Author: Li Li

Downloads per author, site-wide

Preprints

Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity

No download data for this paper yet.

Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis

• Downloaded 26,355 times
• Download rankings, all-time:
  • Site-wide: 417
  • In respiratory medicine: 4
• Year to date:
  • Site-wide: 11,826
• Since beginning of last month:
  • Site-wide: 10,943

The feasibility of convalescent plasma therapy in severe COVID-19 patients: a pilot study

• Downloaded 16,977 times
• Download rankings, all-time:
  • Site-wide: 694
  • In infectious diseases: 257
• Year to date:
  • Site-wide: 2,928
• Since beginning of last month:
  • Site-wide: 6,050

Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experience

• Downloaded 14,412 times
• Download rankings, all-time:
  • Site-wide: 855
  • In pathology: 8
• Year to date:
  • Site-wide: 20,400
• Since beginning of last month:
  • Site-wide: 20,399

Cremation based estimates suggest significant under- and delayed reporting of COVID-19 epidemic data in Wuhan and China

• Downloaded 10,609 times
• Download rankings, all-time:
  • Site-wide: 1,284
  • In infectious diseases: 406
• Year to date:
  • Site-wide: 7,387
• Since beginning of last month:
  • Site-wide: 10,355

Multiplexed confocal and super-resolution fluorescence imaging of cytoskeletal and neuronal synapse proteins

• Downloaded 4,987 times
• Download rankings, all-time:
  • Site-wide: 3,504
  • In bioengineering: 37
• Year to date:
  • Site-wide: 3,810
• Since beginning of last month:
  • Site-wide: 145,230

Acute Kidney Injury in Hospitalized Patients with COVID-19

• Downloaded 4,653 times
• Download rankings, all-time:
  • Site-wide: 3,850
  • In nephrology: 4
• Year to date:
  • Site-wide: 8,773
• Since beginning of last month:
  • Site-wide: 20,491

Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records

• Downloaded 3,586 times
• Download rankings, all-time:
  • Site-wide: 5,622
  • In genetics: 183
• Year to date:
  • Site-wide: 14,464
• Since beginning of last month:
  • Site-wide: 143,191

Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia

• Downloaded 3,496 times
• Download rankings, all-time:
  • Site-wide: 5,841
  • In cardiovascular medicine: 13
• Year to date:
  • Site-wide: 20,291
• Since beginning of last month:
  • Site-wide: 34,372

A Cellular Taxonomy of the Adult Human Spinal Cord

• Downloaded 3,410 times
• Download rankings, all-time:
  • Site-wide: 6,065
  • In neuroscience: 522
• Year to date:
  • Site-wide: 3,382
• Since beginning of last month:
  • Site-wide: 1,950

Analysis of hospitalized COVID-19 patients in the Mount Sinai Health System using electronic medical records (EMR) reveals important prognostic factors for improved clinical outcomes

• Downloaded 3,263 times
• Download rankings, all-time:
  • Site-wide: 6,475
  • In health informatics: 34
• Year to date:
  • Site-wide: 39,077
• Since beginning of last month:
  • Site-wide: 39,253

A Harmonized Atlas of Spinal Cord Cell Types and Their Computational Classification

• Downloaded 2,548 times
• Download rankings, all-time:
  • Site-wide: 9,302
  • In neuroscience: 857
• Year to date:
  • Site-wide: 154,535
• Since beginning of last month:
  • Site-wide: 53,440

Taking Account of Asymptomatic Infections in Modeling the Transmission Potential of the COVID-19 Outbreak on the Diamond Princess Cruise Ship

• Downloaded 2,403 times
• Download rankings, all-time:
  • Site-wide: 10,185
  • In epidemiology: 815
• Year to date:
  • Site-wide: 124,202
• Since beginning of last month:
  • Site-wide: 100,708

Blood glucose levels in elderly subjects with type 2 diabetes during COVID-19 outbreak: a retrospective study in a single center

• Downloaded 2,318 times
• Download rankings, all-time:
  • Site-wide: 10,718
  • In endocrinology: 12
• Year to date:
  • Site-wide: 17,785
• Since beginning of last month:
  • Site-wide: 17,261

Visualizing Long-Term Single-Molecule Dynamics in vivo by Stochastic Protein Labeling

• Downloaded 2,134 times
• Download rankings, all-time:
  • Site-wide: 12,184
  • In biophysics: 255
• Year to date:
  • Site-wide: 192,505
• Since beginning of last month:
  • Site-wide: 151,467

A Fully Automatic Deep Learning System for COVID-19 Diagnostic and Prognostic Analysis

• Downloaded 2,032 times
• Download rankings, all-time:
  • Site-wide: 13,106
  • In health informatics: 70
• Year to date:
  • Site-wide: 48,820
• Since beginning of last month:
  • Site-wide: 103,942

Reliable Multiplex Sequencing with Rare Index Mis-Assignment on DNB-Based NGS Platform

