Author: Mika Ala-Korpela

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Preprints

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 6,436
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• Year to date:
  • Site-wide: 15,597
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  • Site-wide: None

Elevated alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality

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  • Site-wide: 9,101
  • In systems biology: 176
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  • Site-wide: 13,947
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  • Site-wide: 15,285

Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

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  • Site-wide: 11,520
  • In genomics: 1,283
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Machine Learning in Multi-Omics Data to Assess Longitudinal Predictors of Glycaemic Health

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  • Site-wide: 18,909
  • In genomics: 1,945
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  • Site-wide: 55,758
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Efficient estimation and applications of cross-validated genetic predictions

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  • Site-wide: 19,510
  • In genetics: 971
• Year to date:
  • Site-wide: 57,762
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Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

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  • Site-wide: 20,329
  • In epidemiology: 1,175
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  • Site-wide: 74,363
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  • Site-wide: 80,591

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

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  • Site-wide: 23,230
  • In cardiovascular medicine: 33
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  • Site-wide: 100,145

Lower hemoglobin levels associate with lower body mass index and healthier metabolic profile

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  • Site-wide: 26,673
  • In epidemiology: 1,400
• Year to date:
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An interaction map of circulating metabolites, immune gene networks and their genetic regulation

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  • Site-wide: 29,090
  • In genomics: 2,677
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  • Site-wide: 100,888
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  • Site-wide: 75,744

High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease

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  • Site-wide: 29,469
  • In epidemiology: 1,511
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  • Site-wide: 35,372
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  • Site-wide: 36,716

Genetic and environmental perturbations lead to regulatory decoherence

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  • Site-wide: 30,357
  • In genomics: 2,763
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  • Site-wide: 112,320
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  • Site-wide: 96,124

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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  • Site-wide: 36,064
  • In epidemiology: 1,734
• Year to date:
  • Site-wide: 97,097
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  • Site-wide: 76,871

Metabolic Effects Of Risk Alleles In PNPLA3, TM6SF2, GCKR, And LYPLAL1 Inform About Heterogeneity Of Non-Alcoholic Fatty Liver Disease

• Downloaded 593 times
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  • Site-wide: 40,520
  • In epidemiology: 1,910
• Year to date:
  • Site-wide: 75,713
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  • Site-wide: 66,504

Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

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  • Site-wide: 40,602
  • In epidemiology: 1,916
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  • Site-wide: 97,842
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Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

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  • Site-wide: 43,434
  • In epidemiology: 2,013
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  • Site-wide: 100,665
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  • Site-wide: 53,070

Metabolic signatures of birth weight in 18288 adolescents and adults

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  • Site-wide: 45,314
  • In systems biology: 1,056
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  • Site-wide: 107,502
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Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

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  • Site-wide: 46,947
  • In genomics: 3,787
• Year to date:
  • Site-wide: 99,823
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  • Site-wide: 68,123

Direct estimation of HDL-mediated cholesterol efflux capacity from serum

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  • Site-wide: 54,722
  • In epidemiology: 2,361
• Year to date:
  • Site-wide: 105,890
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  • Site-wide: None

The landscape of incident disease risk for the biomarker GlycA and its mortality stratification in angiography patients

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  • Site-wide: 56,296
  • In epidemiology: 2,404
• Year to date:
  • Site-wide: 97,096
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  • Site-wide: None

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

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  • Site-wide: 69,573
  • In epidemiology: 2,894
• Year to date:
  • Site-wide: 87,923
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  • Site-wide: 80,277

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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  • Site-wide: 69,777
  • In genetics: 3,255
• Year to date:
  • Site-wide: 93,070
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  • Site-wide: 82,625

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

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  • Site-wide: 75,423
  • In epidemiology: 3,118
• Year to date:
  • Site-wide: 35,340
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  • Site-wide: 25,889

Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease

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  • Site-wide: 76,664
  • In epidemiology: 3,164
• Year to date:
  • Site-wide: 93,786
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  • Site-wide: 81,191

Metabolic biomarkers for peripheral artery disease compared with coronary artery disease: Lipoprotein and metabolite profiling of 31,657 individuals from five prospective cohorts

• Downloaded 229 times
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  • Site-wide: 95,707
  • In epidemiology: 3,876
• Year to date:
  • Site-wide: 59,549
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  • Site-wide: 42,269

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis

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  • Site-wide: 98,131
  • In cardiovascular medicine: 181
• Year to date:
  • Site-wide: 68,748
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  • Site-wide: 84,732

A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

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  • Site-wide: 99,839
  • In epidemiology: 4,085
• Year to date:
  • Site-wide: 23,804
• Since beginning of last month:
  • Site-wide: 13,788

Elevated glycoprotein acetyl levels in adolescence and early adulthood predict adverse cardiometabolic profiles and risk of metabolic syndrome in up to 10 year follow-up

• Downloaded 134 times
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  • Site-wide: 115,213
  • In cardiovascular medicine: 275
• Year to date:
  • Site-wide: 91,226
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  • Site-wide: 84,712

Metabolic subgroups and cardiometabolic multimorbidity in the UK Biobank

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  • Site-wide: 123,418
  • In epidemiology: 4,938
• Year to date:
  • Site-wide: 14,607
• Since beginning of last month:
  • Site-wide: 4,618