Author: Lei Wang

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Preprints

Incorporating Human Movement Data to Improve Epidemiological Estimates for 2019-nCoV

• Downloaded 7,765 times
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  • Site-wide: 968
  • In epidemiology: 122
• Year to date:
  • Site-wide: 11,349
• Since beginning of last month:
  • Site-wide: 14,233

Correlative three-dimensional super-resolution and block face electron microscopy of whole vitreously frozen cells

• Downloaded 4,979 times
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  • Site-wide: 1,750
  • In cell biology: 24
• Year to date:
  • Site-wide: 31,651
• Since beginning of last month:
  • Site-wide: 17,243

A portable and cost-effective microfluidic system for massively parallel single-cell transcriptome profiling

• Downloaded 4,456 times
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  • Site-wide: 2,058
  • In genomics: 232
• Year to date:
  • Site-wide: 9,048
• Since beginning of last month:
  • Site-wide: 7,614

Greater male than female variability in regional brain structure across the lifespan

• Downloaded 3,522 times
• Download rankings, all-time:
  • Site-wide: 2,883
  • In neuroscience: 229
• Year to date:
  • Site-wide: 8,138
• Since beginning of last month:
  • Site-wide: 7,980

Comprehensive analysis of immune evasion in breast cancer by single-cell RNA-seq

• Downloaded 3,521 times
• Download rankings, all-time:
  • Site-wide: 2,885
  • In cancer biology: 42
• Year to date:
  • Site-wide: 19,097
• Since beginning of last month:
  • Site-wide: 24,206

Genetics of brain age suggest an overlap with common brain disorders

• Downloaded 2,699 times
• Download rankings, all-time:
  • Site-wide: 4,208
  • In neuroscience: 389
• Year to date:
  • Site-wide: 29,712
• Since beginning of last month:
  • Site-wide: 40,107

Multi-route respiratory infection: when a transmission route may dominate

• Downloaded 1,061 times
• Download rankings, all-time:
  • Site-wide: 17,049
  • In infectious diseases: 1,403
• Year to date:
  • Site-wide: 29,696
• Since beginning of last month:
  • Site-wide: 25,480

Large-scale gene losses underlie the genome evolution of parasitic plant Cuscuta australis

• Downloaded 1,008 times
• Download rankings, all-time:
  • Site-wide: 18,438
  • In genomics: 1,924
• Year to date:
  • Site-wide: 81,596
• Since beginning of last month:
  • Site-wide: 107,108

Viral RNA level, serum antibody responses, and transmission risk in discharged COVID-19 patients with recurrent positive SARS-CoV-2 RNA test results: a population-based observational cohort study

• Downloaded 1,001 times
• Download rankings, all-time:
  • Site-wide: 18,662
  • In epidemiology: 1,065
• Year to date:
  • Site-wide: 33,017
• Since beginning of last month:
  • Site-wide: 26,669

Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

• Downloaded 916 times
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  • Site-wide: 21,135
  • In neuroscience: 2,798
• Year to date:
  • Site-wide: 23,815
• Since beginning of last month:
  • Site-wide: 12,637

Lipid perturbation-activated IRE-1 modulates autophagy and lipolysis during endoplasmic reticulum stress

• Downloaded 910 times
• Download rankings, all-time:
  • Site-wide: 21,361
  • In cell biology: 757
• Year to date:
  • Site-wide: 61,412
• Since beginning of last month:
  • Site-wide: 54,661

Effectiveness of Convalescent Plasma for Treatment of COVID-19 Patients

• Downloaded 755 times
• Download rankings, all-time:
  • Site-wide: 27,799
  • In respiratory medicine: 65
• Year to date:
  • Site-wide: 9,814
• Since beginning of last month:
  • Site-wide: 22,087

msCRUSH: fast tandem mass spectra clustering using locality sensitive hashing

• Downloaded 710 times
• Download rankings, all-time:
  • Site-wide: 30,265
  • In bioinformatics: 3,493
• Year to date:
  • Site-wide: 54,695
• Since beginning of last month:
  • Site-wide: 31,918

