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Author: Hao Chen

  • ORCiD: http://orcid.org/0000-0002-2680-6921
  • Most recently observed institution: Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, 01605, USA

Rankings

  • All-time downloads: 189,273 (rank: 580 )
  • Categories:
    • animal behavior and cognition: 611 (rank: 2,873 (tie) )
    • biochemistry: 2,473 (rank: 2,004 )
    • bioengineering: 402 (rank: 12,526 (tie) )
    • bioinformatics: 21,764 (rank: 328 )
    • cancer biology: 1,398 (rank: 7,504 (tie) )
    • cardiovascular medicine: 462 (rank: 2,031 (tie) )
    • cell biology: 1,225 (rank: 9,200 (tie) )
    • developmental biology: 111,380 (rank: 5 (tie) )
    • epidemiology: 562 (rank: 19,573 (tie) )
    • evolutionary biology: 1,549 (rank: 4,960 (tie) )
    • genetics: 3,296 (rank: 6,433 )
    • genomics: 92 (rank: 56,751 (tie) )
    • immunology: 115 (rank: 43,293 (tie) )
    • infectious diseases: 18,732 (rank: 3,836 )
    • molecular biology: 2,202 (rank: 2,748 )
    • neuroscience: 1,775 (rank: 17,251 (tie) )
    • oncology: 2,335 (rank: 170 )
    • plant biology: 803 (rank: 7,173 (tie) )
    • public and global health: 14,553 (rank: 465 )
    • respiratory medicine: 2,383 (rank: 577 )
    • systems biology: 1,161 (rank: 4,698 (tie) )

Downloads per author, site-wide

Preprints

A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing

molecular biology more details view paper

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Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction

neuroscience more details view paper

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Reversing age: dual species measurement of epigenetic age with a single clock

developmental biology more details view paper
  • Downloaded 106,630 times
  • Download rankings, all-time:
    • Site-wide: 64
    • In developmental biology: 1
  • Year to date:
    • Site-wide: 1,010
  • Since beginning of last month:
    • Site-wide: 677

TBtools - an integrative toolkit developed for interactive analyses of big biological data

bioinformatics more details view paper
  • Downloaded 15,967 times
  • Download rankings, all-time:
    • Site-wide: 634
    • In bioinformatics: 17
  • Year to date:
    • Site-wide: 1,945
  • Since beginning of last month:
    • Site-wide: 801

Gut microbiota may underlie the predisposition of healthy individuals to COVID-19

public and global health more details view paper
  • Downloaded 14,095 times
  • Download rankings, all-time:
    • Site-wide: 740
    • In public and global health: 27
  • Year to date:
    • Site-wide: 4,355
  • Since beginning of last month:
    • Site-wide: 4,724

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

infectious diseases more details view paper
  • Downloaded 13,232 times
  • Download rankings, all-time:
    • Site-wide: 805
    • In infectious diseases: 280
  • Year to date:
    • Site-wide: 18,478
  • Since beginning of last month:
    • Site-wide: 20,202

Universal DNA methylation age across mammalian tissues

developmental biology more details view paper
  • Downloaded 4,750 times
  • Download rankings, all-time:
    • Site-wide: 3,038
    • In developmental biology: 20
  • Year to date:
    • Site-wide: 1,111
  • Since beginning of last month:
    • Site-wide: 3,779

Multi-organ Proteomic Landscape of COVID-19 Autopsies

infectious diseases more details view paper
  • Downloaded 2,218 times
  • Download rankings, all-time:
    • Site-wide: 8,966
    • In infectious diseases: 1,434
  • Year to date:
    • Site-wide: 69,894
  • Since beginning of last month:
    • Site-wide: 23,020

Fast functional annotation of metagenomic shotgun data by DNA alignment to a microbial gene catalog

bioinformatics more details view paper
  • Downloaded 1,973 times
  • Download rankings, all-time:
    • Site-wide: 10,634
    • In bioinformatics: 1,182
  • Year to date:
    • Site-wide: 57,611
  • Since beginning of last month:
    • Site-wide: 117,383

Protein Classifier for Thyroid Nodules Learned from Rapidly Acquired Proteotypes

oncology more details view paper
  • Downloaded 1,935 times
  • Download rankings, all-time:
    • Site-wide: 10,961
    • In oncology: 12
  • Year to date:
    • Site-wide: 18,836
  • Since beginning of last month:
    • Site-wide: 6,017

