Author: Ian J Deary

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Preprints

Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

• Downloaded 25,125 times
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  • Site-wide: 251
  • In neuroscience: 7
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

• Downloaded 5,134 times
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  • Site-wide: 1,787
  • In genetics: 68
• Year to date:
  • Site-wide: 25,179
• Since beginning of last month:
  • Site-wide: None

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,504 times
• Download rankings, all-time:
  • Site-wide: 2,148
  • In genetics: 83
• Year to date:
  • Site-wide: 23,603
• Since beginning of last month:
  • Site-wide: 16,090

Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

• Downloaded 4,463 times
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  • Site-wide: 2,180
  • In genetics: 84
• Year to date:
  • Site-wide: 18,563
• Since beginning of last month:
  • Site-wide: 14,771

Genomic analysis of family data reveals additional genetic effects on intelligence and personality

• Downloaded 4,178 times
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  • Site-wide: 2,387
  • In genetics: 94
• Year to date:
  • Site-wide: 21,141
• Since beginning of last month:
  • Site-wide: 19,038

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,247 times
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  • Site-wide: 3,460
  • In genetics: 148
• Year to date:
  • Site-wide: 25,028
• Since beginning of last month:
  • Site-wide: 23,704

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,559 times
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  • Site-wide: 4,838
  • In genetics: 224
• Year to date:
  • Site-wide: 69,647
• Since beginning of last month:
  • Site-wide: None

Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population

• Downloaded 2,302 times
• Download rankings, all-time:
  • Site-wide: 5,682
  • In epidemiology: 471
• Year to date:
  • Site-wide: 25,826
• Since beginning of last month:
  • Site-wide: 25,200

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia.

• Downloaded 1,775 times
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  • Site-wide: 8,310
  • In genetics: 405
• Year to date:
  • Site-wide: 61,291
• Since beginning of last month:
  • Site-wide: 63,793

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,704 times
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  • Site-wide: 8,858
  • In genetics: 440
• Year to date:
  • Site-wide: 54,830
• Since beginning of last month:
  • Site-wide: 52,487

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

• Downloaded 1,686 times
• Download rankings, all-time:
  • Site-wide: 9,027
  • In genetics: 447
• Year to date:
  • Site-wide: 43,143
• Since beginning of last month:
  • Site-wide: 30,374

Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

• Downloaded 1,614 times
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  • Site-wide: 9,632
  • In genetics: 481
• Year to date:
  • Site-wide: 61,313
• Since beginning of last month:
  • Site-wide: 42,506

Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

• Downloaded 1,487 times
• Download rankings, all-time:
  • Site-wide: 10,825
  • In genetics: 537
• Year to date:
  • Site-wide: 71,291
• Since beginning of last month:
  • Site-wide: 49,535

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,347 times
• Download rankings, all-time:
  • Site-wide: 12,558
  • In genetics: 633
• Year to date:
  • Site-wide: 76,023
• Since beginning of last month:
  • Site-wide: 39,281

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 1,320 times
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  • Site-wide: 12,935
  • In genomics: 1,413
• Year to date:
  • Site-wide: 107,091
• Since beginning of last month:
  • Site-wide: 65,323

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

• Downloaded 1,289 times
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  • Site-wide: 13,413
  • In bioinformatics: 1,653
• Year to date:
  • Site-wide: 54,501
• Since beginning of last month:
  • Site-wide: 77,352

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 1,037 times
• Download rankings, all-time:
  • Site-wide: 18,620
  • In genetics: 932
• Year to date:
  • Site-wide: 76,273
• Since beginning of last month:
  • Site-wide: 59,634

Epigenetic prediction of complex traits and death

• Downloaded 982 times
• Download rankings, all-time:
  • Site-wide: 20,150
  • In genomics: 2,035
• Year to date:
  • Site-wide: 77,138
• Since beginning of last month:
  • Site-wide: 90,910

Reliability and validity of the UK Biobank cognitive tests

• Downloaded 896 times
• Download rankings, all-time:
  • Site-wide: 22,990
  • In epidemiology: 1,259
• Year to date:
  • Site-wide: 53,156
• Since beginning of last month:
  • Site-wide: 38,652

Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

• Downloaded 881 times
• Download rankings, all-time:
  • Site-wide: 23,591
  • In genetics: 1,176
• Year to date:
  • Site-wide: 69,597
• Since beginning of last month:
  • Site-wide: 49,784

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

• Downloaded 857 times
• Download rankings, all-time:
  • Site-wide: 24,528
  • In genetics: 1,215
• Year to date:
  • Site-wide: 103,477
• Since beginning of last month:
  • Site-wide: 89,987

Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

• Downloaded 825 times
• Download rankings, all-time:
  • Site-wide: 25,845
  • In neuroscience: 3,467
• Year to date:
  • Site-wide: 81,452
• Since beginning of last month:
  • Site-wide: 92,997

Polygenic architecture of human neuroanatomical diversity

• Downloaded 805 times
• Download rankings, all-time:
  • Site-wide: 26,707
  • In neuroscience: 3,604
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 798 times
• Download rankings, all-time:
  • Site-wide: 27,024
  • In genetics: 1,348
• Year to date:
  • Site-wide: 25,482
• Since beginning of last month:
  • Site-wide: 42,952

Planar cell polarity pathway and development of the human visual cortex

• Downloaded 757 times
• Download rankings, all-time:
  • Site-wide: 29,145
  • In neuroscience: 3,987
• Year to date:
  • Site-wide: 43,216
• Since beginning of last month:
  • Site-wide: 51,421

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 746 times
• Download rankings, all-time:
  • Site-wide: 29,726
  • In genomics: 2,720
• Year to date:
  • Site-wide: 69,284
• Since beginning of last month:
  • Site-wide: 66,339

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 743 times
• Download rankings, all-time:
  • Site-wide: 29,891
  • In genetics: 1,482
• Year to date:
  • Site-wide: 71,302
• Since beginning of last month:
  • Site-wide: 49,381

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

• Downloaded 724 times
• Download rankings, all-time:
  • Site-wide: 31,002
  • In genetics: 1,535
• Year to date:
  • Site-wide: 103,912
• Since beginning of last month:
  • Site-wide: 95,960

Associations between vascular risk factors and brain MRI indices in UK Biobank

• Downloaded 672 times
• Download rankings, all-time:
  • Site-wide: 34,261
  • In neuroscience: 4,807
• Year to date:
  • Site-wide: 104,874
• Since beginning of last month:
  • Site-wide: 90,078

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

• Downloaded 659 times
• Download rankings, all-time:
  • Site-wide: 35,228
  • In genetics: 1,726
• Year to date:
  • Site-wide: 77,045
• Since beginning of last month:
  • Site-wide: 57,314

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 659 times
• Download rankings, all-time:
  • Site-wide: 35,204
  • In genetics: 1,723
• Year to date:
  • Site-wide: 111,273
• Since beginning of last month:
  • Site-wide: 74,809

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

• Downloaded 628 times
• Download rankings, all-time:
  • Site-wide: 37,464
  • In genomics: 3,211
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

• Downloaded 626 times
• Download rankings, all-time:
  • Site-wide: 37,628
  • In genomics: 3,223
• Year to date:
  • Site-wide: 58,337
• Since beginning of last month:
  • Site-wide: 59,062

Cognitive ability and physical health: a Mendelian randomization study

• Downloaded 605 times
• Download rankings, all-time:
  • Site-wide: 39,257
  • In genetics: 1,906
• Year to date:
  • Site-wide: 90,250
• Since beginning of last month:
  • Site-wide: 96,021

Generalisability of Results from UK Biobank: Comparison With a Pooling of 18 Cohort Studies

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 40,850
  • In epidemiology: 1,923
• Year to date:
  • Site-wide: 45,345
• Since beginning of last month:
  • Site-wide: 69,303

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

• Downloaded 490 times
• Download rankings, all-time:
  • Site-wide: 50,750
  • In genomics: 3,997
• Year to date:
  • Site-wide: 87,336
• Since beginning of last month:
  • Site-wide: None

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 474 times
• Download rankings, all-time:
  • Site-wide: 52,696
  • In genetics: 2,503
• Year to date:
  • Site-wide: 88,353
• Since beginning of last month:
  • Site-wide: 74,694

Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

• Downloaded 460 times
• Download rankings, all-time:
  • Site-wide: 54,484
  • In neuroscience: 8,161
• Year to date:
  • Site-wide: 117,800
• Since beginning of last month:
  • Site-wide: 96,683

