Author: Ole Andreassen

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • Site-wide: 982
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• Year to date:
  • Site-wide: 8,215
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  • Site-wide: 18,498

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

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  • Site-wide: 1,027
  • In genetics: 20
• Year to date:
  • Site-wide: 7,716
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  • Site-wide: 20,037

Common risk variants identified in autism spectrum disorder

• Downloaded 9,191 times
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  • Site-wide: 1,437
  • In genetics: 28
• Year to date:
  • Site-wide: 29,837
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  • Site-wide: 27,231

The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,606
  • In genetics: 35
• Year to date:
  • Site-wide: 27,418
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  • Site-wide: 41,648

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,828
  • In genetics: 41
• Year to date:
  • Site-wide: 67,939
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  • Site-wide: 51,367

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 2,729
  • In genetics: 71
• Year to date:
  • Site-wide: 31,587
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  • Site-wide: 32,863

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

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  • Site-wide: 2,927
  • In genetics: 77
• Year to date:
  • Site-wide: 91,702
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  • Site-wide: 123,413

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

• Downloaded 5,125 times
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  • Site-wide: 3,147
  • In genomics: 264
• Year to date:
  • Site-wide: 52,991
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  • Site-wide: 60,694

Greater male than female variability in regional brain structure across the lifespan

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  • Site-wide: 4,567
  • In neuroscience: 313
• Year to date:
  • Site-wide: 64,631
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  • Site-wide: 73,383

A global view of pleiotropy and genetic architecture in complex traits

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  • Site-wide: 5,051
  • In genetics: 182
• Year to date:
  • Site-wide: 9,967
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  • Site-wide: 9,695

Psychiatric Genomics: An Update and an Agenda

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  • Site-wide: 5,251
  • In genetics: 161
• Year to date:
  • Site-wide: 85,536
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  • Site-wide: 55,373

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 5,434
  • In genetics: 172
• Year to date:
  • Site-wide: 75,742
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  • Site-wide: 85,084

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

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  • Site-wide: 5,504
  • In genomics: 489
• Year to date:
  • Site-wide: 50,760
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  • Site-wide: 44,560

Genetics of brain age suggest an overlap with common brain disorders

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  • Site-wide: 6,519
  • In neuroscience: 510
• Year to date:
  • Site-wide: 57,900
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  • Site-wide: 60,297

Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 7,039
  • In genetics: 250
• Year to date:
  • Site-wide: 56,220
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  • Site-wide: 50,103

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 7,555
  • In genetics: 351
• Year to date:
  • Site-wide: 3,357
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  • Site-wide: 20,788

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

• Downloaded 2,657 times
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  • Site-wide: 8,031
  • In genetics: 339
• Year to date:
  • Site-wide: 11,416
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  • Site-wide: 43,432

Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness

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  • Site-wide: 8,984
  • In genomics: 870
• Year to date:
  • Site-wide: 24,854
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  • Site-wide: 37,691

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

• Downloaded 2,136 times
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  • Site-wide: 11,116
  • In genetics: 424
• Year to date:
  • Site-wide: 37,775
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  • Site-wide: 47,340

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 12,780
  • In genetics: 470
• Year to date:
  • Site-wide: 139,119
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  • Site-wide: 85,926

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 13,512
  • In genetics: 498
• Year to date:
  • Site-wide: 130,359
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  • Site-wide: 116,528

The correlation between central and peripheral oxytocin concentrations: a systematic review and meta-analysis

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  • Site-wide: 14,406
  • In physiology: 30
• Year to date:
  • Site-wide: 59,231
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  • Site-wide: 34,209

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,715 times
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  • Site-wide: 15,425
  • In genetics: 627
• Year to date:
  • Site-wide: 59,261
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  • Site-wide: 47,470

Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group

• Downloaded 1,697 times
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  • Site-wide: 15,674
  • In neuroscience: 1,553
• Year to date:
  • Site-wide: 82,982
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  • Site-wide: 67,382

Cerebellar grey matter volume is associated with cognitive function and psychopathology in adolescence

• Downloaded 1,618 times
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  • Site-wide: 16,868
  • In neuroscience: 1,720
• Year to date:
  • Site-wide: 73,593
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  • Site-wide: 126,413

Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis study

• Downloaded 1,609 times
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  • Site-wide: 17,027
  • In neuroscience: 1,701
• Year to date:
  • Site-wide: 106,622
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  • Site-wide: 124,137

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 17,778
  • In genomics: 1,529
• Year to date:
  • Site-wide: 119,158
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  • Site-wide: 123,271

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

• Downloaded 1,557 times
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  • Site-wide: 17,923
  • In neuroscience: 1,787
• Year to date:
  • Site-wide: 146,491
• Since beginning of last month:
  • Site-wide: 123,122

