Author: Andres Metspalu

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 871
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  • Site-wide: 31,719
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  • Site-wide: 34,194

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,202
  • In genetics: 38
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  • Site-wide: 18,677
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  • Site-wide: 18,516

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 3,701
  • In genomics: 418
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  • Site-wide: 60,042
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  • Site-wide: 44,065

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,083 times
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  • Site-wide: 3,982
  • In genetics: 168
• Year to date:
  • Site-wide: 54,712
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  • Site-wide: 72,766

Improved polygenic prediction by Bayesian multiple regression on summary statistics

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  • Site-wide: 4,624
  • In genetics: 204
• Year to date:
  • Site-wide: 68,200
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  • Site-wide: 75,019

Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 5,173
  • In genetics: 236
• Year to date:
  • Site-wide: 22,619
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  • Site-wide: 27,712

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • Site-wide: 5,352
  • In genetics: 246
• Year to date:
  • Site-wide: 92,258
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  • Site-wide: 90,534

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • Site-wide: 6,102
  • In genetics: 287
• Year to date:
  • Site-wide: 108,325
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  • Site-wide: 90,615

Widespread signatures of negative selection in the genetic architecture of human complex traits

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  • Site-wide: 6,287
  • In genetics: 298
• Year to date:
  • Site-wide: 42,038
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  • Site-wide: 23,497

Cell specific eQTL analysis without sorting cells

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  • Site-wide: 7,445
  • In genetics: 350
• Year to date:
  • Site-wide: 104,218
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  • Site-wide: 88,943

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 8,411
  • In genetics: 395
• Year to date:
  • Site-wide: 88,437
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  • Site-wide: 90,901

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 8,833
  • In genetics: 415
• Year to date:
  • Site-wide: 48,558
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  • Site-wide: 57,037

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

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  • Site-wide: 9,454
  • In genetics: 453
• Year to date:
  • Site-wide: 75,470
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  • Site-wide: 81,312

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

• Downloaded 1,641 times
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  • Site-wide: 10,060
  • In genetics: 483
• Year to date:
  • Site-wide: 86,644
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  • Site-wide: 105,522

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 11,939
  • In genomics: 1,296
• Year to date:
  • Site-wide: 75,133
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  • Site-wide: 76,229

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 15,262
  • In genomics: 1,581
• Year to date:
  • Site-wide: 88,594
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  • Site-wide: 119,369

The genetic architecture of sporadic and recurrent miscarriage

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  • Site-wide: 17,167
  • In genetics: 838
• Year to date:
  • Site-wide: 42,770
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  • Site-wide: 32,303

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

• Downloaded 1,121 times
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  • Site-wide: 17,756
  • In hiv aids: 8
• Year to date:
  • Site-wide: 8,111
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  • Site-wide: 5,744

Haplotype sharing provides insights into fine-scale population history and disease in Finland

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  • Site-wide: 17,800
  • In genetics: 872
• Year to date:
  • Site-wide: 66,193
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  • Site-wide: 53,305

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 18,709
  • In genetic and genomic medicine: 64
• Year to date:
  • Site-wide: 7,899
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  • Site-wide: 9,771

Mega-analysis of 31,396 individuals from 6 countries uncovers strong gene-environment interaction for human fertility

• Downloaded 1,031 times
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  • Site-wide: 20,098
  • In genomics: 2,018
• Year to date:
  • Site-wide: 94,122
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  • Site-wide: 96,538

An epigenome-wide association study of educational attainment (n = 10,767)

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  • Site-wide: 21,098
  • In genetics: 1,016
• Year to date:
  • Site-wide: 63,669
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  • Site-wide: 62,670

Personalized Risk Prediction for Type 2 Diabetes: the Potential of Genetic Risk Scores

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  • Site-wide: 26,539
  • In genetics: 1,279
• Year to date:
  • Site-wide: 67,925
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  • Site-wide: 73,284

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

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  • Site-wide: 27,038
  • In genetics: 1,309
• Year to date:
  • Site-wide: 73,125
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  • Site-wide: 63,760

