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Author: George Davey Smith

Rankings

  • All-time downloads: 219,961 (rank: 227 )
  • Categories:
    • bioinformatics: 2,406 (rank: 5,751 (tie) )
    • cardiovascular medicine: 1,154 (rank: 339 (tie) )
    • epidemiology: 133,531 (rank: 96 )
    • evolutionary biology: 427 (rank: 14,992 (tie) )
    • genetic and genomic medicine: 3,566 (rank: 266 )
    • genetics: 69,327 (rank: 46 )
    • genomics: 3,631 (rank: 6,609 )
    • health economics: 319 (rank: 411 (tie) )
    • health informatics: 141 (rank: 2,835 (tie) )
    • neurology: 1,027 (rank: 777 )
    • neuroscience: 508 (rank: 42,599 (tie) )
    • ophthalmology: 294 (rank: 368 (tie) )
    • pharmacology and toxicology: 1,061 (rank: 1,023 (tie) )
    • psychiatry and clinical psychology: 1,071 (rank: 911 )
    • respiratory medicine: 292 (rank: 1,763 )
    • systems biology: 1,206 (rank: 3,524 (tie) )

Downloads per author, site-wide

Preprints

Selection into shift work is influenced by educational attainment and body mass index: A Mendelian randomization study

epidemiology more details view paper
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    • Site-wide: 87
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    • Site-wide: 48,298
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Collider bias undermines our understanding of COVID-19 disease risk and severity

epidemiology more details view paper
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    • Site-wide: 623
    • In epidemiology: 89
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    • Site-wide: 2,339
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    • Site-wide: 2,225

A reference panel of 64,976 haplotypes for genotype imputation

genetics more details view paper
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    • Site-wide: 2,245
    • In genetics: 82
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    • Site-wide: 97,228

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

epidemiology more details view paper
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    • Site-wide: 2,702
    • In epidemiology: 287
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    • Site-wide: 21,428
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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

genetics more details view paper
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    • Site-wide: 2,909
    • In genetics: 113
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    • Site-wide: 9,258
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    • Site-wide: 9,163

PHESANT: a tool for performing automated phenome scans in UK Biobank

epidemiology more details view paper
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    • Site-wide: 3,358
    • In epidemiology: 331
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    • Site-wide: 15,534
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Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

epidemiology more details view paper
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    • Site-wide: 3,419
    • In epidemiology: 335
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Collider Scope: When selection bias can substantially influence observed associations

epidemiology more details view paper
  • Downloaded 2,653 times
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    • Site-wide: 4,933
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Genome-wide association study identifies 48 common genetic variants associated with handedness

genetics more details view paper
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    • Site-wide: 5,167
    • In genetics: 235
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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

genetics more details view paper
  • Downloaded 2,509 times
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    • Site-wide: 5,345
    • In genetics: 245
  • Year to date:
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    • Site-wide: 89,367

Mendelian randomization: a premature burial?

genetics more details view paper
  • Downloaded 2,455 times
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    • Site-wide: 5,541
    • In genetics: 257
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    • Site-wide: 34,412
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    • Site-wide: 49,273

Why are education, socioeconomic position and intelligence genetically correlated?

genetics more details view paper
  • Downloaded 2,435 times
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    • Site-wide: 5,609
    • In genetics: 260
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    • Site-wide: 45,576
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    • Site-wide: 53,799

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

genetics more details view paper
  • Downloaded 2,377 times
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    • Site-wide: 5,794
    • In genetics: 270
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    • Site-wide: 107,700

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

epidemiology more details view paper
  • Downloaded 2,341 times
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    • Site-wide: 5,934
    • In epidemiology: 494
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    • Site-wide: 86,399
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    • Site-wide: 129,184

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

genetics more details view paper
  • Downloaded 2,168 times
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    • Site-wide: 6,620
    • In genetics: 320
  • Year to date:
    • Site-wide: 21,387
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    • Site-wide: 19,344