Linkage Disequilibrium and Heterozygosity Modulate the Genetic Architecture of Human Complex Phenotypes

• Downloaded 1,394 times
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  • Site-wide: 21,291
  • In genomics: 1,815
• Year to date:
  • Site-wide: 75,822
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  • Site-wide: 51,190

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

• Downloaded 1,356 times
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  • Site-wide: 22,214
  • In genetics: 867
• Year to date:
  • Site-wide: 127,992
• Since beginning of last month:
  • Site-wide: 88,312

Genetic liability for schizophrenia and childhood psychopathology in the general population

• Downloaded 1,302 times
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  • Site-wide: 23,694
  • In psychiatry and clinical psychology: 86
• Year to date:
  • Site-wide: 80,836
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  • Site-wide: 82,076

Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

• Downloaded 1,286 times
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  • Site-wide: 24,153
  • In neuroscience: 2,750
• Year to date:
  • Site-wide: 77,286
• Since beginning of last month:
  • Site-wide: 112,597

Partitioning the genetic architecture of amyotrophic lateral sclerosis

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  • Site-wide: 24,264
  • In genetics: 942
• Year to date:
  • Site-wide: 104,196
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  • Site-wide: 67,565

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

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  • Site-wide: 27,440
  • In genetics: 1,035
• Year to date:
  • Site-wide: 162,835
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  • Site-wide: 124,555

Phenotypically independent mental health symptom profiles are genetically related

• Downloaded 1,144 times
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  • Site-wide: 28,988
  • In psychiatry and clinical psychology: 124
• Year to date:
  • Site-wide: 34,741
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  • Site-wide: 12,554

Vaccination history for diphtheria and tetanus is associated with less severe COVID-19

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  • Site-wide: 31,537
  • In epidemiology: 1,725
• Year to date:
  • Site-wide: 56,692
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  • Site-wide: 77,633

A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel disease

• Downloaded 1,074 times
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  • Site-wide: 31,910
  • In genetics: 1,264
• Year to date:
  • Site-wide: 97,652
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  • Site-wide: 102,679

Personalized genetic assessment of age associated Alzheimers disease risk

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  • Site-wide: 33,089
  • In genetics: 1,258
• Year to date:
  • Site-wide: 181,234
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  • Site-wide: 151,922

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • Site-wide: 33,265
  • In genetics: 1,534
• Year to date:
  • Site-wide: 36,438
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  • Site-wide: 47,199

A genetic risk score to guide age-specific, personalized prostate cancer screening

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  • Site-wide: 33,690
  • In genetics: 1,281
• Year to date:
  • Site-wide: 186,108
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  • Site-wide: 125,588

Characterization of the genetic architecture of BMI in infancy and early childhood reveals age-specific effects and implicates pathways involved in Mendelian obesity

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  • Site-wide: 33,795
  • In genetic and genomic medicine: 308
• Year to date:
  • Site-wide: 8,645
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  • Site-wide: 8,064

Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics

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  • Site-wide: 35,236
  • In neuroscience: 4,765
• Year to date:
  • Site-wide: 47,382
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  • Site-wide: 55,540

Molecular and connectomic vulnerability shape cross-disorder cortical abnormalities

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  • Site-wide: 36,191
  • In neuroscience: 9,461
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  • Site-wide: 2,288
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  • Site-wide: 23,526

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 37,691
  • In neuroscience: 4,615
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  • Site-wide: 85,620
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  • Site-wide: 125,362

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 38,498
  • In genetics: 1,450
• Year to date:
  • Site-wide: 171,765
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  • Site-wide: 152,562

Thinner cortex is associated with psychosis onset in individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group mega-analysis

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  • Site-wide: 38,751
  • In psychiatry and clinical psychology: 160
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  • Site-wide: 46,293
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  • Site-wide: 128,333

The genetic structure of Norway

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  • Site-wide: 39,104
  • In genetics: 1,548
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  • Site-wide: 88,878
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  • Site-wide: 163,415

White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction

• Downloaded 938 times
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  • Site-wide: 39,196
  • In neuroscience: 4,854
• Year to date:
  • Site-wide: 88,698
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  • Site-wide: 134,243

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 41,645
  • In genetic and genomic medicine: 211
• Year to date:
  • Site-wide: 93,506
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  • Site-wide: 62,486

Lipid associated polygenic enrichment in Alzheimer's disease

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  • Site-wide: 42,081
  • In genetics: 1,626
• Year to date:
  • Site-wide: 114,162
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  • Site-wide: 87,073

Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

• Downloaded 892 times
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  • Site-wide: 42,203
  • In neuroscience: 5,094
• Year to date:
  • Site-wide: 134,872
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  • Site-wide: 192,064

Genome-wide association study identifies new locus associated with OCD

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  • Site-wide: 42,773
  • In psychiatry and clinical psychology: 263
• Year to date:
  • Site-wide: 9,366
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  • Site-wide: 23,271

The genetic architecture of human cortical folding

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  • Site-wide: 43,001
  • In genomics: 4,227
• Year to date:
  • Site-wide: 19,506
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  • Site-wide: 5,017

The genetic architecture of human brainstem structures and their involvement in common brain disorders

• Downloaded 843 times
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  • Site-wide: 45,950
  • In neuroscience: 5,573
• Year to date:
  • Site-wide: 139,949
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  • Site-wide: 167,000

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

• Downloaded 840 times
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  • Site-wide: 46,195
  • In genetics: 1,775
• Year to date:
  • Site-wide: 108,821
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  • Site-wide: 60,668

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

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  • Site-wide: 47,420
  • In genetics: 1,774
• Year to date:
  • Site-wide: 171,870
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  • Site-wide: 176,014

Functional connectivity directionality between large-scale resting-state networks in children and adolescence from the Healthy Brain Network sample

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  • Site-wide: 48,485
  • In radiology and imaging: 145
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  • Site-wide: 11,438
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  • Site-wide: 3,233

Probing brain developmental patterns of myelination and associations with psychopathology in youth using gray/white matter contrast

• Downloaded 798 times
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  • Site-wide: 49,920
  • In neuroscience: 6,179
• Year to date:
  • Site-wide: 134,346
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  • Site-wide: 76,081

Multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

• Downloaded 787 times
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  • Site-wide: 50,930
  • In genetics: 2,378
• Year to date:
  • Site-wide: 42,494
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  • Site-wide: 15,147

Making the MOSTest of imaging genetics

• Downloaded 786 times
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  • Site-wide: 50,971
  • In neuroscience: 6,243
• Year to date:
  • Site-wide: 148,153
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  • Site-wide: 164,805

Coordinated Cortical Thickness Alterations across Psychiatric Conditions: A Transdiagnostic ENIGMA Study

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  • Site-wide: 51,861
  • In psychiatry and clinical psychology: 345
• Year to date:
  • Site-wide: 3,376
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  • Site-wide: 39,165

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

• Downloaded 766 times
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  • Site-wide: 52,928
  • In genomics: 3,602
• Year to date:
  • Site-wide: 161,230
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  • Site-wide: 154,150

Genome-wide association analysis of the human thalamus identifies novel genomic loci and reveals genetic overlap with distinct cortical regions and ten brain disorders

• Downloaded 754 times
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  • Site-wide: 54,074
  • In genetic and genomic medicine: 258
• Year to date:
  • Site-wide: 93,631
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  • Site-wide: 94,430

Federated Multi-Site Normative Modeling using Hierarchical Bayesian Regression

• Downloaded 732 times
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  • Site-wide: 56,470
  • In bioinformatics: 6,974
• Year to date:
  • Site-wide: 17,848
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  • Site-wide: 26,401

Cortico-genetic mapping links individual brain maturity in youths to cognitive and psychiatric traits

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  • Site-wide: 57,156
  • In neuroscience: 6,970
• Year to date:
  • Site-wide: 188,202
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  • Site-wide: None

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

• Downloaded 722 times
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  • Site-wide: 57,618
  • In genomics: 4,024
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  • Site-wide: 95,584
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  • Site-wide: 83,321

Genome-Wide Association Identifies the First Risk Loci for Psychosis in Alzheimer Disease

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  • Site-wide: 57,573
  • In psychiatry and clinical psychology: 278
• Year to date:
  • Site-wide: 36,292
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  • Site-wide: 13,204

Recently evolved human-specific methylated regions are enriched in schizophrenia signals

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  • Site-wide: 58,040
  • In genomics: 3,839
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  • Site-wide: 187,077
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  • Site-wide: 187,176

How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa)

• Downloaded 715 times
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  • Site-wide: 58,434
  • In genetic and genomic medicine: 273
• Year to date:
  • Site-wide: 164,403
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  • Site-wide: 165,484

Identifying intergenerational risk factors for ADHD symptoms using polygenic scores in the Norwegian Mother, Father and Child Cohort

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  • Site-wide: 58,642
  • In psychiatry and clinical psychology: 342
• Year to date:
  • Site-wide: 18,481
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  • Site-wide: 8,233

Maturation of cortical microstructure and cognitive development in childhood and adolescence: a T1w/T2w ratio MRI study

