Author: Ying Zhang

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Preprints

DEPDC1/ EEF1A1 complex promotes the progression of human osteosarcoma via downregulation of FOXO3a

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Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

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Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target

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  • Site-wide: 795
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Computational Pan-Genomics: Status, Promises and Challenges

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Evaluation of Natural and Botanical Medicines for Activity against Growing and Non-growing Forms of B. burgdorferi

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  • Site-wide: 2,600
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  • Site-wide: 8,240
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High Activity Of Selective Essential Oils Against Stationary Phase Borrelia burgdorferi As A Persister Model

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  • Site-wide: 3,564
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De novo assembly and phasing of dikaryotic genomes from two isolates of Puccinia coronata f. sp. avenae, the causal agent of oat crown rust

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  • Site-wide: 3,861
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Genome-wide characterization of PRE-1 reveals a hidden evolutionary relationship between suidae and primates

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An in-depth investigation of the safety and immunogenicity of an inactivated SARS-CoV-2 vaccine

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  • In public and global health: 163
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  • Site-wide: 2,704

A thermostable, closed, SARS-CoV-2 spike protein trimer.

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H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions

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Template switching causes artificial junction formation and false identification of circular RNAs

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Biofilm/Persister/Stationary Phase Bacteria Cause More Severe Disease Than Log Phase Bacteria I Biofilm Borrelia burgdorferi Not Only Display More Tolerance to Lyme Antibiotics But Also Cause More Severe Pathology In a Mouse Arthritis Model: Implications for Understanding Persistence, PTLDS and Treatment Failure

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Additional Essential Oils with High Activity against Stationary Phase Borrelia burgdorferi

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The Genome of the Zebra Mussel, Dreissena polymorpha: A Resource for Invasive Species Research

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SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism

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Efficacy and tolerability of bevacizumab in patients with severe Covid -19

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  • Site-wide: 12,388
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Identification of essential oils with activity against stationary phase Staphylococcus aureus

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  • Site-wide: 12,726
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  • Site-wide: 14,673

Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study

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  • Site-wide: 13,302
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  • Site-wide: 5,937
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SARS-Coronavirus-2 nucleocapsid protein measured in blood using a Simoa ultra-sensitive immunoassay differentiates COVID-19 infection with high clinical sensitivity.

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  • Site-wide: 14,076
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Identification of essential oils with strong activity against stationary phase uropathogenic Escherichia coli

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  • Site-wide: 16,684
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Discovering in vivo cytokine eQTL interactions from a lupus clinical trial

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Predicting chromatin interactions between open chromatin regions from DNA sequences

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  • Site-wide: 20,877
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The Chronic Kidney Disease and Acute Kidney Injury Involvement in COVID-19 Pandemic: A Systematic Review and Meta-analysis

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  • Site-wide: 24,766
  • In nephrology: 10
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Local and global chromatin interactions are altered by large genomic deletions associated with human brain development

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  • Site-wide: 24,999
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  • Site-wide: 115,765
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Heterogeneity and temporal variation in the management of COVID-19: a multinational drug utilization study including 71,921 hospitalized patients from China, South Korea, Spain, and the United States of America

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  • Site-wide: 26,509
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  • Site-wide: 14,105
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Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data for Chinese Glioma Patients

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High-throughput single-particle tracking reveals nested membrane nanodomain organization that dictates Ras diffusion and trafficking

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  • Site-wide: 29,557
  • In biophysics: 889
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An Array of 60,000 Antibodies for Proteome-Scale Antibody Generation and Target Discovery

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  • In systems biology: 687
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Mutations in efflux pump Rv1258c (Tap) cause resistance to pyrazinamide and other drugs in M. tuberculosis

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  • Site-wide: 31,558
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  • Site-wide: 108,015

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

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  • Site-wide: 31,618
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The influence of molecular reach and diffusivity on the efficacy of membrane-confined reactions

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  • Site-wide: 34,280
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Biofilm/Persister/Stationary Phase Bacteria Cause More Severe Disease Than Log Phase Bacteria II Infection with Persister Forms of Staphylococcus aureus Causes a Chronic Persistent Skin Infection with More Severe Lesion that Takes Longer to Heal and is not Eradicated by the Current Recommended Treatment in Mice

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  • Site-wide: 35,338
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Molecular evolution of SARS-CoV-2 structural genes: evidence of positive selection in spike glycoprotein

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The Role of Weather Conditions in COVID-19 Transmission: A Study of a Global Panel of 1236 Regions

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Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi in vitro

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  • Site-wide: 44,964
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TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in Esophageal Squamous Cell Carcinoma

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A Validation Study for the Successful Isolation Policy in China: a Meta-Analysis in COVID-19

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  • Site-wide: 50,717
  • In respiratory medicine: 100
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A comprehensive plasma metabolomics dataset for a cohort of mouse knockouts within the international mouse phenotyping consortium

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Identification of a Novel Gene argJ involved in Arginine Biosynthesis Critical for Persister Formation in Staphylococcus aureus

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Variation in genome content and predatory phenotypes between Bdellovibrio sp. NC01 isolated from soil and B. bacteriovorus type strain HD100

