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Author: Aarno Palotie

Rankings

  • All-time downloads: 110,990 (rank: 807 )
  • Categories:
    • cardiovascular medicine: 374 (rank: 1,117 (tie) )
    • epidemiology: 275 (rank: 19,686 (tie) )
    • genetic and genomic medicine: 5,265 (rank: 100 )
    • genetics: 64,173 (rank: 52 )
    • genomics: 39,149 (rank: 193 )
    • infectious diseases: 938 (rank: 19,683 (tie) )
    • oncology: 816 (rank: 540 (tie) )

Downloads per author, site-wide

Preprints

Analysis of protein-coding genetic variation in 60,706 humans

genomics more details view paper
  • Downloaded 21,936 times
  • Download rankings, all-time:
    • Site-wide: 296
    • In genomics: 11
  • Year to date:
    • Site-wide: 51,933
  • Since beginning of last month:
    • Site-wide: None

Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

genetics more details view paper
  • Downloaded 10,138 times
  • Download rankings, all-time:
    • Site-wide: 746
    • In genetics: 22
  • Year to date:
    • Site-wide: 3,917
  • Since beginning of last month:
    • Site-wide: 3,771

Common risk variants identified in autism spectrum disorder

genetics more details view paper
  • Downloaded 7,739 times
  • Download rankings, all-time:
    • Site-wide: 1,053
    • In genetics: 34
  • Year to date:
    • Site-wide: 2,057
  • Since beginning of last month:
    • Site-wide: 2,085

A reference panel of 64,976 haplotypes for genotype imputation

genetics more details view paper
  • Downloaded 4,582 times
  • Download rankings, all-time:
    • Site-wide: 2,114
    • In genetics: 80
  • Year to date:
    • Site-wide: 57,920
  • Since beginning of last month:
    • Site-wide: 53,970

Phenome-wide association studies (PheWAS) across large "real-world data" population cohorts support drug target validation

genetics more details view paper
  • Downloaded 3,481 times
  • Download rankings, all-time:
    • Site-wide: 3,143
    • In genetics: 126
  • Year to date:
    • Site-wide: 39,061
  • Since beginning of last month:
    • Site-wide: 37,555

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

genetics more details view paper
  • Downloaded 3,247 times
  • Download rankings, all-time:
    • Site-wide: 3,480
    • In genetics: 149
  • Year to date:
    • Site-wide: 27,161
  • Since beginning of last month:
    • Site-wide: 29,755

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

genetic and genomic medicine more details view paper
  • Downloaded 2,861 times
  • Download rankings, all-time:
    • Site-wide: 4,121
    • In genetic and genomic medicine: 11
  • Year to date:
    • Site-wide: 993
  • Since beginning of last month:
    • Site-wide: 1,101

Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers

genomics more details view paper
  • Downloaded 2,731 times
  • Download rankings, all-time:
    • Site-wide: 4,412
    • In genomics: 509
  • Year to date:
    • Site-wide: 21,673
  • Since beginning of last month:
    • Site-wide: 16,238

Genome-wide association study identifies 48 common genetic variants associated with handedness

genetics more details view paper
  • Downloaded 2,526 times
  • Download rankings, all-time:
    • Site-wide: 4,960
    • In genetics: 229
  • Year to date:
    • Site-wide: 18,021
  • Since beginning of last month:
    • Site-wide: 18,917

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

genetics more details view paper
  • Downloaded 2,502 times
  • Download rankings, all-time:
    • Site-wide: 5,044
    • In genetics: 232
  • Year to date:
    • Site-wide: 73,829
  • Since beginning of last month:
    • Site-wide: 74,463

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

genetics more details view paper
  • Downloaded 2,436 times
  • Download rankings, all-time:
    • Site-wide: 5,252
    • In genetics: 247
  • Year to date:
    • Site-wide: 12,597
  • Since beginning of last month:
    • Site-wide: 16,263