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  • Site-wide: 58,613
  • In neuroscience: 7,591
• Year to date:
  • Site-wide: 116,507
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  • Site-wide: 178,211

Pupillary dilation responses as a midlife indicator of risk for Alzheimer's Disease: Association with Alzheimer's disease polygenic risk

• Downloaded 712 times
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  • Site-wide: 58,759
  • In genetics: 2,195
• Year to date:
  • Site-wide: 161,200
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  • Site-wide: 126,270

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction

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  • Site-wide: 59,254
  • In genetics: None
• Year to date:
  • Site-wide: 3,916
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  • Site-wide: 21,728

Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms

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  • Site-wide: 60,071
  • In psychiatry and clinical psychology: 469
• Year to date:
  • Site-wide: 11,993
• Since beginning of last month:
  • Site-wide: 3,081

Immune-related genetic enrichment in frontotemporal dementia

• Downloaded 696 times
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  • Site-wide: 60,724
  • In genetics: 2,225
• Year to date:
  • Site-wide: 157,900
• Since beginning of last month:
  • Site-wide: 153,014

Polygenic hazard scores in preclinical Alzheimer's disease

• Downloaded 688 times
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  • Site-wide: 61,682
  • In genetics: 2,259
• Year to date:
  • Site-wide: 184,651
• Since beginning of last month:
  • Site-wide: 152,980

Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment

• Downloaded 662 times
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  • Site-wide: 65,033
  • In genomics: 4,232
• Year to date:
  • Site-wide: 116,129
• Since beginning of last month:
  • Site-wide: 153,264

Sex-dependent polygenic effects on the clinical progressions of Alzheimer's disease

• Downloaded 653 times
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  • Site-wide: 66,200
  • In genetics: 2,425
• Year to date:
  • Site-wide: 186,241
• Since beginning of last month:
  • Site-wide: 186,046

Improved prediction of schizophrenia by leveraging genetic overlap with brain morphology

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  • Site-wide: 66,430
  • In psychiatry and clinical psychology: 260
• Year to date:
  • Site-wide: 67,400
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  • Site-wide: 83,480

Deep neural networks learn general and clinically relevant representations of the ageingbrain

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  • Site-wide: 66,918
  • In neurology: 303
• Year to date:
  • Site-wide: 12,771
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  • Site-wide: 91,310

Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study

• Downloaded 635 times
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  • Site-wide: 68,742
  • In neuroscience: 8,983
• Year to date:
  • Site-wide: 138,595
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  • Site-wide: 103,261

Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

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  • Site-wide: 69,087
  • In neurology: None
• Year to date:
  • Site-wide: 4,638
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  • Site-wide: 7,686

FEMA: Fast and efficient mixed-effects algorithm for population-scale whole brain imaging data

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  • Site-wide: 70,104
  • In neuroscience: 22,301
• Year to date:
  • Site-wide: 6,997
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  • Site-wide: 29,140

Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder

• Downloaded 622 times
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  • Site-wide: 70,709
  • In psychiatry and clinical psychology: 269
• Year to date:
  • Site-wide: 105,490
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  • Site-wide: 93,814

All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors

• Downloaded 614 times
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  • Site-wide: 71,873
  • In neuroscience: 9,823
• Year to date:
  • Site-wide: 94,757
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  • Site-wide: 103,432

Population-based neuroimaging reveals traces of childbirth in the maternal brain

• Downloaded 608 times
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  • Site-wide: 72,730
  • In neuroscience: 9,373
• Year to date:
  • Site-wide: 161,839
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  • Site-wide: 186,966

The dark side of the mean: brain structural heterogeneity in schizophrenia and its polygenic risk.

• Downloaded 606 times
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  • Site-wide: 73,132
  • In neuroscience: 9,355
• Year to date:
  • Site-wide: 178,649
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  • Site-wide: 174,191

Genetic overlap between multivariate measures of human functional brain connectivity and psychiatric disorders

• Downloaded 600 times
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  • Site-wide: 73,987
  • In genetic and genomic medicine: 412
• Year to date:
  • Site-wide: 29,128
• Since beginning of last month:
  • Site-wide: 30,212

Cardiometabolic risk factors associated with brain age and accelerate brain ageing

• Downloaded 594 times
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  • Site-wide: 74,918
  • In neurology: 326
• Year to date:
  • Site-wide: 37,213
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  • Site-wide: 15,483

Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammation

• Downloaded 592 times
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  • Site-wide: 75,212
  • In genetics: 3,350
• Year to date:
  • Site-wide: 22,284
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  • Site-wide: 34,844

Association between schizophrenia polygenic score and psychotic symptoms in Alzheimer disease: meta-analysis of 11 cohort studies

