Author: George Davey Smith

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Preprints

An Informatics Consult approach for generating clinical evidence for treatment decisions

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Puberty and sex-specific trajectories of systolic blood pressure: a prospective cohort study

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Selection into shift work is influenced by educational attainment and body mass index: A Mendelian randomization study

• Downloaded 61,419 times
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  • Site-wide: 78
  • In epidemiology: 17
• Year to date:
  • Site-wide: 85,629
• Since beginning of last month:
  • Site-wide: 66

Collider bias undermines our understanding of COVID-19 disease risk and severity

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  • Site-wide: 576
  • In epidemiology: 86
• Year to date:
  • Site-wide: 2,960
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  • Site-wide: 1,594

A reference panel of 64,976 haplotypes for genotype imputation

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  • Site-wide: 1,988
  • In genetics: 80
• Year to date:
  • Site-wide: 104,423
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  • Site-wide: 60,320

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

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  • Site-wide: 2,476
  • In epidemiology: 250
• Year to date:
  • Site-wide: 39,320
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  • Site-wide: 17,504

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

• Downloaded 3,634 times
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  • Site-wide: 2,757
  • In genetics: 111
• Year to date:
  • Site-wide: 15,181
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  • Site-wide: 10,772

PHESANT: a tool for performing automated phenome scans in UK Biobank

• Downloaded 3,359 times
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  • Site-wide: 3,111
  • In epidemiology: 293
• Year to date:
  • Site-wide: 9,925
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  • Site-wide: 20,065

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

• Downloaded 3,261 times
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  • Site-wide: 3,254
  • In epidemiology: 308
• Year to date:
  • Site-wide: 22,409
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  • Site-wide: 12,203

Collider Scope: When selection bias can substantially influence observed associations

• Downloaded 2,591 times
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  • Site-wide: 4,515
  • In epidemiology: 388
• Year to date:
  • Site-wide: 21,665
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  • Site-wide: 44,825

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,489 times
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  • Site-wide: 4,780
  • In genetics: 231
• Year to date:
  • Site-wide: 91,855
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  • Site-wide: 94,842

Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 4,820
  • In genetics: 233
• Year to date:
  • Site-wide: 18,572
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  • Site-wide: 15,714

Mendelian randomization: a premature burial?

• Downloaded 2,405 times
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  • Site-wide: 5,056
  • In genetics: 241
• Year to date:
  • Site-wide: 15,387
• Since beginning of last month:
  • Site-wide: 45,203

Why are education, socioeconomic position and intelligence genetically correlated?

• Downloaded 2,385 times
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  • Site-wide: 5,112
  • In genetics: 247
• Year to date:
  • Site-wide: 67,164
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  • Site-wide: 30,561

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

• Downloaded 2,360 times
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  • Site-wide: 5,187
  • In genetics: 251
• Year to date:
  • Site-wide: 65,310
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  • Site-wide: 82,904

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

• Downloaded 2,324 times
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  • Site-wide: 5,332
  • In epidemiology: 439
• Year to date:
  • Site-wide: 52,064
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  • Site-wide: 102,253

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

• Downloaded 2,070 times
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  • Site-wide: 6,274
  • In genetics: 315
• Year to date:
  • Site-wide: 20,564
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  • Site-wide: 23,507

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

• Downloaded 1,913 times
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  • Site-wide: 7,058
  • In epidemiology: 540
• Year to date:
  • Site-wide: 107,067
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  • Site-wide: 96,123

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

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  • Site-wide: 7,527
  • In genetics: 374
• Year to date:
  • Site-wide: 97,573
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  • Site-wide: 56,103

Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

• Downloaded 1,820 times
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  • Site-wide: 7,578
  • In genetics: 376
• Year to date:
  • Site-wide: 59,191
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  • Site-wide: 80,287

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

• Downloaded 1,731 times
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  • Site-wide: 8,184
  • In epidemiology: 598
• Year to date:
  • Site-wide: 13,036
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  • Site-wide: 47,663

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

• Downloaded 1,719 times
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  • Site-wide: 8,275
  • In genetics: 417
• Year to date:
  • Site-wide: 112,282
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  • Site-wide: 71,207

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,698 times
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  • Site-wide: 8,435
  • In genetics: 425
• Year to date:
  • Site-wide: 54,587
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  • Site-wide: 59,742

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,684 times
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  • Site-wide: 8,560
  • In genetics: 435
• Year to date:
  • Site-wide: 106,575
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  • Site-wide: 63,504

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

• Downloaded 1,657 times
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  • Site-wide: 8,781
  • In genetics: 446
• Year to date:
  • Site-wide: 113,026
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  • Site-wide: 100,761

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

• Downloaded 1,619 times
• Download rankings, all-time:
  • Site-wide: 9,110
  • In genetics: 464
• Year to date:
  • Site-wide: 39,533
• Since beginning of last month:
  • Site-wide: 119,680

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

• Downloaded 1,569 times
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  • Site-wide: 9,532
  • In genetics: 488
• Year to date:
  • Site-wide: 3,378
• Since beginning of last month:
  • Site-wide: 6,402

An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.

