Author: Christian Gieger

Downloads per author, site-wide

Preprints

Genetic insights into the biological mechanisms governing human ovarian ageing

No download data for this paper yet.

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

• Downloaded 4,233 times
• Download rankings, all-time:
  • Site-wide: 2,172
  • In systems biology: 30
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 98,640

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,206 times
• Download rankings, all-time:
  • Site-wide: 3,297
  • In genomics: 391
• Year to date:
  • Site-wide: 105,390
• Since beginning of last month:
  • Site-wide: 92,087

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,052 times
• Download rankings, all-time:
  • Site-wide: 3,539
  • In genetics: 163
• Year to date:
  • Site-wide: 16,767
• Since beginning of last month:
  • Site-wide: 40,428

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,476 times
• Download rankings, all-time:
  • Site-wide: 4,762
  • In genetics: 233
• Year to date:
  • Site-wide: 10,563
• Since beginning of last month:
  • Site-wide: 14,809

Connecting genetic risk to disease endpoints through the human blood plasma proteome

• Downloaded 1,716 times
• Download rankings, all-time:
  • Site-wide: 8,172
  • In genetics: 412
• Year to date:
  • Site-wide: 93,666
• Since beginning of last month:
  • Site-wide: 106,223

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

• Downloaded 1,684 times
• Download rankings, all-time:
  • Site-wide: 8,428
  • In genetics: 429
• Year to date:
  • Site-wide: 98,619
• Since beginning of last month:
  • Site-wide: 58,655

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

• Downloaded 1,629 times
• Download rankings, all-time:
  • Site-wide: 8,869
  • In genetics: 454
• Year to date:
  • Site-wide: 37,450
• Since beginning of last month:
  • Site-wide: 63,992

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,556 times
• Download rankings, all-time:
  • Site-wide: 9,519
  • In genomics: 1,080
• Year to date:
  • Site-wide: 37,901
• Since beginning of last month:
  • Site-wide: 41,801

Genome-wide Association Study Of Plasma Proteins Identifies Putatively Causal Genes, Proteins, And Pathways For Cardiovascular Disease

• Downloaded 1,227 times
• Download rankings, all-time:
  • Site-wide: 13,568
  • In epidemiology: 852
• Year to date:
  • Site-wide: 58,589
• Since beginning of last month:
  • Site-wide: 65,954

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,224 times
• Download rankings, all-time:
  • Site-wide: 13,630
  • In genomics: 1,489
• Year to date:
  • Site-wide: 54,633
• Since beginning of last month:
  • Site-wide: 93,564

RL-SKAT: An exact and efficient score test for heritability and set tests

• Downloaded 1,173 times
• Download rankings, all-time:
  • Site-wide: 14,510
  • In genetics: 758
• Year to date:
  • Site-wide: 16,956
• Since beginning of last month:
  • Site-wide: 60,293

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

• Downloaded 1,028 times
• Download rankings, all-time:
  • Site-wide: 17,702
  • In systems biology: 371
• Year to date:
  • Site-wide: 27,637
• Since beginning of last month:
  • Site-wide: 92,942

Genome-wide methylation data mirror ancestry information

• Downloaded 968 times
• Download rankings, all-time:
  • Site-wide: 19,352
  • In genetics: 982
• Year to date:
  • Site-wide: 89,217
• Since beginning of last month:
  • Site-wide: 112,117

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 965 times
• Download rankings, all-time:
  • Site-wide: 19,446
  • In genetics: 985
• Year to date:
  • Site-wide: 39,064
• Since beginning of last month:
  • Site-wide: 117,281

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 908 times
• Download rankings, all-time:
  • Site-wide: 21,208
  • In genetics: 1,066
• Year to date:
  • Site-wide: 5,355
• Since beginning of last month:
  • Site-wide: 11,632

A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel disease

• Downloaded 894 times
• Download rankings, all-time:
  • Site-wide: 21,699
  • In genetics: 1,091
• Year to date:
  • Site-wide: 41,682
• Since beginning of last month:
  • Site-wide: 53,586

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 853 times
• Download rankings, all-time:
  • Site-wide: 23,224
  • In genetic and genomic medicine: 61
• Year to date:
  • Site-wide: 8,893
• Since beginning of last month:
  • Site-wide: 5,487

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 738 times
• Download rankings, all-time:
  • Site-wide: 28,472
  • In genomics: 2,655
• Year to date:
  • Site-wide: 35,969
• Since beginning of last month:
  • Site-wide: 103,060

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

• Downloaded 730 times
• Download rankings, all-time:
  • Site-wide: 28,868
  • In genetic and genomic medicine: 72
• Year to date:
  • Site-wide: 18,790
• Since beginning of last month:
  • Site-wide: 15,790

Network-based metabolite ratios for an improved functional characterization of genome-wide association study results

• Downloaded 627 times
• Download rankings, all-time:
  • Site-wide: 35,437
  • In genetics: 1,770
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 111,607

Epigenetic derepression of FKBP5 by aging and stress contributes to NF-kB-driven inflammation and cardiovascular risk

• Downloaded 565 times
• Download rankings, all-time:
  • Site-wide: 40,354
  • In genomics: 3,384
• Year to date:
  • Site-wide: 48,484
• Since beginning of last month:
  • Site-wide: 77,527

Defining the genetic control of human blood plasma N-glycome using genome-wide association study

• Downloaded 560 times
• Download rankings, all-time:
  • Site-wide: 40,789
  • In genetics: 1,998
• Year to date:
  • Site-wide: 74,417
• Since beginning of last month:
  • Site-wide: 113,899

Network reconstruction for trans acting genetic loci using multi-omics data and prior information

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 41,528
  • In bioinformatics: 4,542
• Year to date:
  • Site-wide: 21,455
• Since beginning of last month:
  • Site-wide: 28,086

Global variability of the human IgG glycome

• Downloaded 525 times
• Download rankings, all-time:
  • Site-wide: 44,127
  • In biochemistry: 1,139
• Year to date:
  • Site-wide: 83,338
• Since beginning of last month:
  • Site-wide: 76,348

Alcohol consumption is associated with widespread changes in blood DNA methylation: analysis of cross-sectional and longitudinal data

• Downloaded 522 times
• Download rankings, all-time:
  • Site-wide: 44,419
  • In epidemiology: 1,967
• Year to date:
  • Site-wide: 57,266
• Since beginning of last month:
  • Site-wide: 85,800

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 497 times
• Download rankings, all-time:
  • Site-wide: 47,172
  • In genomics: 3,798
• Year to date:
  • Site-wide: 75,412
• Since beginning of last month:
  • Site-wide: 108,299

Cis-epistasis at the LPA locus and risk of coronary artery disease

• Downloaded 471 times
• Download rankings, all-time:
  • Site-wide: 50,160
  • In genetics: 2,432
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 113,851

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 462 times
• Download rankings, all-time:
  • Site-wide: 51,282
  • In genetics: 2,484
• Year to date:
  • Site-wide: 600
• Since beginning of last month:
  • Site-wide: 1,317

Elucidating the genetic risk of obesity through the human blood plasma proteome

• Downloaded 292 times
• Download rankings, all-time:
  • Site-wide: 78,035
  • In endocrinology: 47
• Year to date:
  • Site-wide: 90,182
• Since beginning of last month:
  • Site-wide: 26,894

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 193 times
• Download rankings, all-time:
  • Site-wide: 98,621
  • In genomics: 5,906
• Year to date:
  • Site-wide: 72,748
• Since beginning of last month:
  • Site-wide: 68,404