Author: Daniel J Rader

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Preprints

Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease

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  • Site-wide: 3,666
  • In genetic and genomic medicine: 16
• Year to date:
  • Site-wide: 2,868
• Since beginning of last month:
  • Site-wide: 2,727

SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared to SARS-CoV-2 mRNA vaccinations

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  • Site-wide: 4,155
  • In infectious diseases: 915
• Year to date:
  • Site-wide: 6,985
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  • Site-wide: 28,914

A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

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  • Site-wide: 5,983
  • In genetic and genomic medicine: 32
• Year to date:
  • Site-wide: 3,861
• Since beginning of last month:
  • Site-wide: 3,351

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

• Downloaded 2,789 times
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  • Site-wide: 7,229
  • In infectious diseases: 1,282
• Year to date:
  • Site-wide: 28,271
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  • Site-wide: 22,480

SARS-CoV-2 seropositivity and seroconversion in patients undergoing active cancer-directed therapy

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  • Site-wide: 12,311
  • In oncology: 15
• Year to date:
  • Site-wide: 44,593
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  • Site-wide: 46,203

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

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  • Site-wide: 13,331
  • In genetic and genomic medicine: 64
• Year to date:
  • Site-wide: 68,626
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  • Site-wide: 78,342

A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease

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  • Site-wide: 15,594
  • In genetics: 645
• Year to date:
  • Site-wide: 44,806
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  • Site-wide: 27,751

Sero-monitoring of health care workers reveals complex relationships between common coronavirus antibodies and SARS-CoV-2 severity

• Downloaded 1,580 times
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  • Site-wide: 16,868
  • In infectious diseases: 2,041
• Year to date:
  • Site-wide: 36,590
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  • Site-wide: 21,464

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

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  • Site-wide: 18,031
  • In genetics: 781
• Year to date:
  • Site-wide: 27,584
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  • Site-wide: 21,983

SARS-CoV-2 Seroprevalence Among Parturient Women

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  • Site-wide: 18,544
  • In infectious diseases: 2,130
• Year to date:
  • Site-wide: 42,497
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  • Site-wide: 30,615

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

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  • Site-wide: 26,951
  • In genomics: 2,592
• Year to date:
  • Site-wide: 9,612
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  • Site-wide: 36,447

Exome-by-phenome-wide rare variant gene burden association with electronic health record phenotypes

• Downloaded 1,097 times
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  • Site-wide: 29,561
  • In genomics: 2,465
• Year to date:
  • Site-wide: 95,408
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  • Site-wide: 57,730

Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition

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  • Site-wide: 32,068
  • In infectious diseases: 3,080
• Year to date:
  • Site-wide: 14,258
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  • Site-wide: 8,671

Genome-wide Association Study of Alcohol Consumption and Use Disorder in Multiple Populations (N = 274,424)

• Downloaded 986 times
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  • Site-wide: 34,697
  • In genetics: 1,378
• Year to date:
  • Site-wide: 164,597
• Since beginning of last month:
  • Site-wide: 141,905

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • Site-wide: 38,762
  • In genetics: 1,539
• Year to date:
  • Site-wide: 135,502
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  • Site-wide: 116,384

Genetic And Epigenetic Fine Mapping Of Complex Trait Associated Loci In The Human Liver

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  • Site-wide: 45,778
  • In genetics: 1,793
• Year to date:
  • Site-wide: 159,977
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  • Site-wide: 113,794

Disrupting upstream translation in mRNAs leads to loss-of-function associated with human disease

• Downloaded 782 times
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  • Site-wide: 48,810
  • In genomics: 3,514
• Year to date:
  • Site-wide: 132,113
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  • Site-wide: 125,676

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.

