Author: Caroline Hayward

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Preprints

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

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Genetic mechanisms of critical illness in Covid-19

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  • Site-wide: 810
  • In intensive care and critical care medicine: 7
• Year to date:
  • Site-wide: 1,100
• Since beginning of last month:
  • Site-wide: 4,003

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,392 times
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  • Site-wide: 870
  • In genetics: 26
• Year to date:
  • Site-wide: 31,220
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  • Site-wide: 33,580

A time-resolved proteomic and diagnostic map characterizes COVID-19 disease progression and predicts outcome

• Downloaded 5,882 times
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  • Site-wide: 1,593
  • In infectious diseases: 399
• Year to date:
  • Site-wide: 2,399
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  • Site-wide: 5,410

Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics

• Downloaded 5,728 times
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  • Site-wide: 1,661
  • In infectious diseases: 408
• Year to date:
  • Site-wide: 8,854
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  • Site-wide: 8,778

Genomic analysis of family data reveals additional genetic effects on intelligence and personality

• Downloaded 4,204 times
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  • Site-wide: 2,542
  • In genetics: 95
• Year to date:
  • Site-wide: 31,212
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  • Site-wide: 35,525

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,261 times
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  • Site-wide: 3,680
  • In genetics: 152
• Year to date:
  • Site-wide: 40,700
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  • Site-wide: 83,792

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,082 times
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  • Site-wide: 3,978
  • In genetics: 168
• Year to date:
  • Site-wide: 54,772
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  • Site-wide: 73,606

Genetic analysis identifies molecular systems and biological pathways associated with household income

• Downloaded 2,710 times
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  • Site-wide: 4,785
  • In genetics: 212
• Year to date:
  • Site-wide: 97,671
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  • Site-wide: 103,262

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,567 times
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  • Site-wide: 5,160
  • In genetics: 235
• Year to date:
  • Site-wide: 22,432
• Since beginning of last month:
  • Site-wide: 26,571

Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

• Downloaded 2,511 times
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  • Site-wide: 5,331
  • In genomics: 603
• Year to date:
  • Site-wide: 76,944
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  • Site-wide: 99,197

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 6,000
  • In genetics: 281
• Year to date:
  • Site-wide: 6,398
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  • Site-wide: 6,553

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 2,039 times
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  • Site-wide: 7,238
  • In genetics: 343
• Year to date:
  • Site-wide: 112,829
• Since beginning of last month:
  • Site-wide: 109,085

Genome-wide association study of suicide death and polygenic prediction of clinical antecedents

• Downloaded 1,866 times
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  • Site-wide: 8,291
  • In genomics: 907
• Year to date:
  • Site-wide: 18,455
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  • Site-wide: 13,530

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,851 times
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  • Site-wide: 8,392
  • In genetics: 393
• Year to date:
  • Site-wide: 87,385
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  • Site-wide: 88,827

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,713 times
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  • Site-wide: 9,444
  • In genetics: 453
• Year to date:
  • Site-wide: 75,517
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  • Site-wide: 81,464

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,660 times
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  • Site-wide: 9,878
  • In genetics: 469
• Year to date:
  • Site-wide: 64,626
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  • Site-wide: 44,366

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

• Downloaded 1,641 times
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  • Site-wide: 10,044
  • In genetics: 483
• Year to date:
  • Site-wide: 86,070
• Since beginning of last month:
  • Site-wide: 103,510

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,580 times
• Download rankings, all-time:
  • Site-wide: 10,622
  • In genomics: 1,152
• Year to date:
  • Site-wide: 74,506
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  • Site-wide: 90,401

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,243 times
• Download rankings, all-time:
  • Site-wide: 15,234
  • In genomics: 1,580
• Year to date:
  • Site-wide: 87,169
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  • Site-wide: 121,407

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

• Downloaded 1,198 times
• Download rankings, all-time:
  • Site-wide: 16,087
  • In genetics: 793
• Year to date:
  • Site-wide: 52,845
• Since beginning of last month:
  • Site-wide: 69,504

Proteome-by-phenome Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits

• Downloaded 1,181 times
• Download rankings, all-time:
  • Site-wide: 16,426
  • In genomics: 1,697
• Year to date:
  • Site-wide: 74,432
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  • Site-wide: 69,271

Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility

• Downloaded 1,089 times
• Download rankings, all-time:
  • Site-wide: 18,522
  • In genetic and genomic medicine: 59
• Year to date:
  • Site-wide: 15,197
• Since beginning of last month:
  • Site-wide: 15,511

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

• Downloaded 980 times
• Download rankings, all-time:
  • Site-wide: 21,539
  • In genetics: 1,032
• Year to date:
  • Site-wide: 52,773
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  • Site-wide: 58,578

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

• Downloaded 969 times
• Download rankings, all-time:
  • Site-wide: 21,908
  • In genomics: 2,162
• Year to date:
  • Site-wide: 101,554
• Since beginning of last month:
  • Site-wide: 89,309

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 877 times
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  • Site-wide: 25,376
  • In genetics: 1,225
• Year to date:
  • Site-wide: 19,404
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  • Site-wide: 11,110

