Author: George Davey Smith

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Preprints

The use of negative control outcomes in Mendelian Randomisation to detect potential population stratification or selection bias.

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A reference panel of 64,976 haplotypes for genotype imputation

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MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

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PHESANT: a tool for performing automated phenome scans in UK Biobank

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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

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Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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Collider Scope: When selection bias can substantially influence observed associations

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Mendelian randomization: a premature burial?

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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

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Why are education, socioeconomic position and intelligence genetically correlated?

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Genome-wide association study identifies 48 common genetic variants associated with handedness

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Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

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Common genetic variants and health outcomes appear geographically structured in the UK Biobank sample: Old concerns returning and their implications.

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An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

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Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

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Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

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Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

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Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

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An examination of multivariable Mendelian randomization in the single sample and two-sample summary data settings.

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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank

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Searching for the causal effects of BMI in over 300 000 individuals, using Mendelian randomization

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Do early life non-cognitive skills matter? A systematic review and meta-analysis of early life effects on academic achievement, psychosocial, language and cognitive, and health outcomes

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The genetic architecture of osteoarthritis: insights from UK Biobank

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Causal effects of lifetime smoking on risk for depression and schizophrenia: Evidence from a Mendelian randomisation study

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Systematic Mendelian randomization framework elucidates hundreds of genetic loci which may influence disease through changes in DNA methylation levels

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Cigarette smoking increases coffee consumption: findings from a Mendelian randomisation analysis

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Meffil: efficient normalisation and analysis of very large DNA methylation samples

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Causal epigenome-wide association study identifies CpG sites that influence cardiovascular disease risk

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Selection bias in instrumental variable analyses

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Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

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Narrow-sense heritability estimation of complex traits using identity-by-descent information.

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Body mass index and mortality in UK Biobank: revised estimates using Mendelian randomization

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Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

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Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

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Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

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The effect of education on adult mortality, health, and income: triangulating across genetic and policy reforms

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Detecting and correcting for bias in Mendelian randomization analyses using gene-by-environment interactions

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Causal inference in cancer epidemiology: what is the role of Mendelian randomization?

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An epigenome-wide association study of educational attainment (n = 10,767)

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Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

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Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood

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Can education be personalised using pupils’ genetic data?

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Investigating the role of insulin in increased adiposity: Bi-directional Mendelian randomization study

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Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression

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Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals

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Mendelian randomisation for mediation analysis: current methods and challenges for implementation

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Genetic Epidemiology And Mendelian Randomization For Informing Disease Therapeutics: Conceptual And Methodological Challenges

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Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium.

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The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

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Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

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Examining the genetic influences of educational attainment and the validity of value-added measures of progress

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Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease

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Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

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MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

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Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

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Using genetics to examine a general liability to childhood psychopathology

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Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

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The molecular genetics of participation in the Avon Longitudinal Study of Parents and Children

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Orienting The Causal Relationship Between Imprecisely Measured Traits Using Genetic Instruments

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Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

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Distinct Blood DNA Methylation Profiles In Subtypes Of Orofacial Cleft

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Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

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Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

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Education and coronary heart disease: a Mendelian randomization study

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Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

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Appraising the causal relevance of DNA methylation for risk of lung cancer

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Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

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Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population

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Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

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Genetic Association Study of Childhood Aggression across raters, instruments and age

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Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

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Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer

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Metabolic signatures of birth weight in 18288 adolescents and adults

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Conditioning on a collider may induce spurious associations: Do the results of Gale et al. (2017) support a protective effect of neuroticism in population sub-groups?

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Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

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Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study

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Investigating the longitudinal consistency and genetic architecture of non-cognitive skills, and their relation to educational attainment

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Cigarette smoking and personality: Investigating causality using Mendelian randomization

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Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

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Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

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Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

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What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

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The Parkinsons Disease Mendelian Randomization Research Portal

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Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

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A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank

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Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

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The median and the mode as robust meta-analysis methods in the presence of small study effects

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Systematic evaluation of the causal relationship between DNA methylation and C-reactive protein

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The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study

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Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

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Genetic predictors of participation in optional components of UK Biobank

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Schizophrenia risk and reproductive success: A Mendelian randomization study.

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Association Between Genetically Elevated Levels Of Inflammatory Biomarkers And Risk Of Schizophrenia: A Two-Sample Mendelian Randomisation Study

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The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

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MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

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PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

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Investigating the combined association of BMI and alcohol consumption on liver disease and biomarkers: a Mendelian randomization study of over 90 000 adults from the Copenhagen General Population Study

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Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

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Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

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Epigenetic regulation of PAR4-related platelet activation: mechanistic links between environmental exposure and cardiovascular disease

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Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

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The association between adiposity and inpatient hospital costs in the UK Biobank cohort

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CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

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Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisation

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Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

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Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

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The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

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Identifying novel subtypes of irritability using a developmental genetic approach

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ADHD genetic liability and physical health outcomes - A two-sample Mendelian randomization study

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DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

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Bias in two-sample Mendelian randomization by using covariable-adjusted summary associations

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A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

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Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits

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Is genetic liability to ADHD and ASD causally linked to educational attainment?

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Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health

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Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotype

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Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

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Mendelian randomization does not support serum calcium in prostate cancer risk

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Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

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Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

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Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children

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A robust mean and variance test with application to epigenome-wide association studies

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Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

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