Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 62,198 bioRxiv papers from 276,129 authors.

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Preprints

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

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Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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The genetic architecture of the human cerebral cortex

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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • In genetics: 51 out of 3,537
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Genomic analysis of family data reveals additional genetic effects on intelligence and personality

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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  • In genetics: 166 out of 3,537
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  • Site-wide: 19,181 out of 62,198

Genetic analysis identifies molecular systems and biological pathways associated with household income

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  • In genetics: 169 out of 3,537
• Year to date:
  • Site-wide: 293 out of 62,198
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Molecular genetic contributions to self-rated health

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Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 1,840 times
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  • In genetics: 236 out of 3,537
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GWAS on family history of Alzheimer's disease

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  • In genetics: 249 out of 3,537
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  • Site-wide: 18,409 out of 62,198

Genetic Prediction of Male Pattern Baldness

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Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

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  • In neuroscience: 566 out of 11,101
• Year to date:
  • Site-wide: 36,452 out of 62,198
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Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

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  • In genetics: 336 out of 3,537
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  • Site-wide: 33,931 out of 62,198

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 19,917 out of 62,198

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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  • In genetics: 364 out of 3,537
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  • Site-wide: 6,149 out of 62,198
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  • Site-wide: 6,857 out of 62,198

Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

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Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

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  • In neuroscience: 729 out of 11,101
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  • Site-wide: 33,667 out of 62,198

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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  • In genomics: 864 out of 4,277
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  • Site-wide: 3,976 out of 62,198
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  • Site-wide: 11,550 out of 62,198

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,107 times
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  • In genetics: 480 out of 3,537
• Year to date:
  • Site-wide: 27,359 out of 62,198
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  • Site-wide: 27,653 out of 62,198

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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  • In bioinformatics: 1,321 out of 6,210
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  • Site-wide: 19,268 out of 62,198

OSCA: a tool for omic-data-based complex trait analysis

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  • In bioinformatics: 1,363 out of 6,210
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  • Site-wide: 17,215 out of 62,198

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

• Downloaded 933 times
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  • In neuroscience: 1,214 out of 11,101
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  • Site-wide: 17,721 out of 62,198

Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 39,228 out of 62,198

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

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  • In genetics: 658 out of 3,537
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  • Site-wide: 3,423 out of 62,198
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  • Site-wide: 9,228 out of 62,198

Epigenetic prediction of complex traits and death

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• Year to date:
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  • Site-wide: 32,410 out of 62,198

An epigenome-wide association study of educational attainment (n = 10,767)

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  • In genetics: 683 out of 3,537
• Year to date:
  • Site-wide: 33,815 out of 62,198
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  • Site-wide: 27,819 out of 62,198

The Stratification Of Major Depressive Disorder Into Genetic Subgroups

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  • Site-wide: 34,086 out of 62,198

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

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  • In genetics: 734 out of 3,537
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  • Site-wide: 8,746 out of 62,198

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

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Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

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  • In neuroscience: 1,989 out of 11,101
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  • Site-wide: 42,284 out of 62,198

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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  • Site-wide: 49,875 out of 62,198

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

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  • Site-wide: 23,663 out of 62,198

Is there association between APOE e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

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  • Site-wide: 27,559 out of 62,198

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 615 times
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  • Site-wide: 38,696 out of 62,198

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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  • Site-wide: 46,599 out of 62,198

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

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  • Site-wide: 34,764 out of 62,198

Bayesian reassessment of the epigenetic architecture of complex traits

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  • Site-wide: 48,800 out of 62,198

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 29,850 out of 62,198

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

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  • Site-wide: None out of 62,198

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

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  • Site-wide: 38,895 out of 62,198

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

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Factors associated with sharing email information and mental health survey participation in two large population cohorts

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  • Site-wide: 21,706 out of 62,198

Genetic contributions to self-reported tiredness

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  • Site-wide: 53,573 out of 62,198
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  • Site-wide: 33,628 out of 62,198

Cognitive ability and physical health: a Mendelian randomization study

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  • Site-wide: 49,595 out of 62,198
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  • Site-wide: 39,824 out of 62,198

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 13,073 out of 62,198
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  • Site-wide: 20,883 out of 62,198

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

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  • Site-wide: 4,830 out of 62,198
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  • Site-wide: 11,548 out of 62,198

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

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  • Site-wide: 8,283 out of 62,198

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

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  • Site-wide: 31,928 out of 62,198

Polygenic architecture of human neuroanatomical diversity

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  • Site-wide: 12,981 out of 62,198

DNA methylation age acceleration and risk factors for Alzheimer's disease

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  • Site-wide: 18,450 out of 62,198

Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

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  • Site-wide: 37,973 out of 62,198

Accelerated Epigenetic Ageing in Major Depressive Disorder

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Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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  • Site-wide: 16,475 out of 62,198

Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

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  • Site-wide: 50,819 out of 62,198

Meta-analysis of exome array data identifies six novel genetic loci for lung function

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Polygenic predictors of age-related decline in cognitive ability

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Age-related clonal haemopoiesis is associated with increased epigenetic age

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Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

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An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

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Genetic contributions to trail making test performance in UK Biobank

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  • Site-wide: 37,376 out of 62,198

Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

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  • Site-wide: 39,279 out of 62,198

A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

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  • Site-wide: 44,474 out of 62,198

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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  • Site-wide: 29,557 out of 62,198

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

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Genetic correlations between pain phenotypes and depression and neuroticism

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Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

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Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

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Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

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The effect of network thresholding and weighting on structural brain networks in the UK Biobank

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The influence of X chromosome variants on trait neuroticism.

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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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An epigenome-wide association study of sex-specific chronological ageing

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Association of Facial Aging with DNA Methylation and Epigenetic Age Predictions

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An epigenetic predictor of death captures multi-modal measures of brain health

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Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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Epigenetic signatures of starting and stopping smoking

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Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

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Genetic contributions to health literacy

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Understanding Cognitive Impairment in Mood Disorders: Mediation Analyses in the UK Biobank Cohort

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Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

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Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

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Birth weight predicts psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

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Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

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Age and mortality associated DNA methylation patterns on the X-chromosome in male and female samples

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Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

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Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

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Genetic “General Intelligence,” Objectively Determined and Measured

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