Author: I.J. Deary

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Preprints

Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

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The genetic architecture of the human cerebral cortex

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Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Genomic analysis of family data reveals additional genetic effects on intelligence and personality

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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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Genome-wide association study identifies 48 common genetic variants associated with handedness

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Genetic “General Intelligence,” Objectively Determined and Measured

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Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia.

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Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

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Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

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116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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Bayesian reassessment of the epigenetic architecture of complex traits

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Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

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OSCA: a tool for omic-data-based complex trait analysis

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Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

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Epigenetic prediction of complex traits and death

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Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

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Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

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Polygenic architecture of human neuroanatomical diversity

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

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Factors associated with sharing email information and mental health survey participation in large population cohorts

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Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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Planar cell polarity pathway and development of the human visual cortex

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Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

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Associations between vascular risk factors and brain MRI indices in UK Biobank

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Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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Cognitive ability and physical health: a Mendelian randomization study

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Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

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Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

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Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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Accelerated Epigenetic Ageing in Major Depressive Disorder

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Age-related clonal haemopoiesis is associated with increased epigenetic age

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Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

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Polygenic predictors of age-related decline in cognitive ability

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Meta-analysis of exome array data identifies six novel genetic loci for lung function

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Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

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Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life

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A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

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Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

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Genetic correlations between pain phenotypes and depression and neuroticism

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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

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Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank

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Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

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Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

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Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

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Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

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Dissection of Major Depressive Disorder using polygenic risk scores for Schizophrenia in two independent cohort.

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An epigenetic predictor of death captures multi-modal measures of brain health

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Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

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SNPs associated with HHIP expression have differential effects on lung function in males and females

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The influence of X chromosome variants on trait neuroticism.

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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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An epigenome-wide association study of sex-specific chronological ageing

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Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

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Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

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Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

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Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

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Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

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Age and mortality associated DNA methylation patterns on the X-chromosome in male and female samples

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Quantitative Measurements of Enlarged Perivascular Spaces in the Brain are Associated with Retinal Microvascular Parameters in Older Community-Dwelling Subjects

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DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

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Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?

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