Dean flow assisted single cell and bead encapsulation for high performance single cell expression profiling

• Downloaded 708 times
• Download rankings, all-time:
  • Site-wide: 30,402
  • In bioengineering: 533
• Year to date:
  • Site-wide: 68,522
• Since beginning of last month:
  • Site-wide: 75,287

The genetic architecture of human brainstem structures and their involvement in common brain disorders

• Downloaded 708 times
• Download rankings, all-time:
  • Site-wide: 30,365
  • In neuroscience: 4,260
• Year to date:
  • Site-wide: 61,646
• Since beginning of last month:
  • Site-wide: 78,885

Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

• Downloaded 657 times
• Download rankings, all-time:
  • Site-wide: 33,563
  • In neuroscience: 4,776
• Year to date:
  • Site-wide: 29,437
• Since beginning of last month:
  • Site-wide: 12,928

Single-cell RNA-seq highlights heterogeneity in human primary Wharton's Jelly mesenchymal stem/stromal cells cultured in vitro

• Downloaded 579 times
• Download rankings, all-time:
  • Site-wide: 39,514
  • In cell biology: 1,637
• Year to date:
  • Site-wide: 53,568
• Since beginning of last month:
  • Site-wide: 73,549

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

• Downloaded 578 times
• Download rankings, all-time:
  • Site-wide: 39,572
  • In cell biology: 1,639
• Year to date:
  • Site-wide: 69,050
• Since beginning of last month:
  • Site-wide: 75,286

Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging

• Downloaded 559 times
• Download rankings, all-time:
  • Site-wide: 41,318
  • In neuroscience: 6,050
• Year to date:
  • Site-wide: 80,083
• Since beginning of last month:
  • Site-wide: 94,481

Strategy for Efficient Importing of NAD Analogs

• Downloaded 531 times
• Download rankings, all-time:
  • Site-wide: 44,036
  • In bioengineering: 791
• Year to date:
  • Site-wide: 22,638
• Since beginning of last month:
  • Site-wide: 61,681

Microglial activation results in neuron-type-specific increase in mPFC GABAergic transmission and abnormal behavior in mice

• Downloaded 522 times
• Download rankings, all-time:
  • Site-wide: 44,846
  • In neuroscience: 6,653
• Year to date:
  • Site-wide: 6,388
• Since beginning of last month:
  • Site-wide: 5,519

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

• Downloaded 515 times
• Download rankings, all-time:
  • Site-wide: 45,629
  • In microbiology: 2,874
• Year to date:
  • Site-wide: 2,044
• Since beginning of last month:
  • Site-wide: 1,959

Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

• Downloaded 510 times
• Download rankings, all-time:
  • Site-wide: 46,137
  • In cancer biology: 1,290
• Year to date:
  • Site-wide: 92,917
• Since beginning of last month:
  • Site-wide: 110,527

Single cell atlas of trisomy 21 cerebral cortex

• Downloaded 478 times
• Download rankings, all-time:
  • Site-wide: 49,713
  • In neuroscience: 7,486
• Year to date:
  • Site-wide: 44,651
• Since beginning of last month:
  • Site-wide: 49,165

Small Heat Shock Proteins and Eicosanoid Pathways Modulate Caspase-1 Activity in the Fat Bodies of Antheraea pernyi

• Downloaded 475 times
• Download rankings, all-time:
  • Site-wide: 50,130
  • In immunology: 1,332
• Year to date:
  • Site-wide: 60,176
• Since beginning of last month:
  • Site-wide: 78,009

Push-to-open: The Gating Mechanism of the Tethered Mechanosensitive Ion Channel NompC

• Downloaded 472 times
• Download rankings, all-time:
  • Site-wide: 50,439
  • In biophysics: 1,751
• Year to date:
  • Site-wide: 30,956
• Since beginning of last month:
  • Site-wide: 71,497

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

• Downloaded 465 times
• Download rankings, all-time:
  • Site-wide: 51,391
  • In microbiology: 3,313
• Year to date:
  • Site-wide: 5,991
• Since beginning of last month:
  • Site-wide: 6,182

