Author: George Davey Smith

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Preprints

Selection into shift work is influenced by educational attainment and body mass index: A Mendelian randomization study

• Downloaded 61,469 times
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  • Site-wide: 87
  • In epidemiology: 20
• Year to date:
  • Site-wide: 48,298
• Since beginning of last month:
  • Site-wide: 34,102

Collider bias undermines our understanding of COVID-19 disease risk and severity

• Downloaded 11,992 times
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  • Site-wide: 623
  • In epidemiology: 89
• Year to date:
  • Site-wide: 2,339
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  • Site-wide: 2,225

A reference panel of 64,976 haplotypes for genotype imputation

• Downloaded 4,588 times
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  • Site-wide: 2,245
  • In genetics: 82
• Year to date:
  • Site-wide: 79,874
• Since beginning of last month:
  • Site-wide: 97,228

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

• Downloaded 4,025 times
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  • Site-wide: 2,702
  • In epidemiology: 287
• Year to date:
  • Site-wide: 21,428
• Since beginning of last month:
  • Site-wide: 25,811

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

• Downloaded 3,834 times
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  • Site-wide: 2,909
  • In genetics: 113
• Year to date:
  • Site-wide: 9,258
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  • Site-wide: 9,163

PHESANT: a tool for performing automated phenome scans in UK Biobank

• Downloaded 3,473 times
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  • Site-wide: 3,358
  • In epidemiology: 331
• Year to date:
  • Site-wide: 15,534
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  • Site-wide: 12,823

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

• Downloaded 3,426 times
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  • Site-wide: 3,419
  • In epidemiology: 335
• Year to date:
  • Site-wide: 12,225
• Since beginning of last month:
  • Site-wide: 15,597

Collider Scope: When selection bias can substantially influence observed associations

• Downloaded 2,653 times
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  • Site-wide: 4,933
  • In epidemiology: 440
• Year to date:
  • Site-wide: 32,039
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  • Site-wide: 30,209

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,567 times
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  • Site-wide: 5,167
  • In genetics: 235
• Year to date:
  • Site-wide: 22,449
• Since beginning of last month:
  • Site-wide: 26,966

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,509 times
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  • Site-wide: 5,345
  • In genetics: 245
• Year to date:
  • Site-wide: 90,402
• Since beginning of last month:
  • Site-wide: 89,367

Mendelian randomization: a premature burial?

• Downloaded 2,455 times
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  • Site-wide: 5,541
  • In genetics: 257
• Year to date:
  • Site-wide: 34,412
• Since beginning of last month:
  • Site-wide: 49,273

Why are education, socioeconomic position and intelligence genetically correlated?

• Downloaded 2,435 times
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  • Site-wide: 5,609
  • In genetics: 260
• Year to date:
  • Site-wide: 45,576
• Since beginning of last month:
  • Site-wide: 53,799

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

• Downloaded 2,377 times
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  • Site-wide: 5,794
  • In genetics: 270
• Year to date:
  • Site-wide: 90,371
• Since beginning of last month:
  • Site-wide: 107,700

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

• Downloaded 2,341 times
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  • Site-wide: 5,934
  • In epidemiology: 494
• Year to date:
  • Site-wide: 86,399
• Since beginning of last month:
  • Site-wide: 129,184

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

• Downloaded 2,168 times
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  • Site-wide: 6,620
  • In genetics: 320
• Year to date:
  • Site-wide: 21,387
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  • Site-wide: 19,344

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

• Downloaded 1,930 times
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  • Site-wide: 7,873
  • In epidemiology: 613
• Year to date:
  • Site-wide: 103,413
• Since beginning of last month:
  • Site-wide: 75,400

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

• Downloaded 1,877 times
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  • Site-wide: 8,228
  • In genetics: 380
• Year to date:
  • Site-wide: 50,396
• Since beginning of last month:
  • Site-wide: 33,569

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

• Downloaded 1,856 times
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  • Site-wide: 8,364
  • In genetics: 392
• Year to date:
  • Site-wide: 57,751
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  • Site-wide: 53,623

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

• Downloaded 1,825 times
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  • Site-wide: 8,587
  • In epidemiology: 657
• Year to date:
  • Site-wide: 20,189
• Since beginning of last month:
  • Site-wide: 16,000

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

• Downloaded 1,790 times
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  • Site-wide: 8,822
  • In genetics: 416
• Year to date:
  • Site-wide: 5,826
• Since beginning of last month:
  • Site-wide: 5,686

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

• Downloaded 1,751 times
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  • Site-wide: 9,145
  • In genetics: 437
• Year to date:
  • Site-wide: 70,161
• Since beginning of last month:
  • Site-wide: 60,850