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 871 times
• Download rankings, all-time:
  • Site-wide: 25,590
  • In genetics: 1,233
• Year to date:
  • Site-wide: 92,837
• Since beginning of last month:
  • Site-wide: 98,546

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 825 times
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  • Site-wide: 27,601
  • In genetics: 1,335
• Year to date:
  • Site-wide: 63,018
• Since beginning of last month:
  • Site-wide: 69,665

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 794 times
• Download rankings, all-time:
  • Site-wide: 29,093
  • In genetics: 1,412
• Year to date:
  • Site-wide: 14,138
• Since beginning of last month:
  • Site-wide: 10,599

Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia

• Downloaded 760 times
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  • Site-wide: 30,969
  • In genetics: 1,497
• Year to date:
  • Site-wide: 54,743
• Since beginning of last month:
  • Site-wide: 53,863

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 751 times
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  • Site-wide: 31,502
  • In genomics: 2,811
• Year to date:
  • Site-wide: 94,947
• Since beginning of last month:
  • Site-wide: 111,653

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 745 times
• Download rankings, all-time:
  • Site-wide: 31,865
  • In genetics: 1,540
• Year to date:
  • Site-wide: 105,242
• Since beginning of last month:
  • Site-wide: 124,518

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

• Downloaded 733 times
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  • Site-wide: 32,603
  • In genomics: 2,888
• Year to date:
  • Site-wide: 30,201
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  • Site-wide: 64,343

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 733 times
• Download rankings, all-time:
  • Site-wide: 32,647
  • In genetics: 1,580
• Year to date:
  • Site-wide: 12,305
• Since beginning of last month:
  • Site-wide: 8,392

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

• Downloaded 727 times
• Download rankings, all-time:
  • Site-wide: 32,977
  • In genetics: 1,597
• Year to date:
  • Site-wide: 123,582
• Since beginning of last month:
  • Site-wide: 119,134

Quantifying the extent to which index event biases influence large genetic association studies

• Downloaded 689 times
• Download rankings, all-time:
  • Site-wide: 35,432
  • In genetics: 1,699
• Year to date:
  • Site-wide: 121,299
• Since beginning of last month:
  • Site-wide: 128,000

Electronic Health Record and Genome-wide Genetic Data in Generation Scotland Participants

• Downloaded 663 times
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  • Site-wide: 37,285
  • In genomics: 3,172
• Year to date:
  • Site-wide: 83,509
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  • Site-wide: 84,769

A validation of the diathesis-stress model for depression in Generation Scotland.

• Downloaded 644 times
• Download rankings, all-time:
  • Site-wide: 38,708
  • In genomics: 3,256
• Year to date:
  • Site-wide: 61,430
• Since beginning of last month:
  • Site-wide: 39,423

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

• Downloaded 637 times
• Download rankings, all-time:
  • Site-wide: 39,309
  • In genomics: 3,289
• Year to date:
  • Site-wide: 130,385
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  • Site-wide: 125,646

Novel Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk Of Coronary Artery Disease

• Downloaded 633 times
• Download rankings, all-time:
  • Site-wide: 39,592
  • In genomics: 3,301
• Year to date:
  • Site-wide: 81,336
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  • Site-wide: 90,507

Within-sibship GWAS improve estimates of direct genetic effects

• Downloaded 628 times
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  • Site-wide: 39,941
  • In genetics: 1,900
• Year to date:
  • Site-wide: 2,138
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  • Site-wide: 606

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 613 times
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  • Site-wide: 41,246
  • In genetics: 1,953
• Year to date:
  • Site-wide: 76,817
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  • Site-wide: 69,003

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 587 times
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  • Site-wide: 43,578
  • In sexual and reproductive health: 18
• Year to date:
  • Site-wide: 2,361
• Since beginning of last month:
  • Site-wide: 7,277

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

• Downloaded 576 times
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  • Site-wide: 44,494
  • In genetics: 2,089
• Year to date:
  • Site-wide: 69,175
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  • Site-wide: 85,200

A meta-analysis of genome-wide association studies of epigenetic age acceleration

• Downloaded 570 times
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  • Site-wide: 45,111
  • In genetics: 2,124
• Year to date:
  • Site-wide: 129,889
• Since beginning of last month:
  • Site-wide: 131,075

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

• Downloaded 570 times
• Download rankings, all-time:
  • Site-wide: 45,117
  • In genetics: 2,123
• Year to date:
  • Site-wide: 92,889
• Since beginning of last month:
  • Site-wide: 82,150

Global variability of the human IgG glycome

• Downloaded 546 times
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  • Site-wide: 47,588
  • In biochemistry: 1,228
• Year to date:
  • Site-wide: 90,780
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  • Site-wide: 83,469

Insight into the genetic aetiology of retinal detachment by combining small clinical and large population-based datasets

• Downloaded 506 times
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  • Site-wide: 52,119
  • In genetics: 2,430
• Year to date:
  • Site-wide: 90,713
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  • Site-wide: 100,238

Distinguishing pedigree relationships using multi-way identical by descent sharing and sex-specific genetic maps

