 6,641
  • Since beginning of last month:
    • Site-wide: 10,104

Nonivasive prenatal diagnosis of single-gene disorders using droplet digital PCR

genetics more details view paper
  • Downloaded 1,970 times
  • Download rankings, all-time:
    • Site-wide: 7,641
    • In genetics: 356
  • Year to date:
    • Site-wide: 31,381
  • Since beginning of last month:
    • Site-wide: 24,766

Single-cell analysis identifies EpCAM+/CDH6+/TROP-2- cells as human liver progenitors.

cell biology more details view paper
  • Downloaded 1,934 times
  • Download rankings, all-time:
    • Site-wide: 7,853
    • In cell biology: 184
  • Year to date:
    • Site-wide: 47,819
  • Since beginning of last month:
    • Site-wide: 62,511

Human IgE producing B cells have a unique transcriptional program and generate high affinity, allergen-specific antibodies

immunology more details view paper
  • Downloaded 1,927 times
  • Download rankings, all-time:
    • Site-wide: 7,887
    • In immunology: 228
  • Year to date:
    • Site-wide: 37,303
  • Since beginning of last month:
    • Site-wide: 30,193

Self-assembling Manifolds in Single-cell RNA Sequencing Data

bioinformatics more details view paper
  • Downloaded 1,904 times
  • Download rankings, all-time:
    • Site-wide: 8,032
    • In bioinformatics: 971
  • Year to date:
    • Site-wide: 84,100
  • Since beginning of last month:
    • Site-wide: 74,205

Single cell transcriptome analysis of human pancreas reveals transcriptional signatures of aging and somatic mutation patterns.

genomics more details view paper
  • Downloaded 1,898 times
  • Download rankings, all-time:
    • Site-wide: 8,076
    • In genomics: 878
  • Year to date:
    • Site-wide: 83,432
  • Since beginning of last month:
    • Site-wide: 96,715

Cerebellar nuclei evolved by repeatedly duplicating a conserved cell type set

neuroscience more details view paper
  • Downloaded 1,892 times
  • Download rankings, all-time:
    • Site-wide: 8,112
    • In neuroscience: 837
  • Year to date:
    • Site-wide: 17,392
  • Since beginning of last month:
    • Site-wide: 23,334

Single-cell RNA-seq reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress

systems biology more details view paper
  • Downloaded 1,859 times
  • Download rankings, all-time:
    • Site-wide: 8,346
    • In systems biology: 148
  • Year to date:
    • Site-wide: 98,370
  • Since beginning of last month:
    • Site-wide: 109,078

Molecular hallmarks of heterochronic parabiosis at single cell resolution

genomics more details view paper
  • Downloaded 1,700 times
  • Download rankings, all-time:
    • Site-wide: 9,556
    • In genomics: 1,045
  • Year to date:
    • Site-wide: 2,418
  • Since beginning of last month:
    • Site-wide: 3,489

Humans are colonized by many uncharacterized and highly divergent microbes

microbiology more details view paper
  • Downloaded 1,582 times
  • Download rankings, all-time:
    • Site-wide: 10,602
    • In microbiology: 599
  • Year to date:
    • Site-wide: 123,517
  • Since beginning of last month:
    • Site-wide: 131,934

Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples

microbiology more details view paper
  • Downloaded 1,497 times
  • Download rankings, all-time:
    • Site-wide: 11,452
    • In microbiology: 643
  • Year to date:
    • Site-wide: 126,768
  • Since beginning of last month:
    • Site-wide: 96,362

Mapping single-cell atlases throughout Metazoa unravels cell type evolution

bioinformatics more details view paper
  • Downloaded 1,478 times
  • Download rankings, all-time:
    • Site-wide: 11,668
    • In bioinformatics: 1,422
  • Year to date:
    • Site-wide: 1,605
  • Since beginning of last month:
    • Site-wide: 887

Single-cell transcriptional dynamics of flavivirus infection

microbiology more details view paper
  • Downloaded 1,403 times
  • Download rankings, all-time:
    • Site-wide: 12,654
    • In microbiology: 717
  • Year to date:
    • Site-wide: 87,663
  • Since beginning of last month:
    • Site-wide: 79,553

