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Author: Jennifer A Doudna

Rankings

  • All-time downloads: 35,671 (rank: 1,261 out of 424,841)
  • Categories:
    • biochemistry: 20,612 (rank: 43 out of 20,688)
    • biophysics: 4,860 (rank: 265 out of 17,993)
    • cancer biology: 473 (rank: 13,135 (tie) out of 29,946)
    • microbiology: 3,934 (rank: 2,364 out of 50,033)
    • synthetic biology: 2,472 (rank: 454 (tie) out of 4,408)
    • systems biology: 3,320 (rank: 827 (tie) out of 12,359)

Downloads per author, site-wide

Preprints

Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules

molecular biology more details view paper

No bioRxiv download data for this paper yet.

Structural coordination between active sites of a Cas6-reverse transcriptase-Cas1—Cas2 CRISPR integrase complex

biochemistry more details view paper

No bioRxiv download data for this paper yet.

CRISPR-Cas12a target binding unleashes single-stranded DNase activity

biochemistry more details view paper
  • Downloaded 5,121 times
  • Download rankings, all-time:
    • Site-wide: 812 out of 100,585
    • In biochemistry: 21 out of 3,438
  • Year to date:
    • Site-wide: 3,905 out of 100,585
  • Since beginning of last month:
    • Site-wide: 5,866 out of 100,585

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

biochemistry more details view paper
  • Downloaded 4,787 times
  • Download rankings, all-time:
    • Site-wide: 912 out of 100,585
    • In biochemistry: 26 out of 3,438
  • Year to date:
    • Site-wide: 40,531 out of 100,585
  • Since beginning of last month:
    • Site-wide: 30,380 out of 100,585

A compound that directly and selectively stalls PCSK9 translation

systems biology more details view paper
  • Downloaded 3,320 times
  • Download rankings, all-time:
    • Site-wide: 1,737 out of 100,585
    • In systems biology: 38 out of 2,556
  • Year to date:
    • Site-wide: 67,969 out of 100,585
  • Since beginning of last month:
    • Site-wide: None out of 100,585

Targeted Genome Editing of Bacteria Within Microbial Communities

microbiology more details view paper
  • Downloaded 2,565 times
  • Download rankings, all-time:
    • Site-wide: 2,669 out of 100,585
    • In microbiology: 219 out of 8,907
  • Year to date:
    • Site-wide: 561 out of 100,585
  • Since beginning of last month:
    • Site-wide: 512 out of 100,585

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs

synthetic biology more details view paper
  • Downloaded 2,472 times
  • Download rankings, all-time:
    • Site-wide: 2,842 out of 100,585
    • In synthetic biology: 49 out of 917
  • Year to date:
    • Site-wide: 40,651 out of 100,585
  • Since beginning of last month:
    • Site-wide: 24,920 out of 100,585

RNA binding and HEPN nuclease activation are decoupled in CRISPR-Cas13a

biochemistry more details view paper
  • Downloaded 2,201 times
  • Download rankings, all-time:
    • Site-wide: 3,479 out of 100,585
    • In biochemistry: 95 out of 3,438
  • Year to date:
    • Site-wide: 16,917 out of 100,585
  • Since beginning of last month:
    • Site-wide: 14,277 out of 100,585

Disabling Cas9 by an anti-CRISPR DNA mimic

biochemistry more details view paper
  • Downloaded 1,925 times
  • Download rankings, all-time:
    • Site-wide: 4,311 out of 100,585
    • In biochemistry: 113 out of 3,438
  • Year to date:
    • Site-wide: 65,677 out of 100,585
  • Since beginning of last month:
    • Site-wide: 36,542 out of 100,585

High-throughput biochemical profiling reveals Cas9 off-target binding and unbinding heterogeneity

biochemistry more details view paper
  • Downloaded 1,883 times
  • Download rankings, all-time:
    • Site-wide: 4,479 out of 100,585
    • In biochemistry: 119 out of 3,438
  • Year to date:
    • Site-wide: 66,383 out of 100,585
  • Since beginning of last month:
    • Site-wide: 36,432 out of 100,585

