Author: Caroline Hayward

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Preprints

Genetic insights into the biological mechanisms governing human ovarian ageing

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Genetic mechanisms of critical illness in Covid-19

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  • Site-wide: 756
  • In intensive care and critical care medicine: 7
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  • Site-wide: 405
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  • Site-wide: 115

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 761
  • In genetics: 24
• Year to date:
  • Site-wide: 29,390
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  • Site-wide: 23,263

Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics

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  • Site-wide: 1,532
  • In infectious diseases: 370
• Year to date:
  • Site-wide: 6,880
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  • Site-wide: 7,800

A time-resolved proteomic and diagnostic map characterizes COVID-19 disease progression and predicts outcome

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  • Site-wide: 1,540
  • In infectious diseases: 372
• Year to date:
  • Site-wide: 1,025
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  • Site-wide: 37

Genomic analysis of family data reveals additional genetic effects on intelligence and personality

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  • Site-wide: 2,284
  • In genetics: 94
• Year to date:
  • Site-wide: 33,543
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  • Site-wide: 39,236

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 3,327
  • In genetics: 148
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  • Site-wide: 44,183

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,581
  • In genetics: 164
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  • Site-wide: 27,626
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  • Site-wide: 42,014

Genetic analysis identifies molecular systems and biological pathways associated with household income

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  • Site-wide: 4,234
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• Year to date:
  • Site-wide: 63,252
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  • Site-wide: 24,742

Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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  • Site-wide: 4,789
  • In genomics: 580
• Year to date:
  • Site-wide: 82,358
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  • Site-wide: 112,652

Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 4,820
  • In genetics: 233
• Year to date:
  • Site-wide: 18,572
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  • Site-wide: 15,714

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 6,235
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• Year to date:
  • Site-wide: 8,218
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  • Site-wide: 7,503

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

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  • Site-wide: 6,490
  • In genetics: 328
• Year to date:
  • Site-wide: 117,670
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  • Site-wide: 83,167

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 7,461
  • In genetics: 370
• Year to date:
  • Site-wide: 27,085
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  • Site-wide: 101,435

Genome-wide association study of suicide death and polygenic prediction of clinical antecedents

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  • Site-wide: 8,121
  • In genomics: 930
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  • Site-wide: 64,384
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  • Site-wide: 31,621

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 8,560
  • In genetics: 435
• Year to date:
  • Site-wide: 106,575
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  • Site-wide: 63,504

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 9,030
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• Year to date:
  • Site-wide: 81,743
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  • Site-wide: 38,633

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

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  • Site-wide: 9,094
  • In genetics: 463
• Year to date:
  • Site-wide: 76,969
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  • Site-wide: 80,901

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,556 times
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  • Site-wide: 9,661
  • In genomics: 1,092
• Year to date:
  • Site-wide: 58,433
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  • Site-wide: 45,240

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,224 times
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  • Site-wide: 13,813
  • In genomics: 1,495
• Year to date:
  • Site-wide: 67,635
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  • Site-wide: 97,798

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

• Downloaded 1,169 times
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  • Site-wide: 14,773
  • In genetics: 769
• Year to date:
  • Site-wide: 22,901
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  • Site-wide: 77,843

Proteome-by-phenome Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits

• Downloaded 1,154 times
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  • Site-wide: 15,070
  • In genomics: 1,626
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  • Site-wide: 82,893
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  • Site-wide: 47,399

Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility

• Downloaded 970 times
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  • Site-wide: 19,543
  • In genetic and genomic medicine: 54
• Year to date:
  • Site-wide: 11,115
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  • Site-wide: 8,107

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

• Downloaded 953 times
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  • Site-wide: 20,042
  • In genomics: 2,048
• Year to date:
  • Site-wide: 92,941
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  • Site-wide: 94,736

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

• Downloaded 947 times
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  • Site-wide: 20,232
  • In genetics: 1,012
• Year to date:
  • Site-wide: 30,447
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  • Site-wide: 65,623

