Author: Wei Zhang

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Preprints

Neutrophil-to-Lymphocyte Ratio Predicts Severe Illness Patients with 2019 Novel Coronavirus in the Early Stage

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  • Site-wide: 347
  • In infectious diseases: 127
• Year to date:
  • Site-wide: 6,283
• Since beginning of last month:
  • Site-wide: 8,370

Erythrocyte Sedimentation Rate in COVID-19 Infections

• Downloaded 22,282 times
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  • Site-wide: 515
  • In infectious diseases: 194
• Year to date:
  • Site-wide: 28,915
• Since beginning of last month:
  • Site-wide: 30,131

Viral Kinetics and Antibody Responses in Patients with COVID-19

• Downloaded 17,471 times
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  • Site-wide: 676
  • In infectious diseases: 251
• Year to date:
  • Site-wide: 3,834
• Since beginning of last month:
  • Site-wide: 3,745

The feasibility of convalescent plasma therapy in severe COVID-19 patients: a pilot study

• Downloaded 16,977 times
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  • Site-wide: 694
  • In infectious diseases: 257
• Year to date:
  • Site-wide: 2,928
• Since beginning of last month:
  • Site-wide: 6,050

Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor

• Downloaded 8,808 times
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  • Site-wide: 1,615
  • In microbiology: 151
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 6,934

AI-assisted CT imaging analysis for COVID-19 screening: Building and deploying a medical AI system in four weeks

• Downloaded 5,335 times
• Download rankings, all-time:
  • Site-wide: 3,209
  • In health informatics: 24
• Year to date:
  • Site-wide: 2,340
• Since beginning of last month:
  • Site-wide: 7,565

Recurrence of SARS-CoV-2 PCR positivity in COVID-19 patients: a single center experience and potential implications

• Downloaded 2,513 times
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  • Site-wide: 9,484
  • In infectious diseases: 1,547
• Year to date:
  • Site-wide: 17,613
• Since beginning of last month:
  • Site-wide: 45,832

Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics

• Downloaded 2,482 times
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  • Site-wide: 9,678
  • In cell biology: 213
• Year to date:
  • Site-wide: 20,225
• Since beginning of last month:
  • Site-wide: 13,952

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection During Pregnancy In China: A Retrospective Cohort Study

• Downloaded 2,323 times
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  • Site-wide: 10,694
  • In respiratory medicine: 37
• Year to date:
  • Site-wide: 161,287
• Since beginning of last month:
  • Site-wide: 38,972

Critical Care for Patients with Severe Covid-2019 in Sichuan Province, China: Provincial Cohort Study

• Downloaded 2,280 times
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  • Site-wide: 11,030
  • In intensive care and critical care medicine: 50
• Year to date:
  • Site-wide: 17,744
• Since beginning of last month:
  • Site-wide: 17,240

Leukopenia of Asymptomatic COVID-19 Infections under 18 Years Old in Recovery Stage

• Downloaded 1,902 times
• Download rankings, all-time:
  • Site-wide: 14,514
  • In infectious diseases: 1,955
• Year to date:
  • Site-wide: 90,828
• Since beginning of last month:
  • Site-wide: 65,382

A considerable proportion of individuals with asymptomatic SARS-CoV-2 infection in Tibetan population

• Downloaded 1,721 times
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  • Site-wide: 16,936
  • In infectious diseases: 2,128
• Year to date:
  • Site-wide: 38,266
• Since beginning of last month:
  • Site-wide: 52,491

CAR Macrophages for SARS-CoV-2 Immunotherapy

• Downloaded 1,460 times
• Download rankings, all-time:
  • Site-wide: 21,987
  • In bioengineering: 403
• Year to date:
  • Site-wide: 47,889
• Since beginning of last month:
  • Site-wide: 52,500

Effect of large-scale testing platform in prevention and control of the COVID-19 pandemic: an empirical study with a novel numerical model

• Downloaded 1,391 times
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  • Site-wide: 23,793
  • In epidemiology: 1,470
• Year to date:
  • Site-wide: 65,842
• Since beginning of last month:
  • Site-wide: 79,419

Cardiac Structural and Functional Characteristics in Patients with Coronavirus Disease 2019: A Serial Echocardiographic Study

• Downloaded 1,390 times
• Download rankings, all-time:
  • Site-wide: 23,836
  • In cardiovascular medicine: 46
• Year to date:
  • Site-wide: 48,804
• Since beginning of last month:
  • Site-wide: 34,149

