Author: Jie Huang

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Preprints

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

• Downloaded 6,305 times
• Download rankings, all-time:
  • Site-wide: 2,551
  • In genetics: 72
• Year to date:
  • Site-wide: 3,752
• Since beginning of last month:
  • Site-wide: 7,626

A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

• Downloaded 3,485 times
• Download rankings, all-time:
  • Site-wide: 5,869
  • In genetic and genomic medicine: 33
• Year to date:
  • Site-wide: 11,948
• Since beginning of last month:
  • Site-wide: 20,860

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,604 times
• Download rankings, all-time:
  • Site-wide: 8,987
  • In genetics: 341
• Year to date:
  • Site-wide: 73,971
• Since beginning of last month:
  • Site-wide: 203,036

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

• Downloaded 1,920 times
• Download rankings, all-time:
  • Site-wide: 14,307
  • In genetic and genomic medicine: 85
• Year to date:
  • Site-wide: 28,943
• Since beginning of last month:
  • Site-wide: 53,864

Genome-wide analyses of chromatin interactions after the loss of Pol I, Pol II and Pol III

• Downloaded 1,341 times
• Download rankings, all-time:
  • Site-wide: 25,234
  • In genomics: 2,161
• Year to date:
  • Site-wide: 123,209
• Since beginning of last month:
  • Site-wide: 193,511

Integration of rare large-effect expression variants improves polygenic risk prediction

• Downloaded 1,300 times
• Download rankings, all-time:
  • Site-wide: 26,542
  • In genetic and genomic medicine: 161
• Year to date:
  • Site-wide: 15,226
• Since beginning of last month:
  • Site-wide: 40,063

Measuring genetic variation in the multi-ethnic Million Veteran Program (MVP)

• Downloaded 1,300 times
• Download rankings, all-time:
  • Site-wide: 26,525
  • In genetics: 1,061
• Year to date:
  • Site-wide: 82,623
• Since beginning of last month:
  • Site-wide: 130,610

Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina

• Downloaded 1,239 times
• Download rankings, all-time:
  • Site-wide: 28,609
  • In cell biology: 1,037
• Year to date:
  • Site-wide: 37,706
• Since beginning of last month:
  • Site-wide: 178,309

Haplotype-Resolved Assembly for Synthetic Long Reads Using a Trio-Binning Strategy

• Downloaded 1,100 times
• Download rankings, all-time:
  • Site-wide: 34,437
  • In bioinformatics: 3,677
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 53,188

Development of an ensemble machine learning prognostic model to predict 60-day risk of major adverse cardiac events in adults with chest pain

• Downloaded 1,015 times
• Download rankings, all-time:
  • Site-wide: 38,956
  • In health informatics: 181
• Year to date:
  • Site-wide: 178,669
• Since beginning of last month:
  • Site-wide: 24,932

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 959 times
• Download rankings, all-time:
  • Site-wide: 42,574
  • In genetics: 1,681
• Year to date:
  • Site-wide: 115,765
• Since beginning of last month:
  • Site-wide: 117,515

High-throughput Multimodal Automated Phenotyping (MAP) with Application to PheWAS

• Downloaded 823 times
• Download rankings, all-time:
  • Site-wide: 53,756
  • In bioinformatics: 5,348
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 119,711

Robust Benchmark Structural Variant Calls of An Asian Using the State-of-Art Long Fragment Sequencing Technologies

• Downloaded 755 times
• Download rankings, all-time:
  • Site-wide: 61,057
  • In genomics: 4,255
• Year to date:
  • Site-wide: 122,894
• Since beginning of last month:
  • Site-wide: 54,652

An integrated Asian human SNV and indel benchmark combining multiple sequencing methods

• Downloaded 722 times
• Download rankings, all-time:
  • Site-wide: 65,258
  • In genomics: 4,560
• Year to date:
  • Site-wide: 37,791
• Since beginning of last month:
  • Site-wide: 120,478

Development of a Genomic DNA Reference Material Panel for Thalassemia Genetic Testing

• Downloaded 705 times
• Download rankings, all-time:
  • Site-wide: 67,540
  • In genetics: 2,639
• Year to date:
  • Site-wide: 36,995
• Since beginning of last month:
  • Site-wide: 92,900

High-Resolution Phylogenetic and Population Genetic Analysis of Microbial Communities with RoC-ITS

• Downloaded 538 times
• Download rankings, all-time:
  • Site-wide: 95,775
  • In genomics: 5,904
• Year to date:
  • Site-wide: 88,459
• Since beginning of last month:
  • Site-wide: 124,299

The Calcineurin-FoxO-MuRF1 Signaling Pathway Regulates Myofibril Integrity in Cardiomyocytes

