Author: Yan Wang

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Preprints

Age profile of susceptibility, mixing, and social distancing shape the dynamics of the novel coronavirus disease 2019 outbreak in China

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  • Site-wide: 676
  • In epidemiology: 100
• Year to date:
  • Site-wide: 5,827
• Since beginning of last month:
  • Site-wide: 8,258

Prevalence and Risk Factors of Acute Posttraumatic Stress Symptoms during the COVID-19 Outbreak in Wuhan, China

• Downloaded 5,857 times
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  • Site-wide: 1,385
  • In psychiatry and clinical psychology: 6
• Year to date:
  • Site-wide: 4,249
• Since beginning of last month:
  • Site-wide: 2,590

Detection of 2019 novel coronavirus in semen and testicular biopsy specimen of COVID-19 patients

• Downloaded 4,194 times
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  • Site-wide: 2,223
  • In infectious diseases: 454
• Year to date:
  • Site-wide: 3,051
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  • Site-wide: 4,888

Evolving epidemiology of novel coronavirus diseases 2019 and possible interruption of local transmission outside Hubei Province in China: a descriptive and modeling study

• Downloaded 3,626 times
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  • Site-wide: 2,739
  • In infectious diseases: 511
• Year to date:
  • Site-wide: 16,212
• Since beginning of last month:
  • Site-wide: 11,368

MECAT: an ultra-fast mapping, error correction and de novo assembly tool for single-molecule sequencing reads

• Downloaded 2,566 times
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  • Site-wide: 4,529
  • In bioinformatics: 522
• Year to date:
  • Site-wide: 77,075
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  • Site-wide: 92,845

Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China

• Downloaded 2,349 times
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  • Site-wide: 5,182
  • In infectious diseases: 764
• Year to date:
  • Site-wide: 4,395
• Since beginning of last month:
  • Site-wide: 2,101

Case fatality risk of novel coronavirus diseases 2019 in China

• Downloaded 1,935 times
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  • Site-wide: 6,884
  • In infectious diseases: 892
• Year to date:
  • Site-wide: 24,736
• Since beginning of last month:
  • Site-wide: 26,082

Dual midbrain and forebrain origins of thalamic inhibitory interneurons

• Downloaded 1,813 times
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  • Site-wide: 7,545
  • In neuroscience: 807
• Year to date:
  • Site-wide: 29,111
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  • Site-wide: 16,471

A statistical framework for mapping risk genes from de novo mutations in whole-genome sequencing studies

• Downloaded 1,781 times
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  • Site-wide: 7,742
  • In genetics: 384
• Year to date:
  • Site-wide: 49,101
• Since beginning of last month:
  • Site-wide: 87,805

High risk of infection caused posttraumatic stress symptoms in individuals with poor sleep quality: A study on influence of coronavirus disease (COVID-19) in China

• Downloaded 1,723 times
• Download rankings, all-time:
  • Site-wide: 8,163
  • In psychiatry and clinical psychology: 24
• Year to date:
  • Site-wide: 18,109
• Since beginning of last month:
  • Site-wide: 11,179

Simulating and Forecasting the Cumulative Confirmed Cases of SARS-CoV-2 in China by Boltzmann Function-based Regression Analyses

• Downloaded 1,657 times
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  • Site-wide: 8,694
  • In infectious diseases: 1,014
• Year to date:
  • Site-wide: 55,182
• Since beginning of last month:
  • Site-wide: 53,527

Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2

• Downloaded 1,573 times
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  • Site-wide: 9,420
  • In epidemiology: 656
• Year to date:
  • Site-wide: 13,398
• Since beginning of last month:
  • Site-wide: 11,278

TET1 Modulates H4K16 Acetylation by Interacting with hMOF to Regulate Expression of DNA Repair Genes and Oncogenic Transformation

• Downloaded 1,557 times
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  • Site-wide: 9,551
  • In molecular biology: 256
• Year to date:
  • Site-wide: 107,610
• Since beginning of last month:
  • Site-wide: 48,852

A genome-scale phylogeny of Fungi; insights into early evolution, radiations, and the relationship between taxonomy and phylogeny

• Downloaded 1,371 times
• Download rankings, all-time:
  • Site-wide: 11,554
  • In evolutionary biology: 426
• Year to date:
  • Site-wide: 3,759
• Since beginning of last month:
  • Site-wide: 7,915

Organizing Pneumonia of COVID-19: Time-dependent Evolution and Outcome in CT Findings

• Downloaded 1,184 times
• Download rankings, all-time:
  • Site-wide: 14,369
  • In radiology and imaging: 26
• Year to date:
  • Site-wide: 91,176
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  • Site-wide: 22,062