• Downloaded 587 times
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  • Site-wide: 76,025
  • In genomics: 4,723
• Year to date:
  • Site-wide: 145,570
• Since beginning of last month:
  • Site-wide: 176,099

Genetic control of variability in subcortical and intracranial volumes

• Downloaded 587 times
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  • Site-wide: 76,002
  • In neuroscience: 9,784
• Year to date:
  • Site-wide: 179,407
• Since beginning of last month:
  • Site-wide: 180,406

Multilevel neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

• Downloaded 585 times
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  • Site-wide: 76,377
  • In neuroscience: 14,268
• Year to date:
  • Site-wide: 22,152
• Since beginning of last month:
  • Site-wide: 69,831

Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults

• Downloaded 569 times
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  • Site-wide: 79,054
  • In neurology: 377
• Year to date:
  • Site-wide: 29,299
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  • Site-wide: 8,817

Differences in directed functional brain connectivity related to age, sex and mental health

• Downloaded 565 times
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  • Site-wide: 79,826
  • In neuroscience: 10,419
• Year to date:
  • Site-wide: 155,775
• Since beginning of last month:
  • Site-wide: 167,155

Characterization of Age and Polarity at Onset in Bipolar Disorder

• Downloaded 546 times
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  • Site-wide: 83,188
  • In psychiatry and clinical psychology: 478
• Year to date:
  • Site-wide: 31,240
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  • Site-wide: 8,598

Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition

• Downloaded 542 times
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  • Site-wide: 83,902
  • In genetics: 3,102
• Year to date:
  • Site-wide: 165,809
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  • Site-wide: 121,225

Annotation-Informed Causal Mixture Modeling (AI-MiXeR) reveals phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories

• Downloaded 520 times
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  • Site-wide: 88,258
  • In genetics: 3,348
• Year to date:
  • Site-wide: 115,118
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  • Site-wide: 135,230

Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories

• Downloaded 513 times
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  • Site-wide: 89,706
  • In neuroscience: 11,714
• Year to date:
  • Site-wide: 170,930
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  • Site-wide: 170,491

Heritable cognitive and psychopathology factors in youth are predicted by brain fronto-temporal white matter pathway

• Downloaded 491 times
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  • Site-wide: 93,946
  • In neuroscience: 12,251
• Year to date:
  • Site-wide: 189,739
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  • Site-wide: 121,481

Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry

• Downloaded 489 times
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  • Site-wide: 94,545
  • In neuroscience: 12,421
• Year to date:
  • Site-wide: 178,532
• Since beginning of last month:
  • Site-wide: 185,000

Differences in the presentation and progression of Parkinson's disease by sex

• Downloaded 478 times
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  • Site-wide: 97,032
  • In neurology: 322
• Year to date:
  • Site-wide: 117,000
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  • Site-wide: 132,745

Analysis of differentially methylated regions in primates and non-primates provides support for the evolutionary hypothesis of schizophrenia

• Downloaded 469 times
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  • Site-wide: 99,002
  • In genomics: 5,586
• Year to date:
  • Site-wide: 169,827
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  • Site-wide: 186,127

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 466 times
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  • Site-wide: 99,687
  • In genetics: 3,630
• Year to date:
  • Site-wide: 178,703
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  • Site-wide: 175,626

Prenatal smoking, alcohol and caffeine exposure and maternal reported ADHD symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses

• Downloaded 454 times
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  • Site-wide: 102,460
  • In epidemiology: 5,474
• Year to date:
  • Site-wide: 30,523
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  • Site-wide: 12,094

Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders

• Downloaded 446 times
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  • Site-wide: 104,476
  • In radiology and imaging: 187
• Year to date:
  • Site-wide: 122,502
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  • Site-wide: 96,765

A genetic hazard score to personalize prostate cancer screening, applied to population data

• Downloaded 445 times
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  • Site-wide: 104,667
  • In genetics: 3,770
• Year to date:
  • Site-wide: 188,994
• Since beginning of last month:
  • Site-wide: 185,931

Sex differences in the relationship between social difficulties and executive dysfunction in children and adolescents with autism spectrum disorder

• Downloaded 445 times
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  • Site-wide: 104,649
  • In neuroscience: 14,139
• Year to date:
  • Site-wide: 154,220
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  • Site-wide: 179,472

Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area

• Downloaded 424 times
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  • Site-wide: 109,681
  • In neuroscience: 14,499
• Year to date:
  • Site-wide: 189,522
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  • Site-wide: 142,640

CXCR4 involvement in neurodegenerative diseases

• Downloaded 419 times
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  • Site-wide: 110,755
  • In genetics: 3,931
• Year to date:
  • Site-wide: 194,977
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  • Site-wide: 185,393