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,717 times
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  • Site-wide: 9,415
  • In genetics: 450
• Year to date:
  • Site-wide: 84,041
• Since beginning of last month:
  • Site-wide: 89,315

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,713 times
• Download rankings, all-time:
  • Site-wide: 9,445
  • In genetics: 453
• Year to date:
  • Site-wide: 75,535
• Since beginning of last month:
  • Site-wide: 80,623

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

• Downloaded 1,676 times
• Download rankings, all-time:
  • Site-wide: 9,752
  • In genetics: 465
• Year to date:
  • Site-wide: 98,354
• Since beginning of last month:
  • Site-wide: 107,619

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,622 times
• Download rankings, all-time:
  • Site-wide: 10,220
  • In genetics: 492
• Year to date:
  • Site-wide: 114,977
• Since beginning of last month:
  • Site-wide: 130,910

An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.

• Downloaded 1,547 times
• Download rankings, all-time:
  • Site-wide: 10,965
  • In epidemiology: 781
• Year to date:
  • Site-wide: 44,514
• Since beginning of last month:
  • Site-wide: 34,886

Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis

• Downloaded 1,417 times
• Download rankings, all-time:
  • Site-wide: 12,480
  • In genetics: 613
• Year to date:
  • Site-wide: 40,914
• Since beginning of last month:
  • Site-wide: 46,072

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,413 times
• Download rankings, all-time:
  • Site-wide: 12,529
  • In genetics: 616
• Year to date:
  • Site-wide: 87,649
• Since beginning of last month:
  • Site-wide: 66,731

The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank

• Downloaded 1,406 times
• Download rankings, all-time:
  • Site-wide: 12,616
  • In epidemiology: 851
• Year to date:
  • Site-wide: 69,396
• Since beginning of last month:
  • Site-wide: 78,937

Selection bias in instrumental variable analyses

• Downloaded 1,377 times
• Download rankings, all-time:
  • Site-wide: 13,021
  • In epidemiology: 875
• Year to date:
  • Site-wide: 25,917
• Since beginning of last month:
  • Site-wide: 28,057

Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes

• Downloaded 1,341 times
• Download rankings, all-time:
  • Site-wide: 13,547
  • In epidemiology: 896
• Year to date:
  • Site-wide: 103,666
• Since beginning of last month:
  • Site-wide: 95,917

The genetic architecture of osteoarthritis: insights from UK Biobank

• Downloaded 1,338 times
• Download rankings, all-time:
  • Site-wide: 13,610
  • In genetics: 663
• Year to date:
  • Site-wide: 72,149
• Since beginning of last month:
  • Site-wide: 97,088

Meffil: efficient normalisation and analysis of very large DNA methylation samples

• Downloaded 1,294 times
• Download rankings, all-time:
  • Site-wide: 14,344
  • In bioinformatics: 1,745
• Year to date:
  • Site-wide: 71,907
• Since beginning of last month:
  • Site-wide: 73,854

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

• Downloaded 1,267 times
• Download rankings, all-time:
  • Site-wide: 14,810
  • In genetics: 733
• Year to date:
  • Site-wide: 128,472
• Since beginning of last month:
  • Site-wide: 130,908

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

• Downloaded 1,215 times
• Download rankings, all-time:
  • Site-wide: 15,770
  • In epidemiology: 1,004
• Year to date:
  • Site-wide: 81,181
• Since beginning of last month:
  • Site-wide: 98,846

Multi-omics study revealing tissue-dependent putative mechanisms of SARS-CoV-2 drug targets on viral infections and complex diseases

• Downloaded 1,191 times
• Download rankings, all-time:
  • Site-wide: 16,249
  • In genetic and genomic medicine: 55
• Year to date:
  • Site-wide: 31,614
• Since beginning of last month:
  • Site-wide: 30,749

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

• Downloaded 1,179 times
• Download rankings, all-time:
  • Site-wide: 16,468
  • In genetics: 804
• Year to date:
  • Site-wide: 81,025
• Since beginning of last month:
  • Site-wide: 88,349

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

• Downloaded 1,144 times
• Download rankings, all-time:
  • Site-wide: 17,218
  • In epidemiology: 1,070
• Year to date:
  • Site-wide: 23,929
• Since beginning of last month:
  • Site-wide: 24,783

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,138 times
• Download rankings, all-time:
  • Site-wide: 17,352
  • In genetics: 849
• Year to date:
  • Site-wide: 74,527
• Since beginning of last month:
  • Site-wide: 65,644

Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

• Downloaded 1,126 times
• Download rankings, all-time:
  • Site-wide: 17,638
  • In genetics: 864
• Year to date:
  • Site-wide: 58,173
• Since beginning of last month:
  • Site-wide: 60,579

Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

• Downloaded 1,103 times
• Download rankings, all-time:
  • Site-wide: 18,178
  • In epidemiology: 1,108
• Year to date:
  • Site-wide: 75,765
• Since beginning of last month:
  • Site-wide: 66,578

Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

• Downloaded 1,061 times
• Download rankings, all-time:
  • Site-wide: 19,258
  • In pharmacology and toxicology: 104
• Year to date:
  • Site-wide: 106,155
• Since beginning of last month:
  • Site-wide: 90,437

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

• Downloaded 1,049 times
• Download rankings, all-time:
  • Site-wide: 19,586
  • In epidemiology: 1,166
• Year to date:
  • Site-wide: 46,759
• Since beginning of last month:
  • Site-wide: 33,217

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 1,045 times
• Download rankings, all-time:
  • Site-wide: 19,690
  • In genetics: 951
• Year to date:
  • Site-wide: 93,536
• Since beginning of last month:
  • Site-wide: 90,699

Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions

• Downloaded 1,035 times
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  • Site-wide: 19,967
  • In epidemiology: 1,182
• Year to date:
  • Site-wide: 75,719
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  • Site-wide: 89,729

The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

• Downloaded 1,028 times
• Download rankings, all-time:
  • Site-wide: 20,177
  • In epidemiology: 1,197
• Year to date:
  • Site-wide: 72,410
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  • Site-wide: 85,920

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 996 times
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  • Site-wide: 21,078
  • In genetics: 1,012
• Year to date:
  • Site-wide: 62,856
• Since beginning of last month:
  • Site-wide: 63,046

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

• Downloaded 990 times
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  • Site-wide: 21,261
  • In epidemiology: 1,235
• Year to date:
  • Site-wide: 69,295
• Since beginning of last month:
  • Site-wide: 72,403

Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

• Downloaded 985 times
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  • Site-wide: 21,402
  • In epidemiology: 1,240
• Year to date:
  • Site-wide: 84,009
• Since beginning of last month:
  • Site-wide: 74,778

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

• Downloaded 968 times
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  • Site-wide: 21,973
  • In epidemiology: 1,263
• Year to date:
  • Site-wide: 59,381
• Since beginning of last month:
  • Site-wide: 53,672

The causes and consequences of Alzheimer's disease: A Mendelian randomization analysis

• Downloaded 955 times
• Download rankings, all-time:
  • Site-wide: 22,386
  • In genetic and genomic medicine: 76
• Year to date:
  • Site-wide: 11,160
• Since beginning of last month:
  • Site-wide: 13,606

Can education be personalised using pupils’ genetic data?

• Downloaded 941 times
• Download rankings, all-time:
  • Site-wide: 22,918
  • In genetics: 1,108
• Year to date:
  • Site-wide: 90,221
• Since beginning of last month:
  • Site-wide: 97,199

Genetic Association Study of Childhood Aggression across raters, instruments and age

• Downloaded 916 times
• Download rankings, all-time:
  • Site-wide: 23,863
  • In genomics: 2,301
• Year to date:
  • Site-wide: 14,869
• Since beginning of last month:
  • Site-wide: 8,636

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

• Downloaded 908 times
• Download rankings, all-time:
  • Site-wide: 24,133
  • In cardiovascular medicine: 34
• Year to date:
  • Site-wide: 70,899
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  • Site-wide: 58,809

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

• Downloaded 898 times
• Download rankings, all-time:
  • Site-wide: 24,536
  • In genomics: 2,345
• Year to date:
  • Site-wide: 52,164
• Since beginning of last month:
  • Site-wide: 46,435

Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

• Downloaded 847 times
• Download rankings, all-time:
  • Site-wide: 26,647
  • In epidemiology: 1,447
• Year to date:
  • Site-wide: 119,321
• Since beginning of last month:
  • Site-wide: 116,909

Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges

• Downloaded 792 times
• Download rankings, all-time:
  • Site-wide: 29,222
  • In genetics: 1,418
• Year to date:
  • Site-wide: 124,543
• Since beginning of last month:
  • Site-wide: 107,741

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

• Downloaded 790 times
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  • Site-wide: 29,343
  • In genetics: 1,426
• Year to date:
  • Site-wide: 17,834
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  • Site-wide: 19,620

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

• Downloaded 785 times
• Download rankings, all-time:
  • Site-wide: 29,604
  • In epidemiology: 1,543
• Year to date:
  • Site-wide: 65,105
• Since beginning of last month:
  • Site-wide: 63,122