Transcriptional program of memory B cell activation, broadly binding anti-influenza antibodies, and bystander activation after vaccination revealed by single-cell transcriptomics

immunology more details view paper
  • Downloaded 1,398 times
  • Download rankings, all-time:
    • Site-wide: 12,731
    • In immunology: 361
  • Year to date:
    • Site-wide: 12,226
  • Since beginning of last month:
    • Site-wide: 12,825

Discrete and Continuous Cell Identities of the Adult Murine Striatum

neuroscience more details view paper
  • Downloaded 1,386 times
  • Download rankings, all-time:
    • Site-wide: 12,906
    • In neuroscience: 1,494
  • Year to date:
    • Site-wide: 32,029
  • Since beginning of last month:
    • Site-wide: 43,433

Persistent transcriptional programs are associated with remote memory in diverse cells of the medial prefrontal cortex

neuroscience more details view paper
  • Downloaded 1,367 times
  • Download rankings, all-time:
    • Site-wide: 13,175
    • In neuroscience: 1,530
  • Year to date:
    • Site-wide: 34,209
  • Since beginning of last month:
    • Site-wide: 39,107

Coordinating Receptor Expression and Wiring Specificity in Olfactory Receptor Neurons

neuroscience more details view paper
  • Downloaded 1,347 times
  • Download rankings, all-time:
    • Site-wide: 13,474
    • In neuroscience: 1,569
  • Year to date:
    • Site-wide: 40,884
  • Since beginning of last month:
    • Site-wide: 46,221

Single-Cell RNAseq analysis of infiltrating neoplastic cells at the migrating front of human glioblastoma

cancer biology more details view paper
  • Downloaded 1,175 times
  • Download rankings, all-time:
    • Site-wide: 16,560
    • In cancer biology: 373
  • Year to date:
    • Site-wide: 61,238
  • Since beginning of last month:
    • Site-wide: 52,804

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

genomics more details view paper
  • Downloaded 1,077 times
  • Download rankings, all-time:
    • Site-wide: 18,827
    • In genomics: 1,909
  • Year to date:
    • Site-wide: 94,447
  • Since beginning of last month:
    • Site-wide: 87,521

Signatures of Selection in the Human Antibody Repertoire: Selective Sweeps, Competing Subclones, and Neutral Drift

immunology more details view paper
  • Downloaded 1,077 times
  • Download rankings, all-time:
    • Site-wide: 18,848
    • In immunology: 550
  • Year to date:
    • Site-wide: 119,666
  • Since beginning of last month:
    • Site-wide: 118,589

Molecular and genetic regulation of pig pancreatic islet cell development

developmental biology more details view paper
  • Downloaded 1,066 times
  • Download rankings, all-time:
    • Site-wide: 19,134
    • In developmental biology: 335
  • Year to date:
    • Site-wide: 33,143
  • Since beginning of last month:
    • Site-wide: 36,841

PhaMers identifies novel bacteriophage sequences from thermophilic hot springs

bioinformatics more details view paper
  • Downloaded 1,047 times
  • Download rankings, all-time:
    • Site-wide: 19,637
    • In bioinformatics: 2,335
  • Year to date:
    • Site-wide: 93,015
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    • Site-wide: 121,786

Evolutionary Origin of the Mammalian Hematopoietic System Found in a Colonial Chordate

immunology more details view paper
  • Downloaded 966 times
  • Download rankings, all-time:
    • Site-wide: 22,050
    • In immunology: 642
  • Year to date:
    • Site-wide: 42,614
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    • Site-wide: 26,827

Hydrogenotrophic methanogenesis in archaeal phylum Verstraetearchaeota reveals the shared ancestry of all methanogens

microbiology more details view paper
  • Downloaded 962 times
  • Download rankings, all-time:
    • Site-wide: 22,174
    • In microbiology: 1,259
  • Year to date:
    • Site-wide: 110,142
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    • Site-wide: 96,218