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

genetics more details view paper
  • Downloaded 2,294 times
  • Download rankings, all-time:
    • Site-wide: 5,733
    • In genetics: 274
  • Year to date:
    • Site-wide: 98,187
  • Since beginning of last month:
    • Site-wide: 64,309

Ultra-rare genetic variation in the epilepsies: a whole-exome sequencing study of 17,606 individuals

genetics more details view paper
  • Downloaded 2,009 times
  • Download rankings, all-time:
    • Site-wide: 6,912
    • In genetics: 338
  • Year to date:
    • Site-wide: 30,926
  • Since beginning of last month:
    • Site-wide: 18,771

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

genomics more details view paper
  • Downloaded 1,955 times
  • Download rankings, all-time:
    • Site-wide: 7,220
    • In genomics: 809
  • Year to date:
    • Site-wide: 28,855
  • Since beginning of last month:
    • Site-wide: 24,229

De novo Variants In Neurodevelopmental Disorders With Epilepsy

genetics more details view paper
  • Downloaded 1,943 times
  • Download rankings, all-time:
    • Site-wide: 7,289
    • In genetics: 351
  • Year to date:
    • Site-wide: 24,944
  • Since beginning of last month:
    • Site-wide: 14,219

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

genetics more details view paper
  • Downloaded 1,867 times
  • Download rankings, all-time:
    • Site-wide: 7,731
    • In genetics: 370
  • Year to date:
    • Site-wide: 64,619
  • Since beginning of last month:
    • Site-wide: 68,402

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

genetics more details view paper
  • Downloaded 1,779 times
  • Download rankings, all-time:
    • Site-wide: 8,333
    • In genetics: 405
  • Year to date:
    • Site-wide: 32,216
  • Since beginning of last month:
    • Site-wide: 27,433

Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium

genomics more details view paper
  • Downloaded 1,684 times
  • Download rankings, all-time:
    • Site-wide: 9,096
    • In genomics: 1,021
  • Year to date:
    • Site-wide: 43,034
  • Since beginning of last month:
    • Site-wide: 30,217

Gene family information facilitates variant interpretation and identification of disease-associated genes

genetics more details view paper
  • Downloaded 1,638 times
  • Download rankings, all-time:
    • Site-wide: 9,463
    • In genetics: 464
  • Year to date:
    • Site-wide: 54,925
  • Since beginning of last month:
    • Site-wide: 43,351

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

genetics more details view paper
  • Downloaded 1,529 times
  • Download rankings, all-time:
    • Site-wide: 10,457
    • In genetics: 517
  • Year to date:
    • Site-wide: 93,983
  • Since beginning of last month:
    • Site-wide: 76,196

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

genomics more details view paper
  • Downloaded 1,447 times
  • Download rankings, all-time:
    • Site-wide: 11,333
    • In genomics: 1,260
  • Year to date:
    • Site-wide: 61,962
  • Since beginning of last month:
    • Site-wide: 63,520

Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

genomics more details view paper
  • Downloaded 1,431 times
  • Download rankings, all-time:
    • Site-wide: 11,520
    • In genomics: 1,283
  • Year to date:
    • Site-wide: 37,688
  • Since beginning of last month:
    • Site-wide: 26,906

Burden analysis of missense variants in 1,330 disease-associated genes on 3D provides insights into the mutation effects

genetics more details view paper
  • Downloaded 1,287 times
  • Download rankings, all-time:
    • Site-wide: 13,522
    • In genetics: 681
  • Year to date:
    • Site-wide: 35,953
  • Since beginning of last month:
    • Site-wide: 53,323

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

genetics more details view paper
  • Downloaded 1,193 times
  • Download rankings, all-time:
    • Site-wide: 15,174
    • In genetics: 776
  • Year to date:
    • Site-wide: 21,580
  • Since beginning of last month:
    • Site-wide: 16,409

Genomic prediction of coronary heart disease

genomics more details view paper
  • Downloaded 1,160 times
  • Download rankings, all-time:
    • Site-wide: 15,816
    • In genomics: 1,673
  • Year to date:
    • Site-wide: 98,471
  • Since beginning of last month:
    • Site-wide: 68,039