• Downloaded 1,926 times
• Download rankings, all-time:
  • Site-wide: 14,235
  • In genomics: 1,286
• Year to date:
  • Site-wide: 134,399
• Since beginning of last month:
  • Site-wide: 90,378

CoV Genome Tracker: tracing genomic footprints of Covid-19 pandemic

• Downloaded 1,885 times
• Download rankings, all-time:
  • Site-wide: 14,702
  • In evolutionary biology: 398
• Year to date:
  • Site-wide: 66,068
• Since beginning of last month:
  • Site-wide: 103,309

Defining the core essential genome of Pseudomonas aeruginosa

• Downloaded 1,630 times
• Download rankings, all-time:
  • Site-wide: 18,455
  • In microbiology: 1,067
• Year to date:
  • Site-wide: 173,350
• Since beginning of last month:
  • Site-wide: 91,456

Proliferation impairs cell viability via energy depletion

• Downloaded 1,458 times
• Download rankings, all-time:
  • Site-wide: 22,018
  • In cell biology: 735
• Year to date:
  • Site-wide: 21,117
• Since beginning of last month:
  • Site-wide: 17,276

CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor

• Downloaded 1,360 times
• Download rankings, all-time:
  • Site-wide: 24,670
  • In immunology: 908
• Year to date:
  • Site-wide: 47,142
• Since beginning of last month:
  • Site-wide: 30,079

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells

• Downloaded 1,354 times
• Download rankings, all-time:
  • Site-wide: 24,863
  • In immunology: 915
• Year to date:
  • Site-wide: 67,108
• Since beginning of last month:
  • Site-wide: 65,991

CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor

• Downloaded 1,219 times
• Download rankings, all-time:
  • Site-wide: 29,329
  • In genomics: 2,611
• Year to date:
  • Site-wide: 4,081
• Since beginning of last month:
  • Site-wide: 7,567

Guiding ATR and PARP inhibitor combinations with chemogenomic screens

• Downloaded 1,140 times
• Download rankings, all-time:
  • Site-wide: 32,634
  • In cancer biology: 870
• Year to date:
  • Site-wide: 33,776
• Since beginning of last month:
  • Site-wide: 83,120

Origin and evolution of a pandemic lineage of the kiwifruit pathogen Pseudomonas syringae pv. actinidiae

• Downloaded 1,132 times
• Download rankings, all-time:
  • Site-wide: 32,969
  • In epidemiology: 1,853
• Year to date:
  • Site-wide: 114,411
• Since beginning of last month:
  • Site-wide: 145,918

A diverse network of pericoerulear neurons control arousal states

• Downloaded 1,122 times
• Download rankings, all-time:
  • Site-wide: 33,440
  • In neuroscience: 4,333
• Year to date:
  • Site-wide: 15,776
• Since beginning of last month:
  • Site-wide: 15,675

Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC

• Downloaded 1,102 times
• Download rankings, all-time:
  • Site-wide: 34,359
  • In bioengineering: 740
• Year to date:
  • Site-wide: 4,832
• Since beginning of last month:
  • Site-wide: 2,115

Autophagy determines osimertinib resistance through regulation of stem cell-like properties in EGFR-mutant lung cancer

• Downloaded 1,091 times
• Download rankings, all-time:
  • Site-wide: 34,873
  • In cancer biology: 947
• Year to date:
  • Site-wide: 62,958
• Since beginning of last month:
  • Site-wide: 93,749

Potential transmission chains of variant B.1.1.7 and co-mutations of SARS-CoV-2

• Downloaded 1,087 times
• Download rankings, all-time:
  • Site-wide: 35,024
  • In microbiology: 2,037
• Year to date:
  • Site-wide: 78,189
• Since beginning of last month:
  • Site-wide: 73,709

COVID-19 outcomes among hospitalized men with or without exposure to alpha-1-adrenergic receptor blocking agents

• Downloaded 1,070 times
• Download rankings, all-time:
  • Site-wide: 35,937
  • In infectious diseases: 3,171
• Year to date:
  • Site-wide: 102,977
• Since beginning of last month:
  • Site-wide: 33,764

Systematic Chromatin Architecture Analysis in Xenopus tropicalis Reveals Conserved Three-Dimensional Folding Principles of Vertebrate Genomes

• Downloaded 1,046 times
• Download rankings, all-time:
  • Site-wide: 37,217
  • In genetics: 1,467
• Year to date:
  • Site-wide: 88,035
• Since beginning of last month:
  • Site-wide: 184,264

The ecological genetics of Pseudomonas syringae from kiwifruit leaves

• Downloaded 1,040 times
• Download rankings, all-time:
  • Site-wide: 37,557
  • In microbiology: 2,167
• Year to date:
  • Site-wide: 119,989
• Since beginning of last month:
  • Site-wide: 119,144

Relative genomic impacts of translocation history, hatchery practices, and farm selection in Pacific oyster Crassostrea gigas throughout the Northern Hemisphere

