Author: Andres Metspalu

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Preprints

Genetic insights into the biological mechanisms governing human ovarian ageing

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Genomewide association study identifies 30 loci associated with bipolar disorder

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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Improved polygenic prediction by Bayesian multiple regression on summary statistics

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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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Genome-wide association study identifies 48 common genetic variants associated with handedness

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Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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Widespread signatures of negative selection in the genetic architecture of human complex traits

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Cell specific eQTL analysis without sorting cells

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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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Haplotype sharing provides insights into fine-scale population history and disease in Finland

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The genetic architecture of sporadic and recurrent miscarriage

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Mega-analysis of 31,396 individuals from 6 countries uncovers strong gene-environment interaction for human fertility

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An epigenome-wide association study of educational attainment (n = 10,767)

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A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

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Personalized Risk Prediction for Type 2 Diabetes: the Potential of Genetic Risk Scores

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An interaction map of circulating metabolites, immune gene networks and their genetic regulation

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Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

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Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

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Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

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The effect of X-linked dosage compensation on complex trait variation

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Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

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Polygenic prediction of breast cancer: comparison of genetic predictors and implications for screening

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Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

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PAIRUP-MS: Pathway Analysis and Imputation to Relate Unknowns in Profiles from Mass Spectrometry-based metabolite data

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Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

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Search for early pancreatic cancer blood biomarkers in five European prospective population biobanks using metabolomics

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Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome

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Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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The landscape of autosomal-recessive pathogenic variants in European populations reveals phenotype-specific effects

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Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants

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Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal Structure

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Mendelian randomization identifies the potential causal impact of dietary patterns on circulating blood metabolites

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