Author: Aristotelis Tsirigos

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Preprints

Classification and Mutation Prediction from Non-Small Cell Lung Cancer Histopathology Images using Deep Learning

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HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking

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  • Site-wide: 2,322
  • In bioinformatics: 217
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lncRNA-screen: an interactive platform for computationally screening long non-coding RNAs in large genomics datasets

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  • In bioinformatics: 364
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Dynamic 3D chromosomal landscapes in acute leukemia

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  • In cancer biology: 140
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KLF4 binding is involved in the organization and regulation of 3D enhancer networks during acquisition and maintenance of pluripotency

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  • Site-wide: 8,391
  • In molecular biology: 220
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Stratification of TAD boundaries identified in reproducible Hi-C contact matrices reveals preferential insulation of super-enhancers by strong boundaries

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  • In bioinformatics: 1,320
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NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains

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  • In genomics: 1,699
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Efficient pan-cancer whole-slide image classification and outlier detection using convolutional neural networks

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  • In pathology: 69
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ChIPSeqSpike: A R/Bioconductor package for ChIP-Seq data scaling according to spike-in control

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  • In bioinformatics: 2,326
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Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation

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Mitotic retention of H3K27 acetylation promotes rapid topological and transcriptional resetting of stem cell-related genes and enhancers upon G1 entry

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  • In molecular biology: 706
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A Deep Learning Approach for Rapid Mutational Screening in Melanoma

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  • In pathology: 101
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N-BLR, a primate-specific non-coding transcript, modulates the epithelial-to-mesenchymal transition and leads to colorectal cancer invasion and migration

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  • In genomics: 2,723
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The translatome of adult cortical axons is regulated by learning in vivo

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  • In neuroscience: 4,581
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Context-dependent requirement of H3K9 methyltransferase activity during cellular reprogramming to iPSCs

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  • In developmental biology: 778
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A CRISPR Screen Identifies Myc-associated Zinc Finger Protein (MAZ) as an Insulator Functioning at CTCF boundaries in Hox Clusters

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  • Site-wide: 39,171
  • In biochemistry: 972
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Microbial contributions to oxalate metabolism in health and disease

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Graph Drawing-based Dimensionality Reduction to Identify Hidden Communities in Single-Cell Sequencing Spatial Representation

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  • In bioinformatics: 6,495
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Ontogeny and Vulnerabilities of Lapatinib Drug-Tolerant Persisters in HER2+ Breast Cancer

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  • Site-wide: 76,598
  • In cancer biology: 2,259
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iCellR: Combined Coverage Correction and Principal Component Alignment for Batch Alignment in Single-Cell Sequencing Analysis

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  • Site-wide: 91,383
  • In bioinformatics: 8,051
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A Machine Learning approach for assessing drug development risk

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  • Site-wide: 94,490
  • In bioinformatics: 8,268
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