Author: Jian Yang

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Preprints

Recovery of trait heritability from whole genome sequence data

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  • Site-wide: 655
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• Year to date:
  • Site-wide: 2,287
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  • Site-wide: 2,386

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

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  • Site-wide: 724
  • In genetics: 20
• Year to date:
  • Site-wide: 3,360
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  • Site-wide: 3,846

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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  • Site-wide: 807
  • In genomics: 63
• Year to date:
  • Site-wide: 1,365
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  • Site-wide: 1,351

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,392 times
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  • Site-wide: 870
  • In genetics: 26
• Year to date:
  • Site-wide: 31,379
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  • Site-wide: 33,428

Genetic Consequences of Social Stratification in Great Britain

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  • Site-wide: 1,114
  • In genetics: 35
• Year to date:
  • Site-wide: 9,753
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  • Site-wide: 9,169

LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

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  • Site-wide: 1,231
  • In genomics: 115
• Year to date:
  • Site-wide: 69,137
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  • Site-wide: 71,869

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

• Downloaded 6,620 times
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  • Site-wide: 1,351
  • In genetics: 46
• Year to date:
  • Site-wide: 18,234
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  • Site-wide: 14,676

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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  • Site-wide: 3,262
  • In genetics: 126
• Year to date:
  • Site-wide: 30,789
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  • Site-wide: 29,047

Human Naïve Epiblast Cells Possess Unrestricted Lineage Potential

• Downloaded 3,490 times
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  • Site-wide: 3,339
  • In developmental biology: 29
• Year to date:
  • Site-wide: 1,638
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  • Site-wide: 1,384

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

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  • Site-wide: 3,475
  • In bioinformatics: 355
• Year to date:
  • Site-wide: 57,677
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  • Site-wide: 56,910

Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • Site-wide: 3,983
  • In genetics: 169
• Year to date:
  • Site-wide: 81,380
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  • Site-wide: 74,883

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

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  • Site-wide: 4,217
  • In genetics: 183
• Year to date:
  • Site-wide: 24,315
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  • Site-wide: 16,523

A resource-efficient tool for mixed model association analysis of large-scale data

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  • Site-wide: 4,593
  • In genetics: 202
• Year to date:
  • Site-wide: 11,029
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  • Site-wide: 7,333

Improved polygenic prediction by Bayesian multiple regression on summary statistics

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  • Site-wide: 4,621
  • In genetics: 204
• Year to date:
  • Site-wide: 66,953
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  • Site-wide: 74,354

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.

• Downloaded 2,631 times
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  • Site-wide: 4,980
  • In genetics: 224
• Year to date:
  • Site-wide: 83,672
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  • Site-wide: 89,337

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 6,003
  • In genetics: 281
• Year to date:
  • Site-wide: 6,426
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  • Site-wide: 6,629

Widespread signatures of negative selection in the genetic architecture of human complex traits

• Downloaded 2,240 times
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  • Site-wide: 6,332
  • In genetics: 302
• Year to date:
  • Site-wide: 51,625
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  • Site-wide: 33,140

GWAS on family history of Alzheimer's disease

• Downloaded 1,990 times
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  • Site-wide: 7,521
  • In genetics: 353
• Year to date:
  • Site-wide: 63,035
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  • Site-wide: 49,226

Causal associations between risk factors and common diseases inferred from GWAS summary data

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  • Site-wide: 8,947
  • In genetics: 427
• Year to date:
  • Site-wide: 93,235
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  • Site-wide: 97,091

Establishment In Culture Of Expanded Potential Stem Cells

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  • Site-wide: 9,432
  • In developmental biology: 128
• Year to date:
  • Site-wide: 67,000
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  • Site-wide: 61,634

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,713 times
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  • Site-wide: 9,445
  • In genetics: 453
• Year to date:
  • Site-wide: 75,535
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  • Site-wide: 80,623

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,613 times
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  • Site-wide: 10,299
  • In genetics: 497
• Year to date:
  • Site-wide: 54,446
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  • Site-wide: 45,825

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

• Downloaded 1,501 times
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  • Site-wide: 11,406
  • In genetics: 546
• Year to date:
  • Site-wide: 41,510
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  • Site-wide: 45,748

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

• Downloaded 1,497 times
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  • Site-wide: 11,449
  • In genetics: 552
• Year to date:
  • Site-wide: 17,494
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  • Site-wide: 20,737

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,475 times
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  • Site-wide: 11,714
  • In genetics: 569
• Year to date:
  • Site-wide: 80,258
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  • Site-wide: 79,422

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

• Downloaded 1,429 times
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  • Site-wide: 12,304
  • In genetics: 605
• Year to date:
  • Site-wide: 38,201
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  • Site-wide: 45,338

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

• Downloaded 1,418 times
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  • Site-wide: 12,464
  • In genetics: 612
• Year to date:
  • Site-wide: 105,400
• Since beginning of last month:
  • Site-wide: 89,377

