Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 62,736 bioRxiv papers from 278,376 authors.

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • In genetics: 13 out of 3,562
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  • Site-wide: 9,175 out of 62,736

Recovery of trait heritability from whole genome sequence data

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  • In genetics: 19 out of 3,562
• Year to date:
  • Site-wide: 28 out of 62,736
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  • Site-wide: 385 out of 62,736

LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

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  • Site-wide: 220 out of 62,736
  • In genomics: 64 out of 4,316
• Year to date:
  • Site-wide: 33,285 out of 62,736
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  • Site-wide: 29,864 out of 62,736

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

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  • Site-wide: 239 out of 62,736
  • In genetics: 26 out of 3,562
• Year to date:
  • Site-wide: 92 out of 62,736
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  • Site-wide: 160 out of 62,736

Genetic Consequences of Social Stratification in Great Britain

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  • In genetics: 31 out of 3,562
• Year to date:
  • Site-wide: 720 out of 62,736
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  • Site-wide: 2,828 out of 62,736

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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  • Site-wide: 330 out of 62,736
  • In genomics: 87 out of 4,316
• Year to date:
  • Site-wide: 139 out of 62,736
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  • Site-wide: 290 out of 62,736

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

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  • Site-wide: 337 out of 62,736
  • In genetics: 42 out of 3,562
• Year to date:
  • Site-wide: 672 out of 62,736
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  • Site-wide: 2,816 out of 62,736

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

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  • Site-wide: 960 out of 62,736
  • In bioinformatics: 195 out of 6,251
• Year to date:
  • Site-wide: 24,669 out of 62,736
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  • Site-wide: 33,131 out of 62,736

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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  • In genetics: 96 out of 3,562
• Year to date:
  • Site-wide: 1,109 out of 62,736
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  • Site-wide: 13,598 out of 62,736

Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • Site-wide: 1,148 out of 62,736
  • In genetics: 105 out of 3,562
• Year to date:
  • Site-wide: 35,962 out of 62,736
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  • Site-wide: 34,018 out of 62,736

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

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  • In genetics: 145 out of 3,562
• Year to date:
  • Site-wide: 28,033 out of 62,736
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  • Site-wide: 31,143 out of 62,736

Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.

• Downloaded 2,382 times
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  • In genetics: 159 out of 3,562
• Year to date:
  • Site-wide: 22,467 out of 62,736
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  • Site-wide: 39,470 out of 62,736

Improved polygenic prediction by Bayesian multiple regression on summary statistics

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  • Site-wide: 2,112 out of 62,736
  • In genetics: 205 out of 3,562
• Year to date:
  • Site-wide: 373 out of 62,736
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  • Site-wide: 684 out of 62,736

Widespread signatures of negative selection in the genetic architecture of human complex traits

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  • Site-wide: 2,138 out of 62,736
  • In genetics: 208 out of 3,562
• Year to date:
  • Site-wide: 35,908 out of 62,736
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  • Site-wide: 37,895 out of 62,736

GWAS on family history of Alzheimer's disease

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  • Site-wide: 2,832 out of 62,736
  • In genetics: 253 out of 3,562
• Year to date:
  • Site-wide: 17,676 out of 62,736
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  • Site-wide: 28,247 out of 62,736

Causal associations between risk factors and common diseases inferred from GWAS summary data

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  • Site-wide: 3,318 out of 62,736
  • In genetics: 292 out of 3,562
• Year to date:
  • Site-wide: 39,985 out of 62,736
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  • Site-wide: 46,469 out of 62,736

Establishment In Culture Of Expanded Potential Stem Cells

• Downloaded 1,415 times
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  • Site-wide: 4,020 out of 62,736
  • In developmental biology: 71 out of 1,871
• Year to date:
  • Site-wide: 30,240 out of 62,736
• Since beginning of last month:
  • Site-wide: 21,439 out of 62,736

A resource-efficient tool for mixed model association analysis of large-scale data

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  • Site-wide: 4,391 out of 62,736
  • In genetics: 370 out of 3,562
• Year to date:
  • Site-wide: 866 out of 62,736
• Since beginning of last month:
  • Site-wide: 442 out of 62,736