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

• Downloaded 1,106 times
• Download rankings, all-time:
  • Site-wide: 15,941
  • In biophysics: 400
• Year to date:
  • Site-wide: 47,326
• Since beginning of last month:
  • Site-wide: 60,455

Cleavage of a pathogen apoplastic protein by plant subtilases activates immunity

• Downloaded 941 times
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  • Site-wide: 20,245
  • In plant biology: 341
• Year to date:
  • Site-wide: 14,356
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  • Site-wide: 7,624

The YdiU Domain Modulates Bacterial Stress Signaling through Mn2+-dependent UMPylation

• Downloaded 912 times
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  • Site-wide: 21,180
  • In biochemistry: 462
• Year to date:
  • Site-wide: 72,008
• Since beginning of last month:
  • Site-wide: 40,086

Positive feedback loop of regulating ERK phosphorylation in mESCs mediated by Etv5-Tet2-Fgfr2 axis

• Downloaded 813 times
• Download rankings, all-time:
  • Site-wide: 24,997
  • In developmental biology: 504
• Year to date:
  • Site-wide: 76,894
• Since beginning of last month:
  • Site-wide: 41,914

The landscape of DNA methylation associated with the transcriptomic network in laying hens and broilers generates insight into embryonic muscle development in chicken

• Downloaded 803 times
• Download rankings, all-time:
  • Site-wide: 25,416
  • In bioinformatics: 3,056
• Year to date:
  • Site-wide: 67,517
• Since beginning of last month:
  • Site-wide: 49,496

Molecular dating of the emergence of anaerobic rumen fungi and the impact of laterally acquired genes

• Downloaded 794 times
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  • Site-wide: 25,827
  • In evolutionary biology: 1,261
• Year to date:
  • Site-wide: 52,500
• Since beginning of last month:
  • Site-wide: 65,567

A two-stage ECG signal denoising method based on deep convolutional network

• Downloaded 733 times
• Download rankings, all-time:
  • Site-wide: 28,875
  • In bioengineering: 502
• Year to date:
  • Site-wide: 2,433
• Since beginning of last month:
  • Site-wide: 7,010

Wuhan and Hubei COVID-19 mortality analysis reveals the critical role of timely supply of medical resources

• Downloaded 685 times
• Download rankings, all-time:
  • Site-wide: 31,599
  • In epidemiology: 1,544
• Year to date:
  • Site-wide: 53,659
• Since beginning of last month:
  • Site-wide: 95,501

N-Acetyl Cysteine Alleviates Coxsackievirus B-Induced Myocarditis by Suppressing caspase-1

• Downloaded 677 times
• Download rankings, all-time:
  • Site-wide: 32,187
  • In microbiology: 1,908
• Year to date:
  • Site-wide: 38,868
• Since beginning of last month:
  • Site-wide: 27,918

Negligible Risk of the COVID-19 Resurgence Caused by Work Resuming in China (outside Hubei): a Statistical Probability Study

• Downloaded 667 times
• Download rankings, all-time:
  • Site-wide: 32,772
  • In epidemiology: 1,576
• Year to date:
  • Site-wide: 71,659
• Since beginning of last month:
  • Site-wide: 83,444

Time-resolved digital immunoassay for rapid and sensitive quantitation of procalcitonin with plasmonic imaging

• Downloaded 592 times
• Download rankings, all-time:
  • Site-wide: 38,199
  • In bioengineering: 682
• Year to date:
  • Site-wide: 106,143
• Since beginning of last month:
  • Site-wide: 51,649

T-bet+ CD11c+ B Cells Are Critical For Anti-Chromatin IgG Production In The Development Of Lupus

• Downloaded 530 times
• Download rankings, all-time:
  • Site-wide: 43,939
  • In immunology: 1,153
• Year to date:
  • Site-wide: 116,717
• Since beginning of last month:
  • Site-wide: 118,951

An overexpressed Q allele leads to increased spike density and improved processing quality

• Downloaded 524 times
• Download rankings, all-time:
  • Site-wide: 44,469
  • In genetics: 2,168
• Year to date:
  • Site-wide: 60,555
• Since beginning of last month:
  • Site-wide: 72,429

TSD: A computational tool to study the complex structural variants using PacBio targeted sequencing data

• Downloaded 522 times
• Download rankings, all-time:
  • Site-wide: 44,638
  • In bioinformatics: 4,785
• Year to date:
  • Site-wide: 96,531
• Since beginning of last month:
  • Site-wide: 90,684

A spatiotemporal translatome of mouse tissue development

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 56,555
  • In bioinformatics: 5,745
• Year to date:
  • Site-wide: 52,081
• Since beginning of last month:
  • Site-wide: 43,955

A pattern categorization of CT findings to predict outcome of COVID-19 pneumonia

• Downloaded 414 times
• Download rankings, all-time:
  • Site-wide: 57,804
  • In infectious diseases: 2,504
• Year to date:
  • Site-wide: 43,885
• Since beginning of last month:
  • Site-wide: 39,273