Molecular mechanism of off-target effects in CRISPR-Cas9

biophysics more details view paper
  • Downloaded 1,835 times
  • Download rankings, all-time:
    • Site-wide: 4,691 out of 100,585
    • In biophysics: 129 out of 4,425
  • Year to date:
    • Site-wide: 26,280 out of 100,585
  • Since beginning of last month:
    • Site-wide: None out of 100,585

A Conformational Checkpoint Between DNA Binding And Cleavage By CRISPR-Cas9

biophysics more details view paper
  • Downloaded 1,532 times
  • Download rankings, all-time:
    • Site-wide: 6,350 out of 100,586
    • In biophysics: 182 out of 4,425
  • Year to date:
    • Site-wide: 68,653 out of 100,586
  • Since beginning of last month:
    • Site-wide: 34,600 out of 100,586

Temperature-responsive competitive inhibition of CRISPR-Cas9

biochemistry more details view paper
  • Downloaded 1,524 times
  • Download rankings, all-time:
    • Site-wide: 6,394 out of 100,586
    • In biochemistry: 169 out of 3,438
  • Year to date:
    • Site-wide: 38,387 out of 100,586
  • Since beginning of last month:
    • Site-wide: 44,204 out of 100,586

Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9

biophysics more details view paper
  • Downloaded 1,493 times
  • Download rankings, all-time:
    • Site-wide: 6,603 out of 100,586
    • In biophysics: 192 out of 4,425
  • Year to date:
    • Site-wide: 70,688 out of 100,586
  • Since beginning of last month:
    • Site-wide: 34,606 out of 100,586

CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

biochemistry more details view paper
  • Downloaded 1,078 times
  • Download rankings, all-time:
    • Site-wide: 11,369 out of 100,586
    • In biochemistry: 284 out of 3,438
  • Year to date:
    • Site-wide: 2,051 out of 100,586
  • Since beginning of last month:
    • Site-wide: 13,519 out of 100,586

Machine Learning Predicts New Anti-CRISPR Proteins

biochemistry more details view paper
  • Downloaded 901 times
  • Download rankings, all-time:
    • Site-wide: 15,152 out of 100,586
    • In biochemistry: 407 out of 3,438
  • Year to date:
    • Site-wide: 6,615 out of 100,586
  • Since beginning of last month:
    • Site-wide: 26,496 out of 100,586

Candidate Phyla Radiation Roizmanbacteria from hot springs have novel, unexpectedly abundant, and potentially alternatively functioning CRISPR-Cas systems

microbiology more details view paper
  • Downloaded 793 times
  • Download rankings, all-time:
    • Site-wide: 18,500 out of 100,586
    • In microbiology: 1,197 out of 8,907
  • Year to date:
    • Site-wide: 53,873 out of 100,586
  • Since beginning of last month:
    • Site-wide: None out of 100,586

Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes

biochemistry more details view paper
  • Downloaded 653 times
  • Download rankings, all-time:
    • Site-wide: 24,659 out of 100,586
    • In biochemistry: 714 out of 3,438
  • Year to date:
    • Site-wide: 23,100 out of 100,586
  • Since beginning of last month:
    • Site-wide: 32,475 out of 100,586

Huge and variable diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems

microbiology more details view paper
  • Downloaded 576 times
  • Download rankings, all-time:
    • Site-wide: 29,219 out of 100,586
    • In microbiology: 1,963 out of 8,907
  • Year to date:
    • Site-wide: 5,255 out of 100,586
  • Since beginning of last month:
    • Site-wide: None out of 100,586

Quantification of Cas9 binding and cleavage across diverse guide sequences maps landscapes of target engagement

biochemistry more details view paper
  • Downloaded 539 times
  • Download rankings, all-time:
    • Site-wide: 31,794 out of 100,586
    • In biochemistry: 952 out of 3,438
  • Year to date:
    • Site-wide: 5,840 out of 100,586
  • Since beginning of last month:
    • Site-wide: 283 out of 100,586

Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage

cancer biology more details view paper
  • Downloaded 473 times
  • Download rankings, all-time:
    • Site-wide: 37,367 out of 100,586
    • In cancer biology: 1,197 out of 3,595
  • Year to date:
    • Site-wide: 7,123 out of 100,586
  • Since beginning of last month:
    • Site-wide: 7,590 out of 100,586

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