Cross-sectional and longitudinal brain scans reveal accelerated brain aging in multiple sclerosis

• Downloaded 395 times
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  • Site-wide: 116,867
  • In neuroscience: 15,637
• Year to date:
  • Site-wide: 171,585
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  • Site-wide: 174,701

Population-based body-brain mapping links brain morphology and body composition

• Downloaded 395 times
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  • Site-wide: 116,956
  • In neuroscience: 15,933
• Year to date:
  • Site-wide: 156,561
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  • Site-wide: 140,572

Spatial frequency discrimination in patients with schizophrenia spectrum and bipolar disorders: Evidence of early visual processing deficits and associations with intellectual abilities

• Downloaded 382 times
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  • Site-wide: 120,454
  • In psychiatry and clinical psychology: 609
• Year to date:
  • Site-wide: 44,944
• Since beginning of last month:
  • Site-wide: 38,128

A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia

• Downloaded 370 times
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  • Site-wide: 123,836
  • In neuroscience: 16,730
• Year to date:
  • Site-wide: 173,756
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  • Site-wide: 189,460

Genome-wide association analysis reveals extensive genetic overlap between mood instability and psychiatric disorders but divergent patterns of genetic effects

• Downloaded 347 times
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  • Site-wide: 130,237
  • In psychiatry and clinical psychology: 872
• Year to date:
  • Site-wide: 35,126
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  • Site-wide: 30,556

Genetic overlap between Alzheimer's disease and depression mapped onto the brain

• Downloaded 345 times
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  • Site-wide: 130,805
  • In genetic and genomic medicine: 755
• Year to date:
  • Site-wide: 132,198
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  • Site-wide: 80,147

Sparse Deep Neural Networks on Imaging Genetics for Schizophrenia Case-Control Classification

• Downloaded 344 times
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  • Site-wide: 131,120
  • In psychiatry and clinical psychology: 578
• Year to date:
  • Site-wide: 183,151
• Since beginning of last month:
  • Site-wide: 192,237

Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents

• Downloaded 343 times
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  • Site-wide: 131,391
  • In neuroscience: 17,735
• Year to date:
  • Site-wide: 177,741
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  • Site-wide: 132,904

Maternal and offspring genetic risk score (GRS) analyses of fetal alcohol exposure and ADHD risk in offspring

• Downloaded 341 times
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  • Site-wide: 131,858
  • In epidemiology: 6,611
• Year to date:
  • Site-wide: 34,209
• Since beginning of last month:
  • Site-wide: 8,201

Experience-dependent modulation of the visual evoked potential: testing effect sizes, retention over time, and associations with age in 415 healthy individuals

• Downloaded 338 times
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  • Site-wide: 132,822
  • In neuroscience: 17,773
• Year to date:
  • Site-wide: 185,915
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  • Site-wide: 164,891

Impact of second-generation antipsychotics on white matter microstructure in adolescent-onset psychosis

• Downloaded 334 times
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  • Site-wide: 133,930
  • In neuroscience: 18,577
• Year to date:
  • Site-wide: 138,306
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  • Site-wide: 149,458

Evidence for a moderating effect of drinking severity but not HIV status on brain age in heavy episodic drinkers

• Downloaded 325 times
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  • Site-wide: 136,597
  • In hiv aids: 208
• Year to date:
  • Site-wide: 29,591
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  • Site-wide: 8,163

Birth Order Differences in Education Originate in Post-Natal Environments

• Downloaded 323 times
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  • Site-wide: 137,219
  • In genetics: 5,312
• Year to date:
  • Site-wide: 59,480
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  • Site-wide: 79,381

Brain age estimation is a sensitive marker of processing speed in the early course of multiple sclerosis

• Downloaded 322 times
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  • Site-wide: 137,517
  • In neuroscience: 19,148
• Year to date:
  • Site-wide: 146,049
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  • Site-wide: 146,942

Generalization of Cortical MOSTest Genome-Wide Associations Within and Across Samples

• Downloaded 314 times
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  • Site-wide: 139,775
  • In genomics: 7,408
• Year to date:
  • Site-wide: 77,003
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  • Site-wide: 78,271

The role of liver fat in cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

• Downloaded 290 times
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  • Site-wide: 147,030
  • In genomics: None
• Year to date:
  • Site-wide: 16,652
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  • Site-wide: 48,097

Age dependence of modern clinical risk groups for localized prostate cancer — a population-based study

• Downloaded 289 times
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  • Site-wide: 147,187
  • In epidemiology: 5,662
• Year to date:
  • Site-wide: 162,409
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  • Site-wide: 177,730

