Author: Traver Hart

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Preprints

Evaluation and Design of Genome-wide CRISPR/Cas9 Knockout Screens

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  • Site-wide: 2,186
  • In systems biology: 31
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  • Site-wide: 42,663
• Since beginning of last month:
  • Site-wide: 104,896

Identifying chemogenetic interactions from CRISPR knockout screens with drugZ

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  • Site-wide: 3,250
  • In bioinformatics: 355
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 100,597

A CRISPR screen reveals a WNT7B-FZD5 signaling circuit as a therapeutic opportunity in pancreatic cancer.

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  • Site-wide: 4,159
  • In cancer biology: 64
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 56,732

Systematic discovery and classification of human cell line essential genes

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  • Site-wide: 4,722
  • In genomics: 574
• Year to date:
  • Site-wide: 94,852
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  • Site-wide: 87,345

A consensus set of genetic vulnerabilities to ATR inhibition

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  • Site-wide: 7,471
  • In molecular biology: 190
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 51,997

Hierarchical organization of the human cell from a cancer coessentiality network

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  • Site-wide: 7,653
  • In systems biology: 138
• Year to date:
  • Site-wide: 46,705
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  • Site-wide: 76,427

Biases and Blind-Spots in Genome-Wide CRISPR Knockout Screens

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  • Site-wide: 11,686
  • In systems biology: 234
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  • Site-wide: 36,790

Coessentiality And Cofunctionality: A Network Approach To Learning Genetic Vulnerabilities From Cancer Cell Line Fitness Screens

• Downloaded 1,270 times
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  • Site-wide: 12,883
  • In genomics: 1,424
• Year to date:
  • Site-wide: 64,542
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  • Site-wide: 104,351

Multiplex enCas12a screens show functional buffering by paralogs is systematically absent from genome-wide CRISPR/Cas9 knockout screens

• Downloaded 1,208 times
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  • Site-wide: 13,888
  • In systems biology: 281
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  • Site-wide: 54,946

The functional genomic circuitry of human glioblastoma stem cells

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  • Site-wide: 16,589
  • In cancer biology: 384
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  • Site-wide: None
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  • Site-wide: 71,758

BAGEL: A computational framework for identifying essential genes from pooled library screens.

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  • Site-wide: 20,094
  • In systems biology: 430
• Year to date:
  • Site-wide: 91,018
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  • Site-wide: 77,866

Multiplexed pooled library screening with Cpf1

• Downloaded 932 times
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  • Site-wide: 20,434
  • In systems biology: 439
• Year to date:
  • Site-wide: 99,921
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  • Site-wide: 74,504

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

• Downloaded 708 times
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  • Site-wide: 30,077
  • In systems biology: 702
• Year to date:
  • Site-wide: 95,506
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  • Site-wide: 97,581

Improved analysis of CRISPR fitness screens and reduced off-target effects with the BAGEL2 gene essentiality classifier

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  • Site-wide: 45,757
  • In bioinformatics: 4,892
• Year to date:
  • Site-wide: 28,681
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  • Site-wide: 30,735

Diversity Across the Pancreatic Ductal Adenocarcinoma Disease Spectrum Revealed by Network-Anchored Functional Genomics

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  • Site-wide: 78,041
  • In cancer biology: 2,313
• Year to date:
  • Site-wide: 40,838
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  • Site-wide: 23,216

Discovery of novel tumor suppressors from CRISPR screens reveals lipid-sensitive subtype of AML

• Downloaded 200 times
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  • Site-wide: 97,080
  • In genetics: 4,447
• Year to date:
  • Site-wide: 20,650
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  • Site-wide: 17,034