A global atlas of genetic associations of 220 deep phenotypes

genetic and genomic medicine more details view paper
  • Downloaded 1,139 times
  • Download rankings, all-time:
    • Site-wide: 16,270
    • In genetic and genomic medicine: 50
  • Year to date:
    • Site-wide: 7,196
  • Since beginning of last month:
    • Site-wide: 12,979

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

genetics more details view paper
  • Downloaded 1,126 times
  • Download rankings, all-time:
    • Site-wide: 16,552
    • In genetics: 835
  • Year to date:
    • Site-wide: 65,461
  • Since beginning of last month:
    • Site-wide: 55,811

Haplotype sharing provides insights into fine-scale population history and disease in Finland

genetics more details view paper
  • Downloaded 1,102 times
  • Download rankings, all-time:
    • Site-wide: 17,105
    • In genetics: 869
  • Year to date:
    • Site-wide: 65,868
  • Since beginning of last month:
    • Site-wide: 63,666

Geographic variation and bias in polygenic scores of complex diseases and traits in Finland

genetics more details view paper
  • Downloaded 1,020 times
  • Download rankings, all-time:
    • Site-wide: 19,189
    • In genetics: 955
  • Year to date:
    • Site-wide: 121,013
  • Since beginning of last month:
    • Site-wide: None

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

genomics more details view paper
  • Downloaded 1,015 times
  • Download rankings, all-time:
    • Site-wide: 19,343
    • In genomics: 1,982
  • Year to date:
    • Site-wide: 76,518
  • Since beginning of last month:
    • Site-wide: 76,382

Rare schizophrenia risk variants are enriched in genes shared with neurodevelopmental disorders

genetics more details view paper
  • Downloaded 989 times
  • Download rankings, all-time:
    • Site-wide: 20,046
    • In genetics: 994
  • Year to date:
    • Site-wide: 101,026
  • Since beginning of last month:
    • Site-wide: 93,213

The rate of false polymorphisms introduced when imputing genotypes from global imputation panels

genetics more details view paper
  • Downloaded 962 times
  • Download rankings, all-time:
    • Site-wide: 20,863
    • In genetics: 1,025
  • Year to date:
    • Site-wide: 59,062
  • Since beginning of last month:
    • Site-wide: 34,476

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

genomics more details view paper
  • Downloaded 949 times
  • Download rankings, all-time:
    • Site-wide: 21,269
    • In genomics: 2,128
  • Year to date:
    • Site-wide: 73,999
  • Since beginning of last month:
    • Site-wide: 54,084

Sleep apnoea is a risk factor for severe COVID-19

infectious diseases more details view paper
  • Downloaded 938 times
  • Download rankings, all-time:
    • Site-wide: 21,605
    • In infectious diseases: 1,651
  • Year to date:
    • Site-wide: 10,760
  • Since beginning of last month:
    • Site-wide: 31,037

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma

genetics more details view paper
  • Downloaded 919 times
  • Download rankings, all-time:
    • Site-wide: 22,285
    • In genetics: 1,097
  • Year to date:
    • Site-wide: 52,694
  • Since beginning of last month:
    • Site-wide: 54,163

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

genetics more details view paper
  • Downloaded 893 times
  • Download rankings, all-time:
    • Site-wide: 23,228
    • In genetics: 1,151
  • Year to date:
    • Site-wide: 3,622
  • Since beginning of last month:
    • Site-wide: 2,877

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

genetics more details view paper
  • Downloaded 825 times
  • Download rankings, all-time:
    • Site-wide: 25,984
    • In genetics: 1,289
  • Year to date:
    • Site-wide: 64,597
  • Since beginning of last month:
    • Site-wide: 68,458