• Downloaded 1,507 times
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  • Site-wide: 10,108
  • In epidemiology: 700
• Year to date:
  • Site-wide: 23,636
• Since beginning of last month:
  • Site-wide: 44,859

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,392 times
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  • Site-wide: 11,382
  • In genetics: 582
• Year to date:
  • Site-wide: 85,846
• Since beginning of last month:
  • Site-wide: 61,479

The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank

• Downloaded 1,384 times
• Download rankings, all-time:
  • Site-wide: 11,477
  • In epidemiology: 756
• Year to date:
  • Site-wide: 35,652
• Since beginning of last month:
  • Site-wide: 83,622

Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis

• Downloaded 1,367 times
• Download rankings, all-time:
  • Site-wide: 11,683
  • In genetics: 602
• Year to date:
  • Site-wide: 32,909
• Since beginning of last month:
  • Site-wide: 24,743

Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes

• Downloaded 1,325 times
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  • Site-wide: 12,252
  • In epidemiology: 801
• Year to date:
  • Site-wide: 99,229
• Since beginning of last month:
  • Site-wide: 68,378

Selection bias in instrumental variable analyses

• Downloaded 1,311 times
• Download rankings, all-time:
  • Site-wide: 12,447
  • In epidemiology: 813
• Year to date:
  • Site-wide: 11,935
• Since beginning of last month:
  • Site-wide: 25,722

The genetic architecture of osteoarthritis: insights from UK Biobank

• Downloaded 1,306 times
• Download rankings, all-time:
  • Site-wide: 12,519
  • In genetics: 639
• Year to date:
  • Site-wide: 119,909
• Since beginning of last month:
  • Site-wide: 58,810

Meffil: efficient normalisation and analysis of very large DNA methylation samples

• Downloaded 1,269 times
• Download rankings, all-time:
  • Site-wide: 13,072
  • In bioinformatics: 1,639
• Year to date:
  • Site-wide: 56,067
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  • Site-wide: 64,984

Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

• Downloaded 1,260 times
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  • Site-wide: 13,230
  • In genetics: 688
• Year to date:
  • Site-wide: 97,773
• Since beginning of last month:
  • Site-wide: 111,215

Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

• Downloaded 1,196 times
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  • Site-wide: 14,292
  • In epidemiology: 882
• Year to date:
  • Site-wide: 50,552
• Since beginning of last month:
  • Site-wide: 117,564

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

• Downloaded 1,159 times
• Download rankings, all-time:
  • Site-wide: 14,978
  • In genetics: 775
• Year to date:
  • Site-wide: 53,889
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  • Site-wide: 48,328

Multi-omics study revealing tissue-dependent putative mechanisms of SARS-CoV-2 drug targets on viral infections and complex diseases

• Downloaded 1,130 times
• Download rankings, all-time:
  • Site-wide: 15,545
  • In genetic and genomic medicine: 45
• Year to date:
  • Site-wide: 19,594
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  • Site-wide: 18,367

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,112 times
• Download rankings, all-time:
  • Site-wide: 15,954
  • In genetics: 823
• Year to date:
  • Site-wide: 71,841
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  • Site-wide: 69,447

Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

• Downloaded 1,101 times
• Download rankings, all-time:
  • Site-wide: 16,207
  • In genetics: 837
• Year to date:
  • Site-wide: 24,401
• Since beginning of last month:
  • Site-wide: 91,409

Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

• Downloaded 1,075 times
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  • Site-wide: 16,817
  • In epidemiology: 993
• Year to date:
  • Site-wide: 101,059
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  • Site-wide: 88,114

Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

• Downloaded 1,051 times
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  • Site-wide: 17,376
  • In pharmacology and toxicology: 98
• Year to date:
  • Site-wide: 58,635
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  • Site-wide: 99,364

Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

• Downloaded 1,050 times
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  • Site-wide: 17,409
  • In epidemiology: 1,023
• Year to date:
  • Site-wide: 31,444
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  • Site-wide: 22,590

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

• Downloaded 1,026 times
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  • Site-wide: 17,983
  • In genetics: 918
• Year to date:
  • Site-wide: 88,334
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  • Site-wide: 87,973

Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions

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  • Site-wide: 18,460
  • In epidemiology: 1,058
• Year to date:
  • Site-wide: 68,006
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  • Site-wide: 60,759

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

• Downloaded 1,007 times
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  • Site-wide: 18,540
  • In epidemiology: 1,062
• Year to date:
  • Site-wide: 32,543
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  • Site-wide: 29,892

The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

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  • Site-wide: 18,609
  • In epidemiology: 1,065
• Year to date:
  • Site-wide: 46,792
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  • Site-wide: 53,044

Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

• Downloaded 966 times
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  • Site-wide: 19,681
  • In epidemiology: 1,112
• Year to date:
  • Site-wide: 56,183
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  • Site-wide: 94,883

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 965 times
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  • Site-wide: 19,693
  • In genetics: 993
• Year to date:
  • Site-wide: 60,083
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  • Site-wide: 118,664

Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

• Downloaded 962 times
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  • Site-wide: 19,795
  • In epidemiology: 1,115
• Year to date:
  • Site-wide: 60,942
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  • Site-wide: 117,793

Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

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  • Site-wide: 20,625
  • In epidemiology: 1,142
• Year to date:
  • Site-wide: 51,604
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  • Site-wide: 82,151

Can education be personalised using pupils’ genetic data?

• Downloaded 921 times
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  • Site-wide: 21,069
  • In genetics: 1,055
• Year to date:
  • Site-wide: 91,435
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  • Site-wide: 65,370

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease

• Downloaded 884 times
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  • Site-wide: 22,392
  • In cardiovascular medicine: 31
• Year to date:
  • Site-wide: 44,020
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  • Site-wide: 91,912

Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

• Downloaded 863 times
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  • Site-wide: 23,151
  • In genomics: 2,272
• Year to date:
  • Site-wide: 32,676
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  • Site-wide: 79,457

Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

• Downloaded 834 times
• Download rankings, all-time:
  • Site-wide: 24,318
  • In epidemiology: 1,277
• Year to date:
  • Site-wide: 120,526
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  • Site-wide: 117,045

The causes and consequences of Alzheimer's disease: A Mendelian randomization analysis

• Downloaded 821 times
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  • Site-wide: 24,818
  • In genetic and genomic medicine: 68
• Year to date:
  • Site-wide: 5,402
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  • Site-wide: 24,062

Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges

• Downloaded 782 times
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  • Site-wide: 26,597
  • In genetics: 1,342
• Year to date:
  • Site-wide: 108,412
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  • Site-wide: 116,285

Genetic Association Study of Childhood Aggression across raters, instruments and age

• Downloaded 772 times
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  • Site-wide: 27,052
  • In genomics: 2,556
• Year to date:
  • Site-wide: 32,144
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  • Site-wide: 36,465

The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

• Downloaded 758 times
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  • Site-wide: 27,786
  • In epidemiology: 1,413
• Year to date:
  • Site-wide: 42,613
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  • Site-wide: 79,784

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 757 times
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  • Site-wide: 27,795
  • In genetics: 1,400
• Year to date:
  • Site-wide: 46,247
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  • Site-wide: 74,226

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

• Downloaded 757 times
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  • Site-wide: 27,832
  • In bioinformatics: 3,263
• Year to date:
  • Site-wide: 69,436
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  • Site-wide: 62,225

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

• Downloaded 728 times
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  • Site-wide: 29,333
  • In genetics: 1,474
• Year to date:
  • Site-wide: 69,142
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  • Site-wide: 99,657

Examining the genetic influences of educational attainment and the validity of value-added measures of progress

• Downloaded 727 times
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  • Site-wide: 29,382
  • In genetics: 1,476
• Year to date:
  • Site-wide: 112,259
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  • Site-wide: 110,440

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

• Downloaded 716 times
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  • Site-wide: 30,040
  • In genetics: 1,511
• Year to date:
  • Site-wide: 48,925
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  • Site-wide: 113,085

Using genetics to examine a general liability to childhood psychopathology

• Downloaded 709 times
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  • Site-wide: 30,419
  • In genetics: 1,529
• Year to date:
  • Site-wide: 75,556
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  • Site-wide: 114,377