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 858 times
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  • Site-wide: 23,344
  • In genetics: 1,163
• Year to date:
  • Site-wide: 46,263
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  • Site-wide: 102,212

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 792 times
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  • Site-wide: 26,090
  • In genetics: 1,319
• Year to date:
  • Site-wide: 75,314
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  • Site-wide: 108,115

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 27,421
  • In genetics: 1,385
• Year to date:
  • Site-wide: 28,732
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  • Site-wide: 24,384

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 28,782
  • In genomics: 2,663
• Year to date:
  • Site-wide: 50,044
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  • Site-wide: 109,607

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 729 times
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  • Site-wide: 29,261
  • In genetics: 1,468
• Year to date:
  • Site-wide: 114,255
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  • Site-wide: 91,550

Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia

• Downloaded 728 times
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  • Site-wide: 29,323
  • In genetics: 1,471
• Year to date:
  • Site-wide: 33,014
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  • Site-wide: 69,088

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

• Downloaded 719 times
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  • Site-wide: 29,864
  • In genetics: 1,502
• Year to date:
  • Site-wide: 94,026
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  • Site-wide: 94,585

Quantifying the extent to which index event biases influence large genetic association studies

• Downloaded 679 times
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  • Site-wide: 32,281
  • In genetics: 1,620
• Year to date:
  • Site-wide: 103,828
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  • Site-wide: 115,467

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 33,163
  • In genetics: 1,653
• Year to date:
  • Site-wide: 11,148
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  • Site-wide: 11,241

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

• Downloaded 662 times
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  • Site-wide: 33,372
  • In genomics: 2,962
• Year to date:
  • Site-wide: 27,221
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  • Site-wide: 29,178

Electronic Health Record and Genome-wide Genetic Data in Generation Scotland Participants

• Downloaded 647 times
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  • Site-wide: 34,453
  • In genomics: 3,024
• Year to date:
  • Site-wide: 42,707
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  • Site-wide: 54,846

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

• Downloaded 630 times
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  • Site-wide: 35,672
  • In genomics: 3,097
• Year to date:
  • Site-wide: 114,223
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  • Site-wide: 112,013

A validation of the diathesis-stress model for depression in Generation Scotland.

• Downloaded 612 times
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  • Site-wide: 36,981
  • In genomics: 3,187
• Year to date:
  • Site-wide: 54,098
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  • Site-wide: 85,910

Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

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  • Site-wide: 37,315
  • In genomics: 3,202
• Year to date:
  • Site-wide: 100,833
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  • Site-wide: 69,969

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 587 times
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  • Site-wide: 38,987
  • In genetics: 1,917
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  • Site-wide: 93,094
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  • Site-wide: 65,390

A meta-analysis of genome-wide association studies of epigenetic age acceleration

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  • Site-wide: 40,927
  • In genetics: 2,005
• Year to date:
  • Site-wide: 105,600
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  • Site-wide: 108,290

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 560 times
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  • Site-wide: 41,359
  • In genetics: 2,022
• Year to date:
  • Site-wide: 47,009
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  • Site-wide: 80,983

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

• Downloaded 552 times
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  • Site-wide: 42,112
  • In genetics: 2,058
• Year to date:
  • Site-wide: 76,282
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  • Site-wide: 104,498

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

• Downloaded 544 times
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  • Site-wide: 42,854
  • In genetics: 2,092
• Year to date:
  • Site-wide: 103,936
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  • Site-wide: 75,252

Global variability of the human IgG glycome

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  • Site-wide: 44,332
  • In biochemistry: 1,139
• Year to date:
  • Site-wide: 61,819
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  • Site-wide: 79,101

Insight into the genetic aetiology of retinal detachment by combining small clinical and large population-based datasets

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  • Site-wide: 48,403
  • In genetics: 2,348
• Year to date:
  • Site-wide: 48,636
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  • Site-wide: 68,235

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 468 times
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  • Site-wide: 51,157
  • In genetics: 2,470
• Year to date:
  • Site-wide: 68,275
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  • Site-wide: 114,160