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

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  • Site-wide: 4,471 out of 62,736
  • In genetics: 374 out of 3,562
• Year to date:
  • Site-wide: 54,097 out of 62,736
• Since beginning of last month:
  • Site-wide: 55,699 out of 62,736

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,204 times
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  • Site-wide: 5,218 out of 62,736
  • In genetics: 425 out of 3,562
• Year to date:
  • Site-wide: 10,016 out of 62,736
• Since beginning of last month:
  • Site-wide: 26,669 out of 62,736

Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

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  • Site-wide: 5,697 out of 62,736
  • In neuroscience: 885 out of 11,207
• Year to date:
  • Site-wide: 4,268 out of 62,736
• Since beginning of last month:
  • Site-wide: 17,243 out of 62,736

Imprint of Assortative Mating on the Human Genome

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  • In genetics: 495 out of 3,562
• Year to date:
  • Site-wide: 12,084 out of 62,736
• Since beginning of last month:
  • Site-wide: 25,852 out of 62,736

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

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  • Site-wide: 6,680 out of 62,736
  • In genetics: 538 out of 3,562
• Year to date:
  • Site-wide: 1,388 out of 62,736
• Since beginning of last month:
  • Site-wide: 6,831 out of 62,736

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

• Downloaded 974 times
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  • Site-wide: 7,373 out of 62,736
  • In bioinformatics: 1,333 out of 6,251
• Year to date:
  • Site-wide: 7,359 out of 62,736
• Since beginning of last month:
  • Site-wide: 29,820 out of 62,736

Subtle stratification confounds estimates of heritability from rare variants

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  • Site-wide: 7,668 out of 62,736
  • In genetics: 595 out of 3,562
• Year to date:
  • Site-wide: 37,151 out of 62,736
• Since beginning of last month:
  • Site-wide: 27,605 out of 62,736

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 947 times
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  • Site-wide: 7,714 out of 62,736
  • In bioinformatics: 1,372 out of 6,251
• Year to date:
  • Site-wide: 3,771 out of 62,736
• Since beginning of last month:
  • Site-wide: 23,151 out of 62,736

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 887 times
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  • Site-wide: 8,583 out of 62,736
  • In genetics: 641 out of 3,562
• Year to date:
  • Site-wide: 15,825 out of 62,736
• Since beginning of last month:
  • Site-wide: 30,043 out of 62,736

Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 8,879 out of 62,736
  • In genomics: 1,353 out of 4,316
• Year to date:
  • Site-wide: 31,923 out of 62,736
• Since beginning of last month:
  • Site-wide: 40,607 out of 62,736

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 808 times
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  • Site-wide: 9,897 out of 62,736
  • In genetics: 729 out of 3,562
• Year to date:
  • Site-wide: 2,138 out of 62,736
• Since beginning of last month:
  • Site-wide: 2,931 out of 62,736

Expectation of the intercept from bivariate LD score regression in the presence of population stratification

• Downloaded 769 times
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  • Site-wide: 10,630 out of 62,736
  • In genetics: 767 out of 3,562
• Year to date:
  • Site-wide: 10,834 out of 62,736
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  • Site-wide: 8,749 out of 62,736

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

• Downloaded 671 times
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  • Site-wide: 12,971 out of 62,736
  • In genetics: 915 out of 3,562
• Year to date:
  • Site-wide: 17,271 out of 62,736
• Since beginning of last month:
  • Site-wide: 27,298 out of 62,736

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 668 times
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  • Site-wide: 13,049 out of 62,736
  • In genetics: 920 out of 3,562
• Year to date:
  • Site-wide: 29,098 out of 62,736
• Since beginning of last month:
  • Site-wide: 35,886 out of 62,736

Efficient estimation and applications of cross-validated genetic predictions

• Downloaded 576 times
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  • Site-wide: 15,988 out of 62,736
  • In genetics: 1,095 out of 3,562
• Year to date:
  • Site-wide: 3,857 out of 62,736
• Since beginning of last month:
  • Site-wide: 6,405 out of 62,736

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

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  • Site-wide: 16,576 out of 62,736
  • In genetics: 1,130 out of 3,562
• Year to date:
  • Site-wide: 54,554 out of 62,736
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  • Site-wide: 59,826 out of 62,736