• Downloaded 1,019 times
• Download rankings, all-time:
  • Site-wide: 38,728
  • In genetics: 1,552
• Year to date:
  • Site-wide: 31,652
• Since beginning of last month:
  • Site-wide: 79,921

Longitudinal single-cell immune profiling revealed distinct innate immune response in asymptomatic COVID-19 patients

• Downloaded 975 times
• Download rankings, all-time:
  • Site-wide: 41,480
  • In immunology: 1,455
• Year to date:
  • Site-wide: 87,350
• Since beginning of last month:
  • Site-wide: 66,029

Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis

• Downloaded 941 times
• Download rankings, all-time:
  • Site-wide: 43,852
  • In cell biology: 1,722
• Year to date:
  • Site-wide: 165,805
• Since beginning of last month:
  • Site-wide: 146,198

Lifestyle adaptations of Rhizobium from rhizosphere to symbiosis

• Downloaded 929 times
• Download rankings, all-time:
  • Site-wide: 44,663
  • In microbiology: 2,582
• Year to date:
  • Site-wide: 159,772
• Since beginning of last month:
  • Site-wide: 188,895

Improving Pre-eclampsia Risk Prediction by Modeling Individualized Pregnancy Trajectories Derived from Routinely Collected Electronic Medical Record Data

• Downloaded 855 times
• Download rankings, all-time:
  • Site-wide: 50,720
  • In obstetrics and gynecology: 59
• Year to date:
  • Site-wide: 112,090
• Since beginning of last month:
  • Site-wide: 112,898

Global Quantitative Mapping of Enhancers in Rice Genome by STARR-seq

• Downloaded 833 times
• Download rankings, all-time:
  • Site-wide: 52,824
  • In genomics: 3,821
• Year to date:
  • Site-wide: 171,588
• Since beginning of last month:
  • Site-wide: 152,268

A direct comparison of four high risk human papilloma virus tests versus the cobas test for detecting cervical intraepithelial neoplasia and cervical cancer

• Downloaded 833 times
• Download rankings, all-time:
  • Site-wide: 52,822
  • In epidemiology: 2,630
• Year to date:
  • Site-wide: 117,313
• Since beginning of last month:
  • Site-wide: 43,282

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

• Downloaded 757 times
• Download rankings, all-time:
  • Site-wide: 60,917
  • In immunology: 2,099
• Year to date:
  • Site-wide: 61,608
• Since beginning of last month:
  • Site-wide: 16,471

Continuous cis-regulatory changes in an advantageous gene are linked with adaptive radiation in cichlid fishes

• Downloaded 723 times
• Download rankings, all-time:
  • Site-wide: 65,113
  • In evolutionary biology: 2,833
• Year to date:
  • Site-wide: 86,874
• Since beginning of last month:
  • Site-wide: 113,921

MicroRNA775 Promotes Intrinsic Leaf Size and Reduces Cell Wall Pectin Level via a Target Galactosyltransferase in Arabidopsis

• Downloaded 714 times
• Download rankings, all-time:
  • Site-wide: 66,294
  • In plant biology: 1,514
• Year to date:
  • Site-wide: 154,360
• Since beginning of last month:
  • Site-wide: 65,629

Regulation of mesenchymal stem cell function by TGFβ-1 on mast cell extracellular vesicles — role of endosomal retention

• Downloaded 699 times
• Download rankings, all-time:
  • Site-wide: 68,366
  • In cell biology: 2,967
• Year to date:
  • Site-wide: 191,551
• Since beginning of last month:
  • Site-wide: 93,118

The Mitochondrial Calcium Uniporter of Pulmonary Type 2 Cells Determines Severity of ARDS

• Downloaded 696 times
• Download rankings, all-time:
  • Site-wide: 68,738
  • In physiology: 393
• Year to date:
  • Site-wide: 93,870
• Since beginning of last month:
  • Site-wide: 62,077

A comprehensive digital phenotype for postpartum hemorrhage

• Downloaded 692 times
• Download rankings, all-time:
  • Site-wide: 69,312
  • In obstetrics and gynecology: 83
• Year to date:
  • Site-wide: 178,910
• Since beginning of last month:
  • Site-wide: 157,222

Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers

• Downloaded 686 times
• Download rankings, all-time:
  • Site-wide: 70,174
  • In systems biology: 1,389
• Year to date:
  • Site-wide: 193,279
• Since beginning of last month:
  • Site-wide: 209,668

Genetically modified pigs are protected from classical swine fever virus

• Downloaded 674 times
• Download rankings, all-time:
  • Site-wide: 71,873
  • In genomics: 4,791
• Year to date:
  • Site-wide: 171,724
• Since beginning of last month:
  • Site-wide: 208,121

Learning and Mapping Lyme Disease Patient Trajectories from Electronic Medical Data for Stratification of Disease Risk and Therapeutic Response