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 794 times
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  • Site-wide: 29,177
  • In genetics: 1,415
• Year to date:
  • Site-wide: 14,350
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  • Site-wide: 11,103

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

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  • Site-wide: 30,641
  • In genomics: 2,754
• Year to date:
  • Site-wide: 111,039
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  • Site-wide: 91,351

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

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  • Site-wide: 31,207
  • In genetics: 1,504
• Year to date:
  • Site-wide: 133,716
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  • Site-wide: 129,116

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 31,499
  • In genomics: 2,813
• Year to date:
  • Site-wide: 95,856
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  • Site-wide: 110,540

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

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  • Site-wide: 32,196
  • In genomics: 2,851
• Year to date:
  • Site-wide: 117,005
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  • Site-wide: 130,966

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • Site-wide: 32,633
  • In genetics: 1,580
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  • Site-wide: 12,470
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  • Site-wide: 8,624

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

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  • Site-wide: 35,448
  • In genetic and genomic medicine: 109
• Year to date:
  • Site-wide: 9,840
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  • Site-wide: 10,714

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

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  • Site-wide: 38,274
  • In genetics: 1,823
• Year to date:
  • Site-wide: 124,680
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  • Site-wide: 110,374

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

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  • Site-wide: 42,595
  • In genomics: 3,488
• Year to date:
  • Site-wide: 52,114
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  • Site-wide: 42,274

Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 43,632
  • In sexual and reproductive health: 18
• Year to date:
  • Site-wide: 2,396
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  • Site-wide: 7,479

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

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  • Site-wide: 45,470
  • In genetics: 2,148
• Year to date:
  • Site-wide: 53,231
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  • Site-wide: 58,375

The effect of X-linked dosage compensation on complex trait variation

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  • Site-wide: 49,302
  • In genetics: 2,305
• Year to date:
  • Site-wide: 124,696
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  • Site-wide: 91,190

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for screening

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  • Site-wide: 51,162
  • In genetics: 2,389
• Year to date:
  • Site-wide: 98,883
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  • Site-wide: 91,291

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

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  • Site-wide: 52,113
  • In genomics: 4,039
• Year to date:
  • Site-wide: 120,314
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  • Site-wide: 118,010

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

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  • Site-wide: 65,088
  • In genetic and genomic medicine: 208
• Year to date:
  • Site-wide: 36,344
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  • Site-wide: 36,966

PAIRUP-MS: Pathway Analysis and Imputation to Relate Unknowns in Profiles from Mass Spectrometry-based metabolite data

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  • Site-wide: 67,970
  • In bioinformatics: 6,555
• Year to date:
  • Site-wide: 112,148
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  • Site-wide: 105,252

Search for early pancreatic cancer blood biomarkers in five European prospective population biobanks using metabolomics

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  • Site-wide: 77,261
  • In epidemiology: 3,220
• Year to date:
  • Site-wide: 128,407
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  • Site-wide: 111,943

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome

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  • Site-wide: 78,681
  • In bioinformatics: 7,219
• Year to date:
  • Site-wide: 106,746
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  • Site-wide: 111,434

The landscape of autosomal-recessive pathogenic variants in European populations reveals phenotype-specific effects

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  • Site-wide: 82,411
  • In genetics: 3,734
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  • Site-wide: 20,619
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  • Site-wide: 8,482

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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  • Site-wide: 104,957
  • In genomics: 6,136
• Year to date:
  • Site-wide: 97,646
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  • Site-wide: 76,476

Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants

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  • Site-wide: 112,879
  • In genetic and genomic medicine: 505
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  • Site-wide: 72,744
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  • Site-wide: 51,544

Genome-wide Screen of Otosclerosis in Population Biobanks: 18 Loci and Shared Heritability with Skeletal Structure

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  • Site-wide: 115,103
  • In genetic and genomic medicine: 529
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  • Site-wide: 42,212
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  • Site-wide: 26,168

Mendelian randomization identifies the potential causal impact of dietary patterns on circulating blood metabolites

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  • Site-wide: 117,243
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