Author: Claudia Langenberg

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Preprints

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

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Estimating excess 1- year mortality from COVID-19 according to underlying conditions and age in England: a rapid analysis using NHS health records in 3.8 million adults

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  • Site-wide: 1,108
  • In public and global health: 45
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Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics

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  • Site-wide: 1,655
  • In infectious diseases: 407
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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 3,682
  • In genomics: 415
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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,959
  • In genetics: 168
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Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

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  • Site-wide: 5,220
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A Neanderthal OAS1 Isoform Protects Against COVID-19 Susceptibility and Severity: Results from Mendelian Randomization and Case-Control Studies

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  • Site-wide: 6,211
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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 8,350
  • In genetics: 392
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Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

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  • Site-wide: 9,093
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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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  • Site-wide: 10,569
  • In genomics: 1,145
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  • Site-wide: 72,630
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  • Site-wide: 84,057

Genetic architecture of host proteins interacting with SARS-CoV-2

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  • Site-wide: 10,761
  • In genomics: 1,174
• Year to date:
  • Site-wide: 9,724
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  • Site-wide: 8,746

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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  • Site-wide: 11,704
  • In genetics: 569
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  • Site-wide: 86,864
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  • Site-wide: 102,692

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 12,474
  • In genetics: 612
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  • Site-wide: 86,100
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A Comprehensive Reanalysis Of Publicly Available GWAS Datasets Reveals An X Chromosome Rare Regulatory Variant Associated With High Risk For Type 2 Diabetes.

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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • In genomics: 1,573
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  • Site-wide: 115,551

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 18,583
  • In genetic and genomic medicine: 64
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  • Site-wide: 8,431

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

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  • Site-wide: 19,659
  • In systems biology: 400
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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 26,774
  • In genetics: 1,301
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  • Site-wide: 27,620
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  • Site-wide: 20,730

High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease

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  • Site-wide: 27,696
  • In epidemiology: 1,465
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  • Site-wide: 23,726
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  • Site-wide: 12,022

rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

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  • Site-wide: 28,869
  • In gastroenterology: 22
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  • Site-wide: 30,427
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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 29,022
  • In genetics: 1,402
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  • Site-wide: 13,500
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  • Site-wide: 9,546

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 31,383
  • In genomics: 2,802
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  • Site-wide: 109,877

Cross-platform proteomics to advance genetic prioritisation strategies

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  • Site-wide: 32,992
  • In genetics: 1,597
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  • Site-wide: 1,677
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  • Site-wide: 454

Genetic Disruption of Serine Biosynthesis is a Key Driver of Macular Telangiectasia Type 2 Etiology and Progression

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  • Site-wide: 34,099
  • In genetics: 1,642
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  • Site-wide: 22,148
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  • Site-wide: 36,141

Genome-wide scan and fine-mapping of rare nonsynonymous associations implicates intracellular lipolysis genes in fat distribution and cardio-metabolic risk

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  • Site-wide: 34,978
  • In genetics: 1,680
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  • Site-wide: 62,980
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  • Site-wide: 51,676

Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes

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  • Site-wide: 41,237
  • In genomics: 3,410
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  • Site-wide: 21,553
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  • Site-wide: 26,601

Genetic insights into the biological mechanisms governing human ovarian ageing

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  • Site-wide: 43,415
  • In sexual and reproductive health: 18
• Year to date:
  • Site-wide: 2,262
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  • Site-wide: 6,396

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

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  • Site-wide: 44,578
  • In genetics: 2,090
• Year to date:
  • Site-wide: 68,927
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  • Site-wide: 109,516

Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study

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  • Site-wide: 49,460
  • In genetic and genomic medicine: 156
• Year to date:
  • Site-wide: 29,687
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  • Site-wide: 31,842

Weight change and the incidence of cardiovascular diseases in adults with normal weight, overweight and obesity without chronic diseases; emulating trials using electronic health records

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  • Site-wide: 63,009
  • In cardiovascular medicine: 89
• Year to date:
  • Site-wide: 38,315
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  • Site-wide: 29,625

Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

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  • Site-wide: 64,314
  • In epidemiology: 2,745
• Year to date:
  • Site-wide: 91,137
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  • Site-wide: 85,338

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

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  • Site-wide: 65,389
  • In genetic and genomic medicine: 212
• Year to date:
  • Site-wide: 24,509
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  • Site-wide: 25,407

Actionable druggable genome-wide Mendelian randomization identifies repurposingopportunities for COVID-19

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  • Site-wide: 66,946
  • In epidemiology: 2,850
• Year to date:
  • Site-wide: 15,498
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  • Site-wide: 18,694

Body mass index and heart failure risk: a cohort study in 1.5 million individuals and Mendelian randomisation analysis

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  • Site-wide: 83,917
  • In cardiovascular medicine: 135
• Year to date:
  • Site-wide: 54,203
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  • Site-wide: 66,204

Regional fat depot masses are influenced by protein-coding gene variants

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  • Site-wide: 99,534
  • In genomics: 5,966
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  • Site-wide: 131,795
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  • Site-wide: 130,379

Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap

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  • Site-wide: 110,764
  • In genetic and genomic medicine: 487
• Year to date:
  • Site-wide: 33,099
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  • Site-wide: 21,851

Estimating the Population Benefits of Blood Pressure Lowering: A Wide-Angled Mendelian Randomization Study in UK Biobank

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  • Site-wide: 114,627
  • In epidemiology: 4,720
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  • Site-wide: 13,647
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Identifying high-risk groups for change in weight and body mass index: population cohort of 11 million measurements in 2.3 million adults

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  • Site-wide: 126,049
  • In epidemiology: 5,094
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  • Site-wide: 23,616
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Development and validation of total and regional body composition prediction equations from anthropometry and single frequency segmental bioelectrical impedance with DEXA.

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  • Site-wide: 131,729
  • In epidemiology: 5,330
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