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Role of DNA Methylation in Persister Formation in Uropathogenic E. coli

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Crosstalk between invadopodia and the extracellular matrix

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Baseline phenotype and 30-day outcomes of people tested for COVID-19: an international network cohort including >3.32 million people tested with real-time PCR and >219,000 tested positive for SARS-CoV-2 in South Korea, Spain and the United States

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Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design

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Modeling the relative role of human mobility, land-use and climate factors on dengue outbreak emergence in Sri Lanka

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Specific miRNA-GPCR networks regulate Sox9a/Sox9b activities to promote gonadal renewal in zebrafish

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A dynamic role for dopamine receptors in the control of mammalian spinal networks

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Identification of disease resistance genes from a Chinese wild grapevine (Vitis davidii) by analysing grape transcriptomes and transgenic Arabidopsis

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Cyclin B3 is specifically required for metaphase to anaphase transition in mouse oocyte meiosis I

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Clofazimine targets essential nucleoid associated protein, mycobacterial integration host factor (mIHF), in Mycobacterium tuberculosis

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The circulating lipidome is largely defined by sex descriptors in the GOLDN, GeneBank and the ADNI studies

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Integrative Modeling of a Sin3/HDAC Complex Sub-structure

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Identification of drug candidates that enhance pyrazinamide activity from a clinical drug library

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Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

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Identification of small regulatory RNAs involved in persister formation

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Proteomic Analyses of Morphological Variants of Borrelia burgdorferi Shed New Light on Persistence Mechanisms: Implications for Pathogenesis, Diagnosis and Treatment

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Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization

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ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

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Identification of novel genes including rpmF and yjjQ critical for Type II persister formation in Escherichia coli

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Identification of Polynucleotide Phosphorylase (PNPase) in Escherichia coli Involved in Persister Formation

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A Drug Combination Approach Targeting Both Growing Bacteria and Dormant Persisters Eradicate Persistent Staphylococcus aureus Biofilm Infection

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Identification of novel mutations associated with clofazimine resistance in Mycobacterium abscessus

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The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15

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Chromatin Interaction Neural Network (ChINN): A machine learning-based method for predicting chromatin interactions from DNA sequences

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Spinal V3 interneurons and left-right coordination in mammalian locomotion

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UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTs

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Identification of Genes Regulating Cell Death in Staphylococcus aureus

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Varying Effects of Common Tuberculosis Drugs on Enhancing Clofazimine Activity in vitro

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MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

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Protein kinase CK2 alpha prime and alpha-synuclein constitute a key regulatory pathway in Huntington′s disease

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Driving Integrative Structural Modeling with Serial Capture Affinity Purification

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Development of a novel signature of long noncoding RNAs as a prognostic biomarker for esophageal cancer

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Botanical Medicines with Activity against Stationary Phase Bartonella henselae

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Identification of novel mutations in LprG (rv1411c), rv0521, rv3630, rv0010c, ppsC, cyp128 associated with pyrazinoic acid/pyrazinamide resistance in Mycobacterium tuberculosis

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Local brainstem circuits contribute to reticulospinal output in the mouse

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Characteristics and outcomes of 118,155 COVID-19 individuals with a history of cancer in the United States and Spain

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Introducing RpsA Point Mutation Δ438A or D123A into the Chromosome of M. tuberculosis Confirms its Role in Causing Resistance to Pyrazinamide

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Ranking of Major Classes of Antibiotics for Activity against Stationary Phase Pseudomonas aeruginosa and Identification of Clinafloxacin + Cefuroxime + Gentamicin Drug Combination that Eradicates Persistent P. aeruginosa Infection in a Murine Cystic Fibrosis Model

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Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to construct pluripotency gene regulatory network

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Fibroblast Protection of Borrelia burgdorferi from Doxycycline, Cefuroxime and Daptomycin Combination is Eliminated by Oregano or Carvacrol Essential Oil

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A Novel LysR-Type Global Regulator RpvA Controls Persister Formation and Virulence in Staphylococcus aureus

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FARCI: Fast and Robust Connectome Inference

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Extensive MET alterations confer clinical response to MET inhibitors in gliomas

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Identifying the diagnostic value of microRNA-421 in gastric cancer patients: a meta-analysis

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Self-reported sleep duration and timing: A methodological review of event definitions, context, and timeframe of related questions

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Genome-wide binding analyses of HOXB1 revealed a novel DNA binding motif associated with gene repression

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DLDTI: A learning-based framework for identification of drug-target interaction using neural networks and network representation

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Diversity and Function of the Eastern Oyster (Crassostrea virginica) Microbiome

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The plasticity of the pyruvate dehydrogenase complex confers a labile structure that is associated with its catalytic activity

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Proteome plasticity in response to persistent environmental change

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Species composition and dynamics of aphids and parasitoid wasps in maize fields in Northeastern China

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miRNA-dependent poly(A) length control in uncoupling transcription and translation of haploid male germ cells

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Low oxygen arrests Babesia duncani schizonts and leads to increased drug susceptibilities in hamster erythrocytes

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Integrin α6 upregulation in nucleus pulposus cell under high oxygen tension attenuates intervertebral disc degeneration

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