Author: Yan Zhang

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Preprints

Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis

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Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection

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Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

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Mapping Vector Field of Single Cells

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A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

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Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits and implications for the future

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HiCPlus: Resolution Enhancement of Hi-C interaction heatmap

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ElectroPen: An ultralow-cost piezoelectric electroporator

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Passenger mutations in 2500 cancer genomes: Overall molecular functional impact and consequences

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Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection

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Integration of Mouse and Human Single-cell RNA Sequencing Infers Spatial Cell-type Composition in Human Brains

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Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

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Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer

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A complex structure of arrestin-2 bound to a G protein-coupled receptor

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Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

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5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

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HBP: an integrative and flexible pipeline for the interaction analysis of Hi-C dataset

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Cryo-EM structures reveal interactions of S-OPA1 with membrane and changes upon nucleotide binding

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Consensus interpretation of the Met34Thr and Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel

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Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

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Structural basis of bile acid receptor activation and Gs coupling

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scTPA: A web tool for single-cell transcriptome analysis of pathway activation signatures

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Comparative validation of breast cancer risk prediction models and projections for future risk stratification

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Giant African snail genomes provide insights into molluscan whole-genome duplication and aquatic-terrestrial transition

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Molecular Mapping Of YrTZ2, A Stripe Rust Resistance Gene In Wild Emmer Accession TZ-2 And Its Comparative Analyses With Aegilops tauschii

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Engineering a Functional small RNA Negative Autoregulation Network with Model-guided Design

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Crystal structure of SARS-CoV-2 main protease in complex with a Chinese herb inhibitor shikonin

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Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

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Altered Bacteria-Fungi Inter-Kingdom Network in Gut of Ankylosing Spondylitis Patients

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A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo

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Structure of SARS-CoV-2 main protease in the apo state reveals the inactive conformation

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Structural insights into the insecticidal Vip3A toxin of Bacillus thuringiensis

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Identification of Common Adulterants in Walnut Beverage Based on Plant DNA Barcode Technology

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Tyr1 phosphorylation promotes the phosphorylation of Ser2 on the C-terminal domain of RNA polymerase II by P-TEFb

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LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesis

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Integrated analysis of the miRNA-mRNA network associated with LMP1 gene in nasopharyngeal carcinoma

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Electronic blood vessel

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The loss of ATRX/DAXX complex disturbs rDNA heterochromatinization and promotes development of glioma

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SARS-Cov-2-, HIV-1-, Ebola-neutralizing and anti-PD1 clones are predisposed

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Altered brain function in anorexia nervosa and bulimia nervosa: A hierarchical series of task-based fMRI meta-analyses

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Verification of the phenylpropanoid pinoresinol biosynthetic pathway and its glycosides in Phomopsis sp. XP-8 using 13C stable isotope labeling and liquid chromatography coupled with time-of-flight mass spectrometry

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Source-Sink Modifications Affect Leaf Senescence and Grain Mass in Wheat

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Inferring novel lncRNA associated with Ventricular septal defect by DNA methylation interaction network

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MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

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Proto-sex locus in large yellow croaker provides insights into early evolution of the sex chromosome

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Diagnostic Evidence GAuge of Single cells (DEGAS): A transfer learning framework to infer impressions of cellular and patient phenotypes between patients and single cells

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Adaptive Expansion of Taste Neuron Response Profiles by Congruent Aroma in Drosophila

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DMLDA-LocLIFT: Identification of multi-label protein subcellular localization using DMLDA dimensionality reduction and LIFT classifier

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Impact of serum calcium levels on local and total body bone mineral density: A Mendelian randomization study and an age stratum analysis

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Extracellular histones trigger disseminated intravascular coagulation by lytic cell death

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Calcium ion chelation preserves platelet function during cold storage

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Novel Vβ specific germline contacts shape an elite controller T cell response

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