Author: Ming Sun

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Preprints

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

• Downloaded 17,883 times
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  • Site-wide: 334
  • In biochemistry: 2
• Year to date:
  • Site-wide: 1,029
• Since beginning of last month:
  • Site-wide: 799

Identification of changing ribosome protein compositions using cryo-EM and mass spectrometry

• Downloaded 2,462 times
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  • Site-wide: 4,800
  • In microbiology: 281
• Year to date:
  • Site-wide: 45,474
• Since beginning of last month:
  • Site-wide: 50,405

Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM

• Downloaded 968 times
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  • Site-wide: 19,363
  • In biophysics: 525
• Year to date:
  • Site-wide: 711
• Since beginning of last month:
  • Site-wide: 2,534

Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

• Downloaded 782 times
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  • Site-wide: 26,231
  • In cancer biology: 682
• Year to date:
  • Site-wide: 43,086
• Since beginning of last month:
  • Site-wide: 58,271

Escherichia coli NusG links the lead ribosome with the transcription elongation complex

• Downloaded 778 times
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  • Site-wide: 26,439
  • In molecular biology: 739
• Year to date:
  • Site-wide: 58,810
• Since beginning of last month:
  • Site-wide: 43,042

Real-time structural dynamics of late steps in bacterial translation initiation visualized using time-resolved cryogenic electron microscopy

• Downloaded 763 times
• Download rankings, all-time:
  • Site-wide: 27,125
  • In molecular biology: 756
• Year to date:
  • Site-wide: 100,242
• Since beginning of last month:
  • Site-wide: 120,233

The structural basis for release factor activation during translation termination revealed by time-resolved cryogenic electron microscopy

• Downloaded 761 times
• Download rankings, all-time:
  • Site-wide: 27,252
  • In biophysics: 827
• Year to date:
  • Site-wide: 92,485
• Since beginning of last month:
  • Site-wide: 56,602

Crowdsourcing digital health measures to predict Parkinson’s disease severity: the Parkinson’s Disease Digital Biomarker DREAM Challenge

• Downloaded 701 times
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  • Site-wide: 30,497
  • In bioengineering: 537
• Year to date:
  • Site-wide: 62,665
• Since beginning of last month:
  • Site-wide: 33,074

A porcine ex vivo model of pigmentary glaucoma

• Downloaded 674 times
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  • Site-wide: 32,220
  • In cell biology: 1,292
• Year to date:
  • Site-wide: 61,495
• Since beginning of last month:
  • Site-wide: 70,592

Bacillus thuringiensis targets the host intestinal epithelial junctions for successful infection of Caenorhabditis elegans

• Downloaded 599 times
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  • Site-wide: 37,504
  • In microbiology: 2,295
• Year to date:
  • Site-wide: 39,775
• Since beginning of last month:
  • Site-wide: 33,217

Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation

• Downloaded 529 times
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  • Site-wide: 43,727
  • In cancer biology: 1,226
• Year to date:
  • Site-wide: 5,037
• Since beginning of last month:
  • Site-wide: 16,206

Population genomics and pathotypic evaluation of the bacterial leaf blight pathogen of rice reveals rapid evolutionary dynamics of a plant pathogen

• Downloaded 429 times
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  • Site-wide: 55,459
  • In genomics: 4,236
• Year to date:
  • Site-wide: 51,942
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  • Site-wide: 41,219

RSQ: a statistical method for quantification of isoform-specific structurome using transcriptome-wide structural profiling data

• Downloaded 429 times
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  • Site-wide: 55,465
  • In bioinformatics: 5,704
• Year to date:
  • Site-wide: 92,182
• Since beginning of last month:
  • Site-wide: 91,344

Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1

• Downloaded 383 times
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  • Site-wide: 62,052
  • In biophysics: 2,264
• Year to date:
  • Site-wide: 16,131
• Since beginning of last month:
  • Site-wide: 21,882

An unconventional myosin, myosin 1d regulates Kupffer's vesicle morphogenesis and laterality

• Downloaded 367 times
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  • Site-wide: 64,553
  • In developmental biology: 1,679
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 121,260

Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates

• Downloaded 349 times
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  • Site-wide: 67,731
  • In biophysics: 2,512
• Year to date:
  • Site-wide: 29,216
• Since beginning of last month:
  • Site-wide: 35,134

BtToxin_Digger: a comprehensive and high-throughput pipeline for mining toxin protein genes from Bacillus thuringiensis

• Downloaded 331 times
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  • Site-wide: 70,813
  • In bioinformatics: 6,766
• Year to date:
  • Site-wide: 13,491
• Since beginning of last month:
  • Site-wide: 18,447

Comprehensive and Integrated Genomic Characterization of Human Immunome in Cancer

• Downloaded 316 times
• Download rankings, all-time:
  • Site-wide: 73,470
  • In immunology: 1,948
• Year to date:
  • Site-wide: 46,609
• Since beginning of last month:
  • Site-wide: 46,952

Cryo-EM analysis of human mitochondrial Hsp90 in multiple tetrameric states

• Downloaded 301 times
• Download rankings, all-time:
  • Site-wide: 76,271
  • In biophysics: 2,903
• Year to date:
  • Site-wide: 17,997
• Since beginning of last month:
  • Site-wide: 18,485

Mitochondria surveillance systems trigger innate immune responses to bacterial pathogens via AMPK pathway in C. elegans

• Downloaded 154 times
• Download rankings, all-time:
  • Site-wide: 106,205
  • In immunology: 2,909
• Year to date:
  • Site-wide: 97,351
• Since beginning of last month:
  • Site-wide: 35,867