Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,284 bioRxiv papers from 296,196 authors.

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Preprints

Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

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  • In neuroscience: 6 out of 12,046
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  • Site-wide: 440 out of 67,258
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  • Site-wide: 1,480 out of 67,258

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 153 out of 67,258
  • In genetics: 14 out of 3,777
• Year to date:
  • Site-wide: 2,442 out of 67,258
• Since beginning of last month:
  • Site-wide: 5,636 out of 67,258

The genetic architecture of the human cerebral cortex

• Downloaded 6,378 times
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  • Site-wide: 285 out of 67,258
  • In genetics: 33 out of 3,777
• Year to date:
  • Site-wide: 267 out of 67,258
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  • Site-wide: 819 out of 67,258

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 511 out of 67,258
  • In genetics: 52 out of 3,777
• Year to date:
  • Site-wide: 5,992 out of 67,258
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  • Site-wide: 5,823 out of 67,258

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • In genetics: 70 out of 3,777
• Year to date:
  • Site-wide: 505 out of 67,258
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  • Site-wide: 4,023 out of 67,258

Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

• Downloaded 3,803 times
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  • Site-wide: 757 out of 67,258
  • In genetics: 72 out of 3,777
• Year to date:
  • Site-wide: 912 out of 67,258
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  • Site-wide: 4,014 out of 67,258

Genomic analysis of family data reveals additional genetic effects on intelligence and personality

• Downloaded 3,777 times
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  • Site-wide: 765 out of 67,258
  • In genetics: 73 out of 3,777
• Year to date:
  • Site-wide: 13,056 out of 67,258
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  • Site-wide: 25,343 out of 67,258

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 2,940 times
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  • Site-wide: 1,233 out of 67,258
  • In genetics: 114 out of 3,777
• Year to date:
  • Site-wide: 15,185 out of 67,258
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  • Site-wide: 25,341 out of 67,258

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 2,773 times
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  • Site-wide: 1,366 out of 67,258
  • In genetics: 129 out of 3,777
• Year to date:
  • Site-wide: 14,846 out of 67,258
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  • Site-wide: 30,364 out of 67,258

Genetic analysis identifies molecular systems and biological pathways associated with household income

• Downloaded 2,377 times
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  • Site-wide: 1,799 out of 67,258
  • In genetics: 165 out of 3,777
• Year to date:
  • Site-wide: 392 out of 67,258
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  • Site-wide: 4,532 out of 67,258

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,290 times
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  • In genetics: 178 out of 3,777
• Year to date:
  • Site-wide: 25,551 out of 67,258
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  • Site-wide: 57,714 out of 67,258

Molecular genetic contributions to self-rated health

• Downloaded 1,977 times
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  • Site-wide: 2,485 out of 67,258
  • In genetics: 229 out of 3,777
• Year to date:
  • Site-wide: 39,860 out of 67,258
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  • Site-wide: 56,705 out of 67,258

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 1,865 times
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  • Site-wide: 2,730 out of 67,258
  • In genetics: 249 out of 3,777
• Year to date:
  • Site-wide: 18,817 out of 67,258
• Since beginning of last month:
  • Site-wide: 31,369 out of 67,258

GWAS on family history of Alzheimer's disease

• Downloaded 1,760 times
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  • Site-wide: 3,024 out of 67,258
  • In genetics: 264 out of 3,777
• Year to date:
  • Site-wide: 20,509 out of 67,258
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  • Site-wide: 47,451 out of 67,258

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 1,634 times
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  • Site-wide: 3,411 out of 67,258
  • In genetics: 295 out of 3,777
• Year to date:
  • Site-wide: 802 out of 67,258
• Since beginning of last month:
  • Site-wide: 26 out of 67,258

Genetic Prediction of Male Pattern Baldness

• Downloaded 1,598 times
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  • Site-wide: 3,551 out of 67,258
  • In genetics: 307 out of 3,777
• Year to date:
  • Site-wide: 21,513 out of 67,258
• Since beginning of last month:
  • Site-wide: 40,043 out of 67,258