Genetic architecture of creativity and extensive genetic overlap with psychiatric disorders revealed from genome-wide association analyses of 241,736 individuals

• Downloaded 284 times
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  • Site-wide: 148,720
  • In genomics: None
• Year to date:
  • Site-wide: 17,248
• Since beginning of last month:
  • Site-wide: 755

The effect of sample size on polygenic hazard models for prostate cancer

• Downloaded 281 times
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  • Site-wide: 149,363
  • In genetics: 5,283
• Year to date:
  • Site-wide: 189,931
• Since beginning of last month:
  • Site-wide: 152,704

White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging

• Downloaded 278 times
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  • Site-wide: 150,233
  • In neuroscience: 20,323
• Year to date:
  • Site-wide: 190,043
• Since beginning of last month:
  • Site-wide: 174,063

In vivo amygdala nuclei volumes in schizophrenia and bipolar disorders

• Downloaded 274 times
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  • Site-wide: 151,527
  • In psychiatry and clinical psychology: 756
• Year to date:
  • Site-wide: 152,357
• Since beginning of last month:
  • Site-wide: 156,280

Genetic effects on the timing of parturition and links to fetal birth weight

• Downloaded 273 times
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  • Site-wide: 151,929
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 18,430
• Since beginning of last month:
  • Site-wide: 39,499

Acute COVID-19 severity and 16-month mental morbidity trajectories in patient populations of six nations

• Downloaded 259 times
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  • Site-wide: 155,895
  • In public and global health: 2,251
• Year to date:
  • Site-wide: 40,242
• Since beginning of last month:
  • Site-wide: 109,544

Genome-wide determinants of mortality and clinical progression in Parkinson's disease

• Downloaded 257 times
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  • Site-wide: 156,593
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 20,430
• Since beginning of last month:
  • Site-wide: 876

Gut Microbiota Markers for Antipsychotics Induced Metabolic Disturbance in Drug Naive Patients with First Episode Schizophrenia _ A 24 Weeks Follow-up Study

• Downloaded 255 times
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  • Site-wide: 157,088
  • In psychiatry and clinical psychology: 877
• Year to date:
  • Site-wide: 97,406
• Since beginning of last month:
  • Site-wide: 91,195

Distributed genetic architecture across the hippocampal formation implies common neuropathology across major brain disorders

• Downloaded 252 times
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  • Site-wide: 157,895
  • In genetic and genomic medicine: 1,008
• Year to date:
  • Site-wide: 76,289
• Since beginning of last month:
  • Site-wide: 90,335

Prostate cancer risk stratification improved across multiple ancestries with new polygenic hazard score

• Downloaded 251 times
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  • Site-wide: 158,077
  • In genetic and genomic medicine: 957
• Year to date:
  • Site-wide: 95,925
• Since beginning of last month:
  • Site-wide: 127,885

Additional SNPs improve the performance of a polygenic hazard score for prostate cancer

• Downloaded 247 times
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  • Site-wide: 159,108
  • In genetic and genomic medicine: 953
• Year to date:
  • Site-wide: 152,576
• Since beginning of last month:
  • Site-wide: 133,011

Interplay between the Genetics of Personality Traits, severe Psychiatric Disorders, and COVID-19 Host Genetics in the Susceptibility to SARS-CoV-2 Infection

• Downloaded 245 times
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  • Site-wide: 159,691
  • In genetic and genomic medicine: 998
• Year to date:
  • Site-wide: 109,912
• Since beginning of last month:
  • Site-wide: 90,633

Evidence for reduced long-term potentiation-like visual cortical plasticity in schizophrenia and bipolar disorder

• Downloaded 242 times
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  • Site-wide: 160,629
  • In neuroscience: 22,173
• Year to date:
  • Site-wide: 155,915
• Since beginning of last month:
  • Site-wide: 190,234

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

• Downloaded 239 times
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  • Site-wide: 161,399
  • In genetic and genomic medicine: 959
• Year to date:
  • Site-wide: 152,336
• Since beginning of last month:
  • Site-wide: 103,901

Polygenic resilience scores capture protective genetic effects for Alzheimers disease

• Downloaded 237 times
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  • Site-wide: 162,137
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 23,070
• Since beginning of last month:
  • Site-wide: 28,131

Cannabis use is associated with increased levels of soluble gp130 in schizophrenia but not in bipolar disorder

• Downloaded 235 times
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  • Site-wide: 162,626
  • In pharmacology and toxicology: 1,209
• Year to date:
  • Site-wide: 155,950
• Since beginning of last month:
  • Site-wide: 190,061

