Author: Daniel Rader

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Preprints

Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease

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  • Site-wide: 4,031
  • In genetic and genomic medicine: 16
• Year to date:
  • Site-wide: 1,555
• Since beginning of last month:
  • Site-wide: 2,823

SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared to SARS-CoV-2 mRNA vaccinations

• Downloaded 3,750 times
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  • Site-wide: 4,204
  • In infectious diseases: 899
• Year to date:
  • Site-wide: 2,563
• Since beginning of last month:
  • Site-wide: 1,410

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

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  • Site-wide: 6,904
  • In infectious diseases: 1,240
• Year to date:
  • Site-wide: 23,838
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  • Site-wide: 14,369

A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

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  • Site-wide: 6,999
  • In genetic and genomic medicine: 34
• Year to date:
  • Site-wide: 5,258
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  • Site-wide: 3,435

SARS-CoV-2 seropositivity and seroconversion in patients undergoing active cancer-directed therapy

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  • Site-wide: 11,654
  • In oncology: 14
• Year to date:
  • Site-wide: 20,579
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  • Site-wide: 26,629

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

• Downloaded 1,783 times
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  • Site-wide: 12,362
  • In genetic and genomic medicine: 60
• Year to date:
  • Site-wide: 36,789
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  • Site-wide: 49,524

A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease

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  • Site-wide: 15,069
  • In genetics: 649
• Year to date:
  • Site-wide: 42,041
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  • Site-wide: 31,391

Sero-monitoring of health care workers reveals complex relationships between common coronavirus antibodies and SARS-CoV-2 severity

• Downloaded 1,460 times
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  • Site-wide: 16,767
  • In infectious diseases: 1,979
• Year to date:
  • Site-wide: 60,861
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  • Site-wide: 17,795

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

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  • Site-wide: 18,121
  • In genetics: 783
• Year to date:
  • Site-wide: 6,932
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  • Site-wide: 6,749

SARS-CoV-2 Seroprevalence Among Parturient Women

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  • Site-wide: 18,142
  • In infectious diseases: 2,055
• Year to date:
  • Site-wide: 20,731
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  • Site-wide: 32,836

Exome-by-phenome-wide rare variant gene burden association with electronic health record phenotypes

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  • Site-wide: 27,511
  • In genomics: 2,414
• Year to date:
  • Site-wide: 106,587
• Since beginning of last month:
  • Site-wide: 108,860

Genome-wide Association Study of Alcohol Consumption and Use Disorder in Multiple Populations (N = 274,424)

• Downloaded 967 times
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  • Site-wide: 31,139
  • In genetics: 1,346
• Year to date:
  • Site-wide: 128,204
• Since beginning of last month:
  • Site-wide: 153,551

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 889 times
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  • Site-wide: 35,293
  • In genetics: 1,517
• Year to date:
  • Site-wide: 112,859
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  • Site-wide: 117,888

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

• Downloaded 885 times
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  • Site-wide: 35,499
  • In genomics: 2,919
• Year to date:
  • Site-wide: 4,108
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  • Site-wide: 323

Genetic And Epigenetic Fine Mapping Of Complex Trait Associated Loci In The Human Liver

• Downloaded 799 times
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  • Site-wide: 41,157
  • In genetics: 1,744
• Year to date:
  • Site-wide: 78,523
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  • Site-wide: 81,896

Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition

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  • Site-wide: 41,171
  • In infectious diseases: 3,143
• Year to date:
  • Site-wide: 24,644
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  • Site-wide: 8,768

Disrupting upstream translation in mRNAs leads to loss-of-function associated with human disease

• Downloaded 755 times
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  • Site-wide: 44,717
  • In genomics: 3,469
• Year to date:
  • Site-wide: 95,367
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  • Site-wide: 133,016

RNA-binding protein A1CF modulates plasma triglyceride levels through posttranscriptional regulation of stress-induced VLDL secretion

• Downloaded 705 times
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  • Site-wide: 49,123
  • In genomics: 3,720
• Year to date:
  • Site-wide: 122,739
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  • Site-wide: 121,892

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.