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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  • Site-wide: 20,369 out of 62,736
  • In genetics: 1,365 out of 3,562
• Year to date:
  • Site-wide: 58,842 out of 62,736
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  • Site-wide: 60,607 out of 62,736

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • In genetics: 1,402 out of 3,562
• Year to date:
  • Site-wide: 5,544 out of 62,736
• Since beginning of last month:
  • Site-wide: 6,755 out of 62,736

Widespread associations between grey matter structure and the human phenome

• Downloaded 434 times
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  • Site-wide: 22,690 out of 62,736
  • In neuroscience: 3,811 out of 11,207
• Year to date:
  • Site-wide: 6,202 out of 62,736
• Since beginning of last month:
  • Site-wide: 7,442 out of 62,736

Xist Intron 1 Repression by TALE Transcriptional Factor Improves Somatic Cell Reprogamming in Mice

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  • Site-wide: 23,418 out of 62,736
  • In developmental biology: 619 out of 1,871
• Year to date:
  • Site-wide: 50,149 out of 62,736
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  • Site-wide: 54,245 out of 62,736

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

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  • Site-wide: 23,521 out of 62,736
  • In genetics: 1,557 out of 3,562
• Year to date:
  • Site-wide: 6,517 out of 62,736
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  • Site-wide: 251 out of 62,736

The effect of X-linked dosage compensation on complex trait variation

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  • In genetics: 1,643 out of 3,562
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  • Site-wide: 24,411 out of 62,736
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  • Site-wide: 44,079 out of 62,736

Efficient RNA-mediated reprogramming of human somatic cells to naive pluripotency facilitated by tankyrase inhibition

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  • Site-wide: 26,805 out of 62,736
  • In developmental biology: 741 out of 1,871
• Year to date:
  • Site-wide: 7,993 out of 62,736
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  • Site-wide: 6,701 out of 62,736

Genetic analyses of medication-use and implications for precision medicine

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  • In genetics: 1,837 out of 3,562
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  • Site-wide: 16,588 out of 62,736
• Since beginning of last month:
  • Site-wide: 34,976 out of 62,736

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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  • Site-wide: 30,645 out of 62,736
  • In genetics: 1,951 out of 3,562
• Year to date:
  • Site-wide: 9,990 out of 62,736
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  • Site-wide: 42,707 out of 62,736

Synthesis-Free PET Imaging Of Brown Adipose Tissue And TSPO Via Combination Of Disulfiram And 64CuCl2

• Downloaded 299 times
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  • Site-wide: 32,971 out of 62,736
  • In pharmacology and toxicology: 170 out of 526
• Year to date:
  • Site-wide: 55,592 out of 62,736
• Since beginning of last month:
  • Site-wide: 45,840 out of 62,736

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 275 times
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  • Site-wide: 35,358 out of 62,736
  • In neuroscience: 6,117 out of 11,207
• Year to date:
  • Site-wide: 12,937 out of 62,736
• Since beginning of last month:
  • Site-wide: 14,965 out of 62,736

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

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  • Site-wide: 35,921 out of 62,736
  • In genetics: 2,244 out of 3,562
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  • Site-wide: 54,841 out of 62,736
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  • Site-wide: 56,573 out of 62,736

Exploring morphological motifs for a single neuron based on multiple 3D reconstructions

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  • Site-wide: 36,460 out of 62,736
  • In bioinformatics: 4,467 out of 6,251
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  • Site-wide: 43,014 out of 62,736
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  • Site-wide: 28,691 out of 62,736

DAZL is a master translational regulator of murine spermatogenesis

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  • Site-wide: 40,355 out of 62,736
  • In developmental biology: 1,222 out of 1,871
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  • Site-wide: 30,863 out of 62,736
• Since beginning of last month:
  • Site-wide: 38,449 out of 62,736

The role of glycaemic, lipid, blood pressure and obesity risk factors as mediators of the effect of height on Coronary Artery Disease and Type 2 Diabetes Mellitus: A Mendelian Randomisation Study.

• Downloaded 164 times
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  • Site-wide: 48,652 out of 62,736
  • In genetics: 2,892 out of 3,562
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  • Site-wide: 55,261 out of 62,736

Towards the identification of causal genes for age-related macular degeneration

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  • In genetics: 2,968 out of 3,562
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  • Site-wide: 1,673 out of 62,736