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,511 times
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  • Site-wide: 3,925 out of 67,258
  • In genetics: 339 out of 3,777
• Year to date:
  • Site-wide: 13,906 out of 67,258
• Since beginning of last month:
  • Site-wide: 12,777 out of 67,258

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

• Downloaded 1,507 times
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  • Site-wide: 3,940 out of 67,258
  • In neuroscience: 614 out of 12,046
• Year to date:
  • Site-wide: 39,522 out of 67,258
• Since beginning of last month:
  • Site-wide: 57,033 out of 67,258

Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

• Downloaded 1,471 times
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  • Site-wide: 4,110 out of 67,258
  • In genetics: 355 out of 3,777
• Year to date:
  • Site-wide: 48,364 out of 67,258
• Since beginning of last month:
  • Site-wide: 39,846 out of 67,258

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

• Downloaded 1,391 times
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  • Site-wide: 4,510 out of 67,258
  • In genetics: 377 out of 3,777
• Year to date:
  • Site-wide: 7,003 out of 67,258
• Since beginning of last month:
  • Site-wide: 14,780 out of 67,258

Genetic “General Intelligence,” Objectively Determined and Measured

• Downloaded 1,354 times
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  • Site-wide: 4,717 out of 67,258
  • In genetics: 386 out of 3,777
• Year to date:
  • Site-wide: 1,145 out of 67,258
• Since beginning of last month:
  • Site-wide: 4,009 out of 67,258

Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

• Downloaded 1,347 times
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  • Site-wide: 4,750 out of 67,258
  • In genetics: 388 out of 3,777
• Year to date:
  • Site-wide: 43,835 out of 67,258
• Since beginning of last month:
  • Site-wide: 51,680 out of 67,258

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

• Downloaded 1,284 times
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  • Site-wide: 5,131 out of 67,258
  • In neuroscience: 806 out of 12,046
• Year to date:
  • Site-wide: 50,629 out of 67,258
• Since beginning of last month:
  • Site-wide: 60,569 out of 67,258

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,276 times
• Download rankings, all-time:
  • Site-wide: 5,182 out of 67,258
  • In genomics: 905 out of 4,566
• Year to date:
  • Site-wide: 4,911 out of 67,258
• Since beginning of last month:
  • Site-wide: 31,345 out of 67,258

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,124 times
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  • Site-wide: 6,404 out of 67,258
  • In genetics: 507 out of 3,777
• Year to date:
  • Site-wide: 32,127 out of 67,258
• Since beginning of last month:
  • Site-wide: 40,635 out of 67,258

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

• Downloaded 1,002 times
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  • Site-wide: 7,708 out of 67,258
  • In bioinformatics: 1,365 out of 6,627
• Year to date:
  • Site-wide: 8,687 out of 67,258
• Since beginning of last month:
  • Site-wide: 34,391 out of 67,258

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 965 times
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  • Site-wide: 8,211 out of 67,258
  • In bioinformatics: 1,441 out of 6,627
• Year to date:
  • Site-wide: 4,730 out of 67,258
• Since beginning of last month:
  • Site-wide: 49,577 out of 67,258

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

• Downloaded 947 times
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  • Site-wide: 8,468 out of 67,258
  • In neuroscience: 1,341 out of 12,046
• Year to date:
  • Site-wide: 48,736 out of 67,258
• Since beginning of last month:
  • Site-wide: 37,998 out of 67,258

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 936 times
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  • Site-wide: 8,661 out of 67,258
  • In genetics: 647 out of 3,777
• Year to date:
  • Site-wide: 3,938 out of 67,258
• Since beginning of last month:
  • Site-wide: 11,961 out of 67,258

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 888 times
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  • Site-wide: 9,359 out of 67,258
  • In genomics: 1,410 out of 4,566
• Year to date:
  • Site-wide: 34,372 out of 67,258
• Since beginning of last month:
  • Site-wide: 36,354 out of 67,258