Epigenetic predictors of maximum lifespan and other life history traits in mammals

evolutionary biology more details view paper
  • Downloaded 1,549 times
  • Download rankings, all-time:
    • Site-wide: 15,291
    • In evolutionary biology: 476
  • Year to date:
    • Site-wide: 7,026
  • Since beginning of last month:
    • Site-wide: 12,861

PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression

molecular biology more details view paper
  • Downloaded 1,454 times
  • Download rankings, all-time:
    • Site-wide: 16,870
    • In molecular biology: 449
  • Year to date:
    • Site-wide: 59,788
  • Since beginning of last month:
    • Site-wide: 70,823

Proteomics Uncovers Immunosuppression in COVID-19 Patients with Long Disease Course

respiratory medicine more details view paper
  • Downloaded 1,439 times
  • Download rankings, all-time:
    • Site-wide: 17,132
    • In respiratory medicine: 58
  • Year to date:
    • Site-wide: 68,496
  • Since beginning of last month:
    • Site-wide: 29,796

METTL5, an 18S rRNA-specific m6A methyltransferase, modulates expression of stress response genes

biochemistry more details view paper
  • Downloaded 1,349 times
  • Download rankings, all-time:
    • Site-wide: 18,895
    • In biochemistry: 402
  • Year to date:
    • Site-wide: 72,386
  • Since beginning of last month:
    • Site-wide: 22,578

Integrative pipeline for profiling DNA copy number and inferring tumor phylogeny

bioinformatics more details view paper
  • Downloaded 1,235 times
  • Download rankings, all-time:
    • Site-wide: 21,565
    • In bioinformatics: 2,404
  • Year to date:
    • Site-wide: 116,074
  • Since beginning of last month:
    • Site-wide: 145,260

Identification of piRNA binding sites reveals the Argonaute regulatory landscape of the C. elegans germline

genetics more details view paper
  • Downloaded 1,055 times
  • Download rankings, all-time:
    • Site-wide: 27,436
    • In genetics: 1,188
  • Year to date:
    • Site-wide: 104,989
  • Since beginning of last month:
    • Site-wide: 95,784

Genome wide association study in 3,173 outbred rats identifies multiple loci for body weight, adiposity, and fasting glucose

genetics more details view paper
  • Downloaded 1,017 times
  • Download rankings, all-time:
    • Site-wide: 28,945
    • In genetics: 1,250
  • Year to date:
    • Site-wide: 45,340
  • Since beginning of last month:
    • Site-wide: 147,809

Convergent network effects along the axis of gene expression during prostate cancer progression

systems biology more details view paper
  • Downloaded 978 times
  • Download rankings, all-time:
    • Site-wide: 30,649
    • In systems biology: 597
  • Year to date:
    • Site-wide: 71,605
  • Since beginning of last month:
    • Site-wide: 133,146

CRISPR/Cas9 screens Reveal Dasatinib Targets of Inhibiting T cell Activation and Proliferation

cancer biology more details view paper
  • Downloaded 953 times
  • Download rankings, all-time:
    • Site-wide: 31,892
    • In cancer biology: 808
  • Year to date:
    • Site-wide: 23,898
  • Since beginning of last month:
    • Site-wide: 122,761

SARS-CoV-2 entry related genes are comparably expressed in children's lung as adults

respiratory medicine more details view paper
  • Downloaded 944 times
  • Download rankings, all-time:
    • Site-wide: 32,344
    • In respiratory medicine: 84
  • Year to date:
    • Site-wide: 94,471
  • Since beginning of last month:
    • Site-wide: 110,924

Eleven Routine Clinical Features Predict COVID-19 Severity

infectious diseases more details view paper
  • Downloaded 910 times
  • Download rankings, all-time:
    • Site-wide: 34,163
    • In infectious diseases: 2,858
  • Year to date:
    • Site-wide: 145,905
  • Since beginning of last month:
    • Site-wide: 49,761

Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and early infancy

infectious diseases more details view paper
  • Downloaded 900 times
  • Download rankings, all-time:
    • Site-wide: 34,678
    • In infectious diseases: 2,892
  • Year to date:
    • Site-wide: 1,342
  • Since beginning of last month:
    • Site-wide: 343