• Downloaded 662 times
• Download rankings, all-time:
  • Site-wide: 73,757
  • In bioinformatics: 6,841
• Year to date:
  • Site-wide: 134,612
• Since beginning of last month:
  • Site-wide: 146,114

Transcriptomic Profiling of Developing Melanocortin Neurons Reveals a Role for Prdm12 in Energy Balance

• Downloaded 655 times
• Download rankings, all-time:
  • Site-wide: 74,711
  • In neuroscience: 10,636
• Year to date:
  • Site-wide: 31,352
• Since beginning of last month:
  • Site-wide: 190,786

Shared heritability and functional enrichment across six solid cancers

• Downloaded 649 times
• Download rankings, all-time:
  • Site-wide: 75,609
  • In genomics: 5,012
• Year to date:
  • Site-wide: 171,915
• Since beginning of last month:
  • Site-wide: 146,814

Adequacy of Self-Collected Anterior Nares Swabs for SARS-CoV-2 Testing by Grade School Children

• Downloaded 647 times
• Download rankings, all-time:
  • Site-wide: 75,886
  • In infectious diseases: 4,749
• Year to date:
  • Site-wide: 19,813
• Since beginning of last month:
  • Site-wide: 23,054

Human Chrysomya bezziana myiasis: A systematic review

• Downloaded 640 times
• Download rankings, all-time:
  • Site-wide: 77,051
  • In epidemiology: 3,461
• Year to date:
  • Site-wide: 191,704
• Since beginning of last month:
  • Site-wide: 117,725

Genome of the estuarine oyster provides insights into climate impact and adaptive plasticity

• Downloaded 639 times
• Download rankings, all-time:
  • Site-wide: 77,165
  • In evolutionary biology: 3,465
• Year to date:
  • Site-wide: 103,090
• Since beginning of last month:
  • Site-wide: 86,310

Improving postpartum hemorrhage risk prediction using longitudinal electronic medical records

• Downloaded 610 times
• Download rankings, all-time:
  • Site-wide: 81,983
  • In obstetrics and gynecology: 103
• Year to date:
  • Site-wide: 79,923
• Since beginning of last month:
  • Site-wide: 113,100

Multi-site co-mutations and 5’UTR CpG immunity escape drive the evolution of SARS-CoV-2

• Downloaded 598 times
• Download rankings, all-time:
  • Site-wide: 84,019
  • In evolutionary biology: 3,808
• Year to date:
  • Site-wide: 84,637
• Since beginning of last month:
  • Site-wide: 78,103

Quantitative proteomics and phosphoproteomics of urinary extracellular vesicles define diagnostic biosignatures for Parkinson's Disease

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 86,241
  • In neurology: 368
• Year to date:
  • Site-wide: 22,055
• Since beginning of last month:
  • Site-wide: 25,793

The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish

• Downloaded 580 times
• Download rankings, all-time:
  • Site-wide: 87,336
  • In developmental biology: 2,172
• Year to date:
  • Site-wide: 190,973
• Since beginning of last month:
  • Site-wide: 201,496

Quantitative proteomics reveals the protective effects of ESD against osteoarthritis via attenuating inflammation and modulating immune response

• Downloaded 575 times
• Download rankings, all-time:
  • Site-wide: 88,308
  • In pharmacology and toxicology: 586
• Year to date:
  • Site-wide: 29,454
• Since beginning of last month:
  • Site-wide: 30,761

Localized and Whole-Room Effects of Portable Air Filtration Units on Aerosol Particle Deposition and Concentration in a Classroom Environment

• Downloaded 574 times
• Download rankings, all-time:
  • Site-wide: 88,614
  • In infectious diseases: 5,101
• Year to date:
  • Site-wide: 109,007
• Since beginning of last month:
  • Site-wide: 23,690

Inhibition of HSP90 reversed STAT3 mediated muscle wasting induced by cancer cachexia

• Downloaded 570 times
• Download rankings, all-time:
  • Site-wide: 89,239
  • In pathology: 423
• Year to date:
  • Site-wide: 68,496
• Since beginning of last month:
  • Site-wide: 61,673

Amplification-free Library Preparation Improves Quality of Hi-C Analysis

• Downloaded 566 times
• Download rankings, all-time:
  • Site-wide: 90,177
  • In genomics: 5,625
• Year to date:
  • Site-wide: 115,657
• Since beginning of last month:
  • Site-wide: 200,639

HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development

• Downloaded 539 times
• Download rankings, all-time:
  • Site-wide: 95,689
  • In genetics: 3,611
• Year to date:
  • Site-wide: 169,037
• Since beginning of last month:
  • Site-wide: 200,976

Age-dependent characterization of the carotid and cerebral artery morphologies in a transgenic mouse model of sickle cell anemia using ultrasound and microcomputed tomography

• Downloaded 527 times
• Download rankings, all-time:
  • Site-wide: 98,223
  • In pathology: 477
• Year to date:
  • Site-wide: 74,889
• Since beginning of last month:
  • Site-wide: 152,973