Epigenetic prediction of complex traits and death

• Downloaded 866 times
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  • Site-wide: 9,755 out of 67,258
  • In genomics: 1,457 out of 4,566
• Year to date:
  • Site-wide: 43,591 out of 67,258
• Since beginning of last month:
  • Site-wide: 61,922 out of 67,258

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 855 times
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  • Site-wide: 9,939 out of 67,258
  • In genetics: 729 out of 3,777
• Year to date:
  • Site-wide: 38,372 out of 67,258
• Since beginning of last month:
  • Site-wide: 56,557 out of 67,258

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 840 times
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  • Site-wide: 10,217 out of 67,258
  • In genetics: 750 out of 3,777
• Year to date:
  • Site-wide: 10,519 out of 67,258
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  • Site-wide: 15,565 out of 67,258

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 716 times
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  • Site-wide: 12,978 out of 67,258
  • In genetics: 901 out of 3,777
• Year to date:
  • Site-wide: 42,311 out of 67,258
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  • Site-wide: 53,785 out of 67,258

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 710 times
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  • Site-wide: 13,143 out of 67,258
  • In genetics: 912 out of 3,777
• Year to date:
  • Site-wide: 41,042 out of 67,258
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  • Site-wide: 40,596 out of 67,258

Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

• Downloaded 709 times
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  • Site-wide: 13,175 out of 67,258
  • In neuroscience: 2,145 out of 12,046
• Year to date:
  • Site-wide: 50,923 out of 67,258
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  • Site-wide: 41,405 out of 67,258

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 684 times
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  • Site-wide: 13,862 out of 67,258
  • In genetics: 962 out of 3,777
• Year to date:
  • Site-wide: 32,693 out of 67,258
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  • Site-wide: 44,441 out of 67,258

Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

• Downloaded 678 times
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  • Site-wide: 14,048 out of 67,258
  • In genetics: 974 out of 3,777
• Year to date:
  • Site-wide: 28,192 out of 67,258
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  • Site-wide: 46,146 out of 67,258

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 653 times
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  • Site-wide: 14,772 out of 67,258
  • In genomics: 1,928 out of 4,566
• Year to date:
  • Site-wide: 12,635 out of 67,258
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  • Site-wide: 36,852 out of 67,258

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 627 times
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  • In genetics: 1,068 out of 3,777
• Year to date:
  • Site-wide: 49,974 out of 67,258
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  • Site-wide: 64,426 out of 67,258

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

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  • In genetics: 1,079 out of 3,777
• Year to date:
  • Site-wide: 4,443 out of 67,258
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  • Site-wide: 16,091 out of 67,258

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

• Downloaded 619 times
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  • Site-wide: 15,940 out of 67,258
  • In genetics: 1,088 out of 3,777
• Year to date:
  • Site-wide: 4,503 out of 67,258
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  • Site-wide: 15,558 out of 67,258

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

• Downloaded 617 times
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  • Site-wide: 16,014 out of 67,258
  • In genetics: 1,096 out of 3,777
• Year to date:
  • Site-wide: 59,499 out of 67,258
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  • Site-wide: 57,115 out of 67,258

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 617 times
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  • Site-wide: 16,038 out of 67,258
  • In bioinformatics: 2,501 out of 6,627
• Year to date:
  • Site-wide: 50,912 out of 67,258
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  • Site-wide: 47,092 out of 67,258

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 604 times
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  • Site-wide: 16,489 out of 67,258
  • In genomics: 2,061 out of 4,566
• Year to date:
  • Site-wide: 44,930 out of 67,258
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  • Site-wide: 42,816 out of 67,258

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

• Downloaded 576 times
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  • Site-wide: 17,618 out of 67,258
  • In genomics: 2,155 out of 4,566
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  • Site-wide: 56,438 out of 67,258
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  • Site-wide: 37,075 out of 67,258

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 565 times
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  • Site-wide: 45,583 out of 67,258
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  • Site-wide: 50,457 out of 67,258