The landscape of mouse epididymal cells defined by the single-cell RNA-Seq

cell biology more details view paper
  • Downloaded 818 times
  • Download rankings, all-time:
    • Site-wide: 39,852
    • In cell biology: 1,550
  • Year to date:
    • Site-wide: 43,157
  • Since beginning of last month:
    • Site-wide: 90,234

A Universal Nonparametric Event Detection Framework for Neuropixels Data

neuroscience more details view paper
  • Downloaded 804 times
  • Download rankings, all-time:
    • Site-wide: 40,822
    • In neuroscience: 5,476
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 96,154

GeneCup: mine PubMed for gene relationships using custom ontology and deep learning

bioinformatics more details view paper
  • Downloaded 659 times
  • Download rankings, all-time:
    • Site-wide: 53,914
    • In bioinformatics: 5,358
  • Year to date:
    • Site-wide: 102,568
  • Since beginning of last month:
    • Site-wide: 35,854

3D chromatin organization changes modulate adipogenesis and osteogenesis

genetics more details view paper
  • Downloaded 602 times
  • Download rankings, all-time:
    • Site-wide: 60,663
    • In genetics: 2,537
  • Year to date:
    • Site-wide: 50,967
  • Since beginning of last month:
    • Site-wide: 58,062

The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for proper mitochondrial function

molecular biology more details view paper
  • Downloaded 571 times
  • Download rankings, all-time:
    • Site-wide: 64,787
    • In molecular biology: 1,834
  • Year to date:
    • Site-wide: 81,863
  • Since beginning of last month:
    • Site-wide: 168,658

Gallic Acid Disrupts Aβ1-42 Aggregation and Rescues Cognitive Decline of APP/PS1 Transgenic Mouse

neuroscience more details view paper
  • Downloaded 568 times
  • Download rankings, all-time:
    • Site-wide: 65,226
    • In neuroscience: 9,399
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 118,988

Causally Associations of Blood Lipids Levels with COVID-19 Risk: Mendelian Randomization Study

epidemiology more details view paper
  • Downloaded 562 times
  • Download rankings, all-time:
    • Site-wide: 66,146
    • In epidemiology: 3,034
  • Year to date:
    • Site-wide: 41,020
  • Since beginning of last month:
    • Site-wide: 50,435

An allele-specific functional SNP associated with two autoimmune diseases modulates IRF5 expression by long-range chromatin loop formation

genetics more details view paper
  • Downloaded 537 times
  • Download rankings, all-time:
    • Site-wide: 69,825
    • In genetics: 2,920
  • Year to date:
    • Site-wide: 110,113
  • Since beginning of last month:
    • Site-wide: 156,281

LncRNA and predictive model for improving the diagnosis of clinically diagnosed pulmonary tuberculosis

infectious diseases more details view paper
  • Downloaded 526 times
  • Download rankings, all-time:
    • Site-wide: 71,542
    • In infectious diseases: 4,094
  • Year to date:
    • Site-wide: 26,088
  • Since beginning of last month:
    • Site-wide: 43,184

Computational approaches towards reducing contamination in single-cell RNA-seq data

bioinformatics more details view paper
  • Downloaded 512 times
  • Download rankings, all-time:
    • Site-wide: 73,882
    • In bioinformatics: 6,877
  • Year to date:
    • Site-wide: 94,688
  • Since beginning of last month:
    • Site-wide: 88,693

Chansu Injection Improves the Respiratory Function of Severe COVID-19 Patients

infectious diseases more details view paper
  • Downloaded 505 times
  • Download rankings, all-time:
    • Site-wide: 75,001
    • In infectious diseases: 4,203
  • Year to date:
    • Site-wide: 70,172
  • Since beginning of last month:
    • Site-wide: 56,781

Modeling circRNAs expression pattern with integrated sequence and epigenetic features identifies H3K79me2 as regulators for circRNAs expression

bioinformatics more details view paper
  • Downloaded 476 times
  • Download rankings, all-time:
    • Site-wide: 80,179
    • In bioinformatics: 7,283
  • Year to date:
    • Site-wide: 62,685
  • Since beginning of last month:
    • Site-wide: 117,193