Dynamics Of The Human Antibody Repertoire Following B-cell Depletion In Systemic Sclerosis

immunology more details view paper
  • Downloaded 945 times
  • Download rankings, all-time:
    • Site-wide: 22,781
    • In immunology: 662
  • Year to date:
    • Site-wide: 86,453
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    • Site-wide: 114,414

Virus-inclusive single cell RNA sequencing reveals molecular signature predictive of progression to severe dengue infection

immunology more details view paper
  • Downloaded 917 times
  • Download rankings, all-time:
    • Site-wide: 23,819
    • In immunology: 700
  • Year to date:
    • Site-wide: 120,975
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    • Site-wide: 118,911

A single-parasite transcriptional atlas of Toxoplasma gondii reveals novel control of antigen expression

bioengineering more details view paper
  • Downloaded 908 times
  • Download rankings, all-time:
    • Site-wide: 24,146
    • In bioengineering: 402
  • Year to date:
    • Site-wide: 90,170
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    • Site-wide: 112,140

Northstar enables automatic classification of known and novel cell types from tumor samples

bioinformatics more details view paper
  • Downloaded 866 times
  • Download rankings, all-time:
    • Site-wide: 25,831
    • In bioinformatics: 3,026
  • Year to date:
    • Site-wide: 50,849
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    • Site-wide: 45,250

Latrophilin-2 repels Teneurin-3+ hippocampal axons during target selection

neuroscience more details view paper
  • Downloaded 861 times
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    • Site-wide: 26,003
    • In neuroscience: 3,427
  • Year to date:
    • Site-wide: 6,427
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    • Site-wide: 3,337

A Noninvasive Molecular Clock for Fetal Development Predicts Gestational Age and Preterm Delivery

bioengineering more details view paper
  • Downloaded 811 times
  • Download rankings, all-time:
    • Site-wide: 28,278
    • In bioengineering: 488
  • Year to date:
    • Site-wide: 94,481
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    • Site-wide: 98,998

Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung revealed at single cell resolution

developmental biology more details view paper
  • Downloaded 719 times
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    • Site-wide: 33,462
    • In developmental biology: 694
  • Year to date:
    • Site-wide: 48,111
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    • Site-wide: 45,266

Nucleic Acid Cleavage with a Hyperthermophilic Cas9 from an Unculturable Ignavibacterium

genomics more details view paper
  • Downloaded 702 times
  • Download rankings, all-time:
    • Site-wide: 34,575
    • In genomics: 3,012
  • Year to date:
    • Site-wide: 87,890
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    • Site-wide: 129,150

Single-cell transcriptional atlas of the Chinese horseshoe bat (Rhinolophus sinicus) provides insight into the cellular mechanisms which enable bats to be viral reservoirs

cell biology more details view paper
  • Downloaded 661 times
  • Download rankings, all-time:
    • Site-wide: 37,450
    • In cell biology: 1,526
  • Year to date:
    • Site-wide: 18,039
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    • Site-wide: 22,039

The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection

microbiology more details view paper
  • Downloaded 588 times
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    • Site-wide: 43,481
    • In microbiology: 2,680
  • Year to date:
    • Site-wide: 17,330
  • Since beginning of last month:
    • Site-wide: 9,020

Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons

neuroscience more details view paper
  • Downloaded 551 times
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    • Site-wide: 47,060
    • In neuroscience: 6,863
  • Year to date:
    • Site-wide: 35,321
  • Since beginning of last month:
    • Site-wide: 51,721

Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo

biophysics more details view paper
  • Downloaded 538 times
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    • Site-wide: 48,443
    • In biophysics: 1,635
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    • Site-wide: 58,522
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    • Site-wide: 77,535

Functional characterization and lineage analysis of broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

microbiology more details view paper
  • Downloaded 529 times
  • Download rankings, all-time:
    • Site-wide: 49,351
    • In microbiology: 3,121
  • Year to date:
    • Site-wide: 85,889
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    • Site-wide: 84,759