• Downloaded 590 times
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  • Site-wide: 62,284
  • In genetic and genomic medicine: 317
• Year to date:
  • Site-wide: 60,980
• Since beginning of last month:
  • Site-wide: 12,319

Polygenic risk of psychiatric disorders exhibits cross-trait associations in electronic health record data

• Downloaded 578 times
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  • Site-wide: 63,885
  • In genetics: 2,679
• Year to date:
  • Site-wide: 133,659
• Since beginning of last month:
  • Site-wide: 168,653

Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci

• Downloaded 571 times
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  • Site-wide: 64,796
  • In genomics: 4,571
• Year to date:
  • Site-wide: 75,131
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  • Site-wide: 95,619

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

• Downloaded 530 times
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  • Site-wide: 70,972
  • In genetics: 2,967
• Year to date:
  • Site-wide: 117,041
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  • Site-wide: 83,329

Genetics of Height and Risk of Atrial Fibrillation: A Mendelian Randomization Study

• Downloaded 442 times
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  • Site-wide: 86,802
  • In cardiovascular medicine: 190
• Year to date:
  • Site-wide: 134,514
• Since beginning of last month:
  • Site-wide: 132,406

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

• Downloaded 434 times
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  • Site-wide: 88,415
  • In genetics: 3,645
• Year to date:
  • Site-wide: 9,971
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  • Site-wide: 14,730

Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Historical Cholesterol Exposure

• Downloaded 431 times
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  • Site-wide: 89,006
  • In genetic and genomic medicine: 461
• Year to date:
  • Site-wide: 141,403
• Since beginning of last month:
  • Site-wide: 45,539

Multiplexed targeted resequencing identifies coding and regulatory variation underlying phenotypic extremes of HDL-cholesterol in humans

• Downloaded 390 times
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  • Site-wide: 98,063
  • In genomics: 5,968
• Year to date:
  • Site-wide: 101,909
• Since beginning of last month:
  • Site-wide: 160,365

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 390 times
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  • Site-wide: 98,016
  • In cardiovascular medicine: 222
• Year to date:
  • Site-wide: 135,581
• Since beginning of last month:
  • Site-wide: 35,738

Multi-trait GWAS of atherosclerosis detects novel pleiotropic loci

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  • Site-wide: 109,975
  • In genetic and genomic medicine: 624
• Year to date:
  • Site-wide: 20,211
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  • Site-wide: 48,887

Association of the Transthyretin Variant V122I With Polyneuropathy Among Individuals of African Descent

• Downloaded 331 times
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  • Site-wide: 112,549
  • In genetic and genomic medicine: 645
• Year to date:
  • Site-wide: 94,836
• Since beginning of last month:
  • Site-wide: 59,114

Linking abdominal imaging traits to electronic health record phenotypes

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  • Site-wide: 116,893
  • In radiology and imaging: 244
• Year to date:
  • Site-wide: 90,451
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  • Site-wide: 93,902

Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization Study

• Downloaded 291 times
• Download rankings, all-time:
  • Site-wide: 123,253
  • In cardiovascular medicine: 323
• Year to date:
  • Site-wide: 139,657
• Since beginning of last month:
  • Site-wide: 78,012

Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion

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  • Site-wide: 124,425
  • In immunology: 3,752
• Year to date:
  • Site-wide: 132,337
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  • Site-wide: 145,799

ApoC-III helical structure determines its ability to bind plasma lipoproteins and inhibit Lipoprotein Lipase-mediated triglyceride lipolysis.

• Downloaded 282 times
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  • Site-wide: 125,579
  • In biochemistry: 3,745
• Year to date:
  • Site-wide: 139,489
• Since beginning of last month:
  • Site-wide: 64,112

A genome-first approach to rare variants in hypertrophic cardiomyopathy genes MYBPC3 and MYH7 in a medical biobank

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• Download rankings, all-time:
  • Site-wide: 143,768
  • In genetic and genomic medicine: 885
• Year to date:
  • Site-wide: 83,666
• Since beginning of last month:
  • Site-wide: 46,391