The Tung Tree (Vernicia Fordii) Genome Provides A Resource for Understanding Genome Evolution and Oil Improvement

bioinformatics more details view paper
  • Downloaded 464 times
  • Download rankings, all-time:
    • Site-wide: 82,402
    • In bioinformatics: 7,441
  • Year to date:
    • Site-wide: 100,045
  • Since beginning of last month:
    • Site-wide: 167,647

Diagnostics and prognostic potential of current biomarkers in heart failure with preserved ejection fraction: a systematic review and meta-analysis

cardiovascular medicine more details view paper
  • Downloaded 462 times
  • Download rankings, all-time:
    • Site-wide: 82,915
    • In cardiovascular medicine: 178
  • Year to date:
    • Site-wide: 93,435
  • Since beginning of last month:
    • Site-wide: 44,486

COVID-19 Quarantine Reveals Grade-specific Behavioral Modification of Myopia: One-Million Chinese Schoolchildren Study

public and global health more details view paper
  • Downloaded 458 times
  • Download rankings, all-time:
    • Site-wide: 83,599
    • In public and global health: 1,220
  • Year to date:
    • Site-wide: 74,977
  • Since beginning of last month:
    • Site-wide: 39,553

Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer

cancer biology more details view paper
  • Downloaded 445 times
  • Download rankings, all-time:
    • Site-wide: 86,337
    • In cancer biology: 2,543
  • Year to date:
    • Site-wide: 121,709
  • Since beginning of last month:
    • Site-wide: 120,283

A diagnostic decision-making protocol combines a new-generation of serological assay and PCR to fully resolve ambiguity in COVID-19 diagnosis

infectious diseases more details view paper
  • Downloaded 441 times
  • Download rankings, all-time:
    • Site-wide: 87,025
    • In infectious diseases: 4,561
  • Year to date:
    • Site-wide: 51,380
  • Since beginning of last month:
    • Site-wide: 78,101

Hypoxic Training Increases the Concentration of Serum Irisin and Reduces Weight in Diet-induced Obese Rats

biochemistry more details view paper
  • Downloaded 433 times
  • Download rankings, all-time:
    • Site-wide: 88,681
    • In biochemistry: 2,532
  • Year to date:
    • Site-wide: 55,324
  • Since beginning of last month:
    • Site-wide: 148,612

The repertoire of testicular extracellular vesicles cargoes and their involvement in inter-compartmental communication required for spermatogenesis

cell biology more details view paper
  • Downloaded 407 times
  • Download rankings, all-time:
    • Site-wide: 94,314
    • In cell biology: 4,333
  • Year to date:
    • Site-wide: 52,571
  • Since beginning of last month:
    • Site-wide: 32,495

Social behavior and anxiety contribute to nicotine self-administration in adolescent outbred rats

animal behavior and cognition more details view paper
  • Downloaded 405 times
  • Download rankings, all-time:
    • Site-wide: 94,767
    • In animal behavior and cognition: 1,003
  • Year to date:
    • Site-wide: 121,543
  • Since beginning of last month:
    • Site-wide: 145,101

Multiple modulation synthesis with high spatial resolution for noninvasive deep neurostimulation

neuroscience more details view paper
  • Downloaded 403 times
  • Download rankings, all-time:
    • Site-wide: 95,053
    • In neuroscience: 14,148
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 162,066

Effects of planting density on the growth and photosynthetic characteristics of Alternanthera philoxeroides under different nutrient conditions

plant biology more details view paper
  • Downloaded 403 times
  • Download rankings, all-time:
    • Site-wide: 95,054
    • In plant biology: 2,500
  • Year to date:
    • Site-wide: 114,396
  • Since beginning of last month:
    • Site-wide: 121,559

Differential responses of transplanted stem cells to the diseased environment unveiled by a single molecular NIR II cell tracker

bioengineering more details view paper
  • Downloaded 402 times
  • Download rankings, all-time:
    • Site-wide: 95,316
    • In bioengineering: 1,848
  • Year to date:
    • Site-wide: 68,575
  • Since beginning of last month:
    • Site-wide: 83,858

Analytical and Clinical Validation of an Amplicon-based Next Generation Sequencing Assay for Ultrasensitive Detection of Circulating Tumor DNA

oncology more details view paper
  • Downloaded 400 times
  • Download rankings, all-time:
    • Site-wide: 95,724
    • In oncology: 202
  • Year to date:
    • Site-wide: 38,004
  • Since beginning of last month:
    • Site-wide: 14,028

CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila

biochemistry more details view paper
  • Downloaded 379 times
  • Download rankings, all-time:
    • Site-wide: 100,808
    • In biochemistry: 2,927
  • Year to date:
    • Site-wide: 145,890
  • Since beginning of last month:
    • Site-wide: 165,875

Whole genome sequencing of nearly isogeneic WMI and WLI inbred rats identifies genes potentially involved in depression

bioinformatics more details view paper
  • Downloaded 315 times
  • Download rankings, all-time:
    • Site-wide: 116,765
    • In bioinformatics: 9,590
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 48,929

Sequencing uracil in DNA at single-nucleotide resolution

biochemistry more details view paper
  • Downloaded 312 times
  • Download rankings, all-time:
    • Site-wide: 117,607
    • In biochemistry: 3,473
  • Year to date:
    • Site-wide: 31,056
  • Since beginning of last month:
    • Site-wide: 48,440

Retrograde induction of phyB orchestrates ethylene-auxin hierarchy to regulate growth

plant biology more details view paper
  • Downloaded 264 times
  • Download rankings, all-time:
    • Site-wide: 130,689
    • In plant biology: 3,590
  • Year to date:
    • Site-wide: 143,106
  • Since beginning of last month:
    • Site-wide: 167,900

TailTimer: an open-source device for automating the rodent tail immersion assay

animal behavior and cognition more details view paper
  • Downloaded 206 times
  • Download rankings, all-time:
    • Site-wide: 145,991
    • In animal behavior and cognition: 1,854
  • Year to date:
    • Site-wide: 51,650
  • Since beginning of last month:
    • Site-wide: 138,293

A comprehensive mass spectral library for human thyroid tissues

systems biology more details view paper
  • Downloaded 183 times
  • Download rankings, all-time:
    • Site-wide: 151,429
    • In systems biology: 3,124
  • Year to date:
    • Site-wide: 47,088
  • Since beginning of last month:
    • Site-wide: 49,410

LncRNA and predictive model to improve the diagnosis of clinically diagnosed pulmonary tuberculosis

molecular biology more details view paper
  • Downloaded 177 times
  • Download rankings, all-time:
    • Site-wide: 152,825
    • In molecular biology: 4,588
  • Year to date:
    • Site-wide: 82,347
  • Since beginning of last month:
    • Site-wide: 168,394

Identification of the Novel Pyroptosis-Related Gene Signature in Patients with Esophageal Adenocarcinoma

bioinformatics more details view paper
  • Downloaded 163 times
  • Download rankings, all-time:
    • Site-wide: 155,737
    • In bioinformatics: 11,846
  • Year to date:
    • Site-wide: 48,657
  • Since beginning of last month:
    • Site-wide: 94,128

ORA47 is a transcriptional regulator of a general stress response hub

plant biology more details view paper
  • Downloaded 136 times
  • Download rankings, all-time:
    • Site-wide: 160,921
    • In plant biology: 4,513
  • Year to date:
    • Site-wide: 5,551
  • Since beginning of last month:
    • Site-wide: 4,545

Previously unrecognized non-reproducible antibody-antigen interactions and their implications for diagnosis of viral infections including COVID-19

immunology more details view paper
  • Downloaded 115 times
  • Download rankings, all-time:
    • Site-wide: 164,333
    • In immunology: 5,087
  • Year to date:
    • Site-wide: 89,631
  • Since beginning of last month:
    • Site-wide: 59,632

SVJAM: Joint Analysis of Structural Variants Using Linked Read Sequencing Data

genomics more details view paper
  • Downloaded 92 times
  • Download rankings, all-time:
    • Site-wide: 167,409
    • In genomics: 8,117
  • Year to date:
    • Site-wide: 50,303
  • Since beginning of last month:
    • Site-wide: 45,088

Genome-wide association study of open fieldbehavior in outbred heterogeneous stock ratsidentifies multiple loci implicated inpsychiatric disorders

genetics more details view paper
  • Downloaded 85 times
  • Download rankings, all-time:
    • Site-wide: 168,171
    • In genetics: 6,291
  • Year to date:
    • Site-wide: 24,017
  • Since beginning of last month:
    • Site-wide: 32,591

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