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

• Downloaded 782 times
• Download rankings, all-time:
  • Site-wide: 29,785
  • In bioinformatics: 3,408
• Year to date:
  • Site-wide: 75,550
• Since beginning of last month:
  • Site-wide: 95,862

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 781 times
• Download rankings, all-time:
  • Site-wide: 29,817
  • In genetics: 1,444
• Year to date:
  • Site-wide: 70,279
• Since beginning of last month:
  • Site-wide: 87,172

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

• Downloaded 758 times
• Download rankings, all-time:
  • Site-wide: 31,098
  • In epidemiology: 1,595
• Year to date:
  • Site-wide: 42,750
• Since beginning of last month:
  • Site-wide: 34,928

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

• Downloaded 746 times
• Download rankings, all-time:
  • Site-wide: 31,782
  • In genetics: 1,538
• Year to date:
  • Site-wide: 90,268
• Since beginning of last month:
  • Site-wide: 87,325

Examining the genetic influences of educational attainment and the validity of value-added measures of progress

• Downloaded 739 times
• Download rankings, all-time:
  • Site-wide: 32,213
  • In genetics: 1,559
• Year to date:
  • Site-wide: 118,554
• Since beginning of last month:
  • Site-wide: 112,076

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

• Downloaded 734 times
• Download rankings, all-time:
  • Site-wide: 32,564
  • In genetics: 1,577
• Year to date:
  • Site-wide: 83,301
• Since beginning of last month:
  • Site-wide: 75,181

Using genetics to examine a general liability to childhood psychopathology

• Downloaded 732 times
• Download rankings, all-time:
  • Site-wide: 32,701
  • In genetics: 1,583
• Year to date:
  • Site-wide: 80,069
• Since beginning of last month:
  • Site-wide: 104,344

Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study

• Downloaded 732 times
• Download rankings, all-time:
  • Site-wide: 32,667
  • In epidemiology: 1,643
• Year to date:
  • Site-wide: 68,858
• Since beginning of last month:
  • Site-wide: 58,449

Genetic liability for schizophrenia and childhood psychopathology in the general population

• Downloaded 715 times
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  • Site-wide: 33,620
  • In psychiatry and clinical psychology: 106
• Year to date:
  • Site-wide: 5,194
• Since beginning of last month:
  • Site-wide: 6,834

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 713 times
• Download rankings, all-time:
  • Site-wide: 33,770
  • In genetics: 1,634
• Year to date:
  • Site-wide: 120,987
• Since beginning of last month:
  • Site-wide: 110,876

Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

• Downloaded 711 times
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  • Site-wide: 33,914
  • In genomics: 2,970
• Year to date:
  • Site-wide: 19,581
• Since beginning of last month:
  • Site-wide: 18,179

Consistency of non-cognitive skills and their relation to educational outcomes in a UK cohort

• Downloaded 698 times
• Download rankings, all-time:
  • Site-wide: 34,845
  • In genetics: 1,668
• Year to date:
  • Site-wide: 29,622
• Since beginning of last month:
  • Site-wide: 26,765

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 689 times
• Download rankings, all-time:
  • Site-wide: 35,421
  • In genetic and genomic medicine: 109
• Year to date:
  • Site-wide: 9,719
• Since beginning of last month:
  • Site-wide: 10,458

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

• Downloaded 687 times
• Download rankings, all-time:
  • Site-wide: 35,567
  • In genetics: 1,703
• Year to date:
  • Site-wide: 95,306
• Since beginning of last month:
  • Site-wide: 91,327

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

• Downloaded 685 times
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  • Site-wide: 35,700
  • In neurology: 64
• Year to date:
  • Site-wide: 1,913
• Since beginning of last month:
  • Site-wide: 553

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

• Downloaded 675 times
• Download rankings, all-time:
  • Site-wide: 36,420
  • In genetics: 1,739
• Year to date:
  • Site-wide: 124,571
• Since beginning of last month:
  • Site-wide: 127,767

Detecting heterogeneity of intervention effects using analysis and meta-analysis of differences in variance between arms of a trial

• Downloaded 674 times
• Download rankings, all-time:
  • Site-wide: 36,479
  • In epidemiology: 1,783
• Year to date:
  • Site-wide: 36,667
• Since beginning of last month:
  • Site-wide: 39,263

The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

• Downloaded 670 times
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  • Site-wide: 36,801
  • In genetics: 1,754
• Year to date:
  • Site-wide: 120,370
• Since beginning of last month:
  • Site-wide: 97,048

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

• Downloaded 669 times
• Download rankings, all-time:
  • Site-wide: 36,858
  • In genetics: 1,765
• Year to date:
  • Site-wide: 97,929
• Since beginning of last month:
  • Site-wide: 89,346

Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

• Downloaded 668 times
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  • Site-wide: 36,938
  • In epidemiology: 1,800
• Year to date:
  • Site-wide: 111,962
• Since beginning of last month:
  • Site-wide: 120,762

Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits

• Downloaded 667 times
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  • Site-wide: 36,999
  • In genetics: 1,768
• Year to date:
  • Site-wide: 22,897
• Since beginning of last month:
  • Site-wide: 32,809

Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

• Downloaded 653 times
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  • Site-wide: 38,045
  • In systems biology: 867
• Year to date:
  • Site-wide: 118,880
• Since beginning of last month:
  • Site-wide: 109,043

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 652 times
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  • Site-wide: 38,135
  • In epidemiology: 1,842
• Year to date:
  • Site-wide: 122,070
• Since beginning of last month:
  • Site-wide: 129,256

Education and coronary heart disease: a Mendelian randomization study

• Downloaded 644 times
• Download rankings, all-time:
  • Site-wide: 38,751
  • In epidemiology: 1,860
• Year to date:
  • Site-wide: 121,478
• Since beginning of last month:
  • Site-wide: 120,817

Appraising the causal relevance of DNA methylation for risk of lung cancer

• Downloaded 643 times
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  • Site-wide: 38,818
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• Year to date:
  • Site-wide: 90,848
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  • Site-wide: 72,390

Genetic predictors of participation in optional components of UK Biobank

• Downloaded 640 times
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  • Site-wide: 39,023
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• Year to date:
  • Site-wide: 44,024
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  • Site-wide: 92,338

Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population

• Downloaded 639 times
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  • Site-wide: 39,130
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• Year to date:
  • Site-wide: 65,624
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  • Site-wide: 87,080

Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

• Downloaded 637 times
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  • Site-wide: 39,319
  • In epidemiology: 1,884
• Year to date:
  • Site-wide: 105,887
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  • Site-wide: 129,147

Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life

• Downloaded 634 times
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  • Site-wide: 39,508
  • In genetics: 1,881
• Year to date:
  • Site-wide: 72,535
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  • Site-wide: 81,136

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 630 times
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  • Site-wide: 39,807
  • In genomics: 3,324
• Year to date:
  • Site-wide: 94,747
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  • Site-wide: 89,179

Within-sibship GWAS improve estimates of direct genetic effects

• Downloaded 628 times
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  • Site-wide: 39,950
  • In genetics: 1,899
• Year to date:
  • Site-wide: 2,143
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  • Site-wide: 615

Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

• Downloaded 611 times
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  • Site-wide: 41,425
  • In epidemiology: 1,966
• Year to date:
  • Site-wide: 77,716
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  • Site-wide: 113,566

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 579 times
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  • Site-wide: 44,235
  • In epidemiology: 2,077
• Year to date:
  • Site-wide: 95,729
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  • Site-wide: 73,875

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

• Downloaded 576 times
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  • Site-wide: 44,503
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• Year to date:
  • Site-wide: 69,153
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  • Site-wide: 87,298

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

• Downloaded 572 times
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  • Site-wide: 44,954
  • In epidemiology: 2,093
• Year to date:
  • Site-wide: 95,968
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  • Site-wide: 109,912

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

• Downloaded 572 times
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  • Site-wide: 44,962
  • In genetics: 2,106
• Year to date:
  • Site-wide: 110,738
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  • Site-wide: 111,564

The MRC IEU OpenGWAS data infrastructure

• Downloaded 567 times
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  • Site-wide: 45,480
  • In genetics: 2,142
• Year to date:
  • Site-wide: 9,863
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  • Site-wide: 9,933

Metabolic signatures of birth weight in 18288 adolescents and adults

• Downloaded 553 times
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  • Site-wide: 46,919
  • In systems biology: 1,085
• Year to date:
  • Site-wide: 100,945
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  • Site-wide: 96,316

Cigarette smoking and personality: Investigating causality using Mendelian randomization

• Downloaded 538 times
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  • Site-wide: 48,471
  • In epidemiology: 2,205
• Year to date:
  • Site-wide: 80,550
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  • Site-wide: 62,695

Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?