Characterizing metabolism from bulk and single-cell RNA-seq data using METAFlux

• Downloaded 521 times
• Download rankings, all-time:
  • Site-wide: 99,376
  • In bioinformatics: 8,983
• Year to date:
  • Site-wide: 61,936
• Since beginning of last month:
  • Site-wide: 10,206

Noncanonical WNT activation in human right ventricular heart failure

• Downloaded 510 times
• Download rankings, all-time:
  • Site-wide: 101,965
  • In cardiovascular medicine: 250
• Year to date:
  • Site-wide: 89,873
• Since beginning of last month:
  • Site-wide: 160,594

Resolving a Systematic Error in STARR-seq for Quantitative Enhancer Activity Mapping

• Downloaded 509 times
• Download rankings, all-time:
  • Site-wide: 102,181
  • In genetics: 3,899
• Year to date:
  • Site-wide: 67,663
• Since beginning of last month:
  • Site-wide: 65,738

Live cell biosensors based on the fluorescence lifetime of environment-sensing dyes

• Downloaded 493 times
• Download rankings, all-time:
  • Site-wide: 105,996
  • In cell biology: 4,938
• Year to date:
  • Site-wide: 56,273
• Since beginning of last month:
  • Site-wide: 69,221

Who is pregnant? defining real-world data-based pregnancy episodes in the National COVID Cohort Collaborative (N3C)

• Downloaded 491 times
• Download rankings, all-time:
  • Site-wide: 106,295
  • In health informatics: 556
• Year to date:
  • Site-wide: 4,976
• Since beginning of last month:
  • Site-wide: 4,828

Orchestration of Chlorophyll and Carotenoid Biosynthesis by ORANGE Family Proteins in Plant

• Downloaded 488 times
• Download rankings, all-time:
  • Site-wide: 107,023
  • In plant biology: 2,881
• Year to date:
  • Site-wide: 43,847
• Since beginning of last month:
  • Site-wide: 25,368

Depression and Anxiety in Healthcare Staffs in A Tertiary University Hospital in Luoyang, Henan Province: A Cross-Sectional Observational Study

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 112,016
  • In scientific communication and education: 564
• Year to date:
  • Site-wide: 139,975
• Since beginning of last month:
  • Site-wide: 177,337

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 464 times
• Download rankings, all-time:
  • Site-wide: 112,866
  • In epidemiology: 4,761
• Year to date:
  • Site-wide: 184,900
• Since beginning of last month:
  • Site-wide: 132,089

Comparative analysis of the Accelerated Aged seed transcriptome profiles of maize CSSLs (I178 and X178)

• Downloaded 458 times
• Download rankings, all-time:
  • Site-wide: 114,417
  • In plant biology: 3,031
• Year to date:
  • Site-wide: 95,879
• Since beginning of last month:
  • Site-wide: 203,102

Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex

• Downloaded 457 times
• Download rankings, all-time:
  • Site-wide: 114,488
  • In biochemistry: 3,327
• Year to date:
  • Site-wide: 142,834
• Since beginning of last month:
  • Site-wide: 155,369

Anti-BP180 Autoantibodies Are Present in Stroke and Recognize Human Cutaneous BP180 and BP180-NC16A

• Downloaded 456 times
• Download rankings, all-time:
  • Site-wide: 114,928
  • In neuroscience: 16,666
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 176,738

Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis

• Downloaded 437 times
• Download rankings, all-time:
  • Site-wide: 119,709
  • In genetics: 4,482
• Year to date:
  • Site-wide: 166,287
• Since beginning of last month:
  • Site-wide: 212,060

Genomic signatures of recent adaptation in a wild bumblebee

• Downloaded 428 times
• Download rankings, all-time:
  • Site-wide: 122,194
  • In evolutionary biology: 5,623
• Year to date:
  • Site-wide: 183,084
• Since beginning of last month:
  • Site-wide: 136,809

Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis

• Downloaded 424 times
• Download rankings, all-time:
  • Site-wide: 123,208
  • In cell biology: 5,779
• Year to date:
  • Site-wide: 66,548
• Since beginning of last month:
  • Site-wide: 126,088

Deep learning identifies pathological abnormalities predictive of graft loss in kidney transplant biopsies

• Downloaded 424 times
• Download rankings, all-time:
  • Site-wide: 123,327
  • In pathology: 654
• Year to date:
  • Site-wide: 148,046
• Since beginning of last month:
  • Site-wide: 111,486

A Bidirectional Switch in the Shank3 Phosphorylation State Biases Synapses toward Up or Down Scaling

• Downloaded 420 times
• Download rankings, all-time:
  • Site-wide: 124,264
  • In neuroscience: 18,221
• Year to date:
  • Site-wide: 182,281
• Since beginning of last month:
  • Site-wide: 72,573