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

• Downloaded 704 times
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  • Site-wide: 30,741
  • In epidemiology: 1,518
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  • Site-wide: 66,714
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  • Site-wide: 36,515

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 703 times
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  • Site-wide: 30,790
  • In genetics: 1,549
• Year to date:
  • Site-wide: 96,437
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  • Site-wide: 87,581

Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study

• Downloaded 702 times
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  • Site-wide: 30,824
  • In epidemiology: 1,523
• Year to date:
  • Site-wide: 76,967
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  • Site-wide: 104,418

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

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  • Site-wide: 31,595
  • In genetics: 1,586
• Year to date:
  • Site-wide: 10,977
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  • Site-wide: 4,778

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

• Downloaded 671 times
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  • Site-wide: 32,810
  • In genetics: 1,642
• Year to date:
  • Site-wide: 74,550
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  • Site-wide: 74,687

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

• Downloaded 667 times
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  • Site-wide: 33,059
  • In genetics: 1,648
• Year to date:
  • Site-wide: 93,212
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  • Site-wide: 107,778

The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

• Downloaded 658 times
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  • Site-wide: 33,649
  • In genetics: 1,676
• Year to date:
  • Site-wide: 120,373
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  • Site-wide: 108,498

Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

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  • Site-wide: 33,837
  • In epidemiology: 1,615
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  • Site-wide: 98,331
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  • Site-wide: 87,395

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

• Downloaded 652 times
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  • Site-wide: 34,055
  • In genetics: 1,696
• Year to date:
  • Site-wide: 94,772
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  • Site-wide: 103,990

Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

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  • Site-wide: 34,676
  • In systems biology: 812
• Year to date:
  • Site-wide: 76,290
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  • Site-wide: 116,265

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

• Downloaded 643 times
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  • Site-wide: 34,720
  • In epidemiology: 1,639
• Year to date:
  • Site-wide: 94,834
• Since beginning of last month:
  • Site-wide: 108,036

Education and coronary heart disease: a Mendelian randomization study

• Downloaded 634 times
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  • Site-wide: 35,340
  • In epidemiology: 1,663
• Year to date:
  • Site-wide: 100,439
• Since beginning of last month:
  • Site-wide: 99,283

Investigating the longitudinal consistency and genetic architecture of non-cognitive skills, and their relation to educational attainment

• Downloaded 625 times
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  • Site-wide: 36,023
  • In genetics: 1,790
• Year to date:
  • Site-wide: 27,740
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  • Site-wide: 46,029

Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

• Downloaded 625 times
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  • Site-wide: 36,039
  • In epidemiology: 1,694
• Year to date:
  • Site-wide: 69,212
• Since beginning of last month:
  • Site-wide: 112,010

Appraising the causal relevance of DNA methylation for risk of lung cancer

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  • Site-wide: 36,107
  • In epidemiology: 1,697
• Year to date:
  • Site-wide: 83,238
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  • Site-wide: 113,276

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 616 times
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  • Site-wide: 36,662
  • In genomics: 3,159
• Year to date:
  • Site-wide: 58,707
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  • Site-wide: 92,231

Detecting heterogeneity of intervention effects using analysis and meta-analysis of differences in variance between arms of a trial

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  • Site-wide: 36,821
  • In epidemiology: 1,719
• Year to date:
  • Site-wide: 39,156
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  • Site-wide: 31,894

Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

• Downloaded 614 times
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  • Site-wide: 36,828
  • In genomics: 3,170
• Year to date:
  • Site-wide: 13,843
• Since beginning of last month:
  • Site-wide: 40,322

Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population

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  • Site-wide: 36,969
  • In genetics: 1,824
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• Since beginning of last month:
  • Site-wide: 86,383

Early metabolic features of genetic liability to type 2 diabetes: cohort study with repeated metabolomics across early life

• Downloaded 607 times
• Download rankings, all-time:
  • Site-wide: 37,374
  • In genetics: 1,845
• Year to date:
  • Site-wide: 72,727
• Since beginning of last month:
  • Site-wide: 107,897

Genetic predictors of participation in optional components of UK Biobank

• Downloaded 593 times
• Download rankings, all-time:
  • Site-wide: 38,529
  • In genetics: 1,898
• Year to date:
  • Site-wide: 38,952
• Since beginning of last month:
  • Site-wide: 36,729

Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

• Downloaded 589 times
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  • Site-wide: 38,829
  • In epidemiology: 1,793
• Year to date:
  • Site-wide: 57,412
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  • Site-wide: 121,062

Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 39,118
  • In genetics: 1,918
• Year to date:
  • Site-wide: 13,209
• Since beginning of last month:
  • Site-wide: 44,498

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 559 times
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  • Site-wide: 41,442
  • In epidemiology: 1,900
• Year to date:
  • Site-wide: 108,935
• Since beginning of last month:
  • Site-wide: 106,529

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

• Downloaded 558 times
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  • Site-wide: 41,542
  • In genetics: 2,030
• Year to date:
  • Site-wide: 96,180
• Since beginning of last month:
  • Site-wide: 108,769

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

• Downloaded 556 times
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  • Site-wide: 41,711
  • In epidemiology: 1,912
• Year to date:
  • Site-wide: 71,449
• Since beginning of last month:
  • Site-wide: 113,522

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 546 times
• Download rankings, all-time:
  • Site-wide: 42,718
  • In genetic and genomic medicine: 114
• Year to date:
  • Site-wide: 4,341
• Since beginning of last month:
  • Site-wide: 9,512

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

• Downloaded 544 times
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  • Site-wide: 42,854
  • In genetics: 2,092
• Year to date:
  • Site-wide: 103,936
• Since beginning of last month:
  • Site-wide: 75,252

Metabolic signatures of birth weight in 18288 adolescents and adults

• Downloaded 540 times
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  • Site-wide: 43,315
  • In systems biology: 1,030
• Year to date:
  • Site-wide: 66,261
• Since beginning of last month:
  • Site-wide: 104,716

Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?

• Downloaded 529 times
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  • Site-wide: 44,362
  • In epidemiology: 1,992
• Year to date:
  • Site-wide: 101,907
• Since beginning of last month:
  • Site-wide: 116,256

Cigarette smoking and personality: Investigating causality using Mendelian randomization

• Downloaded 510 times
• Download rankings, all-time:
  • Site-wide: 46,295
  • In epidemiology: 2,052
• Year to date:
  • Site-wide: 117,185
• Since beginning of last month:
  • Site-wide: 113,668

Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study

• Downloaded 509 times
• Download rankings, all-time:
  • Site-wide: 46,388
  • In epidemiology: 2,058
• Year to date:
  • Site-wide: 120,049
• Since beginning of last month:
  • Site-wide: 120,118

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 500 times
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  • Site-wide: 47,391
  • In neuroscience: 7,061
• Year to date:
  • Site-wide: 64,090
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  • Site-wide: 106,088

What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

• Downloaded 493 times
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  • Site-wide: 48,169
  • In epidemiology: 2,113
• Year to date:
  • Site-wide: 111,274
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  • Site-wide: 99,260

The median and the mode as robust meta-analysis methods in the presence of small study effects

• Downloaded 478 times
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  • Site-wide: 49,926
  • In epidemiology: 2,149
• Year to date:
  • Site-wide: 63,576
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  • Site-wide: 77,738

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

• Downloaded 465 times
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  • Site-wide: 51,574
  • In genomics: 4,024
• Year to date:
  • Site-wide: 104,984
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  • Site-wide: 67,205

Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

• Downloaded 455 times
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  • Site-wide: 52,752
  • In genetics: 2,538
• Year to date:
  • Site-wide: 84,136
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  • Site-wide: 93,783

A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

• Downloaded 452 times
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  • Site-wide: 53,093
  • In epidemiology: 2,260
• Year to date:
  • Site-wide: 72,536
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  • Site-wide: 64,312

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

• Downloaded 452 times
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  • Site-wide: 53,089
  • In genetics: 2,549
• Year to date:
  • Site-wide: 76,316
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  • Site-wide: 107,771

The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

• Downloaded 446 times
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  • Site-wide: 53,853
  • In epidemiology: 2,289
• Year to date:
  • Site-wide: 104,759
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  • Site-wide: 116,215

Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

• Downloaded 444 times
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  • Site-wide: 54,116
  • In genetics: 2,604
• Year to date:
  • Site-wide: 73,754
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  • Site-wide: 105,969

Genetic liability for schizophrenia and childhood psychopathology in the general population

• Downloaded 440 times
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  • Site-wide: 54,722
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• Year to date:
  • Site-wide: 5,470
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  • Site-wide: 9,619

Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

• Downloaded 432 times
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  • Site-wide: 55,736
  • In epidemiology: 2,354
• Year to date:
  • Site-wide: 83,143
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  • Site-wide: 110,728

Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

• Downloaded 429 times
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  • Site-wide: 56,142
  • In epidemiology: 2,370
• Year to date:
  • Site-wide: 68,083
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  • Site-wide: 98,132

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood

• Downloaded 427 times
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  • Site-wide: 56,395
  • In epidemiology: 2,378
• Year to date:
  • Site-wide: 112,187
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  • Site-wide: 47,022

PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

• Downloaded 422 times
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  • Site-wide: 57,144
  • In epidemiology: 2,402
• Year to date:
  • Site-wide: 55,849
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  • Site-wide: 67,263

The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

• Downloaded 420 times
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  • Site-wide: 57,403
  • In epidemiology: 2,412
• Year to date:
  • Site-wide: 104,293
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  • Site-wide: 122,101

Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study

• Downloaded 418 times
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  • Site-wide: 57,706
  • In epidemiology: 2,420
• Year to date:
  • Site-wide: 114,099
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  • Site-wide: 99,963

Schizophrenia risk and reproductive success: A Mendelian randomization study.

• Downloaded 414 times
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  • Site-wide: 58,199
  • In evolutionary biology: 3,303
• Year to date:
  • Site-wide: 104,172
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  • Site-wide: 115,952

Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

• Downloaded 410 times
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  • Site-wide: 58,858
  • In epidemiology: 2,453
• Year to date:
  • Site-wide: 49,418
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  • Site-wide: 93,729

Is genetic liability to ADHD and ASD causally linked to educational attainment?

• Downloaded 396 times
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  • Site-wide: 60,975
  • In genetics: 2,907
• Year to date:
  • Site-wide: 35,672
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  • Site-wide: 43,874

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

• Downloaded 394 times
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  • Site-wide: 61,264
  • In epidemiology: 2,560
• Year to date:
  • Site-wide: 99,220
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  • Site-wide: 121,041

Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

• Downloaded 394 times
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  • Site-wide: 61,236
  • In epidemiology: 2,561
• Year to date:
  • Site-wide: 96,172
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  • Site-wide: 76,740

CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

• Downloaded 393 times
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  • Site-wide: 61,313
  • In genetics: 2,923
• Year to date:
  • Site-wide: 118,302
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  • Site-wide: 95,087

Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease

• Downloaded 391 times
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  • Site-wide: 61,564
  • In epidemiology: 2,574
• Year to date:
  • Site-wide: 14,849
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  • Site-wide: 23,987

The association between adiposity and inpatient hospital costs in the UK Biobank cohort

• Downloaded 377 times
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  • Site-wide: 63,856
  • In epidemiology: 2,648
• Year to date:
  • Site-wide: 114,636
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  • Site-wide: 93,500

Examining the effect of smoking on suicidal ideation and attempts: A Mendelian randomisation study

• Downloaded 376 times
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  • Site-wide: 63,931
  • In epidemiology: 2,650
• Year to date:
  • Site-wide: 118,502
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  • Site-wide: 74,773

The MRC IEU OpenGWAS data infrastructure

• Downloaded 375 times
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  • Site-wide: 64,173
  • In genetics: 3,047
• Year to date:
  • Site-wide: 16,738
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  • Site-wide: 13,111

Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation

• Downloaded 374 times
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  • Site-wide: 64,365
  • In epidemiology: 2,661
• Year to date:
  • Site-wide: 81,140
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  • Site-wide: 109,282

Identifying novel subtypes of irritability using a developmental genetic approach

• Downloaded 361 times
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  • Site-wide: 66,495
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• Year to date:
  • Site-wide: 85,907
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  • Site-wide: 71,187

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

• Downloaded 356 times
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  • Site-wide: 67,305
  • In genetics: 3,187
• Year to date:
  • Site-wide: 88,264
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  • Site-wide: 118,401

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

• Downloaded 353 times
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  • Site-wide: 67,834
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• Year to date:
  • Site-wide: 79,347
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  • Site-wide: 115,086

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

• Downloaded 350 times
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  • Site-wide: 68,314
  • In epidemiology: 2,803
• Year to date:
  • Site-wide: 109,493
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  • Site-wide: 104,770

The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

• Downloaded 348 times
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  • Site-wide: 68,725
  • In genetics: 3,250
• Year to date:
  • Site-wide: 55,484
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  • Site-wide: 18,480

A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

• Downloaded 346 times
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  • Site-wide: 69,022
  • In genetics: 3,261
• Year to date:
  • Site-wide: 91,133
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  • Site-wide: 102,728

