Author: zhandong liu

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Preprints

Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach

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  • Site-wide: 4,995
  • In systems biology: 87
• Year to date:
  • Site-wide: 11,691
• Since beginning of last month:
  • Site-wide: 17,140

CRISPRCloud2: A cloud-based platform for deconvoluting CRISPR screen data

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  • Site-wide: 12,862
  • In bioinformatics: 1,616
• Year to date:
  • Site-wide: 58,668
• Since beginning of last month:
  • Site-wide: 24,404

Functional dissection of Alzheimer's disease brain gene expression signatures in humans and mouse models

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  • Site-wide: 15,761
  • In systems biology: 329
• Year to date:
  • Site-wide: 21,201
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  • Site-wide: 66,013

XMRF: An R package to Fit Markov Networks to High-Throughput Genetics Data

• Downloaded 870 times
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  • Site-wide: 22,709
  • In bioinformatics: 2,764
• Year to date:
  • Site-wide: 58,570
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  • Site-wide: 97,667

Co-expression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders

• Downloaded 852 times
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  • Site-wide: 23,379
  • In genetics: 1,179
• Year to date:
  • Site-wide: 28,731
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  • Site-wide: 88,740

Bias toward long gene misregulation in synaptic disorders can be an artefact of amplification-based methods

• Downloaded 769 times
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  • Site-wide: 26,991
  • In neuroscience: 3,736
• Year to date:
  • Site-wide: 73,165
• Since beginning of last month:
  • Site-wide: 86,670

Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer's Disease

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  • Site-wide: 29,011
  • In neuroscience: 4,048
• Year to date:
  • Site-wide: 99,560
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  • Site-wide: 89,787

SAVE: A secure cloud-based pipeline for CRISPR pooled screen deconvolution

• Downloaded 701 times
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  • Site-wide: 30,650
  • In bioinformatics: 3,539
• Year to date:
  • Site-wide: 101,249
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  • Site-wide: 121,258

Epigenetic Drift of H3K27me3 in Aging Links Glycolysis to Healthy Longevity

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  • Site-wide: 35,856
  • In molecular biology: 1,019
• Year to date:
  • Site-wide: 38,996
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  • Site-wide: 66,704

On the Reproducibility of TCGA Ovarian Cancer MicroRNA Profiles

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  • Site-wide: 42,097
  • In genomics: 3,481
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  • Site-wide: None
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  • Site-wide: 106,331

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

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  • Site-wide: 46,977
  • In genomics: 3,784
• Year to date:
  • Site-wide: 24,597
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  • Site-wide: 44,893

Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors

• Downloaded 471 times
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  • Site-wide: 50,362
  • In cancer biology: 1,402
• Year to date:
  • Site-wide: 109,970
• Since beginning of last month:
  • Site-wide: 108,519

PRIME: a probabilistic imputation method to reduce dropout effects in single cell RNA sequencing

• Downloaded 404 times
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  • Site-wide: 59,234
  • In bioinformatics: 5,956
• Year to date:
  • Site-wide: 54,876
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  • Site-wide: 83,152

Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndrome

• Downloaded 374 times
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  • Site-wide: 63,814
  • In neuroscience: 9,884
• Year to date:
  • Site-wide: 47,544
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  • Site-wide: 116,643

Partial loss of CFIm25 causes aberrant alternative polyadenylation and learning deficits

• Downloaded 338 times
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  • Site-wide: 69,762
  • In genomics: 4,873
• Year to date:
  • Site-wide: 85,932
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  • Site-wide: 54,001

Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes

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  • Site-wide: 101,174
  • In genomics: 5,971
• Year to date:
  • Site-wide: 44,098
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  • Site-wide: 46,233

Modulating glial genes involved in synaptic function mitigates pathogenesis and behavioral deficits in a Drosophila model of Huntington's Disease

• Downloaded 146 times
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  • Site-wide: 108,004
  • In systems biology: 2,482
• Year to date:
  • Site-wide: 85,266
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  • Site-wide: 31,681

TraceQC: An R package for quality control of CRISPR lineage tracing data

• Downloaded 143 times
• Download rankings, all-time:
  • Site-wide: 108,494
  • In bioinformatics: 9,096
• Year to date:
  • Site-wide: 55,637
• Since beginning of last month:
  • Site-wide: 104,843

A comparative study of deconvolution methods for RNA-seq data under a dynamic testing landscape

• Downloaded 112 times
• Download rankings, all-time:
  • Site-wide: 114,027
  • In bioinformatics: 9,401
• Year to date:
  • Site-wide: 50,535
• Since beginning of last month:
  • Site-wide: 5,263