• Downloaded 511 times
• Download rankings, all-time:
  • Site-wide: 101,625
  • In cell biology: 4,677
• Year to date:
  • Site-wide: 118,884
• Since beginning of last month:
  • Site-wide: 205,755

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

• Downloaded 485 times
• Download rankings, all-time:
  • Site-wide: 107,915
  • In genetics: 4,075
• Year to date:
  • Site-wide: 139,891
• Since beginning of last month:
  • Site-wide: 152,825

TMT-Based Quantitative Proteomic Analysis of Intestinal Organoids Infected by Listeria monocytogenes with Different Virulence

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 111,908
  • In microbiology: 7,465
• Year to date:
  • Site-wide: 66,274
• Since beginning of last month:
  • Site-wide: 101,105

Enzymatic reactions of AGO4 in RNA-directed DNA methylation: siRNA duplex loading, passenger strand elimination, target RNA slicing and sliced target retention

• Downloaded 447 times
• Download rankings, all-time:
  • Site-wide: 117,291
  • In molecular biology: 3,888
• Year to date:
  • Site-wide: 3,703
• Since beginning of last month:
  • Site-wide: 11,075

A Multi-center Study of COVID-19 with Multivariate Prognostic Analysis

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 140,703
  • In respiratory medicine: 315
• Year to date:
  • Site-wide: 160,219
• Since beginning of last month:
  • Site-wide: 157,181

The identification of an anti-thrombin molecule via the screening of semi-random DNA libraries

• Downloaded 343 times
• Download rankings, all-time:
  • Site-wide: 146,873
  • In molecular biology: 4,313
• Year to date:
  • Site-wide: 174,806
• Since beginning of last month:
  • Site-wide: 150,903

Genetically determined serum testosterone level and Covid-19 illness level: A mendelian randomization study

• Downloaded 324 times
• Download rankings, all-time:
  • Site-wide: 152,741
  • In epidemiology: 6,354
• Year to date:
  • Site-wide: 36,683
• Since beginning of last month:
  • Site-wide: 72,365

Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosis

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 157,117
  • In cell biology: 7,390
• Year to date:
  • Site-wide: 54,945
• Since beginning of last month:
  • Site-wide: 51,315

Chinese fir genome and the evolution of gymnosperms

• Downloaded 307 times
• Download rankings, all-time:
  • Site-wide: 157,878
  • In genomics: 8,199
• Year to date:
  • Site-wide: 21,923
• Since beginning of last month:
  • Site-wide: 12,685

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 161,702
  • In pharmacology and toxicology: 1,251
• Year to date:
  • Site-wide: 184,157
• Since beginning of last month:
  • Site-wide: 138,212

BDdb: a comprehensive platform for exploration and utilization of birth defect multi-omics data

• Downloaded 270 times
• Download rankings, all-time:
  • Site-wide: 168,994
  • In bioinformatics: 12,905
• Year to date:
  • Site-wide: 185,813
• Since beginning of last month:
  • Site-wide: 104,630

Aberrant epigenetic and transcriptional events associated with breast cancer risk

• Downloaded 248 times
• Download rankings, all-time:
  • Site-wide: 175,332
  • In cancer biology: 5,475
• Year to date:
  • Site-wide: 58,327
• Since beginning of last month:
  • Site-wide: 157,159

PAGEANT: Personal Access to Genome and Analysis of Natural Traits

• Downloaded 232 times
• Download rankings, all-time:
  • Site-wide: 179,623
  • In genetic and genomic medicine: 1,339
• Year to date:
  • Site-wide: 44,852
• Since beginning of last month:
  • Site-wide: 72,327

Evaluation of height as a disease risk factor through a phenome-wide association study of genetically-predicted height

• Downloaded 229 times
• Download rankings, all-time:
  • Site-wide: 180,368
  • In epidemiology: 7,211
• Year to date:
  • Site-wide: 61,977
• Since beginning of last month:
  • Site-wide: 156,684

Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates that reduce surface AMPA receptor expression in primary neurons

• Downloaded 226 times
• Download rankings, all-time:
  • Site-wide: 181,079
  • In neuroscience: 26,404
• Year to date:
  • Site-wide: 179,044
• Since beginning of last month:
  • Site-wide: 169,404

The synergistic effect of circRNA methylation promotes pulmonary fibrosis

• Downloaded 209 times
• Download rankings, all-time:
  • Site-wide: 185,410
  • In pharmacology and toxicology: 1,574
• Year to date:
  • Site-wide: 23,006
• Since beginning of last month:
  • Site-wide: 98,570

Multiple-region Gray Matter Atrophy contribute to freezing of gait in Parkinson's Disease

• Downloaded 74 times
• Download rankings, all-time:
  • Site-wide: 212,263
  • In neurology: 1,557
• Year to date:
  • Site-wide: 187,808
• Since beginning of last month:
  • Site-wide: 109,748