Inferring the role of the microbiome on survival in patients treated with immune checkpoint inhibitors: causal modeling, timing, and classes of concomitant medications

• Downloaded 445 times
• Download rankings, all-time:
  • Site-wide: 53,782
  • In oncology: 59
• Year to date:
  • Site-wide: 23,662
• Since beginning of last month:
  • Site-wide: 25,436

Capsidiol, a defensive sesquiterpene produced by wild tobacco in response to attack from the fungal pathogen Alternaria alternata, is regulated by an ERF2-like transcription factor

• Downloaded 442 times
• Download rankings, all-time:
  • Site-wide: 54,257
  • In plant biology: 1,350
• Year to date:
  • Site-wide: 47,461
• Since beginning of last month:
  • Site-wide: 48,057

Characterization Of Imprinted Genes In Rice Reveals Post-Fertilization Regulation And Conservation At Some Loci Of Imprinting In Plant Species

• Downloaded 439 times
• Download rankings, all-time:
  • Site-wide: 54,645
  • In plant biology: 1,364
• Year to date:
  • Site-wide: 89,182
• Since beginning of last month:
  • Site-wide: 109,529

Double Lock of a Potent Human Monoclonal Antibody against SARS-CoV-2

• Downloaded 438 times
• Download rankings, all-time:
  • Site-wide: 54,802
  • In biophysics: 1,939
• Year to date:
  • Site-wide: 7,975
• Since beginning of last month:
  • Site-wide: 4,141

Tissue-specific MicroRNA Expression Alters Cancer Susceptibility Conferred by a TP53 Noncoding Variant

• Downloaded 425 times
• Download rankings, all-time:
  • Site-wide: 56,502
  • In cancer biology: 1,584
• Year to date:
  • Site-wide: 48,516
• Since beginning of last month:
  • Site-wide: 63,939

Deep Learning for Quality Control of Subcortical Brain 3D Shape Models

• Downloaded 424 times
• Download rankings, all-time:
  • Site-wide: 56,665
  • In neuroscience: 8,653
• Year to date:
  • Site-wide: 93,948
• Since beginning of last month:
  • Site-wide: 114,053

Behavioral evidence for memory replay of video episodes in macaque monkeys

• Downloaded 389 times
• Download rankings, all-time:
  • Site-wide: 61,756
  • In neuroscience: 9,501
• Year to date:
  • Site-wide: 45,310
• Since beginning of last month:
  • Site-wide: 102,131

ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: a Multi-disciplinary Team-based, Multifactorial Analytical Approach

• Downloaded 379 times
• Download rankings, all-time:
  • Site-wide: 63,330
  • In cancer biology: 1,805
• Year to date:
  • Site-wide: 115,316
• Since beginning of last month:
  • Site-wide: 105,352

Kindlin2-mediated phase separation underlies integrin adhesion formation

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 66,419
  • In biochemistry: 1,813
• Year to date:
  • Site-wide: 24,390
• Since beginning of last month:
  • Site-wide: 45,819

The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis

• Downloaded 339 times
• Download rankings, all-time:
  • Site-wide: 69,960
  • In developmental biology: 1,844
• Year to date:
  • Site-wide: 66,179
• Since beginning of last month:
  • Site-wide: 121,979

The nervous system is the major target for Gold nanoparticles: Evidence from RNA sequencing data of C. elegans

• Downloaded 335 times
• Download rankings, all-time:
  • Site-wide: 70,663
  • In neuroscience: 10,965
• Year to date:
  • Site-wide: 38,357
• Since beginning of last month:
  • Site-wide: 84,143

Sensitivity in the antioxidant system of discus fish (Symphysodon spp.) to cold temperature: evidence for species-specific cold resistance

• Downloaded 332 times
• Download rankings, all-time:
  • Site-wide: 71,169
  • In ecology: 2,138
• Year to date:
  • Site-wide: 24,529
• Since beginning of last month:
  • Site-wide: 33,887