Single cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis)

• Downloaded 397 times
• Download rankings, all-time:
  • Site-wide: 60,207
  • In developmental biology: 1,549
• Year to date:
  • Site-wide: 15,694
• Since beginning of last month:
  • Site-wide: 21,863

Hypercholesterolemia risk associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol level in human and mouse

• Downloaded 386 times
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  • Site-wide: 61,959
  • In genetics: 2,959
• Year to date:
  • Site-wide: 72,752
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  • Site-wide: 44,179

Coevolution-based prediction of protein-protein interactions in polyketide biosynthetic assembly lines

• Downloaded 376 times
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  • Site-wide: 63,449
  • In bioinformatics: 6,281
• Year to date:
  • Site-wide: 64,503
• Since beginning of last month:
  • Site-wide: 54,783

Plasticity and the role of mass-scaling in allocation, morphology and anatomical trait responses to above and belowground resource limitation in cultivated sunflower (Helianthus annuus L.)

• Downloaded 372 times
• Download rankings, all-time:
  • Site-wide: 64,050
  • In plant biology: 1,663
• Year to date:
  • Site-wide: 48,392
• Since beginning of last month:
  • Site-wide: 63,025

The LIM-Only Protein FHL2 is Involved in Autophagy to Regulate the Development of Skeletal Muscle

• Downloaded 371 times
• Download rankings, all-time:
  • Site-wide: 64,219
  • In molecular biology: 1,890
• Year to date:
  • Site-wide: 49,275
• Since beginning of last month:
  • Site-wide: 87,435

Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep

• Downloaded 370 times
• Download rankings, all-time:
  • Site-wide: 64,421
  • In bioengineering: 1,176
• Year to date:
  • Site-wide: 83,411
• Since beginning of last month:
  • Site-wide: 64,730

Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer

• Downloaded 329 times
• Download rankings, all-time:
  • Site-wide: 71,305
  • In genomics: 4,932
• Year to date:
  • Site-wide: 104,887
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  • Site-wide: 75,386

Structural insights into the Ca 2+-dependent gating of the human mitochondrial calcium uniporter

• Downloaded 291 times
• Download rankings, all-time:
  • Site-wide: 78,533
  • In biochemistry: 2,240
• Year to date:
  • Site-wide: 99,496
• Since beginning of last month:
  • Site-wide: 91,254

Mapping fetal brain development based on automated segmentation and 4D brain atlasing

• Downloaded 288 times
• Download rankings, all-time:
  • Site-wide: 79,127
  • In neuroscience: 12,378
• Year to date:
  • Site-wide: 20,737
• Since beginning of last month:
  • Site-wide: 67,704

Phylogenomic analyses of non-Dikarya fungi supports horizontal gene transfer driving diversification of secondary metabolism in the amphibian gastrointestinal symbiont, Basidiobolus

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 81,523
  • In genomics: 5,306
• Year to date:
  • Site-wide: 91,894
• Since beginning of last month:
  • Site-wide: 60,912

CD44 inhibits α-SMA gene expression via a novel G-actin/MRTF mediated pathway that requires TGFβR/p38MAPK activity in murine skin fibroblasts.

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 81,877
  • In cell biology: 3,797
• Year to date:
  • Site-wide: 86,857
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  • Site-wide: 59,356

Differences of clinical and imaging findings in multiple generations of secondary COVID-19 infection in Xi'an, China

• Downloaded 261 times
• Download rankings, all-time:
  • Site-wide: 84,582
  • In radiology and imaging: 125
• Year to date:
  • Site-wide: 118,461
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  • Site-wide: 65,147

2019 Association of Biomolecular Resource Facilities Multi-Laboratory Data-Independent Acquisition Study

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 86,637
  • In bioinformatics: 7,756
• Year to date:
  • Site-wide: 33,319
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  • Site-wide: 19,368

Drosophila larval epidermal cells only exhibit epidermal aging when they persist to the adult stage

• Downloaded 246 times
• Download rankings, all-time:
  • Site-wide: 87,726
  • In cell biology: 4,089
• Year to date:
  • Site-wide: 75,432
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  • Site-wide: 61,931

The role of BMP6 in the proliferation and differentiation of chicken cartilage cells

• Downloaded 232 times
• Download rankings, all-time:
  • Site-wide: 90,637
  • In cell biology: 4,238
• Year to date:
  • Site-wide: 101,233
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  • Site-wide: 72,787

Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways

• Downloaded 213 times
• Download rankings, all-time:
  • Site-wide: 94,534
  • In neuroscience: 14,944
• Year to date:
  • Site-wide: 71,461
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  • Site-wide: 82,687