• Downloaded 535 times
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  • Site-wide: 48,807
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• Year to date:
  • Site-wide: 130,568
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  • Site-wide: 129,221

Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study

• Downloaded 518 times
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  • Site-wide: 50,639
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• Year to date:
  • Site-wide: 129,075
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  • Site-wide: 109,840

The median and the mode as robust meta-analysis methods in the presence of small study effects

• Downloaded 509 times
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  • Site-wide: 51,714
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  • Site-wide: 65,099
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  • Site-wide: 46,955

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 508 times
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  • Site-wide: 51,852
  • In neuroscience: 7,652
• Year to date:
  • Site-wide: 115,263
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  • Site-wide: 130,706

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

• Downloaded 505 times
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  • Site-wide: 52,208
  • In epidemiology: 2,305
• Year to date:
  • Site-wide: 119,512
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  • Site-wide: 105,547

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood

• Downloaded 489 times
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  • Site-wide: 54,218
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• Year to date:
  • Site-wide: 41,182
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  • Site-wide: 29,866

Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

• Downloaded 486 times
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  • Site-wide: 54,588
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  • Site-wide: 52,991
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  • Site-wide: 29,154

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

• Downloaded 476 times
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  • Site-wide: 55,788
  • In genomics: 4,226
• Year to date:
  • Site-wide: 117,364
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  • Site-wide: 124,057

Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

• Downloaded 473 times
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  • Site-wide: 56,264
  • In genetics: 2,629
• Year to date:
  • Site-wide: 93,190
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  • Site-wide: 98,498

A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

• Downloaded 463 times
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  • Site-wide: 57,551
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• Year to date:
  • Site-wide: 110,751
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  • Site-wide: 107,487

The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

• Downloaded 463 times
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  • Site-wide: 57,557
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• Year to date:
  • Site-wide: 101,811
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  • Site-wide: 110,612

Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

• Downloaded 461 times
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  • Site-wide: 57,790
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  • Site-wide: 70,103
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  • Site-wide: 87,006

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

• Downloaded 457 times
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  • Site-wide: 58,391
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• Year to date:
  • Site-wide: 129,191
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  • Site-wide: 130,791

Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease

• Downloaded 456 times
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  • Site-wide: 58,488
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• Year to date:
  • Site-wide: 28,030
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  • Site-wide: 26,556

PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

• Downloaded 450 times
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  • Site-wide: 59,261
  • In epidemiology: 2,569
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  • Site-wide: 67,229
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  • Site-wide: 61,335

Is genetic liability to ADHD and ASD causally linked to educational attainment?

• Downloaded 442 times
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  • Site-wide: 60,357
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  • Site-wide: 44,292
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  • Site-wide: 49,879

Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

• Downloaded 440 times
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  • Site-wide: 60,672
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• Year to date:
  • Site-wide: 109,454
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  • Site-wide: 118,104

The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

• Downloaded 429 times
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  • Site-wide: 62,195
  • In epidemiology: 2,681
• Year to date:
  • Site-wide: 123,246
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  • Site-wide: 98,758

Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study

• Downloaded 429 times
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  • Site-wide: 62,257
  • In epidemiology: 2,683
• Year to date:
  • Site-wide: 121,721
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  • Site-wide: 106,462

CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

• Downloaded 428 times
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  • Site-wide: 62,451
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  • Site-wide: 67,430
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  • Site-wide: 46,034

Schizophrenia risk and reproductive success: A Mendelian randomization study.

• Downloaded 427 times
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  • Site-wide: 62,597
  • In evolutionary biology: 3,436
• Year to date:
  • Site-wide: 111,337
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  • Site-wide: 113,668

Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

• Downloaded 421 times
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  • Site-wide: 63,504
  • In epidemiology: 2,723
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  • Site-wide: 101,469
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  • Site-wide: 121,734

Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

• Downloaded 414 times
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  • Site-wide: 64,562
  • In epidemiology: 2,756
• Year to date:
  • Site-wide: 94,233
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  • Site-wide: 89,739

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

• Downloaded 405 times
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  • Site-wide: 65,922
  • In epidemiology: 2,821
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  • Site-wide: 120,043
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  • Site-wide: 120,757

Examining the effect of smoking on suicidal ideation and attempts: A Mendelian randomisation study

• Downloaded 405 times
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  • Site-wide: 66,046
  • In epidemiology: 2,820
• Year to date:
  • Site-wide: 78,604
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  • Site-wide: 77,163

Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation

• Downloaded 401 times
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  • Site-wide: 66,631
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  • Site-wide: 74,294
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  • Site-wide: 80,496

The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

• Downloaded 391 times
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  • Site-wide: 68,185
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  • Site-wide: 50,870
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  • Site-wide: 37,338

The association between adiposity and inpatient hospital costs in the UK Biobank cohort

• Downloaded 384 times
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  • Site-wide: 69,319
  • In epidemiology: 2,936
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  • Site-wide: 132,474
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  • Site-wide: 117,710

Identifying novel subtypes of irritability using a developmental genetic approach

• Downloaded 372 times
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  • Site-wide: 71,389
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  • Site-wide: 114,444
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  • Site-wide: 96,687

