Author: Ian J. Deary

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Preprints

Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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The genetic architecture of the human cerebral cortex

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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Genetic analysis identifies molecular systems and biological pathways associated with household income

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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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Molecular genetic contributions to self-rated health

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Genome-wide association study identifies 48 common genetic variants associated with handedness

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GWAS on family history of Alzheimer's disease

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Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N = 112 151) and 24 GWAS consortia.

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Genetic “General Intelligence,” Objectively Determined and Measured

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Genetic Prediction of Male Pattern Baldness

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Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

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Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)

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Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life

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Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

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116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

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Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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Brain imaging correlates of general intelligence in UK Biobank

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Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

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Identification of 55,000 Replicated DNA Methylation QTL

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Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

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Epigenetic prediction of complex traits and death

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An epigenome-wide association study of educational attainment (n = 10,767)

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Bayesian reassessment of the epigenetic architecture of complex traits

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Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

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GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

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Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

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Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

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Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

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Factors associated with sharing email information and mental health survey participation in large population cohorts

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Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

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Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

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Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

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Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

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Genetic contributions to self-reported tiredness

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Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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Cognitive ability and physical health: a Mendelian randomization study

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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

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Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

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DNA methylation age acceleration and risk factors for Alzheimer's disease

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Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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Age-related clonal haemopoiesis is associated with increased epigenetic age

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Accelerated Epigenetic Ageing in Major Depressive Disorder

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An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

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Polygenic predictors of age-related decline in cognitive ability

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Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

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Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

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Estimating the effect-size of gene dosage on cognitive ability across the coding genome

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Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

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The effect of network thresholding and weighting on structural brain networks in the UK Biobank

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Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

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Genetic contributions to trail making test performance in UK Biobank

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Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

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A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

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Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life

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Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

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Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

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Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

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Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

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Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

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Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

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An epigenetic predictor of death captures multi-modal measures of brain health

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The influence of X chromosome variants on trait neuroticism.

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Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

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Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

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Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

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Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

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Age-related changes of Peak width Skeletonized Mean Diffusivity (PSMD) across the adult life span: a multi-cohort study

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Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

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Enhanced prediction of cognitive function using aging-sensitive networks within the human structural connectome

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Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

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Association of Facial Aging with DNA Methylation and Epigenetic Age Predictions

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Epigenetic signatures of starting and stopping smoking

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Genetic contributions to health literacy

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Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

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Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

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Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

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Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

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Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

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DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

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