Treatment of 6 COVID-19 Patients with Convalescent Plasma

• Downloaded 1,249 times
• Download rankings, all-time:
  • Site-wide: 28,264
  • In infectious diseases: 2,758
• Year to date:
  • Site-wide: 156,006
• Since beginning of last month:
  • Site-wide: 65,366

SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta

• Downloaded 1,125 times
• Download rankings, all-time:
  • Site-wide: 33,299
  • In cell biology: 1,270
• Year to date:
  • Site-wide: 16,736
• Since beginning of last month:
  • Site-wide: 15,958

Asymptomatic COVID-19 Have Longer Treatment Cycle Than Moderate Type of Confirmed Patients

• Downloaded 932 times
• Download rankings, all-time:
  • Site-wide: 44,456
  • In infectious diseases: 3,551
• Year to date:
  • Site-wide: 155,955
• Since beginning of last month:
  • Site-wide: 66,388

An Autoantigen Profile of Human A549 Lung Cells Reveals Viral and Host Etiologic Molecular Attributes of Autoimmunity in COVID-19

• Downloaded 916 times
• Download rankings, all-time:
  • Site-wide: 45,680
  • In immunology: 1,574
• Year to date:
  • Site-wide: 102,147
• Since beginning of last month:
  • Site-wide: 55,713

Mapping Human Pluripotent Stem Cell Derived Erythroid Differentiation by Single-Cell Transcriptome Analysis

• Downloaded 906 times
• Download rankings, all-time:
  • Site-wide: 46,436
  • In developmental biology: 984
• Year to date:
  • Site-wide: 37,676
• Since beginning of last month:
  • Site-wide: 190,235

Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier

• Downloaded 872 times
• Download rankings, all-time:
  • Site-wide: 49,307
  • In cell biology: 2,044
• Year to date:
  • Site-wide: 22,089
• Since beginning of last month:
  • Site-wide: 56,926

Prime Editing in Mice Reveals the Essentiality of a Single Base in Driving Tissue-Specific Gene Expression

• Downloaded 855 times
• Download rankings, all-time:
  • Site-wide: 50,747
  • In genetics: 1,980
• Year to date:
  • Site-wide: 86,155
• Since beginning of last month:
  • Site-wide: 80,080

Rapid evaluation of neutralizing antibodies in COVID-19 patients

• Downloaded 811 times
• Download rankings, all-time:
  • Site-wide: 54,983
  • In infectious diseases: 3,957
• Year to date:
  • Site-wide: 156,613
• Since beginning of last month:
  • Site-wide: 85,133

An Autoantigen-ome from HS-Sultan B-Lymphoblasts Offers a Molecular Map for Investigating Autoimmune Sequelae of COVID-19

• Downloaded 707 times
• Download rankings, all-time:
  • Site-wide: 67,242
  • In immunology: 2,251
• Year to date:
  • Site-wide: 33,375
• Since beginning of last month:
  • Site-wide: 56,032

Overexpression-based detection of translatable circular RNAs is vulnerable to coexistent linear RNA byproducts

• Downloaded 637 times
• Download rankings, all-time:
  • Site-wide: 77,579
  • In molecular biology: 2,267
• Year to date:
  • Site-wide: 44,355
• Since beginning of last month:
  • Site-wide: 57,155

CRISPR-Cas12a induced DNA double-strand breaks are repaired by locus-dependent and error-prone pathways in a fungal pathogen

• Downloaded 627 times
• Download rankings, all-time:
  • Site-wide: 79,021
  • In microbiology: 4,965
• Year to date:
  • Site-wide: 33,953
• Since beginning of last month:
  • Site-wide: 82,356

NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats

• Downloaded 626 times
• Download rankings, all-time:
  • Site-wide: 79,224
  • In pharmacology and toxicology: 513
• Year to date:
  • Site-wide: 108,899
• Since beginning of last month:
  • Site-wide: 24,989

Selfee: Self-supervised Features Extraction of animal behaviors

• Downloaded 595 times
• Download rankings, all-time:
  • Site-wide: 84,583
  • In neuroscience: 12,274
• Year to date:
  • Site-wide: 36,278
• Since beginning of last month:
  • Site-wide: 68,584

The COVID-19 outbreak in Sichuan, China: epidemiology and impact of interventions