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

• Downloaded 367 times
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  • Site-wide: 72,379
  • In epidemiology: 3,036
• Year to date:
  • Site-wide: 103,364
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  • Site-wide: 96,081

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

• Downloaded 367 times
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  • Site-wide: 72,346
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• Year to date:
  • Site-wide: 104,190
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  • Site-wide: 89,281

Assortative mating and within-spouse pair comparisons

• Downloaded 367 times
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  • Site-wide: 72,320
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  • Site-wide: 62,035
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  • Site-wide: 37,476

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

• Downloaded 366 times
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  • Site-wide: 72,524
  • In epidemiology: 3,047
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  • Site-wide: 50,615
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  • Site-wide: 51,350

A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

• Downloaded 365 times
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  • Site-wide: 72,689
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  • Site-wide: 93,720
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  • Site-wide: 98,757

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

• Downloaded 363 times
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  • Site-wide: 72,978
  • In genetics: 3,330
• Year to date:
  • Site-wide: 126,132
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  • Site-wide: 121,225

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

• Downloaded 357 times
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  • Site-wide: 74,113
  • In epidemiology: 3,109
• Year to date:
  • Site-wide: 39,469
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  • Site-wide: 33,067

The Multivariate Genome-wide Architecture of Interrelated Literacy, Language and Working Memory Skills Reveals Distinct Etiologies

• Downloaded 350 times
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  • Site-wide: 75,300
  • In genetics: 3,443
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  • Site-wide: 62,498
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  • Site-wide: 69,454

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 349 times
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  • Site-wide: 75,500
  • In epidemiology: 3,161
• Year to date:
  • Site-wide: 78,016
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  • Site-wide: 67,772

Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

• Downloaded 346 times
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  • Site-wide: 76,086
  • In epidemiology: 3,181
• Year to date:
  • Site-wide: 85,432
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  • Site-wide: 50,279

Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

• Downloaded 342 times
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  • Site-wide: 76,862
  • In neurology: 178
• Year to date:
  • Site-wide: 46,234
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  • Site-wide: 43,799

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

• Downloaded 340 times
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  • Site-wide: 77,281
  • In genetics: 3,520
• Year to date:
  • Site-wide: 124,096
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  • Site-wide: 130,789

Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer.

• Downloaded 338 times
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  • Site-wide: 77,594
  • In epidemiology: 3,234
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  • Site-wide: 67,907
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  • Site-wide: 59,765

A robust mean and variance test with application to high-dimensional phenotypes

• Downloaded 330 times
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  • Site-wide: 79,173
  • In bioinformatics: 7,269
• Year to date:
  • Site-wide: 52,588
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  • Site-wide: 55,139

Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

• Downloaded 320 times
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  • Site-wide: 81,013
  • In epidemiology: 3,363
• Year to date:
  • Site-wide: 56,480
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  • Site-wide: 49,707

Estimating the causal effect of genetic liability to prevalent disease on hospital costs using Mendelian Randomization

• Downloaded 319 times
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  • Site-wide: 81,260
  • In health economics: 100
• Year to date:
  • Site-wide: 48,797
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  • Site-wide: 55,170

Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions

• Downloaded 309 times
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  • Site-wide: 83,357
  • In epidemiology: 3,436
• Year to date:
  • Site-wide: 35,257
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  • Site-wide: 42,033

Mendelian randomisation with coarsened exposures

• Downloaded 307 times
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  • Site-wide: 83,618
  • In epidemiology: 3,444
• Year to date:
  • Site-wide: 18,458
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  • Site-wide: 25,627

The relationship between open angle glaucoma, optic disc morphology and Alzheimer's Disease: a Mendelian randomization study

• Downloaded 294 times
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  • Site-wide: 86,417
  • In ophthalmology: 56
• Year to date:
  • Site-wide: 50,105
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  • Site-wide: 37,960

Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

• Downloaded 289 times
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  • Site-wide: 87,598
  • In epidemiology: 3,605
• Year to date:
  • Site-wide: 132,425
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  • Site-wide: 119,818

Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype

• Downloaded 289 times
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  • Site-wide: 87,613
  • In epidemiology: 3,603
• Year to date:
  • Site-wide: 103,859
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  • Site-wide: 118,928

Does Smoking Cause Lower Educational Attainment and General Cognitive Ability? Triangulation of causal evidence using multiple study designs

• Downloaded 281 times
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  • Site-wide: 89,196
  • In epidemiology: 3,668
• Year to date:
  • Site-wide: 104,914
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  • Site-wide: 84,296

Educational inequalities in statin treatment for preventing cardiovascular disease: cross-sectional analysis of UK Biobank

• Downloaded 271 times
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  • Site-wide: 91,388
  • In epidemiology: 3,752
• Year to date:
  • Site-wide: 66,670
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  • Site-wide: 64,327