HIFα regulates developmental myelination independent of autocrine Wnt signaling

• Downloaded 213 times
• Download rankings, all-time:
  • Site-wide: 94,538
  • In neuroscience: 14,954
• Year to date:
  • Site-wide: 46,776
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  • Site-wide: 64,472

Tracking and predicting the African COVID-19 pandemic

• Downloaded 209 times
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  • Site-wide: 95,295
  • In infectious diseases: 3,236
• Year to date:
  • Site-wide: 12,430
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  • Site-wide: 11,965

RNA-seq analysis of laser micro-dissected Arabidopsis thaliana leaf epidermis, mesophyll and vasculature defines tissue-specific transcriptional responses to multiple stress treatments

• Downloaded 195 times
• Download rankings, all-time:
  • Site-wide: 98,522
  • In plant biology: 2,693
• Year to date:
  • Site-wide: 40,805
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  • Site-wide: 12,299

RNF219 interacts with CCR4-NOT in regulating stem cell differentiation

• Downloaded 188 times
• Download rankings, all-time:
  • Site-wide: 100,054
  • In molecular biology: 2,991
• Year to date:
  • Site-wide: 31,083
• Since beginning of last month:
  • Site-wide: 70,529

Assessing deep learning algorithms in cis-regulatory motif finding based on genomic sequencing data

• Downloaded 184 times
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  • Site-wide: 100,823
  • In bioinformatics: 8,636
• Year to date:
  • Site-wide: 16,497
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  • Site-wide: 2,753

Mutant Zp1 results in Zona Pellucida Lacking and Female Infertility in Rats and Humans

• Downloaded 183 times
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  • Site-wide: 101,006
  • In genetics: 4,576
• Year to date:
  • Site-wide: 113,301
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  • Site-wide: 46,414

Genome-scale phylogenetic analyses confirm Olpidium as the closest living zoosporic fungus to the non-flagellated, terrestrial fungi

• Downloaded 173 times
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  • Site-wide: 102,903
  • In evolutionary biology: 5,531
• Year to date:
  • Site-wide: 28,942
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  • Site-wide: 33,169

Site-specific covalent labeling of large RNAs with nanoparticles empowered by expanded genetic alphabet transcription

• Downloaded 171 times
• Download rankings, all-time:
  • Site-wide: 103,319
  • In biophysics: 3,994
• Year to date:
  • Site-wide: 63,546
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  • Site-wide: 58,291

Dicer1 is reduced in APPswe/PSEN1dE9 mice and is regulated by Nrf2

• Downloaded 160 times
• Download rankings, all-time:
  • Site-wide: 105,481
  • In neuroscience: 16,577
• Year to date:
  • Site-wide: 114,618
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  • Site-wide: 93,526

Larger organ size caused by obesity is a mechanism for higher cancer risk.

• Downloaded 158 times
• Download rankings, all-time:
  • Site-wide: 105,872
  • In cancer biology: 3,267
• Year to date:
  • Site-wide: 101,479
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  • Site-wide: 45,345

Phytophthora sojae effector Avr1d functions as E2 competitor and inhibits ubiquitination activity of GmPUB13 to facilitate infection

• Downloaded 134 times
• Download rankings, all-time:
  • Site-wide: 110,297
  • In microbiology: 8,404
• Year to date:
  • Site-wide: 34,014
• Since beginning of last month:
  • Site-wide: 30,753

The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling

• Downloaded 130 times
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  • Site-wide: 110,813
  • In neuroscience: 17,407
• Year to date:
  • Site-wide: 29,309
• Since beginning of last month:
  • Site-wide: 18,673

Dicer1 promotes Aβ clearance via blocking B2 RNA-mediated repression of apolipoprotein E

• Downloaded 105 times
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  • Site-wide: 115,340
  • In neuroscience: 18,058
• Year to date:
  • Site-wide: 49,779
• Since beginning of last month:
  • Site-wide: 55,967

The size of helical pitch is important for microtubule plus end dynamic instability

• Downloaded 92 times
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  • Site-wide: 117,493
  • In cell biology: 5,442
• Year to date:
  • Site-wide: 3,037
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  • Site-wide: 26,908

Development of an electronic frailty index for predicting mortality in patients undergoing transcatheter aortic valve replacement using machine learning

• Downloaded 85 times
• Download rankings, all-time:
  • Site-wide: 118,489
  • In cardiovascular medicine: 293
• Year to date:
  • Site-wide: 13,565
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  • Site-wide: 10,082

Blocking of EGFR Signaling is a Latent Strategy for the Improvement of Prognosis of HPV Induced Cancer

• Downloaded 58 times
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  • Site-wide: 121,910
  • In microbiology: 9,565
• Year to date:
  • Site-wide: 40,152
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  • Site-wide: 57,261