• Downloaded 591 times
• Download rankings, all-time:
  • Site-wide: 85,286
  • In epidemiology: 3,757
• Year to date:
  • Site-wide: 186,643
• Since beginning of last month:
  • Site-wide: 125,881

Molecular evolution of classic Hodgkin lymphoma revealed through whole genome sequencing of Hodgkin and Reed Sternberg cells

• Downloaded 584 times
• Download rankings, all-time:
  • Site-wide: 86,555
  • In cancer biology: 2,686
• Year to date:
  • Site-wide: 22,902
• Since beginning of last month:
  • Site-wide: 16,955

Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

• Downloaded 537 times
• Download rankings, all-time:
  • Site-wide: 95,958
  • In immunology: 3,093
• Year to date:
  • Site-wide: 157,598
• Since beginning of last month:
  • Site-wide: 110,685

COVID-19 cases from the first local outbreak of SARS-CoV-2 B.1.1.7 variant in China presented more serious clinical features: a prospective, comparative cohort study

• Downloaded 528 times
• Download rankings, all-time:
  • Site-wide: 97,855
  • In infectious diseases: 5,323
• Year to date:
  • Site-wide: 184,173
• Since beginning of last month:
  • Site-wide: 83,501

High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions

• Downloaded 508 times
• Download rankings, all-time:
  • Site-wide: 102,570
  • In neuroscience: 14,769
• Year to date:
  • Site-wide: 148,725
• Since beginning of last month:
  • Site-wide: 156,795

Aging-related cerebral microvascular changes visualized using Ultrasound Localization Microscopy in the living mouse

• Downloaded 504 times
• Download rankings, all-time:
  • Site-wide: 103,289
  • In neuroscience: 15,102
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 86,491

Extensive MET alterations confer clinical response to MET inhibitors in gliomas

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 104,046
  • In neuroscience: 15,087
• Year to date:
  • Site-wide: 86,081
• Since beginning of last month:
  • Site-wide: 132,292

Exploring cell surface-nanopillar interactions with 3D super-resolution microscopy

• Downloaded 465 times
• Download rankings, all-time:
  • Site-wide: 112,629
  • In biophysics: 4,234
• Year to date:
  • Site-wide: 45,265
• Since beginning of last month:
  • Site-wide: 71,016

Nanoscale surface topography reduces focal adhesions and cell stiffness by enhancing integrin endocytosis

• Downloaded 461 times
• Download rankings, all-time:
  • Site-wide: 113,614
  • In bioengineering: 2,309
• Year to date:
  • Site-wide: 45,572
• Since beginning of last month:
  • Site-wide: 159,798

Shared brain and genetic architectures between mental health and physical activity

• Downloaded 439 times
• Download rankings, all-time:
  • Site-wide: 119,303
  • In psychiatry and clinical psychology: 675
• Year to date:
  • Site-wide: 61,474
• Since beginning of last month:
  • Site-wide: 70,517

Genome sequencing sheds light on the contribution of structural variants to Brassica oleracea diversification

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 125,228
  • In plant biology: 3,298
• Year to date:
  • Site-wide: 186,777
• Since beginning of last month:
  • Site-wide: 186,464

Thinking like a structural biologist: A pocket-based 3D molecule generative model fueled by electron density

• Downloaded 411 times
• Download rankings, all-time:
  • Site-wide: 127,020
  • In bioinformatics: 10,510
• Year to date:
  • Site-wide: 188,217
• Since beginning of last month:
  • Site-wide: 36,169

Ancient genomes redate the extinction of Sussemionus, a subgenus of Equus, to late Holocene

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 137,187
  • In genomics: 7,385
• Year to date:
  • Site-wide: 181,766
• Since beginning of last month:
  • Site-wide: 45,086

Deep Linear Modeling of Hierarchical Functional Connectivity in the Human Brain

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 141,709
  • In neuroscience: 20,897
• Year to date:
  • Site-wide: 126,227
• Since beginning of last month:
  • Site-wide: 85,380

Human immunodeficiency virus type 2 capsid protein mutagenesis reveals amino acid residues important for virus particle assembly

• Downloaded 352 times
• Download rankings, all-time:
  • Site-wide: 144,222
  • In microbiology: 10,257
• Year to date:
  • Site-wide: 23,834
• Since beginning of last month:
  • Site-wide: 46,766

Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosis

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 157,117
  • In cell biology: 7,390
• Year to date:
  • Site-wide: 54,945
• Since beginning of last month:
  • Site-wide: 51,315

A Potential Novel COVID-19 Vaccine With RBD-HR1/HR2 Hexamer Structure

• Downloaded 303 times
• Download rankings, all-time:
  • Site-wide: 158,951
  • In biochemistry: 5,013
• Year to date:
  • Site-wide: 22,630
• Since beginning of last month:
  • Site-wide: 71,879

Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 159,383
  • In biochemistry: 4,959
• Year to date:
  • Site-wide: 104,376
• Since beginning of last month:
  • Site-wide: 136,766

The role of miR-31-5p in the development of intervertebral disk degeneration and its therapeutic potential

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 167,784
  • In molecular biology: 5,002
• Year to date:
  • Site-wide: 66,233
• Since beginning of last month:
  • Site-wide: 186,043

Molecular Mechanisms for Frequency Specificity in a Drosophila Hearing Organ

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 172,822
  • In neuroscience: 25,257
• Year to date:
  • Site-wide: 145,918
• Since beginning of last month:
  • Site-wide: 49,466

The Endothelin Receptor Antagonist Macitentan Ameliorates Endothelin-Mediated Vasoconstriction and Promotes Neuroprotection of Retinal Ganglion Cells in Rats

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 174,411
  • In neuroscience: 25,377
• Year to date:
  • Site-wide: 162,415
• Since beginning of last month:
  • Site-wide: 127,965

Genome-wide Analysis Reflects Novel 5-Hydroxymethylcytosines Implicated in Diabetic Nephropathy

• Downloaded 212 times
• Download rankings, all-time:
  • Site-wide: 184,545
  • In genetic and genomic medicine: 1,375
• Year to date:
  • Site-wide: 145,753
• Since beginning of last month:
  • Site-wide: 168,736

The synergistic effect of circRNA methylation promotes pulmonary fibrosis

• Downloaded 209 times
• Download rankings, all-time:
  • Site-wide: 185,410
  • In pharmacology and toxicology: 1,574
• Year to date:
  • Site-wide: 23,006
• Since beginning of last month:
  • Site-wide: 98,570

The trifecta of disease avoidance, silique shattering resistance and flowering period elongation achieved by the BnaIDA editing in Brassica napus

• Downloaded 172 times
• Download rankings, all-time:
  • Site-wide: 193,784
  • In plant biology: 5,437
• Year to date:
  • Site-wide: 71,663
• Since beginning of last month:
  • Site-wide: 66,663

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma

• Downloaded 168 times
• Download rankings, all-time:
  • Site-wide: 194,575
  • In cancer biology: 6,079
• Year to date:
  • Site-wide: 77,220
• Since beginning of last month:
  • Site-wide: 84,966

The Isl1/Shh/Wnt5a cascade controls the invasion of myoblasts by tuning the CXCL12/CXCR4 axis during tongue morphogenesis

• Downloaded 162 times
• Download rankings, all-time:
  • Site-wide: 195,889
  • In developmental biology: 5,097
• Year to date:
  • Site-wide: 105,678
• Since beginning of last month:
  • Site-wide: 194,140

Discovery of an alternate mechanism for the inhibition of particulate guanylyl cyclases by the natriuretic peptide 'clearance' receptor

• Downloaded 97 times
• Download rankings, all-time:
  • Site-wide: 208,069
  • In biochemistry: 6,484
• Year to date:
  • Site-wide: 69,864
• Since beginning of last month:
  • Site-wide: 69,391

Replacing continuous stimulation of one set of electrodes with successive stimulation of multiple sets of electrodes can improve the focality of transcranial temporal interference stimulation (tTIS), especially the focality of stimulation towards deep brain regions: A simulation study.

• Downloaded 51 times
• Download rankings, all-time:
  • Site-wide: 215,834
  • In bioengineering: None
• Year to date:
  • Site-wide: 2,801
• Since beginning of last month:
  • Site-wide: None

Neuroinflammation in the amygdala is associated with recent depressive symptoms.

• Downloaded 49 times
• Download rankings, all-time:
  • Site-wide: 216,011
  • In psychiatry and clinical psychology: None
• Year to date:
  • Site-wide: 39,500
• Since beginning of last month:
  • Site-wide: 9,935