Venom Isosolenopsin A Delivers Rapid Knockdown of Fire Ant Competitors

• Downloaded 331 times
• Download rankings, all-time:
  • Site-wide: 71,367
  • In zoology: 270
• Year to date:
  • Site-wide: 121,613
• Since beginning of last month:
  • Site-wide: 104,183

Deep learning-based adaptive detection of fetal nucleated red blood cells

• Downloaded 330 times
• Download rankings, all-time:
  • Site-wide: 71,589
  • In pathology: 361
• Year to date:
  • Site-wide: 23,584
• Since beginning of last month:
  • Site-wide: 13,725

Adaptive modification of lipid droplets mediated by Plin1 functions in infection-induced pathogenesis in Drosophila

• Downloaded 325 times
• Download rankings, all-time:
  • Site-wide: 72,381
  • In immunology: 1,922
• Year to date:
  • Site-wide: 37,357
• Since beginning of last month:
  • Site-wide: 29,420

Bacterial fucosidase enables the production of Bombay red blood cells

• Downloaded 325 times
• Download rankings, all-time:
  • Site-wide: 72,438
  • In molecular biology: 2,147
• Year to date:
  • Site-wide: 69,454
• Since beginning of last month:
  • Site-wide: 58,558

Inferring Disease-Associated Piwi-Interacting RNAs via Graph Attention Networks

• Downloaded 319 times
• Download rankings, all-time:
  • Site-wide: 73,481
  • In bioinformatics: 6,925
• Year to date:
  • Site-wide: 76,503
• Since beginning of last month:
  • Site-wide: 41,451

Exploring the influence of surface proteins on probiotic activity of Lactobacillus pentosus HC-2 in Litopenaeus vannamei midgut via Label-free quantitative proteomic analysis

• Downloaded 318 times
• Download rankings, all-time:
  • Site-wide: 73,619
  • In microbiology: 5,104
• Year to date:
  • Site-wide: 45,619
• Since beginning of last month:
  • Site-wide: 85,406

Transfer Learning for Predicting Conversion from Mild Cognitive Impairment to Dementia of Alzheimer Type based on 3D-Convolutional Neural Network

• Downloaded 272 times
• Download rankings, all-time:
  • Site-wide: 82,697
  • In bioinformatics: 7,494
• Year to date:
  • Site-wide: 16,670
• Since beginning of last month:
  • Site-wide: 72,235

Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation

• Downloaded 254 times
• Download rankings, all-time:
  • Site-wide: 86,400
  • In physiology: 796
• Year to date:
  • Site-wide: 92,015
• Since beginning of last month:
  • Site-wide: 113,837

Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

• Downloaded 247 times
• Download rankings, all-time:
  • Site-wide: 87,867
  • In biophysics: 3,406
• Year to date:
  • Site-wide: 84,758
• Since beginning of last month:
  • Site-wide: 62,265

Gene prioritization based on systems biology revealed new insight into genetic basis and pathophysiology underlying schizophrenia

• Downloaded 229 times
• Download rankings, all-time:
  • Site-wide: 91,674
  • In psychiatry and clinical psychology: 313
• Year to date:
  • Site-wide: 16,311
• Since beginning of last month:
  • Site-wide: 66,508

Sparse Deep Neural Networks on Imaging Genetics for Schizophrenia Case-Control Classification

• Downloaded 211 times
• Download rankings, all-time:
  • Site-wide: 95,462
  • In psychiatry and clinical psychology: 343
• Year to date:
  • Site-wide: 29,585
• Since beginning of last month:
  • Site-wide: 81,514

Intein-assisted bisection mapping systematically splits proteins for Boolean logic and inducibility engineering

• Downloaded 184 times
• Download rankings, all-time:
  • Site-wide: 101,335
  • In synthetic biology: 940
• Year to date:
  • Site-wide: 10,067
• Since beginning of last month:
  • Site-wide: 3,242

Convergent evolution of distinct immune sensor systems for fungal polygalacturonases in Brassicaceae

• Downloaded 183 times
• Download rankings, all-time:
  • Site-wide: 101,578
  • In plant biology: 2,786
• Year to date:
  • Site-wide: 26,009
• Since beginning of last month:
  • Site-wide: 2,706