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 1,930 times
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    • Site-wide: 7,873
    • In epidemiology: 613
  • Year to date:
    • Site-wide: 103,413
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    • Site-wide: 75,400

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

genetics more details view paper
  • Downloaded 1,877 times
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    • Site-wide: 8,228
    • In genetics: 380
  • Year to date:
    • Site-wide: 50,396
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    • Site-wide: 33,569

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

genetics more details view paper
  • Downloaded 1,856 times
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    • Site-wide: 8,364
    • In genetics: 392
  • Year to date:
    • Site-wide: 57,751
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Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

epidemiology more details view paper
  • Downloaded 1,825 times
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    • Site-wide: 8,587
    • In epidemiology: 657
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    • Site-wide: 20,189
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    • Site-wide: 16,000

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

genetics more details view paper
  • Downloaded 1,790 times
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    • Site-wide: 8,822
    • In genetics: 416
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    • Site-wide: 5,826
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    • Site-wide: 5,686

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

genetics more details view paper
  • Downloaded 1,751 times
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    • Site-wide: 9,145
    • In genetics: 437
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    • Site-wide: 70,161
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    • Site-wide: 60,850

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

genetics more details view paper
  • Downloaded 1,717 times
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    • Site-wide: 9,415
    • In genetics: 450
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    • Site-wide: 84,041
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    • Site-wide: 89,315

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

genetics more details view paper
  • Downloaded 1,713 times
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    • Site-wide: 9,445
    • In genetics: 453
  • Year to date:
    • Site-wide: 75,535
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    • Site-wide: 80,623

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

genetics more details view paper
  • Downloaded 1,676 times
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    • Site-wide: 9,752
    • In genetics: 465
  • Year to date:
    • Site-wide: 98,354
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    • Site-wide: 107,619

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

genetics more details view paper
  • Downloaded 1,622 times
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    • Site-wide: 10,220
    • In genetics: 492
  • Year to date:
    • Site-wide: 114,977
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    • Site-wide: 130,910

An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.

epidemiology more details view paper
  • Downloaded 1,547 times
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    • Site-wide: 10,965
    • In epidemiology: 781
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    • Site-wide: 44,514
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    • Site-wide: 34,886

Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis

genetics more details view paper
  • Downloaded 1,417 times
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    • Site-wide: 12,480
    • In genetics: 613
  • Year to date:
    • Site-wide: 40,914
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    • Site-wide: 46,072

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

genetics more details view paper
  • Downloaded 1,413 times
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    • Site-wide: 12,529
    • In genetics: 616
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    • Site-wide: 87,649
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    • Site-wide: 66,731

The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank

epidemiology more details view paper
  • Downloaded 1,406 times
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    • Site-wide: 12,616
    • In epidemiology: 851
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    • Site-wide: 78,937

Selection bias in instrumental variable analyses

epidemiology more details view paper
  • Downloaded 1,377 times
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    • Site-wide: 13,021
    • In epidemiology: 875
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    • Site-wide: 25,917
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    • Site-wide: 28,057

Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes

epidemiology more details view paper
  • Downloaded 1,341 times
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    • Site-wide: 13,547
    • In epidemiology: 896
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    • Site-wide: 95,917

The genetic architecture of osteoarthritis: insights from UK Biobank

genetics more details view paper
  • Downloaded 1,338 times
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    • Site-wide: 13,610
    • In genetics: 663
  • Year to date:
    • Site-wide: 72,149
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    • Site-wide: 97,088

Meffil: efficient normalisation and analysis of very large DNA methylation samples

bioinformatics more details view paper
  • Downloaded 1,294 times
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    • Site-wide: 14,344
    • In bioinformatics: 1,745
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    • Site-wide: 71,907
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    • Site-wide: 73,854

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

genetics more details view paper
  • Downloaded 1,267 times
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    • Site-wide: 14,810
    • In genetics: 733
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    • Site-wide: 128,472
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    • Site-wide: 130,908