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

• Downloaded 433 times
• Download rankings, all-time:
  • Site-wide: 58,076
  • In genetics: 2,750
• Year to date:
  • Site-wide: 26,678
• Since beginning of last month:
  • Site-wide: 12,843

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

• Downloaded 429 times
• Download rankings, all-time:
  • Site-wide: 58,516
  • In neuroscience: 8,897
• Year to date:
  • Site-wide: 94,999
• Since beginning of last month:
  • Site-wide: 103,687

A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

• Downloaded 415 times
• Download rankings, all-time:
  • Site-wide: 60,679
  • In genetics: 2,879
• Year to date:
  • Site-wide: 82,616
• Since beginning of last month:
  • Site-wide: 74,791

Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

• Downloaded 410 times
• Download rankings, all-time:
  • Site-wide: 61,343
  • In neuroscience: 9,344
• Year to date:
  • Site-wide: 120,630
• Since beginning of last month:
  • Site-wide: 103,381

Epigenetic prediction of major depressive disorder

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 62,872
  • In psychiatry and clinical psychology: 186
• Year to date:
  • Site-wide: 121,037
• Since beginning of last month:
  • Site-wide: 85,842

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

• Downloaded 392 times
• Download rankings, all-time:
  • Site-wide: 64,194
  • In genomics: 4,629
• Year to date:
  • Site-wide: 87,289
• Since beginning of last month:
  • Site-wide: 60,907

Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD

• Downloaded 383 times
• Download rankings, all-time:
  • Site-wide: 65,639
  • In neurology: 130
• Year to date:
  • Site-wide: 79,250
• Since beginning of last month:
  • Site-wide: 85,405

Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

• Downloaded 378 times
• Download rankings, all-time:
  • Site-wide: 66,390
  • In neuroscience: 10,170
• Year to date:
  • Site-wide: 96,260
• Since beginning of last month:
  • Site-wide: 78,789

SNPs associated with HHIP expression have differential effects on lung function in males and females

• Downloaded 375 times
• Download rankings, all-time:
  • Site-wide: 66,894
  • In genetics: 3,129
• Year to date:
  • Site-wide: 110,799
• Since beginning of last month:
  • Site-wide: None

The influence of X chromosome variants on trait neuroticism.

• Downloaded 372 times
• Download rankings, all-time:
  • Site-wide: 67,312
  • In genetics: 3,154
• Year to date:
  • Site-wide: 103,611
• Since beginning of last month:
  • Site-wide: 80,373

An epigenetic predictor of death captures multi-modal measures of brain health

• Downloaded 365 times
• Download rankings, all-time:
  • Site-wide: 68,513
  • In neuroscience: 10,514
• Year to date:
  • Site-wide: 118,202
• Since beginning of last month:
  • Site-wide: 83,837

Blood pressure and cognitive function across the eighth decade: a prospective study of the Lothian Birth Cohort of 1936

• Downloaded 352 times
• Download rankings, all-time:
  • Site-wide: 70,721
  • In geriatric medicine: 31
• Year to date:
  • Site-wide: 113,504
• Since beginning of last month:
  • Site-wide: 101,263

Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

• Downloaded 344 times
• Download rankings, all-time:
  • Site-wide: 72,108
  • In epidemiology: 2,990
• Year to date:
  • Site-wide: 108,534
• Since beginning of last month:
  • Site-wide: 80,249

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

• Downloaded 337 times
• Download rankings, all-time:
  • Site-wide: 73,435
  • In genetics: 3,423
• Year to date:
  • Site-wide: 109,982
• Since beginning of last month:
  • Site-wide: 95,181

An epigenome-wide association study of sex-specific chronological ageing

• Downloaded 320 times
• Download rankings, all-time:
  • Site-wide: 76,428
  • In genomics: 5,130
• Year to date:
  • Site-wide: 122,866
• Since beginning of last month:
  • Site-wide: 103,724

Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 85,272
  • In neuroscience: 13,266
• Year to date:
  • Site-wide: 70,013
• Since beginning of last month:
  • Site-wide: 51,822

An epigenetic proxy of chronic inflammation outperforms serum levels as a biomarker of brain ageing

