Author: Claudia Langenberg

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Preprints

Identifying high-risk groups for change in weight and body mass index: population cohort of 11 million measurements in 2.3 million adults

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Genetic insights into the biological mechanisms governing human ovarian ageing

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Estimating excess 1- year mortality from COVID-19 according to underlying conditions and age in England: a rapid analysis using NHS health records in 3.8 million adults

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Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics

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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

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A Neanderthal OAS1 Isoform Protects Against COVID-19 Susceptibility and Severity: Results from Mendelian Randomization and Case-Control Studies

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Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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Genetic architecture of host proteins interacting with SARS-CoV-2

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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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A Comprehensive Reanalysis Of Publicly Available GWAS Datasets Reveals An X Chromosome Rare Regulatory Variant Associated With High Risk For Type 2 Diabetes.

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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

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  • Site-wide: 17,781
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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease

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rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

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Genome-wide scan and fine-mapping of rare nonsynonymous associations implicates intracellular lipolysis genes in fat distribution and cardio-metabolic risk

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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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Genetic Disruption of Serine Biosynthesis is a Key Driver of Macular Telangiectasia Type 2 Etiology and Progression

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Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

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Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes

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Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study

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Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

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Weight change and the incidence of cardiovascular diseases in adults with normal weight, overweight and obesity without chronic diseases; emulating trials using electronic health records

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  • Site-wide: 66,233
  • In cardiovascular medicine: 91
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Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

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  • Site-wide: 74,486
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Actionable druggable genome-wide Mendelian randomization identifies repurposingopportunities for COVID-19

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Body mass index and heart failure risk: a cohort study in 1.5 million individuals and Mendelian randomisation analysis

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Regional fat depot masses are influenced by protein-coding gene variants

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Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap

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Development and validation of total and regional body composition prediction equations from anthropometry and single frequency segmental bioelectrical impedance with DEXA.

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