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

epidemiology more details view paper
  • Downloaded 1,215 times
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    • Site-wide: 15,770
    • In epidemiology: 1,004
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    • Site-wide: 81,181
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    • Site-wide: 98,846

Multi-omics study revealing tissue-dependent putative mechanisms of SARS-CoV-2 drug targets on viral infections and complex diseases

genetic and genomic medicine more details view paper
  • Downloaded 1,191 times
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    • Site-wide: 16,249
    • In genetic and genomic medicine: 55
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    • Site-wide: 31,614
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    • Site-wide: 30,749

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

genetics more details view paper
  • Downloaded 1,179 times
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    • Site-wide: 16,468
    • In genetics: 804
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    • Site-wide: 81,025
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    • Site-wide: 88,349

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

epidemiology more details view paper
  • Downloaded 1,144 times
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    • Site-wide: 17,218
    • In epidemiology: 1,070
  • Year to date:
    • Site-wide: 23,929
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    • Site-wide: 24,783

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

genetics more details view paper
  • Downloaded 1,138 times
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    • Site-wide: 17,352
    • In genetics: 849
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    • Site-wide: 74,527
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Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

genetics more details view paper
  • Downloaded 1,126 times
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    • Site-wide: 17,638
    • In genetics: 864
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    • Site-wide: 58,173
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Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

epidemiology more details view paper
  • Downloaded 1,103 times
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    • Site-wide: 18,178
    • In epidemiology: 1,108
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    • Site-wide: 75,765
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Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

pharmacology and toxicology more details view paper
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    • Site-wide: 19,258
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    • Site-wide: 106,155
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    • Site-wide: 90,437

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

epidemiology more details view paper
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    • Site-wide: 19,586
    • In epidemiology: 1,166
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    • Site-wide: 33,217

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

genetics more details view paper
  • Downloaded 1,045 times
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    • Site-wide: 19,690
    • In genetics: 951
  • Year to date:
    • Site-wide: 93,536
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    • Site-wide: 90,699

Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions

epidemiology more details view paper
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    • Site-wide: 19,967
    • In epidemiology: 1,182
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    • Site-wide: 89,729

The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

epidemiology more details view paper
  • Downloaded 1,028 times
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    • Site-wide: 20,177
    • In epidemiology: 1,197
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    • Site-wide: 72,410
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    • Site-wide: 85,920

An epigenome-wide association study of educational attainment (n = 10,767)

genetics more details view paper
  • Downloaded 996 times
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    • Site-wide: 21,078
    • In genetics: 1,012
  • Year to date:
    • Site-wide: 62,856
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    • Site-wide: 63,046

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

epidemiology more details view paper
  • Downloaded 990 times
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    • Site-wide: 21,261
    • In epidemiology: 1,235
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    • Site-wide: 69,295
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    • Site-wide: 72,403

Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

epidemiology more details view paper
  • Downloaded 985 times
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    • Site-wide: 21,402
    • In epidemiology: 1,240
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    • Site-wide: 84,009
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    • Site-wide: 74,778

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

epidemiology more details view paper
  • Downloaded 968 times
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    • Site-wide: 21,973
    • In epidemiology: 1,263
  • Year to date:
    • Site-wide: 59,381
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    • Site-wide: 53,672

The causes and consequences of Alzheimer's disease: A Mendelian randomization analysis

genetic and genomic medicine more details view paper
  • Downloaded 955 times
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    • Site-wide: 22,386
    • In genetic and genomic medicine: 76
  • Year to date:
    • Site-wide: 11,160
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    • Site-wide: 13,606

Can education be personalised using pupils’ genetic data?

genetics more details view paper
  • Downloaded 941 times
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    • Site-wide: 22,918
    • In genetics: 1,108
  • Year to date:
    • Site-wide: 90,221
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    • Site-wide: 97,199