• Downloaded 265 times
• Download rankings, all-time:
  • Site-wide: 87,683
  • In neurology: 220
• Year to date:
  • Site-wide: 18,493
• Since beginning of last month:
  • Site-wide: 16,224

Quantitative Measurements of Enlarged Perivascular Spaces in the Brain are Associated with Retinal Microvascular Parameters in Older Community-Dwelling Subjects

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 89,797
  • In neuroscience: 14,021
• Year to date:
  • Site-wide: 78,627
• Since beginning of last month:
  • Site-wide: 103,588

Age and mortality associated DNA methylation patterns on the X-chromosome in male and female samples

• Downloaded 244 times
• Download rankings, all-time:
  • Site-wide: 92,191
  • In genetics: 4,206
• Year to date:
  • Site-wide: 89,458
• Since beginning of last month:
  • Site-wide: 64,564

DNA methylation outlier burden, health and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936.

• Downloaded 226 times
• Download rankings, all-time:
  • Site-wide: 96,027
  • In genetic and genomic medicine: 358
• Year to date:
  • Site-wide: 101,677
• Since beginning of last month:
  • Site-wide: 69,235

Childhood coordination and survival up to six decades later: extended follow-up of participants in the National Child Development Study

• Downloaded 225 times
• Download rankings, all-time:
  • Site-wide: 96,301
  • In epidemiology: 3,895
• Year to date:
  • Site-wide: 105,789
• Since beginning of last month:
  • Site-wide: 101,602

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 97,767
  • In neuroscience: 15,312
• Year to date:
  • Site-wide: 122,502
• Since beginning of last month:
  • Site-wide: 103,650

Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 97,720
  • In neuroscience: 15,297
• Year to date:
  • Site-wide: 119,032
• Since beginning of last month:
  • Site-wide: 97,590

DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

• Downloaded 210 times
• Download rankings, all-time:
  • Site-wide: 99,458
  • In neuroscience: 15,557
• Year to date:
  • Site-wide: 113,931
• Since beginning of last month:
  • Site-wide: 77,059

Health literacy, cognitive ability and self-reported diabetes in the English Longitudinal Study of Ageing

• Downloaded 202 times
• Download rankings, all-time:
  • Site-wide: 101,254
  • In epidemiology: 4,124
• Year to date:
  • Site-wide: 99,395
• Since beginning of last month:
  • Site-wide: 69,294

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 101,916
  • In genomics: 6,014
• Year to date:
  • Site-wide: 99,026
• Since beginning of last month:
  • Site-wide: 100,787

DNA methylation proxies for 16 plasma proteins predict the incidence of 7 leading causes of morbidity

• Downloaded 192 times
• Download rankings, all-time:
  • Site-wide: 103,510
  • In genomics: 6,061
• Year to date:
  • Site-wide: 16,350
• Since beginning of last month:
  • Site-wide: 22,203

Life course air pollution exposure and cognitive decline: modelled historical air pollution data and the Lothian Birth Cohort 1936

• Downloaded 152 times
• Download rankings, all-time:
  • Site-wide: 111,388
  • In epidemiology: 4,528
• Year to date:
  • Site-wide: 28,903
• Since beginning of last month:
  • Site-wide: 31,096

The Influence of Phenotyping Method on Neuroimaging Associations with Depression in UK Biobank

• Downloaded 113 times
• Download rankings, all-time:
  • Site-wide: 118,751
  • In psychiatry and clinical psychology: 527
• Year to date:
  • Site-wide: 26,939
• Since beginning of last month:
  • Site-wide: 25,334

Birth weight is associated with brain tissue volumes seven decades later, but not with age-associated changes to brain structure

• Downloaded 109 times
• Download rankings, all-time:
  • Site-wide: 119,459
  • In neuroscience: 18,523
• Year to date:
  • Site-wide: 51,138
• Since beginning of last month:
  • Site-wide: 70,520

A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

• Downloaded 105 times
• Download rankings, all-time:
  • Site-wide: 120,223
  • In neuroscience: 18,623
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

• Downloaded 90 times
• Download rankings, all-time:
  • Site-wide: 122,639
  • In radiology and imaging: 250
• Year to date:
  • Site-wide: 12,779
• Since beginning of last month:
  • Site-wide: 3,425