Factors associated with sharing email information and mental health survey participation in two large population cohorts

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  • In genetics: 1,228 out of 3,777
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  • Site-wide: 15,383 out of 67,258
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  • Site-wide: 56,501 out of 67,258

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

• Downloaded 546 times
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  • Site-wide: 18,909 out of 67,258
  • In genomics: 2,251 out of 4,566
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  • Site-wide: 11,983 out of 67,258
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  • Site-wide: 6,264 out of 67,258

Genetic contributions to self-reported tiredness

• Downloaded 528 times
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  • Site-wide: 19,769 out of 67,258
  • In genetics: 1,314 out of 3,777
• Year to date:
  • Site-wide: 60,932 out of 67,258
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  • Site-wide: 54,809 out of 67,258

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 20,127 out of 67,258
  • In neuroscience: 3,383 out of 12,046
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  • Site-wide: 15,285 out of 67,258
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  • Site-wide: 45,930 out of 67,258

Cognitive ability and physical health: a Mendelian randomization study

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  • Site-wide: 20,967 out of 67,258
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• Year to date:
  • Site-wide: 55,976 out of 67,258
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  • Site-wide: 57,536 out of 67,258

Polygenic architecture of human neuroanatomical diversity

• Downloaded 488 times
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  • Site-wide: 21,746 out of 67,258
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  • Site-wide: 6,732 out of 67,258
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  • Site-wide: 10,306 out of 67,258

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

• Downloaded 473 times
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  • Site-wide: 22,651 out of 67,258
  • In genetics: 1,509 out of 3,777
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  • Site-wide: 64,478 out of 67,258
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  • Site-wide: 58,843 out of 67,258

DNA methylation age acceleration and risk factors for Alzheimer's disease

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  • Site-wide: 29,812 out of 67,258
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  • Site-wide: 51,122 out of 67,258

Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

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  • Site-wide: 24,039 out of 67,258
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  • Site-wide: 43,439 out of 67,258

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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  • Site-wide: 24,960 out of 67,258

Accelerated Epigenetic Ageing in Major Depressive Disorder

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  • Site-wide: 44,964 out of 67,258

Age-related clonal haemopoiesis is associated with increased epigenetic age

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  • Site-wide: 16,866 out of 67,258

Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

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  • Site-wide: 65,545 out of 67,258

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

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  • In epidemiology: 399 out of 1,556
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  • Site-wide: 48,427 out of 67,258

Meta-analysis of exome array data identifies six novel genetic loci for lung function

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  • Site-wide: 64,536 out of 67,258

Polygenic predictors of age-related decline in cognitive ability

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  • Site-wide: 56,664 out of 67,258

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

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  • Site-wide: 57,833 out of 67,258

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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  • Site-wide: 20,086 out of 67,258

Genetic contributions to trail making test performance in UK Biobank

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  • Site-wide: 60,771 out of 67,258
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  • Site-wide: 60,376 out of 67,258

Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

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  • Site-wide: 65,581 out of 67,258

A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

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  • Site-wide: 64,561 out of 67,258
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  • Site-wide: 58,864 out of 67,258

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

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Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

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The effect of network thresholding and weighting on structural brain networks in the UK Biobank

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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

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Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

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Genetic correlations between pain phenotypes and depression and neuroticism

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Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

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Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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The influence of X chromosome variants on trait neuroticism.

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Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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An epigenetic predictor of death captures multi-modal measures of brain health

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An epigenome-wide association study of sex-specific chronological ageing

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Epigenetic signatures of starting and stopping smoking

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Association of Facial Aging with DNA Methylation and Epigenetic Age Predictions

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Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

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Genetic contributions to health literacy

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Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

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Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

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Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

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Birth weight predicts psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

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Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

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Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

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Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

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Age and mortality associated DNA methylation patterns on the X-chromosome in male and female samples

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Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

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DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

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Quantitative Measurements of Enlarged Perivascular Spaces in the Brain are Associated with Retinal Microvascular Parameters in Older Community-Dwelling Subjects

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