Molecular and Morphological Signatures of Chordate Development: Two Distinct Pathways, One Tunicate

developmental biology more details view paper
  • Downloaded 528 times
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    • Site-wide: 49,542
    • In developmental biology: 1,177
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    • Site-wide: 70,911
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    • Site-wide: 57,209

Modeling Spatial Correlation of Transcripts With Application to Developing Pancreas

bioinformatics more details view paper
  • Downloaded 514 times
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    • Site-wide: 51,130
    • In bioinformatics: 5,254
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    • Site-wide: 109,721
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    • Site-wide: 97,826

Matrix-corrected mass spectrometry enables sensitive detection of food allergens and reveals widespread soy contamination of processed foods

immunology more details view paper
  • Downloaded 512 times
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    • Site-wide: 51,369
    • In immunology: 1,441
  • Year to date:
    • Site-wide: 79,791
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    • Site-wide: 56,589

Viral Taxonomy Derived From Evolutionary Genome Relationships

genomics more details view paper
  • Downloaded 509 times
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    • Site-wide: 51,769
    • In genomics: 4,019
  • Year to date:
    • Site-wide: 102,390
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    • Site-wide: 78,741

An inexpensive semi-automated sample processing pipeline for cell-free RNA

bioengineering more details view paper
  • Downloaded 495 times
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    • Site-wide: 53,425
    • In bioengineering: 989
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    • Site-wide: 19,612
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    • Site-wide: 17,818

Single-cell analysis of Schistosoma mansoni reveals a conserved genetic program controlling germline stem cell fate

developmental biology more details view paper
  • Downloaded 466 times
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    • Site-wide: 57,071
    • In developmental biology: 1,404
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    • Site-wide: 43,076
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    • Site-wide: 54,532

Non-invasive characterization of human bone marrow by cell free messenger-RNA reveals response to growth factor stimulation and hematopoietic reconstitution after transplantation

molecular biology more details view paper
  • Downloaded 430 times
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    • Site-wide: 62,108
    • In molecular biology: 1,783
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    • Site-wide: 118,951
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    • Site-wide: 116,960

Differential Impacts on Host Transcription by ROP and GRA Effectors from the Intracellular Parasite Toxoplasma gondii

microbiology more details view paper
  • Downloaded 379 times
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    • Site-wide: 70,141
    • In microbiology: 4,763
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    • Site-wide: 104,727
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    • Site-wide: 92,309

Cell-free DNA Reveals Potential Zoonotic Reservoirs in Non-Human Primates

microbiology more details view paper
  • Downloaded 372 times
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    • Site-wide: 71,402
    • In microbiology: 4,852
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    • Site-wide: 101,372
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    • Site-wide: 113,222

NFIA regulates granule recruitment and exocytosis in the adult pancreas

cell biology more details view paper
  • Downloaded 356 times
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    • Site-wide: 74,220
    • In cell biology: 3,395
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    • Site-wide: 79,168
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    • Site-wide: 104,079

Kinetics and Fidelity of Psychrophilic DNA Polymerases

biochemistry more details view paper
  • Downloaded 317 times
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    • In biochemistry: 2,336
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    • Site-wide: 31,058
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Single-cell RNA Expression of SARS-CoV-2 Cell Entry Factors in Human Endometrium during Preconception

cell biology more details view paper
  • Downloaded 222 times
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    • Site-wide: 102,222
    • In cell biology: 4,749
  • Year to date:
    • Site-wide: 63,982
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    • Site-wide: 50,664

Early prediction of preeclampsia in pregnancy with circulating, cell-free RNA

obstetrics and gynecology more details view paper
  • Downloaded 183 times
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    • Site-wide: 110,830
    • In obstetrics and gynecology: 93
  • Year to date:
    • Site-wide: 12,318
  • Since beginning of last month:
    • Site-wide: 3,535

Global Age-Specific Patterns of Cyclic Gene Expression Revealed by Tunicate Transcriptome Atlas

developmental biology more details view paper
  • Downloaded 97 times
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    • Site-wide: 127,796
    • In developmental biology: 3,387
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    • Site-wide: 69,027
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