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Author: Yan Zhang

  • ORCiD: http://orcid.org/0000-0002-9360-5388
  • Most recently observed institution: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College

Rankings

  • All-time downloads: 58,048 (rank: 705 out of 426,025)
  • Categories:
    • biochemistry: 1,666 (rank: 1,625 out of 20,760)
    • bioengineering: 4,771 (rank: 162 out of 13,236)
    • bioinformatics: 5,016 (rank: 2,024 out of 36,200)
    • biophysics: 2,630 (rank: 895 (tie) out of 18,183)
    • cancer biology: 314 (rank: 19,152 (tie) out of 30,395)
    • cell biology: 93 (rank: 31,120 (tie) out of 32,894)
    • developmental biology: 492 (rank: 7,433 (tie) out of 16,934)
    • epidemiology: 782 (rank: 2,182 (tie) out of 9,545)
    • evolutionary biology: 191 (rank: 18,879 (tie) out of 21,771)
    • genetics: 6,235 (rank: 2,906 out of 37,998)
    • genomics: 16,747 (rank: 607 out of 44,631)
    • immunology: 509 (rank: 11,574 (tie) out of 26,443)
    • microbiology: 1,563 (rank: 6,456 (tie) out of 50,802)
    • molecular biology: 9,348 (rank: 183 out of 23,399)
    • neuroscience: 427 (rank: 40,002 (tie) out of 72,365)
    • physiology: 268 (rank: 4,861 (tie) out of 9,536)
    • plant biology: 646 (rank: 5,142 (tie) out of 16,798)
    • synthetic biology: 1,029 (rank: 1,480 out of 4,412)
    • systems biology: 5,321 (rank: 518 (tie) out of 12,462)

Downloads per author, site-wide

Preprints

Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis

biochemistry more details view paper

No bioRxiv download data for this paper yet.

Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection

genomics more details view paper
  • Downloaded 9,169 times
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    • Site-wide: 323 out of 100,856
    • In genomics: 60 out of 6,254
  • Year to date:
    • Site-wide: 134 out of 100,856
  • Since beginning of last month:
    • Site-wide: 539 out of 100,856

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

molecular biology more details view paper
  • Downloaded 7,060 times
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    • Site-wide: 496 out of 100,856
    • In molecular biology: 17 out of 3,501
  • Year to date:
    • Site-wide: 182 out of 100,856
  • Since beginning of last month:
    • Site-wide: 4,119 out of 100,856

Mapping Vector Field of Single Cells

systems biology more details view paper
  • Downloaded 5,321 times
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    • Site-wide: 783 out of 100,856
    • In systems biology: 20 out of 2,563
  • Year to date:
    • Site-wide: 1,136 out of 100,856
  • Since beginning of last month:
    • Site-wide: 1,122 out of 100,856

A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

bioengineering more details view paper
  • Downloaded 2,424 times
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    • In bioengineering: 57 out of 2,346
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    • Site-wide: 673 out of 100,856
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    • Site-wide: 3,572 out of 100,856

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits and implications for the future

genetics more details view paper
  • Downloaded 2,334 times
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    • In genetics: 241 out of 5,020
  • Year to date:
    • Site-wide: 10,885 out of 100,856
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    • Site-wide: 9,541 out of 100,856

HiCPlus: Resolution Enhancement of Hi-C interaction heatmap

bioinformatics more details view paper
  • Downloaded 2,098 times
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    • Site-wide: 3,894 out of 100,856
    • In bioinformatics: 694 out of 9,260
  • Year to date:
    • Site-wide: 71,927 out of 100,856
  • Since beginning of last month:
    • Site-wide: 82,283 out of 100,856

ElectroPen: An ultralow-cost piezoelectric electroporator

bioengineering more details view paper
  • Downloaded 2,025 times
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    • Site-wide: 4,111 out of 100,856
    • In bioengineering: 77 out of 2,346
  • Year to date:
    • Site-wide: 5,837 out of 100,856
  • Since beginning of last month:
    • Site-wide: 8,753 out of 100,856

Passenger mutations in 2500 cancer genomes: Overall molecular functional impact and consequences

genomics more details view paper
  • Downloaded 2,002 times
  • Download rankings, all-time:
    • Site-wide: 4,192 out of 100,856
    • In genomics: 713 out of 6,254
  • Year to date:
    • Site-wide: 16,084 out of 100,856
  • Since beginning of last month:
    • Site-wide: 36,806 out of 100,856

Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection

genomics more details view paper
  • Downloaded 1,939 times
  • Download rankings, all-time:
    • Site-wide: 4,427 out of 100,856
    • In genomics: 737 out of 6,254
  • Year to date:
    • Site-wide: 940 out of 100,856
  • Since beginning of last month:
    • Site-wide: 5,168 out of 100,856

Integration of Mouse and Human Single-cell RNA Sequencing Infers Spatial Cell-type Composition in Human Brains

bioinformatics more details view paper
  • Downloaded 1,718 times
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    • Site-wide: 5,419 out of 100,856
    • In bioinformatics: 959 out of 9,260
  • Year to date:
    • Site-wide: 8,396 out of 100,856
  • Since beginning of last month:
    • Site-wide: 17,086 out of 100,856

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

genetics more details view paper
  • Downloaded 1,595 times
  • Download rankings, all-time:
    • Site-wide: 6,154 out of 100,856
    • In genetics: 435 out of 5,020
  • Year to date:
    • Site-wide: 12,012 out of 100,856
  • Since beginning of last month:
    • Site-wide: 19,010 out of 100,856

Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer

molecular biology more details view paper
  • Downloaded 1,488 times
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    • Site-wide: 6,932 out of 100,856
    • In molecular biology: 248 out of 3,501
  • Year to date:
    • Site-wide: 1,418 out of 100,856
  • Since beginning of last month:
    • Site-wide: 15,971 out of 100,856

A complex structure of arrestin-2 bound to a G protein-coupled receptor

biophysics more details view paper
  • Downloaded 1,243 times
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    • Site-wide: 9,382 out of 100,856
    • In biophysics: 292 out of 4,449
  • Year to date:
    • Site-wide: 14,646 out of 100,856
  • Since beginning of last month:
    • Site-wide: 18,557 out of 100,856

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

genomics more details view paper
  • Downloaded 1,129 times
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    • Site-wide: 11,027 out of 100,856
    • In genomics: 1,541 out of 6,254
  • Year to date:
    • Site-wide: 2,187 out of 100,856
  • Since beginning of last month:
    • Site-wide: 17,430 out of 100,856

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

genomics more details view paper
  • Downloaded 1,030 times
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    • Site-wide: 12,770 out of 100,856
    • In genomics: 1,725 out of 6,254
  • Year to date:
    • Site-wide: 78,754 out of 100,856
  • Since beginning of last month:
    • Site-wide: 83,176 out of 100,856

HBP: an integrative and flexible pipeline for the interaction analysis of Hi-C dataset

bioinformatics more details view paper
  • Downloaded 927 times
  • Download rankings, all-time:
    • Site-wide: 15,141 out of 100,856
    • In bioinformatics: 2,316 out of 9,260
  • Year to date:
    • Site-wide: 96,267 out of 100,856
  • Since beginning of last month:
    • Site-wide: 98,628 out of 100,856

Cryo-EM structures reveal interactions of S-OPA1 with membrane and changes upon nucleotide binding

biophysics more details view paper
  • Downloaded 871 times
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    • In biophysics: 562 out of 4,449
  • Year to date:
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  • Since beginning of last month:
    • Site-wide: 47,363 out of 100,856

Consensus interpretation of the Met34Thr and Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel

genetics more details view paper
  • Downloaded 857 times
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    • Site-wide: 17,116 out of 100,856
    • In genetics: 1,073 out of 5,020
  • Year to date:
    • Site-wide: 19,328 out of 100,856
  • Since beginning of last month:
    • Site-wide: 17,989 out of 100,856

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

genetics more details view paper
  • Downloaded 824 times
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    • Site-wide: 18,200 out of 100,856
    • In genetics: 1,133 out of 5,020
  • Year to date:
    • Site-wide: 23,214 out of 100,856
  • Since beginning of last month:
    • Site-wide: 40,270 out of 100,856

Structural basis of bile acid receptor activation and Gs coupling

biochemistry more details view paper
  • Downloaded 815 times
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    • Site-wide: 18,506 out of 100,856
    • In biochemistry: 488 out of 3,446
  • Year to date:
    • Site-wide: 3,522 out of 100,856
  • Since beginning of last month:
    • Site-wide: 23,301 out of 100,856

scTPA: A web tool for single-cell transcriptome analysis of pathway activation signatures

genomics more details view paper
  • Downloaded 794 times
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    • Site-wide: 19,261 out of 100,856
    • In genomics: 2,299 out of 6,254
  • Year to date:
    • Site-wide: 3,697 out of 100,856
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    • Site-wide: 6,174 out of 100,856