ESD1 Affects Seed Setting Rate in Rice by Controlling Embryo Sac Development

• Downloaded 420 times
• Download rankings, all-time:
  • Site-wide: 124,288
  • In plant biology: 3,323
• Year to date:
  • Site-wide: 93,798
• Since beginning of last month:
  • Site-wide: 95,947

Association of in-hospital use of ACE-I/ARB and COVID-19 outcomes in African American population

• Downloaded 414 times
• Download rankings, all-time:
  • Site-wide: 126,010
  • In infectious diseases: 6,268
• Year to date:
  • Site-wide: 77,920
• Since beginning of last month:
  • Site-wide: 86,238

Crystallographic observation of nonenzymatic RNA primer extension

• Downloaded 406 times
• Download rankings, all-time:
  • Site-wide: 128,115
  • In biochemistry: 3,792
• Year to date:
  • Site-wide: 116,297
• Since beginning of last month:
  • Site-wide: 90,452

The Histone Methyltransferase SETD2 Modulates Oxidative Stress to Attenuate Colonic Inflammation and Tumorigenesis in Mice

• Downloaded 402 times
• Download rankings, all-time:
  • Site-wide: 129,460
  • In cell biology: 6,010
• Year to date:
  • Site-wide: 122,948
• Since beginning of last month:
  • Site-wide: 184,278

A high-fat diet changes astrocytic metabolism to enhance synaptic plasticity and promote exploratory behavior

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 129,762
  • In neuroscience: 19,235
• Year to date:
  • Site-wide: 80,872
• Since beginning of last month:
  • Site-wide: 71,743

Identification and genetic validation of drug-comorbidity interactions in type 2 diabetes using data-driven disease trajectory analysis

• Downloaded 398 times
• Download rankings, all-time:
  • Site-wide: 130,531
  • In bioinformatics: 10,628
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 101,201

Ab initio Spillover Compensation in CyTOF Data

• Downloaded 397 times
• Download rankings, all-time:
  • Site-wide: 130,882
  • In bioinformatics: 10,632
• Year to date:
  • Site-wide: 91,698
• Since beginning of last month:
  • Site-wide: 66,251

Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia

• Downloaded 396 times
• Download rankings, all-time:
  • Site-wide: 131,227
  • In neuroscience: 19,161
• Year to date:
  • Site-wide: 127,180
• Since beginning of last month:
  • Site-wide: 191,481

Identification and quantification of Lyme pathogen strains by deep sequencing of outer surface protein C (ospC) amplicons

• Downloaded 393 times
• Download rankings, all-time:
  • Site-wide: 132,258
  • In microbiology: 9,022
• Year to date:
  • Site-wide: 134,246
• Since beginning of last month:
  • Site-wide: 174,039

Di-Ras2 Promotes Renal Cell Carcinoma Formation by Activating the MAPK Pathway in the Absence of VHL

• Downloaded 383 times
• Download rankings, all-time:
  • Site-wide: 135,099
  • In cancer biology: 4,145
• Year to date:
  • Site-wide: 142,044
• Since beginning of last month:
  • Site-wide: 154,746

Genetic architectures of proximal and distal colorectal cancer are partly distinct

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 137,948
  • In genetic and genomic medicine: 955
• Year to date:
  • Site-wide: 161,156
• Since beginning of last month:
  • Site-wide: 165,331

AMP-Kinase mediates regulation of glomerular volume and podocyte survival

• Downloaded 367 times
• Download rankings, all-time:
  • Site-wide: 139,918
  • In systems biology: 2,824
• Year to date:
  • Site-wide: 178,101
• Since beginning of last month:
  • Site-wide: 97,479

Structural and Functional Analyses of Hub MicroRNAs in an Integrated Gene Regulatory Network of Arabidopsis

• Downloaded 359 times
• Download rankings, all-time:
  • Site-wide: 142,046
  • In bioinformatics: 11,326
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 122,624

Antigenicity and Potential Use of A Novel Brucella Multiepitope Recombinant Protein in the Diagnosis of Brucellosis

• Downloaded 359 times
• Download rankings, all-time:
  • Site-wide: 142,088
  • In zoology: 558
• Year to date:
  • Site-wide: 24,250
• Since beginning of last month:
  • Site-wide: 120,606

Optimal fertigation for high yield and fruit quality of greenhouse strawberry

• Downloaded 357 times
• Download rankings, all-time:
  • Site-wide: 142,660
  • In plant biology: 3,918
• Year to date:
  • Site-wide: 64,149
• Since beginning of last month:
  • Site-wide: 127,930

Annealing synchronizes the 70S ribosome into a minimum-energy conformation

• Downloaded 342 times
• Download rankings, all-time:
  • Site-wide: 147,251
  • In biophysics: 5,637
• Year to date:
  • Site-wide: 77,458
• Since beginning of last month:
  • Site-wide: 133,679

GLKs directly regulate carotenoid biosynthesis via interacting with GBFs in nuclear condensates in plants