Mendelian randomization does not support serum calcium in prostate cancer risk

• Downloaded 270 times
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  • Site-wide: 91,606
  • In epidemiology: 3,766
• Year to date:
  • Site-wide: 119,231
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  • Site-wide: 89,732

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 269 times
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  • Site-wide: 91,971
  • In genetics: 4,133
• Year to date:
  • Site-wide: 121,192
• Since beginning of last month:
  • Site-wide: 104,841

Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

• Downloaded 253 times
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  • Site-wide: 95,479
  • In genetics: 4,273
• Year to date:
  • Site-wide: 126,168
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  • Site-wide: 127,541

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis

• Downloaded 246 times
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  • Site-wide: 96,938
  • In cardiovascular medicine: 180
• Year to date:
  • Site-wide: 54,281
• Since beginning of last month:
  • Site-wide: 36,441

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

• Downloaded 245 times
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  • Site-wide: 97,098
  • In epidemiology: 3,975
• Year to date:
  • Site-wide: 32,821
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  • Site-wide: 47,416

The role of school enjoyment in the association between externalising and depressive symptoms and academic attainment: findings from a UK prospective cohort study

• Downloaded 237 times
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  • Site-wide: 99,015
  • In epidemiology: 4,061
• Year to date:
  • Site-wide: 46,085
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  • Site-wide: 39,015

Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

• Downloaded 236 times
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  • Site-wide: 99,150
  • In genetics: 4,417
• Year to date:
  • Site-wide: 122,214
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  • Site-wide: 124,589

The effect of smoking on multiple sclerosis: a mendelian randomization study

• Downloaded 235 times
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  • Site-wide: 99,322
  • In genetic and genomic medicine: 398
• Year to date:
  • Site-wide: 62,450
• Since beginning of last month:
  • Site-wide: 59,267

A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

• Downloaded 234 times
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  • Site-wide: 99,570
  • In epidemiology: 4,086
• Year to date:
  • Site-wide: 33,056
• Since beginning of last month:
  • Site-wide: 29,964

Examining the bidirectional association between emotion recognition and ASD symptoms using observational and genetic analyses

• Downloaded 225 times
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  • Site-wide: 101,547
  • In genetic and genomic medicine: 415
• Year to date:
  • Site-wide: 66,624
• Since beginning of last month:
  • Site-wide: 57,661

Association of genetic liability to smoking initiation with e-cigarette use in young adults.

• Downloaded 224 times
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  • Site-wide: 101,722
  • In epidemiology: 4,187
• Year to date:
  • Site-wide: 38,203
• Since beginning of last month:
  • Site-wide: 27,004

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

• Downloaded 224 times
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  • Site-wide: 101,663
  • In genetics: 4,520
• Year to date:
  • Site-wide: 96,104
• Since beginning of last month:
  • Site-wide: 123,635

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

• Downloaded 219 times
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  • Site-wide: 102,827
  • In epidemiology: 4,239
• Year to date:
  • Site-wide: 47,442
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  • Site-wide: 40,470

Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity

• Downloaded 219 times
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  • Site-wide: 102,834
  • In epidemiology: 4,241
• Year to date:
  • Site-wide: 49,982
• Since beginning of last month:
  • Site-wide: 32,910

Risk of death among teachers in England and Wales during the Covid19 pandemic

• Downloaded 216 times
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  • Site-wide: 103,550
  • In epidemiology: 4,274
• Year to date:
  • Site-wide: 9,923
• Since beginning of last month:
  • Site-wide: 5,279

Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank

• Downloaded 202 times
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  • Site-wide: 106,646
  • In psychiatry and clinical psychology: 425
• Year to date:
  • Site-wide: 10,868
• Since beginning of last month:
  • Site-wide: 15,375

The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

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Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study

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Interrogating structural inequalities in COVID-19 Mortality in England and Wales

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Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

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Examining the possible causal relationship between Lung Function, COPD and Alzheimers Disease. A Mendelian Randomization Study

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Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment

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Identifying intergenerational risk factors for ADHD symptoms using polygenic scores in the Norwegian Mother, Father and Child Cohort

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An Informatics Consult approach for generating clinical evidence for treatment decisions

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Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study

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Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers

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Epidemiology and Genetics of Preserved Ratio Impaired SpiroMetry (PRISm): An Analysis of UK Biobank

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Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

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Sex-specific associations of adiposity with cardiometabolic traits: multi-life-stage cohort study with repeat metabolomics

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Puberty and sex-specific trajectories of systolic blood pressure: a prospective cohort study

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Educational attainment as a modifier of the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank

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Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

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