Assortative mating and within-spouse pair comparisons

• Downloaded 336 times
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  • Site-wide: 70,782
  • In genetics: 3,344
• Year to date:
  • Site-wide: 53,000
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  • Site-wide: 66,963

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

• Downloaded 333 times
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  • Site-wide: 71,226
  • In genetics: 3,368
• Year to date:
  • Site-wide: 78,199
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  • Site-wide: 106,641

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

• Downloaded 327 times
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  • Site-wide: 72,317
  • In epidemiology: 2,951
• Year to date:
  • Site-wide: 37,055
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  • Site-wide: 92,046

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 326 times
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  • Site-wide: 72,440
  • In epidemiology: 2,964
• Year to date:
  • Site-wide: 60,945
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  • Site-wide: 24,460

Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

• Downloaded 321 times
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  • Site-wide: 73,403
  • In epidemiology: 2,999
• Year to date:
  • Site-wide: 114,979
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  • Site-wide: 57,855

The Multivariate Genome-wide Architecture of Interrelated Literacy, Language and Working Memory Skills Reveals Distinct Etiologies

• Downloaded 321 times
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  • Site-wide: 73,387
  • In genetics: 3,468
• Year to date:
  • Site-wide: 43,762
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  • Site-wide: 30,971

Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

• Downloaded 305 times
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  • Site-wide: 76,268
  • In neurology: 165
• Year to date:
  • Site-wide: 22,934
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  • Site-wide: 38,274

Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer.

• Downloaded 305 times
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  • Site-wide: 76,282
  • In epidemiology: 3,100
• Year to date:
  • Site-wide: 101,066
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  • Site-wide: 47,398

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

• Downloaded 301 times
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  • Site-wide: 77,070
  • In epidemiology: 3,125
• Year to date:
  • Site-wide: 40,207
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  • Site-wide: 21,038

A robust mean and variance test with application to high-dimensional phenotypes

• Downloaded 289 times
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  • Site-wide: 79,512
  • In bioinformatics: 7,305
• Year to date:
  • Site-wide: 55,281
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  • Site-wide: 66,733

Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

• Downloaded 289 times
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  • Site-wide: 79,477
  • In epidemiology: 3,225
• Year to date:
  • Site-wide: 33,379
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  • Site-wide: 91,135

Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

• Downloaded 284 times
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  • Site-wide: 80,547
  • In epidemiology: 3,254
• Year to date:
  • Site-wide: 104,389
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  • Site-wide: 102,150

Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype

• Downloaded 279 times
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  • Site-wide: 81,454
  • In epidemiology: 3,293
• Year to date:
  • Site-wide: 53,050
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  • Site-wide: 106,957

Estimating the causal effect of genetic liability to prevalent disease on hospital costs using Mendelian Randomization

• Downloaded 279 times
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  • Site-wide: 81,565
  • In health economics: 92
• Year to date:
  • Site-wide: 34,444
• Since beginning of last month:
  • Site-wide: 42,054

Does Smoking Cause Lower Educational Attainment and General Cognitive Ability? Triangulation of causal evidence using multiple study designs

• Downloaded 266 times
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  • Site-wide: 84,199
  • In epidemiology: 3,400
• Year to date:
  • Site-wide: 95,222
• Since beginning of last month:
  • Site-wide: 75,504

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 259 times
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  • Site-wide: 85,751
  • In genetics: 3,960
• Year to date:
  • Site-wide: 101,432
• Since beginning of last month:
  • Site-wide: 108,060

Mendelian randomization does not support serum calcium in prostate cancer risk

• Downloaded 259 times
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  • Site-wide: 85,698
  • In epidemiology: 3,451
• Year to date:
  • Site-wide: 99,322
• Since beginning of last month:
  • Site-wide: 118,417

The relationship between open angle glaucoma, optic disc morphology and Alzheimer's Disease: a Mendelian randomization study

• Downloaded 253 times
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  • Site-wide: 86,831
  • In ophthalmology: 61
• Year to date:
  • Site-wide: 45,449
• Since beginning of last month:
  • Site-wide: 14,167

Educational inequalities in statin treatment for preventing cardiovascular disease: cross-sectional analysis of UK Biobank

• Downloaded 250 times
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  • Site-wide: 87,522
  • In epidemiology: 3,527
• Year to date:
  • Site-wide: 28,695
• Since beginning of last month:
  • Site-wide: 28,822

Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions

• Downloaded 249 times
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  • Site-wide: 87,891
  • In epidemiology: 3,530
• Year to date:
  • Site-wide: 30,597
• Since beginning of last month:
  • Site-wide: 35,000

Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

• Downloaded 245 times
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  • Site-wide: 88,644
  • In genetics: 4,095
• Year to date:
  • Site-wide: 99,651
• Since beginning of last month:
  • Site-wide: 118,548

Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

• Downloaded 225 times
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  • Site-wide: 92,894
  • In genetics: 4,276
• Year to date:
  • Site-wide: 111,774
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  • Site-wide: 113,819

Mendelian randomisation with coarsened exposures

• Downloaded 223 times
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  • Site-wide: 93,176
  • In epidemiology: 3,732
• Year to date:
  • Site-wide: 7,178
• Since beginning of last month:
  • Site-wide: 10,057

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

• Downloaded 210 times
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  • Site-wide: 96,044
  • In genetics: 4,395
• Year to date:
  • Site-wide: 57,816
• Since beginning of last month:
  • Site-wide: 57,006

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis

• Downloaded 209 times
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  • Site-wide: 96,267
  • In cardiovascular medicine: 173
• Year to date:
  • Site-wide: 46,940
• Since beginning of last month:
  • Site-wide: 36,755

The effect of smoking on multiple sclerosis: a mendelian randomization study

• Downloaded 205 times
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  • Site-wide: 97,120
  • In genetic and genomic medicine: 349
• Year to date:
  • Site-wide: 48,289
• Since beginning of last month:
  • Site-wide: 60,529

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

• Downloaded 199 times
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  • Site-wide: 98,426
  • In epidemiology: 3,972
• Year to date:
  • Site-wide: 11,912
• Since beginning of last month:
  • Site-wide: 34,306

Examining the bidirectional association between emotion recognition and ASD symptoms using observational and genetic analyses

• Downloaded 197 times
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  • Site-wide: 98,786
  • In genetic and genomic medicine: 358
• Year to date:
  • Site-wide: 50,312
• Since beginning of last month:
  • Site-wide: 41,953

The role of school enjoyment in the association between externalising and depressive symptoms and academic attainment: findings from a UK prospective cohort study

• Downloaded 193 times
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  • Site-wide: 99,699
  • In epidemiology: 4,027
• Year to date:
  • Site-wide: 38,526
• Since beginning of last month:
  • Site-wide: 51,434

Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity

• Downloaded 176 times
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  • Site-wide: 103,180
  • In epidemiology: 4,174
• Year to date:
  • Site-wide: 49,700
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  • Site-wide: 56,265

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

• Downloaded 175 times
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  • Site-wide: 103,206
  • In epidemiology: 4,179
• Year to date:
  • Site-wide: 39,978
• Since beginning of last month:
  • Site-wide: 11,744

Association of genetic liability to smoking initiation with e-cigarette use in young adults.

• Downloaded 173 times
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  • Site-wide: 103,602
  • In epidemiology: 4,195
• Year to date:
  • Site-wide: 25,113
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  • Site-wide: 47,796

The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

• Downloaded 172 times
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  • Site-wide: 103,820
  • In epidemiology: 4,212
• Year to date:
  • Site-wide: 76,911
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  • Site-wide: 67,148

A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation

• Downloaded 164 times
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  • Site-wide: 105,547
  • In epidemiology: 4,268
• Year to date:
  • Site-wide: 45,152
• Since beginning of last month:
  • Site-wide: 23,237

Examining the possible causal relationship between Lung Function, COPD and Alzheimers Disease. A Mendelian Randomization Study

• Downloaded 138 times
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  • Site-wide: 110,295
  • In respiratory medicine: 187
• Year to date:
  • Site-wide: 59,709
• Since beginning of last month:
  • Site-wide: 61,884

Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study

• Downloaded 129 times
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  • Site-wide: 111,943
  • In epidemiology: 4,496
• Year to date:
  • Site-wide: 87,603
• Since beginning of last month:
  • Site-wide: 58,171

Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study

• Downloaded 126 times
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  • Site-wide: 112,471
  • In epidemiology: 4,520
• Year to date:
  • Site-wide: 48,596
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Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment

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Epidemiology and Genetics of Preserved Ratio Impaired SpiroMetry (PRISm): An Analysis of UK Biobank

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Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

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Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

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Sex-specific associations of adiposity with cardiometabolic traits: multi-life-stage cohort study with repeat metabolomics

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