Distinguishing pedigree relationships using multi-way identical by descent sharing and sex-specific genetic maps

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  • Site-wide: 54,171
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• Year to date:
  • Site-wide: 13,325
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  • Site-wide: 30,470

A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank

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  • Site-wide: 56,412
  • In genetics: 2,705
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  • Site-wide: 61,452
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  • Site-wide: 55,325

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

• Downloaded 403 times
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  • Site-wide: 59,842
  • In genetics: 2,858
• Year to date:
  • Site-wide: 71,797
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  • Site-wide: 71,814

A strategy to incorporate prior knowledge into correlation network cutoff selection

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  • Site-wide: 60,059
  • In bioinformatics: 5,983
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  • Site-wide: 46,646
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  • Site-wide: 104,991

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

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  • Site-wide: 62,379
  • In genomics: 4,540
• Year to date:
  • Site-wide: 68,504
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  • Site-wide: 73,231

Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys

• Downloaded 373 times
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  • Site-wide: 64,428
  • In psychiatry and clinical psychology: 188
• Year to date:
  • Site-wide: 2,586
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  • Site-wide: 1,470

The influence of X chromosome variants on trait neuroticism.

• Downloaded 367 times
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  • Site-wide: 65,469
  • In genetics: 3,109
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  • Site-wide: 90,490
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  • Site-wide: 81,198

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 340 times
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  • Site-wide: 70,026
  • In genetics: 3,301
• Year to date:
  • Site-wide: 87,480
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  • Site-wide: 111,237

Epigenome-wide analyses identify DNA methylation signatures of dementia risk

• Downloaded 328 times
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  • Site-wide: 72,036
  • In genetic and genomic medicine: 206
• Year to date:
  • Site-wide: 57,334
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  • Site-wide: 30,978

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2

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  • Site-wide: 72,961
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  • Site-wide: 64,094
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  • Site-wide: 44,389

Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression

• Downloaded 258 times
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  • Site-wide: 85,807
  • In genetics: 3,974
• Year to date:
  • Site-wide: 112,963
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  • Site-wide: 117,911

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

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  • Site-wide: 89,912
  • In psychiatry and clinical psychology: 302
• Year to date:
  • Site-wide: 2,871
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  • Site-wide: 3,754

Systematic evaluation of normalization methods for glycomics data based on performance of network inference

• Downloaded 223 times
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  • Site-wide: 93,231
  • In bioinformatics: 8,164
• Year to date:
  • Site-wide: 76,804
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  • Site-wide: 85,451

Associations of ‘Relative corticosterone deficiency’ with genetic variation in CYP17A1 and metabolic syndrome features

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  • Site-wide: 94,600
  • In epidemiology: 3,803
• Year to date:
  • Site-wide: 120,205
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  • Site-wide: 86,927

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

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  • Site-wide: 103,206
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  • Site-wide: 39,978
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  • Site-wide: 11,744

Subthreshold psychosis symptoms associated with molecular genetic risk in a population-based cohort: Findings from Generation Scotland

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  • Site-wide: 103,655
  • In genetics: 4,669
• Year to date:
  • Site-wide: 113,721
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  • Site-wide: 111,670

DNA methylation proxies for 16 plasma proteins predict the incidence of 7 leading causes of morbidity

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  • Site-wide: 105,772
  • In genomics: 6,119
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  • Site-wide: 8,658
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  • Site-wide: 4,425

Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap

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  • Site-wide: 113,181
  • In genetic and genomic medicine: 468
• Year to date:
  • Site-wide: 28,491
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  • Site-wide: 8,763

A multi-omics study of circulating phospholipid markers of blood pressure

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  • Site-wide: 119,369
  • In cardiovascular medicine: 300
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  • Site-wide: 30,901
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  • Site-wide: 8,938

Omics versus Questionnaires: Using methylation data to assess the environmental impact of smoking on obesity-related traits

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  • Site-wide: 120,982
  • In genomics: 6,549
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  • Site-wide: 75,926
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  • Site-wide: 42,837