Potential role of heat shock protein 90 in regulation of hyperthermia-driven differentiation of neural stem cells

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 102,526
  • In cell biology: 4,747
• Year to date:
  • Site-wide: 99,205
• Since beginning of last month:
  • Site-wide: 115,261

mRNA translation control by Dhx36 binding to 5’UTR G-quadruplex structures is essential for skeletal muscle stem cell regenerative functions

• Downloaded 171 times
• Download rankings, all-time:
  • Site-wide: 103,800
  • In cell biology: 4,806
• Year to date:
  • Site-wide: 27,257
• Since beginning of last month:
  • Site-wide: 42,987

Observation of the Transport and Removal of Lipofuscin from the Mouse Myocardium using Transmission Electron Microscope

• Downloaded 168 times
• Download rankings, all-time:
  • Site-wide: 104,410
  • In physiology: 1,131
• Year to date:
  • Site-wide: 77,482
• Since beginning of last month:
  • Site-wide: 73,532

Dissecting Response to Cancer Immunotherapy by Applying Bayesian Network Analysis to Flow Cytometry Data

• Downloaded 147 times
• Download rankings, all-time:
  • Site-wide: 108,460
  • In systems biology: 2,490
• Year to date:
  • Site-wide: 36,687
• Since beginning of last month:
  • Site-wide: 117,881

iMDA-BN: Identification of miRNA-Disease Associations based on the Biological Network and Graph Embedding Algorithm

• Downloaded 145 times
• Download rankings, all-time:
  • Site-wide: 108,786
  • In bioinformatics: 9,090
• Year to date:
  • Site-wide: 102,450
• Since beginning of last month:
  • Site-wide: 120,824

Potential mechanisms of action of celastrol against rheumatoid arthritis: transcriptomic and proteomic analysis

• Downloaded 124 times
• Download rankings, all-time:
  • Site-wide: 112,560
  • In immunology: 3,123
• Year to date:
  • Site-wide: 89,549
• Since beginning of last month:
  • Site-wide: 77,334

Annexin a2 as a target protein for chlorogenic acid in human lung cancer A549 cells

• Downloaded 116 times
• Download rankings, all-time:
  • Site-wide: 114,020
  • In pharmacology and toxicology: 937
• Year to date:
  • Site-wide: 114,227
• Since beginning of last month:
  • Site-wide: 48,289

Pitfalls in EEG analysis in patients with non-convulsive status epilepticus

• Downloaded 116 times
• Download rankings, all-time:
  • Site-wide: 114,137
  • In health informatics: 415
• Year to date:
  • Site-wide: 64,904
• Since beginning of last month:
  • Site-wide: 30,676

Schistosoma haematobium extracellular vesicle proteins confer protection in a heterologous model of schistosomiasis

• Downloaded 106 times
• Download rankings, all-time:
  • Site-wide: 115,805
  • In microbiology: 8,897
• Year to date:
  • Site-wide: 63,263
• Since beginning of last month:
  • Site-wide: 113,268

Integrin-linked kinase is a key signal factor involved in Nogo-66-induced inhibition of neurite outgrowth

• Downloaded 101 times
• Download rankings, all-time:
  • Site-wide: 116,663
  • In neuroscience: 18,216
• Year to date:
  • Site-wide: 93,957
• Since beginning of last month:
  • Site-wide: 112,582

SPRDA: a matrix completion approach based on the structural perturbation to infer disease-associated Piwi-Interacting RNAs

• Downloaded 76 times
• Download rankings, all-time:
  • Site-wide: 120,545
  • In bioinformatics: 9,734
• Year to date:
  • Site-wide: 69,599
• Since beginning of last month:
  • Site-wide: 96,844

Exendin-4 improves neuron protection and functional recovery in experimental spinal cord injury in rats through regulating PCBP2 expression

• Downloaded 66 times
• Download rankings, all-time:
  • Site-wide: 121,701
  • In animal behavior and cognition: 1,656
• Year to date:
  • Site-wide: 53,398
• Since beginning of last month:
  • Site-wide: 49,034