Genetic Association Study of Childhood Aggression across raters, instruments and age

genomics more details view paper
  • Downloaded 916 times
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    • Site-wide: 23,863
    • In genomics: 2,301
  • Year to date:
    • Site-wide: 14,869
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    • Site-wide: 8,636

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

cardiovascular medicine more details view paper
  • Downloaded 908 times
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    • Site-wide: 24,133
    • In cardiovascular medicine: 34
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    • Site-wide: 70,899
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    • Site-wide: 58,809

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

genomics more details view paper
  • Downloaded 898 times
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    • Site-wide: 24,536
    • In genomics: 2,345
  • Year to date:
    • Site-wide: 52,164
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    • Site-wide: 46,435

Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

epidemiology more details view paper
  • Downloaded 847 times
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    • Site-wide: 26,647
    • In epidemiology: 1,447
  • Year to date:
    • Site-wide: 119,321
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    • Site-wide: 116,909

Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges

genetics more details view paper
  • Downloaded 792 times
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    • Site-wide: 29,222
    • In genetics: 1,418
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    • Site-wide: 124,543
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    • Site-wide: 107,741

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

genetics more details view paper
  • Downloaded 790 times
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    • Site-wide: 29,343
    • In genetics: 1,426
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    • Site-wide: 17,834
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    • Site-wide: 19,620

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

epidemiology more details view paper
  • Downloaded 785 times
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    • Site-wide: 29,604
    • In epidemiology: 1,543
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    • Site-wide: 65,105
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    • Site-wide: 63,122

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

bioinformatics more details view paper
  • Downloaded 782 times
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    • Site-wide: 29,785
    • In bioinformatics: 3,408
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    • Site-wide: 75,550
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Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

genetics more details view paper
  • Downloaded 781 times
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    • Site-wide: 29,817
    • In genetics: 1,444
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    • Site-wide: 70,279
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    • Site-wide: 87,172

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

epidemiology more details view paper
  • Downloaded 758 times
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    • Site-wide: 31,098
    • In epidemiology: 1,595
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    • Site-wide: 42,750
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    • Site-wide: 34,928

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

genetics more details view paper
  • Downloaded 746 times
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    • Site-wide: 31,782
    • In genetics: 1,538
  • Year to date:
    • Site-wide: 90,268
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    • Site-wide: 87,325

Examining the genetic influences of educational attainment and the validity of value-added measures of progress

genetics more details view paper
  • Downloaded 739 times
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    • Site-wide: 32,213
    • In genetics: 1,559
  • Year to date:
    • Site-wide: 118,554
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    • Site-wide: 112,076

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

genetics more details view paper
  • Downloaded 734 times
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    • Site-wide: 32,564
    • In genetics: 1,577
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    • Site-wide: 83,301
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    • Site-wide: 75,181

Using genetics to examine a general liability to childhood psychopathology

genetics more details view paper
  • Downloaded 732 times
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    • Site-wide: 32,701
    • In genetics: 1,583
  • Year to date:
    • Site-wide: 80,069
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    • Site-wide: 104,344

Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study

epidemiology more details view paper
  • Downloaded 732 times
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    • Site-wide: 32,667
    • In epidemiology: 1,643
  • Year to date:
    • Site-wide: 68,858
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    • Site-wide: 58,449

Genetic liability for schizophrenia and childhood psychopathology in the general population

psychiatry and clinical psychology more details view paper
  • Downloaded 715 times
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    • Site-wide: 33,620
    • In psychiatry and clinical psychology: 106
  • Year to date:
    • Site-wide: 5,194
  • Since beginning of last month:
    • Site-wide: 6,834

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

genetics more details view paper
  • Downloaded 713 times
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    • Site-wide: 33,770
    • In genetics: 1,634
  • Year to date:
    • Site-wide: 120,987
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    • Site-wide: 110,876

Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

genomics more details view paper
  • Downloaded 711 times
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    • Site-wide: 33,914
    • In genomics: 2,970
  • Year to date:
    • Site-wide: 19,581
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    • Site-wide: 18,179