Polygenic risk, susceptibility genes, and breast cancer over the life course

oncology more details view paper
  • Downloaded 816 times
  • Download rankings, all-time:
    • Site-wide: 26,382
    • In oncology: 26
  • Year to date:
    • Site-wide: 32,094
  • Since beginning of last month:
    • Site-wide: 35,546

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

genomics more details view paper
  • Downloaded 760 times
  • Download rankings, all-time:
    • Site-wide: 29,090
    • In genomics: 2,677
  • Year to date:
    • Site-wide: 100,888
  • Since beginning of last month:
    • Site-wide: 75,744

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

genomics more details view paper
  • Downloaded 747 times
  • Download rankings, all-time:
    • Site-wide: 29,857
    • In genomics: 2,733
  • Year to date:
    • Site-wide: 71,399
  • Since beginning of last month:
    • Site-wide: 67,805

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

genomics more details view paper
  • Downloaded 701 times
  • Download rankings, all-time:
    • Site-wide: 32,583
    • In genomics: 2,909
  • Year to date:
    • Site-wide: 112,577
  • Since beginning of last month:
    • Site-wide: 96,375

CCR5-del32 is not deleterious in the homozygous state in humans

genetics more details view paper
  • Downloaded 660 times
  • Download rankings, all-time:
    • Site-wide: 35,378
    • In genetics: 1,730
  • Year to date:
    • Site-wide: 59,830
  • Since beginning of last month:
    • Site-wide: 33,207

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

genetics more details view paper
  • Downloaded 633 times
  • Download rankings, all-time:
    • Site-wide: 37,304
    • In genetics: 1,816
  • Year to date:
    • Site-wide: 15,442
  • Since beginning of last month:
    • Site-wide: 6,776

An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease

genetics more details view paper
  • Downloaded 625 times
  • Download rankings, all-time:
    • Site-wide: 37,937
    • In genetics: 1,848
  • Year to date:
    • Site-wide: 14,433
  • Since beginning of last month:
    • Site-wide: 9,171

Identification of pathogenic variant enriched regions across genes and gene families

genetics more details view paper
  • Downloaded 616 times
  • Download rankings, all-time:
    • Site-wide: 38,630
    • In genetics: 1,884
  • Year to date:
    • Site-wide: 71,237
  • Since beginning of last month:
    • Site-wide: 52,155

Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

genomics more details view paper
  • Downloaded 608 times
  • Download rankings, all-time:
    • Site-wide: 39,218
    • In genomics: 3,317
  • Year to date:
    • Site-wide: 52,271
  • Since beginning of last month:
    • Site-wide: 44,005

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

genomics more details view paper
  • Downloaded 576 times
  • Download rankings, all-time:
    • Site-wide: 41,984
    • In genomics: 3,466
  • Year to date:
    • Site-wide: 47,558
  • Since beginning of last month:
    • Site-wide: 37,656

Evaluation of copy number burden in specific epilepsy types from a genome-wide study of 18,564 subjects

genetics more details view paper
  • Downloaded 557 times
  • Download rankings, all-time:
    • Site-wide: 43,801
    • In genetics: 2,107
  • Year to date:
    • Site-wide: 65,203
  • Since beginning of last month:
    • Site-wide: 76,497

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

genomics more details view paper
  • Downloaded 490 times
  • Download rankings, all-time:
    • Site-wide: 50,994
    • In genomics: 4,009
  • Year to date:
    • Site-wide: 92,075
  • Since beginning of last month:
    • Site-wide: None

Whole genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

genetics more details view paper
  • Downloaded 477 times
  • Download rankings, all-time:
    • Site-wide: 52,595
    • In genetics: 2,492
  • Year to date:
    • Site-wide: 118,658
  • Since beginning of last month:
    • Site-wide: 99,672

Communicating polygenic and non-genetic risk for atherosclerotic cardiovascular disease - An observational follow-up study

genetic and genomic medicine more details view paper
  • Downloaded 418 times
  • Download rankings, all-time:
    • Site-wide: 60,561
    • In genetic and genomic medicine: 181
  • Year to date:
    • Site-wide: 40,169
  • Since beginning of last month:
    • Site-wide: 47,456