• Downloaded 339 times
• Download rankings, all-time:
  • Site-wide: 148,394
  • In plant biology: 4,623
• Year to date:
  • Site-wide: 5,527
• Since beginning of last month:
  • Site-wide: 8,029

5-HAYED peptide can protect AD brain by scavenging the redundant iron ions and the catalyzed radicals

• Downloaded 329 times
• Download rankings, all-time:
  • Site-wide: 151,457
  • In neuroscience: 22,153
• Year to date:
  • Site-wide: 135,750
• Since beginning of last month:
  • Site-wide: 117,915

SETD2 deficiency impairs β-catenin destruction complex to facilitate renal cell carcinoma formation

• Downloaded 325 times
• Download rankings, all-time:
  • Site-wide: 152,530
  • In cancer biology: 4,729
• Year to date:
  • Site-wide: 50,390
• Since beginning of last month:
  • Site-wide: 160,870

Epac1 regulates cellular SUMOylation by promoting the formation of SUMO-activating nuclear condensates

• Downloaded 317 times
• Download rankings, all-time:
  • Site-wide: 154,733
  • In cell biology: 7,379
• Year to date:
  • Site-wide: 45,391
• Since beginning of last month:
  • Site-wide: 47,953

Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver Russell Syndrome-like mouse models

• Downloaded 316 times
• Download rankings, all-time:
  • Site-wide: 155,202
  • In developmental biology: 4,175
• Year to date:
  • Site-wide: 78,796
• Since beginning of last month:
  • Site-wide: 18,877

Extensive Chromatin Structure-Function Association Revealed by Accurate Compartmentalization Characterization

• Downloaded 314 times
• Download rankings, all-time:
  • Site-wide: 155,830
  • In bioinformatics: 12,161
• Year to date:
  • Site-wide: 80,659
• Since beginning of last month:
  • Site-wide: 113,708

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

• Downloaded 294 times
• Download rankings, all-time:
  • Site-wide: 161,911
  • In cancer biology: 4,977
• Year to date:
  • Site-wide: 164,194
• Since beginning of last month:
  • Site-wide: 123,506

A novel nonsense mutation c.424G>T (p. G142X) in the first exon of XLas leading to osteopetrosis

• Downloaded 288 times
• Download rankings, all-time:
  • Site-wide: 163,765
  • In genetics: 6,052
• Year to date:
  • Site-wide: 139,876
• Since beginning of last month:
  • Site-wide: 118,026

Primary pterygium was not associated with corneal endothelial cell decrease in a rural Chinese population

• Downloaded 284 times
• Download rankings, all-time:
  • Site-wide: 165,022
  • In epidemiology: 6,663
• Year to date:
  • Site-wide: 94,451
• Since beginning of last month:
  • Site-wide: 207,921

Structural insight into molecular inhibitory mechanism of InsP6 on African Swine Fever Virus mRNA-decapping enzyme g5Rp

• Downloaded 273 times
• Download rankings, all-time:
  • Site-wide: 168,066
  • In biochemistry: 5,203
• Year to date:
  • Site-wide: 146,378
• Since beginning of last month:
  • Site-wide: 171,173

Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance

• Downloaded 271 times
• Download rankings, all-time:
  • Site-wide: 168,629
  • In cancer biology: 5,214
• Year to date:
  • Site-wide: 152,944
• Since beginning of last month:
  • Site-wide: 122,872

Transcriptome profiling reveals the mechanism of ripening and epidermal senescence in passionfruit (Passiflora edulia Sims)

• Downloaded 256 times
• Download rankings, all-time:
  • Site-wide: 172,972
  • In plant biology: 4,827
• Year to date:
  • Site-wide: 158,498
• Since beginning of last month:
  • Site-wide: 78,170

Actin fence therapy with exogenous V12Rac1 protects against Acute Lung Injury

• Downloaded 252 times
• Download rankings, all-time:
  • Site-wide: 174,070
  • In physiology: 1,937
• Year to date:
  • Site-wide: 185,219
• Since beginning of last month:
  • Site-wide: 132,998

Structural variation, functional differentiation and expression characteristics of the AP2/ERF gene family and its response to cold stress and methyl jasmonate in Panax ginseng C.A. Meyer

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 174,432
  • In genomics: 8,542
• Year to date:
  • Site-wide: 143,994
• Since beginning of last month:
  • Site-wide: 211,241

Characterization of a KDM5 Small Molecule Inhibitor with Antiviral Activity against Hepatitis B Virus

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 179,918
  • In pharmacology and toxicology: 1,531
• Year to date:
  • Site-wide: 26,204
• Since beginning of last month:
  • Site-wide: 66,793

The impact of Illinois' comprehensive handheld phone ban on talking on handheld and handsfree cellphones while driving

• Downloaded 229 times
• Download rankings, all-time:
  • Site-wide: 180,288
  • In epidemiology: 7,213
• Year to date:
  • Site-wide: 181,486
• Since beginning of last month:
  • Site-wide: 35,769