• Downloaded 735 times
• Download rankings, all-time:
  • Site-wide: 53,333
  • In genetic and genomic medicine: 305
• Year to date:
  • Site-wide: 29,060
• Since beginning of last month:
  • Site-wide: 31,457

RNA-binding protein A1CF modulates plasma triglyceride levels through posttranscriptional regulation of stress-induced VLDL secretion

• Downloaded 727 times
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  • Site-wide: 54,209
  • In genomics: 3,774
• Year to date:
  • Site-wide: 152,645
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  • Site-wide: 139,715

Polygenic risk of psychiatric disorders exhibits cross-trait associations in electronic health record data

• Downloaded 591 times
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  • Site-wide: 71,533
  • In genetics: 2,722
• Year to date:
  • Site-wide: 183,046
• Since beginning of last month:
  • Site-wide: 166,597

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

• Downloaded 588 times
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  • Site-wide: 71,917
  • In genetics: 3,422
• Year to date:
  • Site-wide: 23,826
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  • Site-wide: 21,528

Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci

• Downloaded 587 times
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  • Site-wide: 72,052
  • In genomics: 4,657
• Year to date:
  • Site-wide: 166,899
• Since beginning of last month:
  • Site-wide: 144,148

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

• Downloaded 558 times
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  • Site-wide: 76,807
  • In genetics: 3,009
• Year to date:
  • Site-wide: 132,354
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  • Site-wide: 74,062

Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Historical Cholesterol Exposure

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  • Site-wide: 94,109
  • In genetic and genomic medicine: 479
• Year to date:
  • Site-wide: 108,633
• Since beginning of last month:
  • Site-wide: 137,868

Genetics of Height and Risk of Atrial Fibrillation: A Mendelian Randomization Study

• Downloaded 460 times
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  • Site-wide: 95,920
  • In cardiovascular medicine: 197
• Year to date:
  • Site-wide: 167,264
• Since beginning of last month:
  • Site-wide: 181,678

Multi-trait GWAS of atherosclerosis detects novel pleiotropic loci

• Downloaded 427 times
• Download rankings, all-time:
  • Site-wide: 103,706
  • In genetic and genomic medicine: 654
• Year to date:
  • Site-wide: 48,185
• Since beginning of last month:
  • Site-wide: 60,024

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 410 times
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  • Site-wide: 107,745
  • In cardiovascular medicine: 231
• Year to date:
  • Site-wide: 158,798
• Since beginning of last month:
  • Site-wide: 136,388

Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors

• Downloaded 405 times
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  • Site-wide: 108,999
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 6,794
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  • Site-wide: 12,860

Multiplexed targeted resequencing identifies coding and regulatory variation underlying phenotypic extremes of HDL-cholesterol in humans

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  • Site-wide: 109,050
  • In genomics: 6,082
• Year to date:
  • Site-wide: 174,133
• Since beginning of last month:
  • Site-wide: 177,444

Association of the Transthyretin Variant V122I With Polyneuropathy Among Individuals of African Descent

• Downloaded 398 times
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  • Site-wide: 110,727
  • In genetic and genomic medicine: 677
• Year to date:
  • Site-wide: 67,991
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  • Site-wide: 36,102

Linking abdominal imaging traits to electronic health record phenotypes

• Downloaded 339 times
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  • Site-wide: 126,517
  • In radiology and imaging: 258
• Year to date:
  • Site-wide: 140,474
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  • Site-wide: 98,789

Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study

• Downloaded 321 times
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  • Site-wide: 131,772
  • In cardiovascular medicine: 328
• Year to date:
  • Site-wide: 127,099
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  • Site-wide: 100,215

ApoC-III helical structure determines its ability to bind plasma lipoproteins and inhibit Lipoprotein Lipase-mediated triglyceride lipolysis.

• Downloaded 313 times
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  • Site-wide: 134,086
  • In biochemistry: 3,867
• Year to date:
  • Site-wide: 124,407
• Since beginning of last month:
  • Site-wide: 102,516

Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion

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  • Site-wide: 137,351
  • In immunology: 3,884
• Year to date:
  • Site-wide: 171,401
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  • Site-wide: 173,667

A genome-first approach to rare variants in hypertrophic cardiomyopathy genes MYBPC3 and MYH7 in a medical biobank

• Downloaded 270 times
• Download rankings, all-time:
  • Site-wide: 146,914
  • In genetic and genomic medicine: 932
• Year to date:
  • Site-wide: 77,123
• Since beginning of last month:
  • Site-wide: 60,486