Consistency of non-cognitive skills and their relation to educational outcomes in a UK cohort

genetics more details view paper
  • Downloaded 698 times
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    • Site-wide: 34,845
    • In genetics: 1,668
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Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

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Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

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Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

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Detecting heterogeneity of intervention effects using analysis and meta-analysis of differences in variance between arms of a trial

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The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

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Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

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Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

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Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits

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Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

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Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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Education and coronary heart disease: a Mendelian randomization study

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Appraising the causal relevance of DNA methylation for risk of lung cancer

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Genetic predictors of participation in optional components of UK Biobank

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Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population

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Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

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Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life

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Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

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Within-sibship GWAS improve estimates of direct genetic effects

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Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

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Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

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Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

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Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

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Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

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The MRC IEU OpenGWAS data infrastructure

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Metabolic signatures of birth weight in 18288 adolescents and adults

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Cigarette smoking and personality: Investigating causality using Mendelian randomization

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Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?

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Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study

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The median and the mode as robust meta-analysis methods in the presence of small study effects

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The Parkinsons Disease Mendelian Randomization Research Portal

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What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

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Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood

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Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

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Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

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Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

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A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

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The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

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Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

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Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

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Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease

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PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

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Is genetic liability to ADHD and ASD causally linked to educational attainment?

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Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

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The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

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Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study

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CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

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Schizophrenia risk and reproductive success: A Mendelian randomization study.

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Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

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Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

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MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

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Examining the effect of smoking on suicidal ideation and attempts: A Mendelian randomisation study

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Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation

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The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

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The association between adiposity and inpatient hospital costs in the UK Biobank cohort

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Identifying novel subtypes of irritability using a developmental genetic approach

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The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

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Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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Assortative mating and within-spouse pair comparisons

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Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

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A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

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Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

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Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

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The Multivariate Genome-wide Architecture of Interrelated Literacy, Language and Working Memory Skills Reveals Distinct Etiologies

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Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

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Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

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Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

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DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

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Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer.

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A robust mean and variance test with application to high-dimensional phenotypes

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Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

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Estimating the causal effect of genetic liability to prevalent disease on hospital costs using Mendelian Randomization

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Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions

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Mendelian randomisation with coarsened exposures

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The relationship between open angle glaucoma, optic disc morphology and Alzheimer's Disease: a Mendelian randomization study

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Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

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Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype

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Does Smoking Cause Lower Educational Attainment and General Cognitive Ability? Triangulation of causal evidence using multiple study designs

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Educational inequalities in statin treatment for preventing cardiovascular disease: cross-sectional analysis of UK Biobank

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Mendelian randomization does not support serum calcium in prostate cancer risk

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Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

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Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis

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Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

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The role of school enjoyment in the association between externalising and depressive symptoms and academic attainment: findings from a UK prospective cohort study

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Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

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The effect of smoking on multiple sclerosis: a mendelian randomization study

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A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

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Examining the bidirectional association between emotion recognition and ASD symptoms using observational and genetic analyses

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Association of genetic liability to smoking initiation with e-cigarette use in young adults.

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Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

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Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

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Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity

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Risk of death among teachers in England and Wales during the Covid19 pandemic

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Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank

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The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

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Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study

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Interrogating structural inequalities in COVID-19 Mortality in England and Wales

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Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

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Examining the possible causal relationship between Lung Function, COPD and Alzheimers Disease. A Mendelian Randomization Study

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Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment

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Identifying intergenerational risk factors for ADHD symptoms using polygenic scores in the Norwegian Mother, Father and Child Cohort

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An Informatics Consult approach for generating clinical evidence for treatment decisions

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Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study

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Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers

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Epidemiology and Genetics of Preserved Ratio Impaired SpiroMetry (PRISm): An Analysis of UK Biobank

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Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

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Sex-specific associations of adiposity with cardiometabolic traits: multi-life-stage cohort study with repeat metabolomics

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Puberty and sex-specific trajectories of systolic blood pressure: a prospective cohort study

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Educational attainment as a modifier of the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank

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Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

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