Expectation of the intercept from bivariate LD score regression in the presence of population stratification

• Downloaded 1,332 times
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  • Site-wide: 13,693
  • In genetics: 669
• Year to date:
  • Site-wide: 18,768
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  • Site-wide: 18,106

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

• Downloaded 1,322 times
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  • Site-wide: 13,894
  • In genetics: 676
• Year to date:
  • Site-wide: 23,687
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  • Site-wide: 19,321

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

• Downloaded 1,311 times
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  • Site-wide: 14,057
  • In bioinformatics: 1,715
• Year to date:
  • Site-wide: 57,686
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  • Site-wide: 57,013

Imprint of Assortative Mating on the Human Genome

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  • Site-wide: 14,611
  • In genetics: 726
• Year to date:
  • Site-wide: 120,673
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  • Site-wide: 127,703

Organizing Pneumonia of COVID-19: Time-dependent Evolution and Outcome in CT Findings

• Downloaded 1,231 times
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  • Site-wide: 15,467
  • In radiology and imaging: 31
• Year to date:
  • Site-wide: 51,009
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  • Site-wide: 55,005

Subtle stratification confounds estimates of heritability from rare variants

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  • Site-wide: 16,884
  • In genetics: 827
• Year to date:
  • Site-wide: 74,491
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  • Site-wide: 65,858

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,138 times
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  • Site-wide: 17,352
  • In genetics: 849
• Year to date:
  • Site-wide: 74,527
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  • Site-wide: 65,644

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 1,114 times
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  • Site-wide: 17,907
  • In bioinformatics: 2,149
• Year to date:
  • Site-wide: 111,044
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  • Site-wide: 111,245

A comprehensive evaluation of polygenic score methods across cohorts in psychiatric disorders

• Downloaded 1,085 times
• Download rankings, all-time:
  • Site-wide: 18,657
  • In genetic and genomic medicine: 62
• Year to date:
  • Site-wide: 4,819
• Since beginning of last month:
  • Site-wide: 4,718

Efficient estimation and applications of cross-validated genetic predictions

• Downloaded 1,060 times
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  • Site-wide: 19,299
  • In genetics: 937
• Year to date:
  • Site-wide: 35,899
• Since beginning of last month:
  • Site-wide: 33,172

Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 19,628
  • In genomics: 1,975
• Year to date:
  • Site-wide: 86,204
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  • Site-wide: 80,794

Efficient RNA-mediated reprogramming of human somatic cells to naive pluripotency facilitated by tankyrase inhibition

• Downloaded 996 times
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  • Site-wide: 21,085
  • In developmental biology: 378
• Year to date:
  • Site-wide: 36,548
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  • Site-wide: 38,784

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

• Downloaded 872 times
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  • Site-wide: 25,568
  • In genetics: 1,232
• Year to date:
  • Site-wide: 93,144
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  • Site-wide: 62,198

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 797 times
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  • Site-wide: 28,976
  • In genetics: 1,403
• Year to date:
  • Site-wide: 95,574
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  • Site-wide: 79,614

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

• Downloaded 757 times
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  • Site-wide: 31,184
  • In genetics: 1,503
• Year to date:
  • Site-wide: 96,791
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  • Site-wide: 77,171

Quantifying genetic heterogeneity between continental populations for human height and body mass index

• Downloaded 741 times
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  • Site-wide: 32,079
  • In genetics: 1,550
• Year to date:
  • Site-wide: 59,824
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  • Site-wide: 68,668

Genome-wide analyses of behavioural traits biased by misreports and longitudinal changes

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  • Site-wide: 33,784
  • In genetic and genomic medicine: 106
• Year to date:
  • Site-wide: 37,746
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  • Site-wide: 83,202

Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors

• Downloaded 685 times
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  • Site-wide: 35,697
  • In genetics: 1,706
• Year to date:
  • Site-wide: 28,173
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  • Site-wide: 24,343

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

• Downloaded 651 times
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  • Site-wide: 38,181
  • In genetics: 1,818
• Year to date:
  • Site-wide: 123,445
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  • Site-wide: 111,861

The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for human complex diseases

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  • Site-wide: 39,160
  • In microbiology: 2,366
• Year to date:
  • Site-wide: 73,571
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  • Site-wide: 68,989

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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  • Site-wide: 44,121
  • In genetics: 2,067
• Year to date:
  • Site-wide: 106,652
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  • Site-wide: 106,792

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

• Downloaded 574 times
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  • Site-wide: 44,723
  • In genetics: 2,094
• Year to date:
  • Site-wide: 112,241
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  • Site-wide: 87,053

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

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  • Site-wide: 44,904
  • In genetics: 2,108
• Year to date:
  • Site-wide: 13,186
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  • Site-wide: 10,922

Xist Intron 1 Repression by TALE Transcriptional Factor Improves Somatic Cell Reprogamming in Mice