Hsa-miR-31-5p controls a metabolic switch in psoriatic keratinocytes that identifies therapeutic intervention

• Downloaded 219 times
• Download rankings, all-time:
  • Site-wide: 183,024
  • In immunology: 5,920
• Year to date:
  • Site-wide: 42,992
• Since beginning of last month:
  • Site-wide: 48,488

Real-world genetic screening with molecular ancestry supports comprehensive pan-ethnic carrier screening

• Downloaded 215 times
• Download rankings, all-time:
  • Site-wide: 183,911
  • In genetic and genomic medicine: 1,432
• Year to date:
  • Site-wide: 9,076
• Since beginning of last month:
  • Site-wide: 66,772

An Iron-Calcium-Miro Axis Influences Parkinson Risk and Neurodegeneration

• Downloaded 215 times
• Download rankings, all-time:
  • Site-wide: 183,883
  • In cell biology: 8,238
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Disease-associated patterns of acetylation stabilize tau fibril formation

• Downloaded 181 times
• Download rankings, all-time:
  • Site-wide: 191,783
  • In biophysics: None
• Year to date:
  • Site-wide: 401
• Since beginning of last month:
  • Site-wide: None

Talking on handsfree and handheld cellphones while driving in association with handheld phone bans.

• Downloaded 173 times
• Download rankings, all-time:
  • Site-wide: 193,458
  • In epidemiology: 7,635
• Year to date:
  • Site-wide: 112,114
• Since beginning of last month:
  • Site-wide: 108,451

Ex vivo and in vivo evidence that cigarette smoke-exposed T regulatory cells impair host immunity against Mycobacterium tuberculosis

• Downloaded 154 times
• Download rankings, all-time:
  • Site-wide: 197,522
  • In immunology: 6,386
• Year to date:
  • Site-wide: 78,018
• Since beginning of last month:
  • Site-wide: 168,610

Aging impairs astrocytes in the human cerebral cortex

• Downloaded 141 times
• Download rankings, all-time:
  • Site-wide: 199,995
  • In neuroscience: 29,423
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 22,823

Salicylic acid and risk of colorectal cancer: a two sample Mendelian randomization study

• Downloaded 138 times
• Download rankings, all-time:
  • Site-wide: 200,484
  • In epidemiology: 7,861
• Year to date:
  • Site-wide: 150,148
• Since beginning of last month:
  • Site-wide: 158,330

Anatomical and functional maturation of the mid-gestation human intestine

• Downloaded 125 times
• Download rankings, all-time:
  • Site-wide: 203,075
  • In developmental biology: 5,261
• Year to date:
  • Site-wide: 40,569
• Since beginning of last month:
  • Site-wide: 138,767

Probing the diabetes and colorectal cancer relationship using gene-environment interaction analyses

• Downloaded 125 times
• Download rankings, all-time:
  • Site-wide: 203,050
  • In epidemiology: 8,019
• Year to date:
  • Site-wide: 18,229
• Since beginning of last month:
  • Site-wide: 36,467

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

• Downloaded 123 times
• Download rankings, all-time:
  • Site-wide: 203,434
  • In immunology: 6,555
• Year to date:
  • Site-wide: 70,153
• Since beginning of last month:
  • Site-wide: 47,335

Treatment of non-alcoholic steatohepatitis with recombinant Orosomucoid 2, an acute phase protein that attenuates the Erk1/2-PPARγ-Cd36 signaling pathway

• Downloaded 101 times
• Download rankings, all-time:
  • Site-wide: 207,407
  • In molecular biology: 6,286
• Year to date:
  • Site-wide: 133,706
• Since beginning of last month:
  • Site-wide: 41,519

Development of recombinant monoclonal antibodies targeting conserved VlsE epitopes in Lyme disease pathogens

• Downloaded 101 times
• Download rankings, all-time:
  • Site-wide: 207,309
  • In microbiology: 15,778
• Year to date:
  • Site-wide: 182,477
• Since beginning of last month:
  • Site-wide: 195,466

Selection of optimal cell lines for high-content phenotypic screening

• Downloaded 96 times
• Download rankings, all-time:
  • Site-wide: 208,196
  • In pharmacology and toxicology: None
• Year to date:
  • Site-wide: 1,045
• Since beginning of last month:
  • Site-wide: None

SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signaling pathway in the absence of VHL

• Downloaded 83 times
• Download rankings, all-time:
  • Site-wide: 210,598
  • In molecular biology: 6,391
• Year to date:
  • Site-wide: 101,243
• Since beginning of last month:
  • Site-wide: 106,806

Environmental exposures are important risk factors for advanced liver fibrosis in African American adults: NHANES 1999-2018

• Downloaded 57 times
• Download rankings, all-time:
  • Site-wide: 215,047
  • In gastroenterology: 382
• Year to date:
  • Site-wide: 53,320
• Since beginning of last month:
  • Site-wide: 9,542