Genetic and phenotypic associations between brain imaging, psychopathology and educational attainment in children aged 9-11

• Downloaded 231 times
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  • Site-wide: 163,740
  • In psychiatry and clinical psychology: 1,109
• Year to date:
  • Site-wide: 23,904
• Since beginning of last month:
  • Site-wide: 99,419

Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

• Downloaded 221 times
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  • Site-wide: 166,385
  • In neuroscience: None
• Year to date:
  • Site-wide: 25,486
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  • Site-wide: 53,482

Multimodal monitoring of human cortical organoids implanted in mice using transparent graphene microelectrodes reveal functional connection between organoid and mouse visual cortex

• Downloaded 208 times
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  • Site-wide: 169,529
  • In neuroscience: None
• Year to date:
  • Site-wide: 27,638
• Since beginning of last month:
  • Site-wide: 25,114

Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

• Downloaded 200 times
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  • Site-wide: 171,642
  • In genetics: None
• Year to date:
  • Site-wide: 29,390
• Since beginning of last month:
  • Site-wide: 40,911

The Genetic Architecture of Amygdala Nuclei

• Downloaded 194 times
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  • Site-wide: 172,979
  • In genetic and genomic medicine: 1,160
• Year to date:
  • Site-wide: 90,520
• Since beginning of last month:
  • Site-wide: 63,059

Challenges at the APOE locus: A robust quality control approach for accurate APOE genotyping

• Downloaded 194 times
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  • Site-wide: 172,972
  • In neurology: 993
• Year to date:
  • Site-wide: 93,656
• Since beginning of last month:
  • Site-wide: 188,139

The relationship of maternal gestational mass spectrometry-derived metabolites with offspring congenital heart disease: results from multivariable and Mendelian randomization analyses

• Downloaded 187 times
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  • Site-wide: 174,740
  • In epidemiology: 7,193
• Year to date:
  • Site-wide: 32,143
• Since beginning of last month:
  • Site-wide: 144,902

Functional characterisation of single nucleotide variants of the psychiatric risk gene cacna1c in the zebrafish

• Downloaded 186 times
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  • Site-wide: 174,947
  • In neuroscience: 24,655
• Year to date:
  • Site-wide: 77,804
• Since beginning of last month:
  • Site-wide: 108,333

Childhood temperamental, emotional, and behavioral predictors of clinical mood and anxiety disorders in adolescence

• Downloaded 180 times
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  • Site-wide: 176,202
  • In psychiatry and clinical psychology: None
• Year to date:
  • Site-wide: 34,110
• Since beginning of last month:
  • Site-wide: 68,702

The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomization study

• Downloaded 170 times
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  • Site-wide: 178,538
  • In epidemiology: 7,200
• Year to date:
  • Site-wide: 37,111
• Since beginning of last month:
  • Site-wide: 47,734

Smoking and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study

• Downloaded 165 times
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  • Site-wide: 179,512
  • In sexual and reproductive health: 112
• Year to date:
  • Site-wide: 102,276
• Since beginning of last month:
  • Site-wide: 109,358

In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis via the ENIGMA Consortium.

• Downloaded 162 times
• Download rankings, all-time:
  • Site-wide: 180,155
  • In psychiatry and clinical psychology: 1,200
• Year to date:
  • Site-wide: 39,588
• Since beginning of last month:
  • Site-wide: 53,850

The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1

• Downloaded 153 times
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  • Site-wide: 181,970
  • In genetics: None
• Year to date:
  • Site-wide: 42,785
• Since beginning of last month:
  • Site-wide: 8,473

Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings

• Downloaded 144 times
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  • Site-wide: 183,684
  • In addiction medicine: None
• Year to date:
  • Site-wide: 46,214
• Since beginning of last month:
  • Site-wide: 42,035

Health behaviours prior to pregnancy and fertility outcomes: Triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)

• Downloaded 75 times
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  • Site-wide: 193,430
  • In epidemiology: None
• Year to date:
  • Site-wide: 81,360
• Since beginning of last month:
  • Site-wide: 81,288

Bounding the average causal effect in Mendelian randomization studies with multiple proposed instruments: An application to prenatal alcohol exposure and attention deficit hyperactivity disorder

• Downloaded 70 times
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  • Site-wide: 193,971
  • In epidemiology: None
• Year to date:
  • Site-wide: 85,021
• Since beginning of last month:
  • Site-wide: 74,828

Shared genetic architecture between mental health and the brain functional connectome in the UK Biobank

• Downloaded 58 times
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  • Site-wide: 195,024
  • In genetic and genomic medicine: None
• Year to date:
  • Site-wide: 98,000
• Since beginning of last month:
  • Site-wide: 28,044