• Downloaded 479 times
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  • Site-wide: 55,401
  • In genetics: 2,569
• Year to date:
  • Site-wide: 40,038
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  • Site-wide: 75,407

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 476 times
• Download rankings, all-time:
  • Site-wide: 55,875
  • In genetics: 2,586
• Year to date:
  • Site-wide: 118,903
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  • Site-wide: 132,079

A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank

• Downloaded 465 times
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  • Site-wide: 57,284
  • In genetics: 2,664
• Year to date:
  • Site-wide: 56,061
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  • Site-wide: 43,046

Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys

• Downloaded 447 times
• Download rankings, all-time:
  • Site-wide: 59,698
  • In psychiatry and clinical psychology: 183
• Year to date:
  • Site-wide: 12,138
• Since beginning of last month:
  • Site-wide: 34,827

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

• Downloaded 434 times
• Download rankings, all-time:
  • Site-wide: 61,493
  • In genetics: 2,854
• Year to date:
  • Site-wide: 65,569
• Since beginning of last month:
  • Site-wide: 73,254

A strategy to incorporate prior knowledge into correlation network cutoff selection

• Downloaded 415 times
• Download rankings, all-time:
  • Site-wide: 64,381
  • In bioinformatics: 6,269
• Year to date:
  • Site-wide: 91,833
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  • Site-wide: 96,750

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

• Downloaded 396 times
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  • Site-wide: 67,497
  • In genomics: 4,758
• Year to date:
  • Site-wide: 113,542
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  • Site-wide: 114,603

The influence of X chromosome variants on trait neuroticism.

• Downloaded 382 times
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  • Site-wide: 69,683
  • In genetics: 3,192
• Year to date:
  • Site-wide: 102,704
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  • Site-wide: 82,521

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2

• Downloaded 355 times
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  • Site-wide: 74,337
  • In genetics: 3,398
• Year to date:
  • Site-wide: 63,187
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  • Site-wide: 78,532

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

• Downloaded 355 times
• Download rankings, all-time:
  • Site-wide: 74,331
  • In psychiatry and clinical psychology: 236
• Year to date:
  • Site-wide: 9,600
• Since beginning of last month:
  • Site-wide: 25,619

Epigenome-wide analyses identify DNA methylation signatures of dementia risk

• Downloaded 353 times
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  • Site-wide: 74,713
  • In genetic and genomic medicine: 253
• Year to date:
  • Site-wide: 73,064
• Since beginning of last month:
  • Site-wide: 72,381

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 348 times
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  • Site-wide: 75,660
  • In genetics: 3,461
• Year to date:
  • Site-wide: 122,877
• Since beginning of last month:
  • Site-wide: 119,439

A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

• Downloaded 319 times
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  • Site-wide: 81,176
  • In bioinformatics: 7,425
• Year to date:
  • Site-wide: 5,643
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  • Site-wide: 5,609

Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression

• Downloaded 267 times
• Download rankings, all-time:
  • Site-wide: 92,219
  • In genetics: 4,151
• Year to date:
  • Site-wide: 126,233
• Since beginning of last month:
  • Site-wide: 128,108

Systematic evaluation of normalization methods for glycomics data based on performance of network inference

• Downloaded 237 times
• Download rankings, all-time:
  • Site-wide: 98,889
  • In bioinformatics: 8,510
• Year to date:
  • Site-wide: 104,089
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  • Site-wide: 86,078

DNA methylation proxies for 16 plasma proteins predict the incidence of 7 leading causes of morbidity

• Downloaded 232 times
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  • Site-wide: 99,902
  • In genomics: 5,990
• Year to date:
  • Site-wide: 22,566
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  • Site-wide: 24,639

Associations of ‘Relative corticosterone deficiency’ with genetic variation in CYP17A1 and metabolic syndrome features

• Downloaded 226 times
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  • Site-wide: 101,336
  • In epidemiology: 4,161
• Year to date:
  • Site-wide: 126,587
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  • Site-wide: 109,235

Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population

• Downloaded 219 times
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  • Site-wide: 102,816
  • In epidemiology: 4,236
• Year to date:
  • Site-wide: 47,342
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  • Site-wide: 40,543

Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap

• Downloaded 182 times
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  • Site-wide: 111,133
  • In genetic and genomic medicine: 486
• Year to date:
  • Site-wide: 34,677
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  • Site-wide: 23,885

Subthreshold psychosis symptoms associated with molecular genetic risk in a population-based cohort: Findings from Generation Scotland

• Downloaded 181 times
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  • Site-wide: 111,338
  • In genetics: 4,853
• Year to date:
  • Site-wide: 129,789
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  • Site-wide: 133,089

Omics versus Questionnaires: Using methylation data to assess the environmental impact of smoking on obesity-related traits

• Downloaded 113 times
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  • Site-wide: 124,988
  • In genomics: 6,719
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  • Site-wide: 56,534
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  • Site-wide: 87,790

A multi-omics study of circulating phospholipid markers of blood pressure

• Downloaded 101 times
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  • Site-wide: 127,171
  • In cardiovascular medicine: 342
• Year to date:
  • Site-wide: 76,752
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  • Site-wide: 88,353