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  • Site-wide: 47,924
  • In developmental biology: 1,124
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  • Site-wide: 83,785
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  • Site-wide: 105,376

Genetic analyses of medication-use and implications for precision medicine

• Downloaded 542 times
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  • Site-wide: 48,030
  • In genetics: 2,255
• Year to date:
  • Site-wide: 61,309
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  • Site-wide: 61,920

The effect of X-linked dosage compensation on complex trait variation

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  • Site-wide: 49,332
  • In genetics: 2,304
• Year to date:
  • Site-wide: 123,941
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  • Site-wide: 90,865

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 508 times
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  • Site-wide: 51,852
  • In neuroscience: 7,652
• Year to date:
  • Site-wide: 115,263
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  • Site-wide: 130,706

Evolution in Sinocyclocheilus cavefish is marked by rate shifts, reversals and origin of novel traits

• Downloaded 491 times
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  • Site-wide: 53,902
  • In evolutionary biology: 2,928
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  • Site-wide: 55,268
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  • Site-wide: 58,479

Towards the identification of causal genes for age-related macular degeneration

• Downloaded 463 times
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  • Site-wide: 57,504
  • In genetics: 2,676
• Year to date:
  • Site-wide: 89,300
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  • Site-wide: 114,735

A pattern categorization of CT findings to predict outcome of COVID-19 pneumonia

• Downloaded 438 times
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  • Site-wide: 61,004
  • In infectious diseases: 2,914
• Year to date:
  • Site-wide: 73,417
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  • Site-wide: 69,805

Exploring morphological motifs for a single neuron based on multiple 3D reconstructions

• Downloaded 420 times
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  • Site-wide: 63,627
  • In bioinformatics: 6,230
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  • Site-wide: 74,895
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  • Site-wide: 43,289

Synthesis-Free PET Imaging Of Brown Adipose Tissue And TSPO Via Combination Of Disulfiram And 64CuCl2

• Downloaded 411 times
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  • Site-wide: 64,973
  • In pharmacology and toxicology: 399
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  • Site-wide: 104,161
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  • Site-wide: 90,436

DAZL is a master translational regulator of murine spermatogenesis

• Downloaded 408 times
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  • Site-wide: 65,485
  • In developmental biology: 1,663
• Year to date:
  • Site-wide: 72,504
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  • Site-wide: 78,361

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

• Downloaded 363 times
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  • Site-wide: 72,978
  • In genetics: 3,330
• Year to date:
  • Site-wide: 126,132
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  • Site-wide: 121,225

Differences of clinical and imaging findings in multiple generations of secondary COVID-19 infection in Xi'an, China

• Downloaded 275 times
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  • Site-wide: 90,520
  • In radiology and imaging: 148
• Year to date:
  • Site-wide: 116,688
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  • Site-wide: 102,149

The role of glycaemic, lipid, blood pressure and obesity risk factors as mediators of the effect of height on Coronary Artery Disease and Type 2 Diabetes Mellitus: A Mendelian Randomisation Study.

• Downloaded 274 times
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  • Site-wide: 90,759
  • In genetics: 4,095
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  • Site-wide: 128,301
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  • Site-wide: 114,381

Efficacy and Acceptability Comparisons of Cognitive Behavior Therapy, Drugs, and Their Combination for Panic Disorder in Adults: a Network Meta-analysis

• Downloaded 246 times
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  • Site-wide: 97,012
  • In psychiatry and clinical psychology: 363
• Year to date:
  • Site-wide: 73,878
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  • Site-wide: 58,548

A parsimonious model for mass-univariate vertex-wise analysis

• Downloaded 240 times
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  • Site-wide: 98,198
  • In neuroscience: 15,263
• Year to date:
  • Site-wide: 8,566
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  • Site-wide: 14,964

Cross-Species Integration of Transcriptomic Effects of Tobacco and Nicotine Exposure Helps to Prioritize Genetic Effects on Human Tobacco Consumption

• Downloaded 186 times
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  • Site-wide: 110,312
  • In genetics: 4,810
• Year to date:
  • Site-wide: 116,342
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  • Site-wide: 115,348

Characterization and expression QTL analysis of TaABI4, a pre-harvest sprouting related gene in wheat

• Downloaded 157 times
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  • Site-wide: 116,410
  • In genetics: 5,015
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  • Site-wide: 56,434
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  • Site-wide: 83,712

Circuit-free, optoelectronic sensing of electrodermal activities based on photon recycling of a micro-LED

• Downloaded 138 times
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  • Site-wide: 120,212
  • In bioengineering: 2,403
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  • Site-wide: 91,900
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  • Site-wide: 116,091

Once delayed non-invasive remote ischemic preconditioning protects against early stroke by modulating  neuroinflammatory responses in rats

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  • Site-wide: 132,160
  • In neuroscience: 20,211
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