Comparative validation of breast cancer risk prediction models and projections for future risk stratification

epidemiology more details view paper
  • Downloaded 782 times
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    • Site-wide: 19,751 out of 100,856
    • In epidemiology: 217 out of 1,556
  • Year to date:
    • Site-wide: 25,370 out of 100,856
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    • Site-wide: 23,162 out of 100,856

Giant African snail genomes provide insights into molluscan whole-genome duplication and aquatic-terrestrial transition

genomics more details view paper
  • Downloaded 684 times
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    • Site-wide: 24,055 out of 100,856
    • In genomics: 2,649 out of 6,254
  • Year to date:
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    • Site-wide: 9,658 out of 100,856

Molecular Mapping Of YrTZ2, A Stripe Rust Resistance Gene In Wild Emmer Accession TZ-2 And Its Comparative Analyses With Aegilops tauschii

plant biology more details view paper
  • Downloaded 646 times
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    • Site-wide: 26,082 out of 100,856
    • In plant biology: 631 out of 3,184
  • Year to date:
    • Site-wide: 79,780 out of 100,856
  • Since beginning of last month:
    • Site-wide: 76,120 out of 100,856

Engineering a Functional small RNA Negative Autoregulation Network with Model-guided Design

synthetic biology more details view paper
  • Downloaded 553 times
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    • Site-wide: 32,053 out of 100,856
    • In synthetic biology: 485 out of 920
  • Year to date:
    • Site-wide: 80,671 out of 100,856
  • Since beginning of last month:
    • Site-wide: 73,665 out of 100,856

Crystal structure of SARS-CoV-2 main protease in complex with a Chinese herb inhibitor shikonin

biophysics more details view paper
  • Downloaded 516 times
  • Download rankings, all-time:
    • Site-wide: 35,004 out of 100,856
    • In biophysics: 1,377 out of 4,449
  • Year to date:
    • Site-wide: 7,158 out of 100,856
  • Since beginning of last month:
    • Site-wide: 7,206 out of 100,856

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

genetics more details view paper
  • Downloaded 511 times
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    • Site-wide: 35,486 out of 100,856
    • In genetics: 2,056 out of 5,020
  • Year to date:
    • Site-wide: 7,269 out of 100,856
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    • Site-wide: 7,710 out of 100,856

Altered Bacteria-Fungi Inter-Kingdom Network in Gut of Ankylosing Spondylitis Patients

microbiology more details view paper
  • Downloaded 505 times
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    • Site-wide: 36,073 out of 100,856
    • In microbiology: 2,532 out of 8,949
  • Year to date:
    • Site-wide: 59,971 out of 100,856
  • Since beginning of last month:
    • Site-wide: 48,564 out of 100,856

A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo

synthetic biology more details view paper
  • Downloaded 476 times
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    • Site-wide: 38,687 out of 100,856
    • In synthetic biology: 560 out of 920
  • Year to date:
    • Site-wide: 23,391 out of 100,856
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    • Site-wide: 37,533 out of 100,856

Structure of SARS-CoV-2 main protease in the apo state reveals the inactive conformation

biochemistry more details view paper
  • Downloaded 471 times
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    • Site-wide: 39,215 out of 100,856
    • In biochemistry: 1,152 out of 3,446
  • Year to date:
    • Site-wide: 8,336 out of 100,856
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    • Site-wide: 19,696 out of 100,856

Structural insights into the insecticidal Vip3A toxin of Bacillus thuringiensis

microbiology more details view paper
  • Downloaded 445 times
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    • Site-wide: 41,853 out of 100,856
    • In microbiology: 2,995 out of 8,949
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    • Site-wide: 15,053 out of 100,856

Identification of Common Adulterants in Walnut Beverage Based on Plant DNA Barcode Technology

molecular biology more details view paper
  • Downloaded 442 times
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    • Site-wide: 42,200 out of 100,856
    • In molecular biology: 1,384 out of 3,501
  • Year to date:
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    • Site-wide: 38,428 out of 100,856

Tyr1 phosphorylation promotes the phosphorylation of Ser2 on the C-terminal domain of RNA polymerase II by P-TEFb

biochemistry more details view paper
  • Downloaded 380 times
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    • Site-wide: 49,556 out of 100,856
    • In biochemistry: 1,494 out of 3,446
  • Year to date:
    • Site-wide: 49,222 out of 100,856
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    • Site-wide: 65,282 out of 100,856

LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesis

molecular biology more details view paper
  • Downloaded 358 times
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    • Site-wide: 52,508 out of 100,856
    • In molecular biology: 1,717 out of 3,501
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    • Site-wide: 27,283 out of 100,856

Integrated analysis of the miRNA-mRNA network associated with LMP1 gene in nasopharyngeal carcinoma

microbiology more details view paper
  • Downloaded 340 times
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    • Site-wide: 55,062 out of 100,856
    • In microbiology: 4,171 out of 8,949
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    • Site-wide: 33,725 out of 100,856

Electronic blood vessel

bioengineering more details view paper
  • Downloaded 322 times
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    • Site-wide: 57,727 out of 100,856
    • In bioengineering: 1,159 out of 2,346
  • Year to date:
    • Site-wide: 14,819 out of 100,856
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    • Site-wide: 12,105 out of 100,856

The loss of ATRX/DAXX complex disturbs rDNA heterochromatinization and promotes development of glioma

cancer biology more details view paper
  • Downloaded 314 times
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    • Site-wide: 58,847 out of 100,856
    • In cancer biology: 1,919 out of 3,613
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    • Site-wide: 42,212 out of 100,856

SARS-Cov-2-, HIV-1-, Ebola-neutralizing and anti-PD1 clones are predisposed

immunology more details view paper
  • Downloaded 303 times
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    • Site-wide: 60,541 out of 100,856
    • In immunology: 1,710 out of 3,141
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    • Site-wide: 9,586 out of 100,856

Altered brain function in anorexia nervosa and bulimia nervosa: A hierarchical series of task-based fMRI meta-analyses

neuroscience more details view paper
  • Downloaded 275 times
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    • Site-wide: 65,200 out of 100,856
    • In neuroscience: 11,588 out of 17,976
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    • Site-wide: 67,751 out of 100,856

Verification of the phenylpropanoid pinoresinol biosynthetic pathway and its glycosides in Phomopsis sp. XP-8 using 13C stable isotope labeling and liquid chromatography coupled with time-of-flight mass spectrometry

microbiology more details view paper
  • Downloaded 273 times
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    • In microbiology: 5,151 out of 8,949
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    • Site-wide: 86,146 out of 100,856

Source-Sink Modifications Affect Leaf Senescence and Grain Mass in Wheat

physiology more details view paper
  • Downloaded 268 times
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    • In physiology: 641 out of 1,437
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    • Site-wide: 40,031 out of 100,856

Inferring novel lncRNA associated with Ventricular septal defect by DNA methylation interaction network

developmental biology more details view paper
  • Downloaded 249 times
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    • In developmental biology: 2,188 out of 3,012
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    • Site-wide: 74,367 out of 100,856

MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

developmental biology more details view paper
  • Downloaded 243 times
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    • In developmental biology: 2,222 out of 3,012
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    • Site-wide: 42,211 out of 100,856

Proto-sex locus in large yellow croaker provides insights into early evolution of the sex chromosome

evolutionary biology more details view paper
  • Downloaded 191 times
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    • Site-wide: 80,187 out of 100,856
    • In evolutionary biology: 5,034 out of 6,019
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    • Site-wide: 13,232 out of 100,856

Diagnostic Evidence GAuge of Single cells (DEGAS): A transfer learning framework to infer impressions of cellular and patient phenotypes between patients and single cells

bioinformatics more details view paper
  • Downloaded 153 times
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    • Site-wide: 27,831 out of 100,856

Adaptive Expansion of Taste Neuron Response Profiles by Congruent Aroma in Drosophila

neuroscience more details view paper
  • Downloaded 152 times
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    • Site-wide: 90,129 out of 100,856

DMLDA-LocLIFT: Identification of multi-label protein subcellular localization using DMLDA dimensionality reduction and LIFT classifier

bioinformatics more details view paper
  • Downloaded 120 times
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Impact of serum calcium levels on local and total body bone mineral density: A Mendelian randomization study and an age stratum analysis

genetics more details view paper
  • Downloaded 114 times
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    • Site-wide: 83,642 out of 100,856

Extracellular histones trigger disseminated intravascular coagulation by lytic cell death

immunology more details view paper
  • Downloaded 113 times
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    • Site-wide: 29,093 out of 100,856

Calcium ion chelation preserves platelet function during cold storage

cell biology more details view paper
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    • Site-wide: 21,274 out of 100,856

Novel Vβ specific germline contacts shape an elite controller T cell response

immunology more details view paper
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