Author: Konstantin Strauch

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Preprints

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 3,679
  • In genomics: 415
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Cell specific eQTL analysis without sorting cells

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  • Site-wide: 7,402
  • In genetics: 351
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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 8,334
  • In genetics: 391
• Year to date:
  • Site-wide: 85,043
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  • Site-wide: 81,681

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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  • Site-wide: 9,232
  • In genetics: 441
• Year to date:
  • Site-wide: 103,655
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  • Site-wide: 107,898

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 9,826
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Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

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  • Site-wide: 9,913
  • In genetics: 477
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  • Site-wide: 76,351
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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 15,126
  • In genomics: 1,569
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  • Site-wide: 114,514

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 16,673
  • In genetics: 817
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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 18,544
  • In genetic and genomic medicine: 64
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Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

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  • Site-wide: 19,613
  • In systems biology: 400
• Year to date:
  • Site-wide: 80,394
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  • Site-wide: 126,889

Genome-wide methylation data mirror ancestry information

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  • Site-wide: 21,503
  • In genetics: 1,034
• Year to date:
  • Site-wide: 124,473
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  • Site-wide: 125,498

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 26,731
  • In genetics: 1,300
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  • Site-wide: 19,389

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

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  • Site-wide: 28,075
  • In genetic and genomic medicine: 89
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  • Site-wide: 19,039

Network reconstruction for trans acting genetic loci using multi-omics data and prior information

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  • Site-wide: 40,579
  • In bioinformatics: 4,401
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  • Site-wide: 33,153

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

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  • Site-wide: 41,009
  • In genetics: 1,949
• Year to date:
  • Site-wide: 73,733
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  • Site-wide: 63,938

Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 43,335
  • In sexual and reproductive health: 18
• Year to date:
  • Site-wide: 2,215
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  • Site-wide: 6,029

Discovering patterns of pleiotropy in genome-wide association studies

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  • Site-wide: 43,973
  • In genetics: 2,068
• Year to date:
  • Site-wide: 113,088
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Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

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  • Site-wide: 44,835
  • In genetics: 2,114
• Year to date:
  • Site-wide: 89,839
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  • Site-wide: 74,345

Genome wide association analysis in dilated cardiomyopathy reveals two new key players in systolic heart failure on chromosome 3p25.1 and 22q11.23

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  • Site-wide: 49,353
  • In genomics: 3,893
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  • Site-wide: 16,677

annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusions

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  • Site-wide: 50,259
  • In bioinformatics: 5,197
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Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

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  • Site-wide: 51,792
  • In genomics: 4,020
• Year to date:
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Cis-epistasis at the LPA locus and risk of coronary artery disease

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  • Site-wide: 52,476
  • In genetics: 2,444
• Year to date:
  • Site-wide: 92,515
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  • Site-wide: 117,408

Meta-analysis of exome array data identifies six novel genetic loci for lung function

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  • Site-wide: 55,515
  • In genetics: 2,571
• Year to date:
  • Site-wide: 116,122
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  • Site-wide: 128,615

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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  • Site-wide: 91,651
  • In genetics: 4,136
• Year to date:
  • Site-wide: 121,590
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  • Site-wide: 105,957

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter

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  • Site-wide: 91,822
  • In genetics: 4,140
• Year to date:
  • Site-wide: 129,293
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  • Site-wide: 125,698

Biomarker-based outcome prediction in prostate adenocarcinoma depends on the TMPRSS2-ERG status

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  • Site-wide: 96,304
  • In cancer biology: 2,924
• Year to date:
  • Site-wide: 103,168
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  • Site-wide: 98,668

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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  • Site-wide: 104,515
  • In genomics: 6,111
• Year to date:
  • Site-wide: 96,101
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  • Site-wide: 69,196