High heritability of ascending aortic diameter and multi-ethnic prediction of thoracic aortic disease.

cardiovascular medicine more details view paper
  • Downloaded 374 times
  • Download rankings, all-time:
    • Site-wide: 67,413
    • In cardiovascular medicine: 98
  • Year to date:
    • Site-wide: 27,471
  • Since beginning of last month:
    • Site-wide: 20,865

An efficient and accurate frailty model approach for genome-wide survival association analysis controlling for population structure and relatedness in large-scale biobanks

genomics more details view paper
  • Downloaded 352 times
  • Download rankings, all-time:
    • Site-wide: 70,992
    • In genomics: 4,930
  • Year to date:
    • Site-wide: 8,509
  • Since beginning of last month:
    • Site-wide: 9,279

Reassessment Of Lesion-Associated Gene And Variant Pathogenicity In Focal Human Epilepsies

genetics more details view paper
  • Downloaded 339 times
  • Download rankings, all-time:
    • Site-wide: 73,344
    • In genetics: 3,413
  • Year to date:
    • Site-wide: 67,222
  • Since beginning of last month:
    • Site-wide: 92,083

ANGPTL8 protein-truncating variant and the risk of coronary disease, type 2 diabetes and adverse effects

genetic and genomic medicine more details view paper
  • Downloaded 317 times
  • Download rankings, all-time:
    • Site-wide: 77,470
    • In genetic and genomic medicine: 241
  • Year to date:
    • Site-wide: 56,404
  • Since beginning of last month:
    • Site-wide: 58,963

High-resolution population-specific recombination rates and their effect on phasing and genotype imputation

genomics more details view paper
  • Downloaded 316 times
  • Download rankings, all-time:
    • Site-wide: 77,572
    • In genomics: 5,185
  • Year to date:
    • Site-wide: 91,340
  • Since beginning of last month:
    • Site-wide: 72,124

Polygenic Hyperlipidemias and Coronary Artery Disease Risk

genomics more details view paper
  • Downloaded 291 times
  • Download rankings, all-time:
    • Site-wide: 82,633
    • In genomics: 5,358
  • Year to date:
    • Site-wide: 70,577
  • Since beginning of last month:
    • Site-wide: 82,797

Coronary artery disease risk and lipidomic profiles are similar in familial and population-ascertained hyperlipidemias

epidemiology more details view paper
  • Downloaded 275 times
  • Download rankings, all-time:
    • Site-wide: 85,797
    • In epidemiology: 3,512
  • Year to date:
    • Site-wide: 81,209
  • Since beginning of last month:
    • Site-wide: 77,045

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

genetic and genomic medicine more details view paper
  • Downloaded 272 times
  • Download rankings, all-time:
    • Site-wide: 86,489
    • In genetic and genomic medicine: 285
  • Year to date:
    • Site-wide: 3,106
  • Since beginning of last month:
    • Site-wide: 4,626

Association of Structural Variation with Cardiometabolic Traits in Finns

genetics more details view paper
  • Downloaded 240 times
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    • Site-wide: 93,293
    • In genetics: 4,259
  • Year to date:
    • Site-wide: 14,072
  • Since beginning of last month:
    • Site-wide: 11,185

Mitochondrial genome copy number in human blood-derived DNA is strongly associated with insulin levels and related metabolic traits and primarily reflects cell-type composition differences

genetic and genomic medicine more details view paper
  • Downloaded 135 times
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    • Site-wide: 115,049
    • In genetic and genomic medicine: 505
  • Year to date:
    • Site-wide: 36,882
  • Since beginning of last month:
    • Site-wide: 23,136

Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal Structure

genetic and genomic medicine more details view paper
  • Downloaded 123 times
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    • Site-wide: 117,333
    • In genetic and genomic medicine: 523
  • Year to date:
    • Site-wide: 60,257
  • Since beginning of last month:
    • Site-wide: 72,714

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